References of "Reginster, Jean-Yves"
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See detailThe effect of health related quality of life on reported use of health care resources in patients with osteoarthritis and rheumatoid arthritis: a longitudinal analysis.
Ethgen, Olivier ULiege; Kahler, Kristijan H; Kong, Sheldon X et al

in Journal of Rheumatology (2002), 29(6), 1147-55

OBJECTIVE: In today's cost conscious environment, health services researchers are consistently trying to find ways to predict future health care resource utilization (HCRU) and its associated costs. We ... [more ▼]

OBJECTIVE: In today's cost conscious environment, health services researchers are consistently trying to find ways to predict future health care resource utilization (HCRU) and its associated costs. We evaluated the impact of health related quality of life (HRQL) on future HCRU in patients with arthritis. METHODS: A total of 642 patients with rheumatoid arthritis (RA) and 395 patients with osteoarthritis (OA) completed at least 2 and as many as 6 consecutive surveys at 6 mo intervals. Information collected included demographics, HRQL questionnaires [Medical Outcome Study Short Form 36 (SF-36), Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), and the Stanford Health Assessment Questionnaire (HAQ)], and HCRU over the previous 6 months. Longitudinal data analysis was perfomed to assess the effect of HRQL on future HCRU. RESULTS: Statistically significant associations between HCRU and HRQL variables were noted. Higher rates of HCRU were found in those in the worst quarter compared with those in the best quarter of HRQL. With the HAQ, OA and RA patients in the worst quarter reported a 199% (p < 0.05) and 48% (p < 0.05) increase in rheumatologist visits, respectively. With the WOMAC Function, increases were as high as 196% (p < 0.05) in rheumatologist visits for patients with OA. Patients with RA with a high level of HRQL as measured by the SF-36 (physical component score) reported a decrease of 31% (p < 0.01) in general practitioner visits and a decrease of 52% (p < 0.01) in hospitalization (mental component score). CONCLUSION: These findings suggest that HRQL may be used to predict future health care consumption. Such an approach may lead to a more efficient allocation of resources by providing useful information to health care providers and health care decision makers. [less ▲]

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See detailCharacterization of the Metabolism of Osteoarthritic Chondrocytes Cultured in Alginate Beads
Sanchez, Christelle ULiege; Mathy, Marianne ULiege; Deberg, Michelle ULiege et al

in Osteoarthritis and Cartilage (2002), 10(SA), 34

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See detailStructure-modifying drugs in osteoarthritis
Reginster, Jean-Yves ULiege; Kvasz, Angela ULiege

in Osteoporosis International (2002), 13(Suppl. 1), 49-50

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See detailStrontium ranelate réduit le risque de fracture vertébrale chez des patientes traitées 3 ans pour ostéoporose postménopausique
Meunier, P. J.; Roux, C.; Fardellone, P. et al

in Revue du Rhumatisme (2002), 69

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See detailUsing the OST index to identify women at risk of osteoporosis : a validation study in Belgium
Ben Sedrine, Wafa ULiege; Reginster, Jean-Yves ULiege

in Osteoporosis International (2002), 13(S1), 109-110

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See detailPrediction of bone mineral density by estrogens precursors, estradiol, SHBG and BMI in elderly women at risk for osteoporotic fractures
Goemaere, S.; Zmierczak, H.; Van Pottelbergh, I. et al

in Osteoporosis International (2002), 13(S1), 102

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See detailComparison of quantitative ultrasound at the heel with a clinical risk factor score for the assessment of postmenopausal osteoporosis
Goemaere, S.; Zmierczak, H.; Lauwerier, D. et al

in Osteoporosis International (2002), 13(S1), 73-74

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See detailThe effect on bone turnover of monofluorophosphate (MFP) combined with raloxifene (RLX) as compared to MFP alone in postmenopausal women with low bone mass
Stepan, J.; Payer, J.; Resch, H. et al

in Osteoporosis International (2002), 13(S1), 54

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See detailA short-term run-in study can significantly contribute to increasing the quality of long-term osteoporosis trials. The strontium-ranelate phase 3 program
Reginster, Jean-Yves ULiege; Spector, T.; Badurski, J. et al

in Osteoporosis International (2002), 13(S1), 30

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See detailCalcium-vitamin D supplementation in clinical trials of osteoporosis should be titrated on the basis of pre-study assessments
Reginster, Jean-Yves ULiege; Diez-Perez, A.; Ortolani, S. et al

in Osteoporosis International (2002), 13(S1), 24

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See detailBMD and fracture effects of monofluorophosphate (MFP) combined with raloxifene (RLX) as compared to MFP alone in postmenopausal women with low bone mass
Reginster, Jean-Yves ULiege; Felsenberg, D.; Gluer, C. C. et al

in Osteoporosis International (2002), 13(S1), 18-19

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See detailOnce weekly alendronate produces a greater decrease in bone resorption than daily risedronate
Hosking, D.; Adami, S.; Felsenberg, D. et al

in Osteoporosis International (2002), 13(S1), 18

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See detailExpression of TGF-betas and their receptors is differentially modulated by reactive oxygen species and nitric oxide in human articular chondrocytes.
Ayache, N.; Boumediene, K.; Mathy, Marianne ULiege et al

in Osteoarthritis and Cartilage (2002), 10(5), 344-52

OBJECTIVES: To study the effects exerted by two antioxidants, N-monomethyl-L-arginine (L-NMMA), as an inhibitor of nitric oxide (NO) synthesis, and N-acetylcysteine (NAC), a reactive oxygen species (ROS ... [more ▼]

OBJECTIVES: To study the effects exerted by two antioxidants, N-monomethyl-L-arginine (L-NMMA), as an inhibitor of nitric oxide (NO) synthesis, and N-acetylcysteine (NAC), a reactive oxygen species (ROS) scavenger, on the expression of the major growth factor involved in cartilage repair, TGF-beta, under the three isoforms beta1, beta2 and beta3, and the receptors I and II of this factor, using lipopolysaccharide (LPS)-treated human chondrocytes in culture. METHODS: Suspension cultures of human chondrocytes derived from the knee of osteoarthritic patients were treated for 48 h with lipopolysaccharide (LPS) (10 microg/ml), L-NMMA (0.5 mM) or NAC (1 mM). Nitrite levels were assayed on the culture media using the Griess spectrophotometric method. After total RNA extraction, the expression of inducible NO synthase (iNOS), TGF-beta1, TGF-beta2, TGF-beta3, TGF-beta receptors I and II, was determined by semi-quantitative polymerase chain-reaction (RT-PCR). RESULTS: LPS induced a dramatic increase of both NO production and iNOS mRNA level. The addition of L-NMMA (0.5 mM) abolished NO production without affecting iNOS mRNA levels. In contrast NAC (1 mM) strongly synergized with LPS to stimulate NO synthesis. LPS treatment did not significantly alter TGF-beta1 expression whereas L-NMMA inhibited its production. TGF-beta2 mRNA level was decreased by LPS and was not changed in the presence of L-NMMA. On the other hand, NAC was capable of counteracting the LPS-induced inhibition of TGF-beta2 expression. TGFbeta3 mRNA level was markedly reduced by LPS alone, or with both L-NMMA and NAC. Finally, the expression of TGF-betaRI was slightly increased in the presence of combined LPS and L-NMMA or NAC whereas that of TGFbeta-RII was reduced in the same conditions. CONCLUSIONS: The modulation of TGF-beta system was found to be differentially controlled by NO and ROS productions. Indeed, the control exerted on TGF-beta expression varied according to the isoform: TGF-beta1 mRNA level depends on NO whereas that of TGF-beta2 is regulated by ROS and TGF-beta3 seems to be unaffected by both of them. The expression of TGF-beta receptors appeared to be modulated by NO and ROS levels. The relevance of the present findings to osteoarthritis (OA) physiopathology and the potential use of antioxidant therapy to treat this disease are discussed. [less ▲]

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See detailRegulation by reactive oxygen species of pro-inflammatory genes in chondrocytes
Henrotin, Yves ULiege; Mathy, Marianne ULiege; Sanchez, Christelle ULiege et al

in Osteoarthritis and Cartilage (2002), 10(Suppl A), 34

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See detailAccompagnement ambulatoire des patients à haut risque de réhospitalisation et/ou institutionnalisation.
Counet, Laurence ULiege; de Froidmont, C.; Filée, D. et al

Report (2002)

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