References of "Reginster, Jean-Yves"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailRepublished: Value of biomarkers in osteoarthritis: current status and perspectives.
Lotz, M.; Martel-Pelletier, J.; Christiansen, C. et al

in Postgraduate Medical Journal (2014), 90(1061), 171-8

Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint ... [more ▼]

Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article was prepared following a working meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis convened to discuss the value of biochemical markers of matrix metabolism in drug development in osteoarthritis. The best candidates are generally molecules or molecular fragments present in cartilage, bone or synovium and may be specific to one type of joint tissue or common to them all. Many currently investigated biomarkers are associated with collagen metabolism in cartilage or bone, or aggrecan metabolism in cartilage. Other biomarkers are related to non-collagenous proteins, inflammation and/or fibrosis. Biomarkers in osteoarthritis can be categorised using the burden of disease, investigative, prognostic, efficacy of intervention, diagnostic and safety classification. There are a number of promising candidates, notably urinary C-terminal telopeptide of collagen type II and serum cartilage oligomeric protein, although none is sufficiently discriminating to differentiate between individual patients and controls (diagnostic) or between patients with different disease severities (burden of disease), predict prognosis in individuals with or without osteoarthritis (prognostic) or perform so consistently that it could function as a surrogate outcome in clinical trials (efficacy of intervention). Future avenues for research include exploration of underlying mechanisms of disease and development of new biomarkers; technological development; the 'omics' (genomics, metabolomics, proteomics and lipidomics); design of aggregate scores combining a panel of biomarkers and/or imaging markers into single diagnostic algorithms; and investigation into the relationship between biomarkers and prognosis. [less ▲]

Detailed reference viewed: 21 (10 ULg)
Full Text
Peer Reviewed
See detailCorrection of vitamin D insufficiency with combined strontium ranelate and vitamin D3 in osteoporotic patients.
Rizzoli, R.; Dawson-Hughes, B.; Kaufman, J.-M. et al

in European Journal of Endocrinology (2014), 170(3), 441-50

OBJECTIVE: This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D ... [more ▼]

OBJECTIVE: This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D insufficiency in osteoporosis. DESIGN: A 6-month international, randomized, double-blind, parallel-group, phase 3 study. METHODS: A total of 518 men and postmenopausal women aged >/=50 years with primary osteoporosis (T-score </=-2.5 s.d.) and serum 25-hydroxyvitamin D (25(OH)D) >22.5 nmol/l were included. Patients were allocated to strontium ranelate 2 g/vitamin D3 1000 IU daily (n=413) or strontium ranelate 2 g daily (n=105). The participants received calcium 1 g daily. The primary endpoint was serum 25(OH)D at last post-baseline evaluation during 3 months. RESULTS: Both groups were comparable at baseline. Mean baseline of 25(OH)D was 44.1+/-14.6 nmol/l. After 3 months, the percentage of patients with 25(OH)D >/=50 nmol/l was higher with strontium ranelate/vitamin D3 vs strontium ranelate (84 vs 44%, P<0.001; adjusted between-group odds ratio=6.7; 95% CI, 4.2-10.9). The efficacy of the fixed-dose combination on 25(OH)D was maintained at 6 months (86 vs 40%, P<0.001). Mean 25(OH)D was 65.1 and 49.5 nmol/l, respectively, after 3 months and 66.9 and 45.4 nmol/l after 6 months. Physical performance improved in both groups. Falls were 17 and 20% in the strontium ranelate/vitamin D3 and strontium ranelate groups respectively. Parathyroid hormone levels were inversely correlated with 25(OH)D. No clinically relevant differences in safety were observed. CONCLUSIONS: This study confirms the efficacy and safety of fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU for correction of vitamin D insufficiency in osteoporotic patients. [less ▲]

Detailed reference viewed: 18 (4 ULg)
Full Text
Peer Reviewed
See detailCardiovascular safety of strontium ranelate: real-life assessment in clinical practice.
Donneau, Anne-Françoise ULg; Reginster, Jean-Yves ULg

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25

Detailed reference viewed: 25 (15 ULg)
Full Text
Peer Reviewed
See detailResponse to Dr Bolland's eLetter: Strontium and cardiovascular events.
REGINSTER, Jean-Yves ULg

in Annals of the rheumatic diseases (2014), 73(2), 9

Detailed reference viewed: 7 (2 ULg)
Full Text
Peer Reviewed
See detailLong-term fracture rates seen with continued ibandronate treatment : pooled analysis of DIVA and MOBILE long-term extension studies
Miller, PD; Recker, RR; Harris, S et al

in Osteoporosis International (2014), 25(1), 349-357

Detailed reference viewed: 34 (3 ULg)
Full Text
Peer Reviewed
See detailOsteonecrosis of the jaw in a male osteoporotic patient treated with denosumab
NEUPREZ, Audrey ULg; Coste, S; Rompen, Eric ULg et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the ... [more ▼]

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the receptor activator of nuclear factor kappa-B ligand. It prevents osteoclast-mediated bone resorption and is widely prescribed for the management of postmenopausal osteoporosis. Whereas ONJ has already been reported in women treated with DMab, we report for the first time the development of ONJ, following tooth extraction, in a male patient treated for idiopathic osteoporosis with DMab. Due to the constant increase in DMab prescription, for the management of osteoporosis, in both genders, physicians should be made aware of this potential risk. [less ▲]

Detailed reference viewed: 46 (14 ULg)
Full Text
Peer Reviewed
See detailLe tradipraticien est un acteur crédible dans l'offre des soins en territoire périurbain: Résultats d'une étude menée dans la commune de Kisenso à Kinshasa, Congo
Manzambi Kuwekita, Joseph ULg; Mbadu Kivuidi, Véronique; Bruyère, Olivier ULg et al

Conference (2013, December 19)

Cette étude examine la perception des tradipraticiens par les populations, afin d’envisager leur intégration dans les politiques de développement de Kisenso par des focus groupes en juillet 2013. 100% de ... [more ▼]

Cette étude examine la perception des tradipraticiens par les populations, afin d’envisager leur intégration dans les politiques de développement de Kisenso par des focus groupes en juillet 2013. 100% de participants reconnaissent l’existence de tradipraticiens et les avoir déjà consultés, 80% déclarent avoir expérimenté la guérison totale. Le recours au tradipraticien est justifié par l’efficacité des soins, le type de maladie, la compétence, la proximité et la possibilité de paiement à crédit. Pour 70% des participants, le tradipraticien doit améliorer les conditions d’hygiène dans la manipulation des produits. La quasi-totalité des tradipraticiens ne sont pas autorisés à fonctionner, dû notamment au coût d’actes administratifs pour l’obtention de l’autorisation et la peur de s’ouvrir aux intellectuels. 20% d’entre eux disent collaborer avec la biomédecine pour les soins de "mbasu", 20% se déclarent spécialistes en ostéologie, 20% dans les soins de "mbasu" et 60% disent tout soigner. Si l’on veut intégrer les tradipraticiens dans les politiques de développement local, on devra supprimer le coût d’actes administratifs, leur accorder des formations, intégrer les soins traditionnels dans les paquets d’activités et leur accorder le statut d’agent de l’Etat. [less ▲]

Detailed reference viewed: 98 (15 ULg)
Full Text
Peer Reviewed
See detailLes acteurs non étatiques jouent un rôle déterminant dans le fonctionnement des services publics en territoires périurbains
Manzambi Kuwekita, Joseph ULg; Bruyère, Olivier ULg; REGINSTER, Jean-Yves ULg et al

Poster (2013, December 19)

Cette étude répertorie les acteurs étatiques et non étatiques qui offrent des services publics aux populations en territoire périurbain en vue d’améliorer leur intégration dans les politiques de ... [more ▼]

Cette étude répertorie les acteurs étatiques et non étatiques qui offrent des services publics aux populations en territoire périurbain en vue d’améliorer leur intégration dans les politiques de développement local de la commune périurbaine de Kisenso à Kinshasa, par des focus groups en juillet 2013. La question de recherche était : « quels sont les acteurs étatiques et non étatiques qui offrent les services publics en territoire périurbain, leurs rapports avec l’administration publique et comment envisager leur intégration dans les politiques de développement local » ? Les principaux résultats de cette étude montrent qu’à Kisenso, 5 acteurs étatiques et 75 acteurs non étatiques opèrent dans la commune de Kisenso, essentiellement dans les domaines suivants : santé, éducation, justice, social, environnement, énergie, PME, etc. en ce qui concerne les rapports qu’entretiennent les acteurs non étatiques avec l’Etat, (i) tous sont reconnus par la Commune car ils détiennent des autorisations délivrées par les instances de niveau national, (ii) ils ne rendent pas compte à la commune de leurs activités de manière formelle parce la loi ne les y oblige pas. 109 structures de santé sont fonctionnelles. Néanmoins, environ une trentaine d’ONGs transmettent leurs rapports d’activités à la Commune en fin d’année. De même, les acteurs non étatiques évoluant dans le secteur des soins de santé transmettent tous leurs rapports épidémiologiques, mais seulement 15/109 (soit 13,7%) rapportent sur les activités (SNIS). À la question de savoir pourquoi la population recourt aux services offerts par les différents acteurs, cette étude montre que les choix des populations pour un service ou un autre sont motivés essentiellement par la qualité de ces services, la compétence du personnel, l’efficacité, l’accueil, les coûts accessibles, l’accueil et la proximité du service avec le ménage. Quant à la manière d’intégrer les acteurs non étatiques dans les politiques de développement local, les acteurs ont proposé le processus suivant : (i) inventorier les structures et/ou les acteurs œuvrant dans la zone de santé et/ou la commune, (ii) faire les états des lieux pour identifier leur degré de fonctionnement, (iii) accorder les autorisations aux structures qui remplissent les conditions de fonctionnement, (iv) aider celles qui ne remplissent pas ces conditions à les remplir par la formation du personnel, la subvention des structures, etc.). Les résultats de cette recherche suggèrent que si l’on veut éviter que certains acteurs continuent à opérer dans la clandestinité pour des raisons d’ordre financier, à l’instar de tradipraticiens, ils devraient être exonérés de toutes taxes. Les résultats de cette recherche montrent que si l’on veut intégrer les acteurs non étatiques dans les politiques de développement local, les différentes autorités municipales devraient les associer, en amont, aux activités organisées telles la formation et la supervision, sans que cela ne leur soit facturé ; leur demander ensuite de rapporter sur leurs activités ne devrait plus entraîner de résistance. [less ▲]

Detailed reference viewed: 71 (11 ULg)
Full Text
Peer Reviewed
See detailÉtude des conditions de vie et d’accessibilité aux soins de santé de qualité des populations en situation de précarité, dans la zone de sante de Bandalungwa à Kinshasa (Congo) grâce à la micro-assurance santé en 2008.
Manzambi Kuwekita, Joseph ULg; Guillaume, Michèle ULg; Balula Semutsari, Marie-Paule et al

in Journal d’Épidémiologie et de Santé Publique (2013), 12

This study investigates the conditions under which populations living in poverty are able to accumulate savings and contribute to a micro-insurance health system to improve their living standards and ... [more ▼]

This study investigates the conditions under which populations living in poverty are able to accumulate savings and contribute to a micro-insurance health system to improve their living standards and access quality health care. We carried out a comprehensive survey in 2008 in the Bandalungwa health zone of Kinshasa. It was based on the Manzambi Model for health financing and the extension of social protection to the poor in developing countries. Each day, the leader of the group hands the members’ contributions to a loan officer. Two micro -entrepreneurs (3%) paid by these funds have disappeared, with the help of a loan officer. The main results of this study show that of all those contributing to the scheme, 78.1% improved their living conditions. 50% were able to start saving while 71.9% of these regularly contributed 1 US$ to the micro-insurance fund. 40.6% regularly contributed 1 US$ to the health micro-insurance fund, 88.5% of these improved their access to health care. When micro-credit promotes significant compulsory savings, the obligatory contribution of one dollar a day to the micro-insurance fund becomes easier and results in improved access to care (p<0.000) for household members. 68% of micro-entrepreneurs who paid their dues improved their purchasing power. If we want to keep people out of poverty, we must find a way to help them with these compulsory savings. The results of this study show that micro-entrepreneurs who have improved their living conditions also saw an improvement in their access to care (86.4%) (p=0.003). The Manzambi model provides a sustainable solution to the problem of health financing and extends social protection to fragile populations in developing countries. It also brings us closer to the objective of "health for all". [less ▲]

Detailed reference viewed: 226 (15 ULg)
Full Text
Peer Reviewed
See detailMicro-crédit, Augmentation du pouvoir d’achat et Amélioration des conditions de vie des populations précaires en milieu urbain africain : Résultats d’une expérience menée dans la zone de santé de Bandalungwa à Kinshasa, Congo.
Manzambi Kuwekita, Joseph ULg; Gosset, Christiane ULg; Guillaume, Michèle ULg et al

in Psychologie et Société Nouvelle (2013), XII(3), 3-14

Purchasing power increase, improvement of living conditions and health funding of vulnerable people in African urban areas: the case of the health zone of Bandalungwa, Kinshasa (Congo) Through a survey ... [more ▼]

Purchasing power increase, improvement of living conditions and health funding of vulnerable people in African urban areas: the case of the health zone of Bandalungwa, Kinshasa (Congo) Through a survey, the study analyses the living improvement possibilities for microentrepreneurs, by the improvement of their purchasing power through microcredits provided by the Programme National d’Appui à la Protection Sociale (PNPS), in the health zone of Bandalungwa (Kinshasa). The credits were affected to wheat flour, starches, fresh food, fruits and vegetables, small restoration, smoked fish, clothing, electronic devices. Main results suggest that 68% of the microentrepreneurs financed by the program have declared improved living conditions. This improvement was associated to access to health care, children schooling, household’s access to food, loan reimbursement, and rent payment. The bivariate analysis has shown that those who had invested the whole credit in the funded activity experienced living improvement. To help vulnerable people in increasing their purchasing power, the loans should be linked to projects that are helpful to the households, and avoid that households use the credit in unsuitable ways, which could maintain them in a high level of debt. [less ▲]

Detailed reference viewed: 153 (17 ULg)
Full Text
Peer Reviewed
See detailRisk of hip fracture in community-dwelling and institutionalized osteoporotic patients: A 3-year study.
Bruyère, Olivier ULg; Hiligsmann, Mickaël ULg; Zegels, Brigitte ULg et al

in International Journal of Gerontology (2013), 7(3), 167-70

Background and aims: It has been previously suggested that the incidence of hip fracture is higher among <br />people living in nursing homes than among community-dwelling people. However, it is not clear ... [more ▼]

Background and aims: It has been previously suggested that the incidence of hip fracture is higher among <br />people living in nursing homes than among community-dwelling people. However, it is not clear <br />whether this is a consequence of nursing home residency or of the greater age of the residents. We have <br />examined the relationship between the place of residence and hip fracture incidence, in a prospective 3- <br />year study. <br />Methods: Women from nine countries included in this study were part of the placebo group of <br />a randomized controlled trial having assessed the long-term effect of a new antiosteoporotic drug. All <br />women were osteoporotic and received placebo and vitamin D during the 3 years of follow-up. All the <br />institutionalized (nursing home, medical house) women (n ¼ 217) were included in this post hoc analysis <br />and three noninstitutionalized age- and country-matched controls were included (n ¼ 651). <br />Results: The mean (and standard deviation) age of the patients was 80.4 (5.6) years in the institutionalized <br />women and 80.2 (5.8) years in the noninstitutionalized women (p ¼ 0.87). After 3 years of followup, <br />37 fractures occurred: 12 (5.5%) in institutionalized women and 25 (3.8%) in noninstitutionalized <br />women. The difference between the two groups was not statistically significant (p ¼ 0.29). After <br />controlling for age, body mass index, femoral neck bone mineral density and prevalent nonvertebral <br />fracture, the residence status of the patient (institutionalized vs. noninstitutionalized) was not significantly <br />associated with hip fracture incidence (p ¼ 0.63). <br />Conclusions: We suggest that living in an institutionalized place is not an independent risk factor for hip <br />fracture for osteoporotic women receiving calcium and vitamin D. [less ▲]

Detailed reference viewed: 64 (24 ULg)
Full Text
Peer Reviewed
See detailCritères de retour sur le terrain après plastie LCA chez le footballeur professionnel
Croisier, Jean-Louis ULg; Rochcongar, Pierre; Bruyère, Olivier ULg et al

in European Journal of Sports Medicine (2013, September), 1(1),

Detailed reference viewed: 81 (14 ULg)
Full Text
Peer Reviewed
See detailCaractéristiques cliniques des sujets répondeurs à la vibrotonie corporelle totale
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Maquet, Didier ULg et al

in Cahiers de l'Année Gérontologique (Les) (2013, September), 5(1-2), 118-119

Detailed reference viewed: 29 (11 ULg)
Full Text
Peer Reviewed
See detailImportance du déficit en vitamine D chez les femmes françaises ostéoporotiques et ostéopéniques âgées de plus de 80 ans
Bruyère, Olivier ULg; Slomian, Justine ULg; Beaudart, Charlotte ULg et al

in Cahiers de l'Année Gérontologique (Les) (2013, September), 5(1-2), 75

Detailed reference viewed: 44 (22 ULg)
Full Text
Peer Reviewed
See detailLes effets d'une supplémentation en vitamine D sur la force musculaire : une méta-analyse d'essais randomisés contrôlés
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Rabenda, Véronique ULg et al

in Cahiers de l'Année Gérontologique (Les) (2013, September), 5(1-2), 38

Detailed reference viewed: 38 (11 ULg)
Full Text
Peer Reviewed
See detailQuality of life in sarcopenia and frailty
Rizzoli, René; Reginster, Jean-Yves ULg; Arnal, Jean-François et al

in Calcified Tissue International (2013), 93

The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may ... [more ▼]

The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrumentfor sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate. [less ▲]

Detailed reference viewed: 36 (15 ULg)
Full Text
Peer Reviewed
See detailHow to define responders in osteoarthritis
Cooper, Cyrus; Adachi, Jonathan D; Bardin, Thomas et al

in Current Medical Research & Opinion (2013), 29(6), 719-29

Background: Osteoarthritis is a clinical syndrome of failure of the joint accompanied by varying degrees of joint pain, functional limitation, and reduced quality of life due to deterioration of articular ... [more ▼]

Background: Osteoarthritis is a clinical syndrome of failure of the joint accompanied by varying degrees of joint pain, functional limitation, and reduced quality of life due to deterioration of articular cartilage and involvement of other joint structures. Scope: Regulatory agencies require relevant clinical benefit on symptoms and structure modification for registration of a new therapy as a disease-modifying osteoarthritis drug (DMOAD). An international Working Group of the European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and International Osteoporosis Foundation was convened to explore the current burden of osteoarthritis, review current regulatory guidelines for the conduct of clinical trials, and examine the concept of responder analyses for improving drug evaluation in osteoarthritis. Findings: The ESCEO considers that the major challenges in DMOAD development are the absence of a precise definition of the disease, particularly in the early stages, and the lack of consensus on how to detect structural changes and link them to clinically meaningful endpoints. Responder criteria should help identify progression of disease and be clinically meaningful. The ideal criterion should be sensitive to change over time and should predict disease progression and outcomes such as joint replacement. Conclusion: The ESCEO considers that, for knee osteoarthritis, clinical trial data indicate that radiographic joint space narrowing40.5mm over 2 or 3 years might be a reliable surrogate measure for total joint replacement. On-going research using techniques such as magnetic resonance imaging and biochemical markers may allow the identification of these patients earlier in the disease process [less ▲]

Detailed reference viewed: 27 (4 ULg)
Full Text
Peer Reviewed
See detailReturn-To-Play criteria after hamstring injury: actual medicine practice in professional soccer
Delvaux, François ULg; Rochcongar, Pierre; Bruyère, Olivier ULg et al

Poster (2013, April 25)

Detailed reference viewed: 196 (14 ULg)