References of "REGINSTER, Jean-Yves"
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See detailClinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis
Bruyère, Olivier ULiege; Reginster, Jean-Yves ULiege; Bellamy, Nicholas et al

in Rheumatology (2014), 53

Objectives. The aim of this study was to assess the efficacy of strontium ranelate in improving symptoms in knee OA. Methods. Symptoms were assessed over 3 years in patients with primary knee OA receiving ... [more ▼]

Objectives. The aim of this study was to assess the efficacy of strontium ranelate in improving symptoms in knee OA. Methods. Symptoms were assessed over 3 years in patients with primary knee OA receiving strontium ranelate 2 g/day (n = 454), 1 g/day (n = 445) or placebo (n = 472) in the Strontium Ranelate Efficacy in Knee Osteoarthritis Trial. Clinical response was evaluated using WOMAC subscores, minimal perceptible clinical improvement (MPCI), minimal clinically important improvement (MCII) and a modified OMERACT Osteoarthritis Research Society International (OARSI) responder definition. Patients who withdrew prematurely from the study were considered non-responders. Results. There was no significant effect on symptoms for strontium ranelate 1 g/day. At the dosage of 2 g/day, strontium ranelate was associated with greater response than placebo in terms of 520% improvement in WOMAC pain from baseline to the last visit (58% vs 47%, P = 0.002) and 550% improvement in WOMAC pain (42% vs 36%, P = 0.083). Significant differences were found in MPCI response for WOMAC pain (52% vs 40%, P<0.001), stiffness (47% vs 39%, P = 0.009) and physical function (46% vs 37%, P = 0.009) and in MCII response for WOMAC physical function (46% vs 37%, P = 0.013). There were also more OMERACT-OARSI-like responders with strontium ranelate (44% vs 35%, P = 0.004). The treatment placebo difference in MPCI response for WOMAC pain was significant after 6 months (P = 0.024), while that in MPCI and MCII response for WOMAC physical function reached significance after 12 months (P = 0.027 and P = 0.019, respectively). Conclusion. Treatment with strontium ranelate 2 g/day over 3 years is associated with a clinically meaningful improvement in pain from 6 months as well as physical function and stiffness as assessed by the number of responders above thresholds of clinical relevance. [less ▲]

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See detailEffets de la vibrotonie corporelle totale sur le risque de chute de la personne âgée: Mise au point
Buckinx, Fanny ULiege; Reginster, Jean-Yves ULiege; Petermans, Jean ULiege et al

in Ortho-Rhumato (2014), 12(6), 6-9

Les chutes constituent un problème majeur de santé publique. Si le bénéfice de l’exercice physique sur la prévention des chutes est avéré, les exercices classiques ne sont pas toujours adaptés pour les ... [more ▼]

Les chutes constituent un problème majeur de santé publique. Si le bénéfice de l’exercice physique sur la prévention des chutes est avéré, les exercices classiques ne sont pas toujours adaptés pour les personnes âgées. C’est pourquoi la vibrotonie corporelle totale, en permettant la réalisation d’exercices isométriques, pourrait théoriquement s’avérer être une bonne alternative pour les séniors. Depuis les années 2000, plusieurs études ont évalué les effets de la vibrotonie corporelle totale sur le risque de chute. Les résultats individuels de ces recherches sont assez variables, ce qui pourrait, entre autres, s’expliquer par la variété des protocoles utilisés, des populations cibles, des critères d’évaluation choisis et de la qualité méthodologique. Globalement, il semblerait que les appareils de vibrotonie du corps entier puissent améliorer, de manière statistiquement significative, différents paramètres de la marche et de l’équilibre et pourraient dès lors réduire le risque de chute des patients âgés. Toutefois, les durées d’exposition, les fréquences de stimulation et les amplitudes d’oscillations varient sensiblement d’une étude à l’autre et il est actuellement impossible d’en dégager un protocole précis. [less ▲]

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See detailLes effets d'une supplémentation en vitamine D sur la fonction musculaire
Beaudart, Charlotte ULiege; Reginster, Jean-Yves ULiege; Cavalier, Etienne ULiege et al

in Ortho-Rhumato (2014), 12(5), 33-37

Au-delà de ses rôles classiques sur la santé osseuse, il y a de plus en plus de raisons de penser que la vitamine D aurait également des actions non négligeables sur les tissus extra-squelettiques tels ... [more ▼]

Au-delà de ses rôles classiques sur la santé osseuse, il y a de plus en plus de raisons de penser que la vitamine D aurait également des actions non négligeables sur les tissus extra-squelettiques tels que les muscles. En effet, plusieurs enquêtes épidémiologiques suggèrent une association transversale entre un faible taux sérique de 25-hydroxy-vitamine D (25[OH]D) et une faiblesse musculaire, tant au niveau de la masse musculaire que de la force musculaire. Suite à ces constatations, plusieurs équipes de recherche ont décidé d’évaluer le potentiel thérapeutique de la vitamine D en mesurant les effets d’une supplémentation en vitamine D sur la force musculaire, la masse musculaire, mais également la puissance musculaire. En raison principalement de l’hétérogénéité très importante des différents protocoles de supplémentation, tant au niveau du type de population ciblée que de la dose de vitamine D, du mode d’administration ou encore de la durée de l’étude, les conclusions de ces études restent controversées. Très récemment, notre équipe de recherche a publié une méta-analyse visant à combiner les résultats de l’ensemble de ces études afin de synthétiser les effets de cette supplémentation en vitamine D sur la fonction musculaire. Les résultats, combinant 30 études randomisées contrôlées, tendent à montrer que la vitamine D améliorerait de manière faible mais significative la force musculaire, en particulier la force des membres inférieurs. Aucun effet sur la masse et la puissance musculaires n’a toutefois été démontré. Cette recherche pose l’hypothèse d’un intérêt thérapeutique de la vitamine D dans le domaine des pathologies musculosquelettiques, de plus en plus présentes dans nos populations vieillissantes. [less ▲]

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See detailDabigatran Etexilate and Risk of Myocardial Infarction, Other Cardiovascular Events, Major Bleeding, and All-Cause Mortality: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Douxfils, Jonathan; Buckinx, Fanny ULiege; Mullier, Francois et al

in Journal of the American Heart Association (2014), 3(3), 000515

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of ... [more ▼]

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of the published literature and a clinical trials registry maintained by the drug manufacturer. Criteria for inclusion in our meta-analysis included all RCTs and the availability of outcome data for MI, other cardiovascular events, major bleeding, and all-cause mortality. Among the 501 unique references identified, 14 RCTs fulfilled the inclusion criteria. Stratification analyses by comparators and doses of dabigatran etexilate were conducted. Peto odds ratio (ORPETO) values using the fixed-effect model (FEM) for MI, other cardiovascular events, major bleeding, and all-cause mortality were 1.34 (95% CI 1.08 to 1.65, P=0.007), 0.93 (95%CI 0.83 to 1.06, P=0.270), 0.88 (95% CI 0.79 to 0.99, P=0.029), and 0.89 (95% CI 0.80 to 1.00, P=0.041). When compared with warfarin, ORPETO values using FEM were 1.41 (95% CI 1.11 to 1.80, P=0.005), 0.94 (95%CI 0.83 to 1.06, P=0.293), 0.85 (95% CI 0.76 to 0.96, P=0.007), and 0.90 (95% CI 0.81 to 1.01, P=0.061), respectively. In RCTs using the 150-mg BID dosage, the ORPETO values using FEM were 1.45 (95% CI 1.11 to 1.91, P=0.007), 0.95 (95% CI 0.82 to 1.09, P=0.423), 0.92 (95% CI 0.81 to 1.05, P=0.228), and 0.88 (95% CI 0.78 to 1.00, P=0.045), respectively. The results of the 110-mg BID dosage were mainly driven by the RE-LY trial. CONCLUSIONS: This meta-analysis provides evidence that dabigatran etexilate is associated with a significantly increased risk of MI. This increased risk should be considered taking into account the overall benefit in terms of major bleeding and all-cause mortality. [less ▲]

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See detailPrevalence of vitamin D inadequacy in European women aged over 80 years
Bruyère, Olivier ULiege; Slomian, Justine ULiege; Beaudart, Charlotte ULiege et al

in Osteoporosis International (2014), 25(2), 196

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See detailLes chutes de la personne âgée
GILLAIN, Sophie ULiege; ELBOUZ, Leila ULiege; Beaudart, Charlotte ULiege et al

in Revue Médicale de Liège (2014), 69(5-6), 258-264

Falls are frequent in the elderly; they can have severe consequences, and sometimes reveal some underlying pathology. They represent a real public health problem which prompts numerous teams to search for ... [more ▼]

Falls are frequent in the elderly; they can have severe consequences, and sometimes reveal some underlying pathology. They represent a real public health problem which prompts numerous teams to search for adequate preventative measures, adapted therapeutic options, and means to reduce the various resulting costs. This paper describes the multidisciplinary hospital day service organized, by the CHU of Liege, for older patients who fall, or are at risk of falling. [less ▲]

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See detailReturn-to-play criteria after hamstring injury: Actual medicine practice in professional soccer teams
Delvaux, François ULiege; Rochcongar, p; Bruyère, Olivier ULiege et al

in Journal of Sports Science & Medicine (2014), 13

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See detailPatient engagement in clinical research through mobile technology
LoPresti, Melissa; Appelboom, Geoff; Bruyère, Olivier ULiege et al

in Clinical Practice (2014), 11(6), 549-51

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See detailConcordance entre la masse musculaire mesurée par impédance bioélectrique et par absorptiométrie radiologique à double énergie
Buckinx, Fanny ULiege; Reginster, Jean-Yves ULiege; Dardenne, Nadia ULiege et al

in Cahiers de l'Année Gérontologique (Les) (2014), 6(Suppl. 1), 182

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See detailEvaluation du nombre de résidents en maison de retraite médicalisée bénéficiant d'une supplémentation en vitamine D
Buckinx, Fanny ULiege; Reginster, Jean-Yves ULiege; Cavalier, Etienne ULiege et al

in Cahiers de l'Année Gérontologique (Les) (2014), 6(Suppl. 1), 68

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See detailValidation des paramètres de marche par un système accélérométrique (Locométrix ®) à l’aide d’un système opto-électronique 3D (Coda Motion ®)
GILLAIN, Sophie ULiege; Schwartz, C; Dramé, M et al

in Cahiers de l'Année Gérontologique (Les) (2014), 6(Suppl. 1), 186

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See detailAssociation entre la masse musculaire totale et la densité minérale osseuse de la hanche
Beaudart, Charlotte ULiege; Reginster, Jean-Yves ULiege; Slomian, Justine ULiege et al

in Cahiers de l'Année Gérontologique (Les) (2014), 6(Suppl. 1), 125-6

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See detailImplication des troubles métaboliques dans la progression radiologique de la gonarthrose : analyse post-hoc issue de l'essai randomisé SEKOIA
Eymard, F; Parsons, C; Edwards, M et al

in Revue du Rhumatisme (2014), 81(Suppl. 1), 92

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See detailValidity and Reliability of the French Version of the STarT Back Screening Tool for Patients With Low Back Pain.
Bruyère, Olivier ULiege; Demoulin, Maryline; Beaudart, Charlotte ULiege et al

in Spine (2014), 39(2), 123-128

Study Design. Observational prospective study.Objective. Our objective was to assess the reliability and validity of the French version of the Keele STarT Back Screening Tool (SBST).Summary of Background ... [more ▼]

Study Design. Observational prospective study.Objective. Our objective was to assess the reliability and validity of the French version of the Keele STarT Back Screening Tool (SBST).Summary of Background Data. The SBST is a recently validated tool developed to identify subgroups of patients with low back pain (LBP) to guide early secondary prevention in primary care.Methods. Outpatients with LBP aged 18 years or more, attending a rehabilitation centre, a back school, a private physiotherapy unit or a fitness centre were included. Patients were assessed through the SBST, Roland-Morris Disability Questionnaire (RMDQ), Orebro Musculoskeletal Pain Screening Questionnaire (OMPSQ), Medical Outcomes Survey Short Form 36 (SF-36) questionnaire, and a pain visual analogic scale (VAS). Test-retest reliability was assessed with Kappa score or the intraclass correlation coefficient (ICC), internal consistency of the psychological subscale with the Cronbach alpha coefficient, construct validity with the Spearman's correlation coefficient, and floor and ceiling effects by percentage frequency of lowest or highest possible score achieved by respondents.Results. 108 patients with LBP were included. The test-retest reliability of the SBST total score was excellent with an ICC of 0.90 (0.81-0.95). The Cronbach alpha coefficient was 0.73 showing a good internal consistency for the psychological subscale. High Spearman's correlation coefficients of 0.74 between SBST and RMDQ, and 0.74 between the SBST and OMPSQ were observed. As expected, low to moderate correlations were observed between the SBST total score and some dissimilar measures of the SF-36. The lowest possible SBST score was observed for 8 patients (7.4%) whereas only three patients (2.8%) had the highest possible SBST score.Conclusion. The French version of the SBST is a reliable and valid questionnaire consistent with the original English version. Therefore, this new version may help French-speaking clinicians and scientists to stratify patients with LBP. [less ▲]

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See detailEconomic evaluation of an osteoporosis screening campaign: using FRAX as a prescreening tool
Hiligsmann, Mickaël ULiege; Ben Sedrine, Wafa ULiege; Bruyère, Olivier ULiege et al

in Osteoporosis International (2014), 25(2), 38-39

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See detailEvaluation of the impact of 6-month training by whole body vibration on the risk of falls among nursing home residents, observed over a 12-month period: a single blind, randomized controlled trial.
Buckinx, Fanny ULiege; Beaudart, Charlotte ULiege; Maquet, Didier ULiege et al

in Aging Clinical & Experimental Research (2014), 26(4), 369-376

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement ... [more ▼]

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement of motor capacity were observed. OBJECTIVE: The objective of the present study was to evaluate the impact of 6-month training by WBV on functional and motor abilities among nursing home residents observed over a 12-month period. METHODS: Patients were randomized into two groups: the WBV group which received three training sessions every week composed of five series of 15 s of vibration at 30 Hz intensity for a period of 6 months and a control group with normal daily life. The impact of this training on the risk of falls was assessed blindly after 6 and 12 months by the Tinetti Test, the "Timed Up and Go" test and a quantitative evaluation of a 10-s walk performed with a tri-axial accelerometer. The occurrence of falls was also observed. RESULTS: 62 elderly healthy volunteers, (47 women and 15 men, mean age 83.2 +/- 7.9 years) were included in this study. There was no significant difference between the two groups regarding the Tinetti test (p = 0.75), the "Timed Up and Go" test (p = 0.19) and the Locometrix(R) test, except for the step length, measured by dual task (p < 0.01). No significant inter-group difference in the frequency of falls was observed during the 12 months of research. A total of 42 falls were recorded during the first 6 months of experimentation: 24 falls in the treated group and 18 in the control group (p = 0.60). During the next 6 months, 19 falls occurred: 8 falls in the treated group and 11 in the control group (p = 0.52). CONCLUSION: This study failed to establish the effectiveness of low doses of WBV, under the conditions used in our study, on functional and motor abilities of institutionalized elderly patients. However, given the positive results of other studies, further investigations, with modified therapeutic protocols, seem necessary to clarify the effects of WBV in the elderly. [less ▲]

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See detailClinical and biological determinants of sclerostin plasma concentration in hemodialysis patients
DELANAYE, Pierre ULiege; KRZESINSKI, Jean-Marie ULiege; Warling, Xavier et al

in Nephron. Clinical Practice (2014), 128

Background: Sclerostin is a potent inhibitor of bone formation, but the meaning of its serum levels remains undetermined. We evaluated the association between sclerostin levels and clinical or biological ... [more ▼]

Background: Sclerostin is a potent inhibitor of bone formation, but the meaning of its serum levels remains undetermined. We evaluated the association between sclerostin levels and clinical or biological data in hemodialyzed patients (HD), notably parathormone (PTH), biomarkers of bone turnover, vascular calcifications and mortality after 2 years. Methods: 164 HD patients were included in this observational study. The calcification score was assessed with the Kauppila method. Patients were followed for 2 years. Results: Median sclerostin levels were significantly (p < 0.0001) higher in HD versus healthy subjects (n = 94) (1,375 vs. 565 pg/ml, respectively). In univariate analysis a significant association (p < 0.05) was found between sclerostin and age, height, dialysis vintage, albumin, troponin, homocysteine, PTH, C-terminal telopeptide of collagen type I, bone-specific alkaline phosphatase and osteoprotegerin, but not with the calcification score. In a multivariate model, the association remained with age, height, dialysis vintage, troponin, homocysteine, phosphate, PTH, but also with vascular calcifications. Association was positive for all variables, except PTH and vascular calcifications. The baseline sclerostin concentration was not different in survivors and non-survivors. Conclusions: We confirm a higher concentration of sclerostin in HD patients, a positive association with age and a negative association with PTH. A positive association with phosphate, homocysteine and troponin calls for additional research. The clinical interest of sclerostin to assess vascular calcifications in HD is limited and no association was found between sclerostin and mortality. [less ▲]

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