References of "Quetin-Leclercq, Joëlle"
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See detailIn vitro evaluation of antiplasmodial activity of plant samples used in traditional medicine in Benin
Ganfon, H.; Gbaguidi, F.; Frederich, Michel ULg et al

in Planta Medica (2008), 74(9), 1140-1140

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See detailIn vitro antiplasmodial activity of five plants used in Benin in traditional medicine to treat malaria
Bero, J.; Frederich, Michel ULg; De Mol, Patrick ULg et al

in Planta Medica (2008), 74(9), 1002-1002

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See detailValidation of a method for the determination of sterols and triterpenes in the aerial part of Justicia anselliana (Nees) T. Anders by capillary gas chromatography.
Kpoviessi, Dossou Sika Salome; Gbaguidi, Fernand; Gbenou, Joachim et al

in Journal of Pharmaceutical & Biomedical Analysis (2008), 48(4), 1127-35

An accurate and sensitive method, combining soxhlet extraction, solid phase-extraction and capillary gas chromatography is described for the quantitative determination of one triterpene (lupeol) and three ... [more ▼]

An accurate and sensitive method, combining soxhlet extraction, solid phase-extraction and capillary gas chromatography is described for the quantitative determination of one triterpene (lupeol) and three sterols (stigmasterol, campesterol and beta-sitosterol) and the detection of another triterpene (alpha-amyrin) from the aerial part of Justicia anselliana. This is the first method allowing the quantification of sterols and triterpenes in this plant. It has been fully validated in order to be able to compare the sterol and triterpene composition of different samples of J. anselliana and therefore help to explain the allelopathic activity due to these compounds. This method showed that the aerial part of J. anselliana contained (292+/-2)mg/kg of lupeol, (206+/-1)mg/kg of stigmasterol, (266+/-2)mg/kg of campesterol and (184+/-9)mg/kg of beta-sitosterol. [less ▲]

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See detailN1,N2,N3-trisisopentenyl guanidine and N1,N2-diisopentenyl guanidine, two cytotoxic alkaloids from Alchornea cordifolia (Schumach.& Thonn.) Mull. Arg. (Euphorbiaceae) root barks.
Mavar-Manga, H.; Chapon, David; Hoet, Sara et al

in Natural Product Communications [=NPC] (2006), 1(12), 1097-1100

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See detailInduction of Apoptosis in Human Promyelocytic Leukemia Cells by a Natural Trachylobane Diterpene
Block, Sébastien; Gerkens, Pascal; Peulen, Olivier ULg et al

in Anticancer Research (2005), 25(1A), 363-368

Background: Trachylobane diterpenes are secondary metabolites quite rare in nature and their bioactivities are poorly known. Recently we have described the cytotoxic activity of ent- trachyloban-3‚-ol ... [more ▼]

Background: Trachylobane diterpenes are secondary metabolites quite rare in nature and their bioactivities are poorly known. Recently we have described the cytotoxic activity of ent- trachyloban-3‚-ol isolated from the leaves of Croton zambesicus, a plant used in African folk medicine. Materials and Methods: Cell viability on several cell lines, cell morphology, DNA laddering, annexin V and caspase-3 activation experiments were undertaken in order to analyse the cytotoxicty of trachylobane diterpene and to determine if this compound is able to induce apoptosis. Results: ent-trachyloban-3‚-ol exerts a dose-dependent cytotoxic effect and which varies between cell lines. Induction of apoptosis in HL-60 cells could be detected at a concentration of 50 ÌM after 24-h treatment. Conclusion: We show here, for the first time, that a trachylobane diterpene is able to induce apoptosis in human promyelocytic leukemia cells via caspase-3 activation in a concentration-dependent manner. [less ▲]

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See detailDiterpenes from the leaves of Croton Zambesicus
Block, Sébastien; Baccelli, Chiara; Tinant, Bernard et al

in Phytochemistry (2004), 65

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3b-ol, were isolated from the leaves of Croton zambesicus ... [more ▼]

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3b-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, b-sitosterol, a-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines. [less ▲]

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See detailContribution to the study of Alchornea cordifolia (Schumach. & Thonn.)
Mavar-Manga, H; Brkic, D; De Pauw-Gillet, Marie-Claire ULg et al

Conference (2002, March)

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See detailEnt-Trachyloban-3beta-ol, a new cytotoxic diterpene frm Croton zambesicus
Block, Sebastien; Stevigny, Caroline; De Pauw-Gillet, Marie-Claire ULg et al

in Planta Medica (2002), 68

The dichloromethane extract of leaves of Croton Zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against huma cervix carcinoma cells was investigated in order to identify its active compounds. A ... [more ▼]

The dichloromethane extract of leaves of Croton Zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against huma cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 ùg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene. [less ▲]

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See detailCytotoxic aporphine alkaloids from Cassytha filiformis L
Stévigny, caroline; De Pauw-Gillet, Marie-Claire ULg; de Hoffmann, E et al

Poster (2001)

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See detailEvaluation of the antitrypanosomal activity of several plants traditionally used in Benin to treat sleeping sickness
Hoet, Sarah; Cottem, D; Opperdoes, F et al

Poster (2001)

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See detailLysosomal phospholipases inhibition by emetine, strychnopentamine and usambarensine
Quetin-Leclercq, Joelle; Schomer, G; Van Bambeke, F et al

Poster (1999)

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See detail9-Methoxygeissoschizol, an alkaloid from bark of strychnos guianensis
Mavar-Manga, Hélène; Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg et al

in Phytochemistry (1996), 43(5), 1125-1127

The isolation and structure determination of 9-methoxygeissoschizol from the stem bark of Strychnos guianensis is described. Elucidation of its structure is mainly based on NMR studies.

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See detailGuianensine, a zwitterionic alkaloid from Strychnos guianensis
Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg; Warin, Roger et al

in Phytochemistry (1995), 40(5), 1557-1560

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new ... [more ▼]

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new alkaloid has a zwitterionic asymmetrical bis-indole structure and is named guianensine. [less ▲]

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See detail2,7-dihydroapogeissoschizine from root bark of strychnos Gossweileri
Quetin-Leclercq, Joëlle; Dive, Georges ULg; Delaude, Clément et al

in Phytochemistry (1994), 35(2), 533-536

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based ... [more ▼]

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on 1D and 2D NMR studies; its conformation was optimized by energy minimization. This type of skeleton is related to geissoschizine but with the notable diffrence that the 1 and 17 positions are joined giving an additional fused ring. Such a seven-membered ring has ,to our knowledge, only been observed in apogeissoschizine, obtained after chemical tratment of two alkaloids ( geissospermine and geissoschizine). 2,7-dihydroxyapogeissoschizine is therefore, the first natural product possessing this skeleton. According to a preliminary test, this new alkaloid shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.THese results have to be confirmed by further tests. [less ▲]

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See detailEffects of α-Hederin on cells cultured in vitro
Quetin-Leclercq, Joelle; Danloy, Sophie; Coucke, Paul et al

Poster (1993, June)

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