References of "Quetin-Leclercq, Joëlle"
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See detailContribution to the study of Alchornea cordifolia (Schumach. & Thonn.)
Mavar-Manga, H; Brkic, D; Gillet, Marie-Claire ULg et al

Conference (2002, March)

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See detailEnt-Trachyloban-3beta-ol, a new cytotoxic diterpene frm Croton zambesicus
Block, Sebastien; Stevigny, Caroline; Gillet, Marie-Claire ULg et al

in Planta Medica (2002), 68

The dichloromethane extract of leaves of Croton Zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against huma cervix carcinoma cells was investigated in order to identify its active compounds. A ... [more ▼]

The dichloromethane extract of leaves of Croton Zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against huma cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 ùg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene. [less ▲]

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See detailCytotoxic aporphine alkaloids from Cassytha filiformis L
Stévigny, caroline; Gillet, Marie-Claire ULg; de Hoffmann, E et al

Poster (2001)

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See detailEvaluation of the antitrypanosomal activity of several plants traditionally used in Benin to treat sleeping sickness
Hoet, Sarah; Cottem, D; Opperdoes, F et al

Poster (2001)

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See detailLysosomal phospholipases inhibition by emetine, strychnopentamine and usambarensine
Quetin-Leclercq, Joelle; Schomer, G; Van Bambeke, F et al

Poster (1999)

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See detail9-Methoxygeissoschizol, an alkaloid from bark of strychnos guianensis
Mavar-Manga, Hélène; Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg et al

in Phytochemistry (1996), 43(5), 1125-1127

The isolation and structure determination of 9-methoxygeissoschizol from the stem bark of Strychnos guianensis is described. Elucidation of its structure is mainly based on NMR studies.

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See detailPurification and analysis by mass spectometry of low M.W. soluble factors released into conditioned culture media by B16 melanoma cells
Gillet, Marie-Claire ULg; Siwek, Brigitte; Quetin-Leclercq, Joelle et al

Poster (1995, July)

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See detailGuianensine, a zwitterionic alkaloid from Strychnos guianensis
Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg; Warin, Roger et al

in Phytochemistry (1995), 40(5), 1557-1560

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new ... [more ▼]

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new alkaloid has a zwitterionic asymmetrical bis-indole structure and is named guianensine. [less ▲]

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See detail2,7-dihydroapogeissoschizine from root bark of strychnos Gossweileri
Quetin-Leclercq, Joëlle; Dive, Georges ULg; Delaude, Clément et al

in Phytochemistry (1994), 35(2), 533-536

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based ... [more ▼]

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on 1D and 2D NMR studies; its conformation was optimized by energy minimization. This type of skeleton is related to geissoschizine but with the notable diffrence that the 1 and 17 positions are joined giving an additional fused ring. Such a seven-membered ring has ,to our knowledge, only been observed in apogeissoschizine, obtained after chemical tratment of two alkaloids ( geissospermine and geissoschizine). 2,7-dihydroxyapogeissoschizine is therefore, the first natural product possessing this skeleton. According to a preliminary test, this new alkaloid shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.THese results have to be confirmed by further tests. [less ▲]

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See detailEffects of α-Hederin on cells cultured in vitro
Quetin-Leclercq, Joelle; Danloy, Sophie; Coucke, Paul et al

Poster (1993, June)

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See detailRevision of the structure of strychnofluorine
Quetin-Leclercq, Joëlle; Warin, Roger; Delaude, Clément et al

in Journal de Pharmacie de Belgique (1992), 47(3), 242

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See detailAntiparasitic Properties of Diploceline, a Quaternary Alkaloid from Strychnos gossweileri
Gasquet, Monique; Quetin-Leclercq, Joëlle; Timon-David, Pierre et al

in Planta Medica (1992), 58

The activity of diploceline is relatively weak as compared to metronidazole on Entamoeba histolytica and Trichomonas vaginalis. The quaternary alkaloid does not produce any inhibition of Plasmodium ... [more ▼]

The activity of diploceline is relatively weak as compared to metronidazole on Entamoeba histolytica and Trichomonas vaginalis. The quaternary alkaloid does not produce any inhibition of Plasmodium falciparum growth at 25 micrograms/ml (maximum tested concentration). [less ▲]

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See detailRevision of the structure of strychnofluorine, an alkaloid of Strychnos gossweileri
Quetin-Leclercq, Joëlle; Coune, Claude; Delaude, Clément et al

in Phytochemistry (1992), 31(12), 4347-4349

The structure of strychnofluorine, an indole alkaloid isolated in 1980 from the root bark of Strychnos gossweileri, has been revised. Strychnofluorine proved to be identical with 18 ... [more ▼]

The structure of strychnofluorine, an indole alkaloid isolated in 1980 from the root bark of Strychnos gossweileri, has been revised. Strychnofluorine proved to be identical with 18-hydroxynorfluorocurarine that has been isolated as a minor (contaminated) alkaloid from Strychnos ngouniensis in 1983. [less ▲]

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See detailMatadine, a cytotoxic alkaloid from Strychnos gossweileri
Quetin-Leclercq, Joëlle; Coucke, P.; Delaude, Clément et al

in Phytochemistry (1991), 30(5), 1697-1700

Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on ... [more ▼]

Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on cancer cells and normal cells. Matadine is an anhydronium base as serpentine, that exerts also a selective inhibiting activity on B16 melanoma cells while it is less toxic in human 2002 non-cancer cells. This selective activity might be well due , as it seems to be the case for serpentine and alstonine, to a higher affinity of matadine for destabilized single-stranded DNA as mainly present in cancer cells. [less ▲]

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See detailRevision of the Structure of Strychnochromine
Quetin-Leclercq, Joëlle; Angenot, Luc ULg; Dupont, Léon et al

in Tetrahedron Letters (1991), 32(34), 4295-4298

The structure of strychnochromine, an unusual alkaloid isolated from a new batch of the root bark of Strychnos gossweileri has been revised . To confirm the indoline structure ( proposed in 1988) and to ... [more ▼]

The structure of strychnochromine, an unusual alkaloid isolated from a new batch of the root bark of Strychnos gossweileri has been revised . To confirm the indoline structure ( proposed in 1988) and to establish the stereochemistry of the compound extensive 2D-NMR experiments were carried out. The COSY experiments mostly confirmed the previous observations but the COLOC maps did not fit the first proposed structure!The problem was solved by single-crystal X-ray analysis of the p-bromobenzoyl ester of strychnochromine. The new structure, with its tetrahydroquinoline ring, is very unusual in Strychnos species but the formation of quinolines from indole alkaloids has already mentioned in some other plants ( Cinchona, Alstonia, Hunteria..). [less ▲]

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See detailFrom ethnobotanical uses of Strychnos henningsii to antiinflammatories, analgesics and antispasmodics
Tits, Monique ULg; Damas, Jacques ULg; Quetin-Leclercq, Joëlle et al

in Journal of Ethnopharmacology (1991), 34

Strychnos henningsii GILG is used in African traditional medicine for the treatment of various ailments, including rheumatism, gastrointestinal complaints, malaria and snake bites. Different preliminary ... [more ▼]

Strychnos henningsii GILG is used in African traditional medicine for the treatment of various ailments, including rheumatism, gastrointestinal complaints, malaria and snake bites. Different preliminary pharmacological experiments are described. The results show that some of the reported folk medicinal applications of S. henningsii can be at least partially explained by the presence of retuline-like alkaloids, whose use could lead to new antinociceptive (antiinflammatory and analgesic) and antispasmodic drugs. [less ▲]

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