References of "Quertemont, Etienne"
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See detailAnxiety in adult female mice following perinatal exposure to chlorpyrifos.
Braquenier, Jean-Baptiste; Quertemont, Etienne ULg; Tirelli, Ezio ULg et al

in Neurotoxicology & Teratology (2010), 32

Epidemiologic studies suggested a possible link between prenatal exposure to organophosphate insecticides (OP) and long-term mental delay and some behavioral troubles. Experimental studies in rats and ... [more ▼]

Epidemiologic studies suggested a possible link between prenatal exposure to organophosphate insecticides (OP) and long-term mental delay and some behavioral troubles. Experimental studies in rats and mice have confirmed that a relatively short exposure to low doses of OP such as chlorpyrifos (CPF) during specific perinatal periods decreased anxiety-like behaviors. In the present study, we report that chronic perinatal exposure (GD15-PND14) to low doses of CPF leads to an increase (and not a decrease) in anxiety-like behaviors of female mouse offspring. Pregnant or lactating female mice were exposed to CPF (0.2; 1; or 5 mg/kg day) by oral treatment during 18 consecutive days. Following a recovery period of several weeks, the anxiety of adult female offspring was determined using neurobehavioral tests (elevated plus-maze and light/dark box tests). Our results showed that CPF-exposed female offspring were more anxious than controls. In addition, the magnitude of anxiety profile alterations depended on the level of exposure to CPF during gestation and lactation with a maximal effect observed at the 1 mg/kg day dose. Our results confirm that OP exposure during the perinatal period can induce long-term alterations in mouse anxiety-like behaviors and suggest that the routes of administration and the duration of OP exposure during brain development may be factors to consider when studying the development of anxiety. [less ▲]

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See detailEffects of brand presence and stimulus of comparison on response inhibition toward alcohol cues in male and female heavy drinkers
Kreusch, Fanny ULg; Quertemont, Etienne ULg

in 2010 annual meeting of the Belgian Association for Psychological Sciences (2010)

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See detailResponse inhibition toward alcohol cues in heavy drinkers and alcohol dependent patients
Kreusch, Fanny ULg; Quertemont, Etienne ULg

in Alcoholism, Clinical & Experimental Research (2010), 34(8), 139-139

Alcohol addictive behaviors have been recently associated with a combination of deficits in executive function, such as a weak response inhibition, and potent automatic appetitive responses for alcohol ... [more ▼]

Alcohol addictive behaviors have been recently associated with a combination of deficits in executive function, such as a weak response inhibition, and potent automatic appetitive responses for alcohol-related cues. The aim of the present studies was to investigate response inhibition for alcohol and neutral or soft drink cues in alcohol abusers and alcohol dependent patients. Response inhibition was assessed in a go/nogo task with pictures of alcohols, soft drinks or neutrals objects. In this task, participants had to respond to specific stimuli (go trial) and inhibit that action under a different set of stimuli (nogo trial). Faster responses for alcohol in go trials reflect approach tendency for alcohol cues while false alarm responses for alcohol in nogo trials reflect a deficit in response inhibition toward alcohol-related cues. Moreover, since standard alcohol cues are not equally appreciated across participants, the preference for the different alcoholic drinks presented were measured and analyzed in reference to task responses. Both light and heavy drinkers showed faster responses to alcohol cues in go trial relative to soft/neutral cues. Preliminary results indicate a negative relationship between the preference scores for alcohols and the reaction times to those stimuli in go trials. The present study also demonstrated that the presence of brands logo significantly altered the discrimination and reactions time patterns of response to alcohol and soft cues. [less ▲]

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See detailComparison of the amnesic, ataxic and hypothermic effects of ethanol and acetaldehyde in mice
Closon, Catherine ULg; Quertemont, Etienne ULg

in Alcoholism, Clinical & Experimental Research (2010), 34(8), 92-92

Acetaldehyde, the first metabolite of ethanol, has been suggested to be involved in many behavioral effects of ethanol. However, very few studies have been published on the role of acetaldehyde in the ... [more ▼]

Acetaldehyde, the first metabolite of ethanol, has been suggested to be involved in many behavioral effects of ethanol. However, very few studies have been published on the role of acetaldehyde in the amnesic and ataxic effects of ethanol. The aim of the present studies was to compare the profiles of ethanol and acetaldehyde in several behavioral tests, measuring motor coordination, learning and memory in mice. Female Swiss mice were injected intraperitoneally with ethanol (0-3g/kg) and acetaldehyde (100-300mg/kg). The effects of these substances on a series of representative behaviors were investigated. The amnesic effects were tested with an object recognition task and a one-trial passive avoidance test. Additionally, the rectal temperatures were used to evaluate the hypothermic effects of the two substances. Finally, motor coordination was assessed using the accelerating rotarod test. The results showed that acetaldehyde, like ethanol, altered memory as shown by a reduced performance in the passive avoidance test and the object recognition task. In addition, acetaldehyde at doses between 100 and 300 mg/kg induced significant hypothermic effects, but that was of shorter duration than ethanol-induced hypothermia. Finally, significant ataxic effects of both acetaldehyde and ethanol were observed in the accelerating rotarod test. Overall, the results of the present study clearly show that acetaldehyde, like ethanol, has amnesic, hypothermic and ataxic properties in mice at least at relatively high concentrations. [less ▲]

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See detailInvolvement of the brain histaminergic system in addiction and addiction-related behaviors: a comprehensive review with emphasis on the potential therapeutic use of histaminergic compounds in drug dependence
Brabant, Christian ULg; Alleva, Livia ULg; Quertemont, Etienne ULg et al

in Progress in Neurobiology (2010), 92

Neurons that produce histamine are exclusively located in the tuberomamillary nucleus of the posterior hypothalamus and send widespread projections to almost all brain areas. Neuronal histamine is ... [more ▼]

Neurons that produce histamine are exclusively located in the tuberomamillary nucleus of the posterior hypothalamus and send widespread projections to almost all brain areas. Neuronal histamine is involved in many physiological and behavioral functions such as arousal, feeding behavior and learning. Although conflicting data have been published, several studies have also demonstrated a role of histamine in the psychomotor and rewarding effects of addictive drugs. Pharmacological and brain lesion experiments initially led to the proposition that the histaminergic system exerts an inhibitory influence on drug reward processes, opposed to that of the dopaminergic system. The purpose of this review is to summarize the relevant literature on this topic and to discuss whether the inhibitory function of histamine on drug reward is supported by current evidence from published results. Research conducted during the past decade demonstrated that the ability of many antihistaminic drugs to potentiate addictionrelated behaviors essentially results from non-specific effects and does not constitute a valid argument in support of an inhibitory function of histamine on reward processes. The reviewed findings also indicate that histamine can either stimulate or inhibit the dopamine mesolimbic system through distinct neuronal mechanisms involving different histamine receptors. Finally, the hypothesis that the histaminergic system plays an inhibitory role on drug reward appears to be essentially supported by place conditioning studies that focused on morphine reward. The present review suggests that the development of drugs capable of activating the histaminergic system may offer promising therapeutic tools for the treatment of opioid dependence. [less ▲]

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See detailEffects of histamine H3 receptor modulators on sedative effects induced by ethanol
Didone, Vincent ULg; Quertemont, Etienne ULg

in Alcoholism, Clinical & Experimental Research (2010), 34(8), 93-93

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See detailEthanol-induced behaviors in mice genetically deficient in MCH1 receptors
Didone, Vincent ULg; Tirelli, Ezio ULg; Quertemont, Etienne ULg et al

in Alcoholism, Clinical & Experimental Research (2010), 34(8), 93-93

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See detailLa dépendance au cannabis : propriétés addictives, tolérance et sevrage
Quertemont, Etienne ULg; Tirelli, Ezio ULg

in Seutin, Vincent; Scuvée, Jacqueline; Quertemont, Etienne (Eds.) Regards croisés sur le cannabis (2010)

En dépit de controverses récurrentes, les données expérimentales récoltées dans de nombreuses études animales et humaines indiquent que le cannabis présente toutes les caractéristiques associées aux ... [more ▼]

En dépit de controverses récurrentes, les données expérimentales récoltées dans de nombreuses études animales et humaines indiquent que le cannabis présente toutes les caractéristiques associées aux autres drogues toxicomanogènes. Le cannabis induit manifestement une dépendance psychologique primaire chez l’homme et les modèles animaux ont démontré qu’il possède des propriétés renforçantes, quoique de moindre intensité que celles d’autres drogues comme la cocaïne ou les opiacés. La consommation chronique de cannabis produit une tolérance envers certains de ses effets, ce qui est susceptible d’entraîner un accroissement des doses utilisées par un utilisateur régulier. On reconnaît aussi au cannabis la capacité d’induire une véritable dépendance physiologique chez les plus gros consommateurs. Cette dépendance physiologique se manifeste par un syndrome de sevrage typique lors de l’arrêt de la consommation. Toutefois, il est clair que la dépendance au cannabis (aussi bien psychologique que physiologique) est moins sévère que celle induite par d’autres drogues majeures comme l’alcool, la cocaïne ou les opiacés. De plus, elle ne concerne qu’une petite fraction des consommateurs de cannabis. Depuis de nombreuses années, on s’interroge sur le risque d’escalade vers la consommation de drogues « plus dures » que produirait la consommation de cannabis. Les études scientifiques ont clairement démontré qu’il existe un lien statistique significatif entre usage de cannabis et consommation d’autres drogues illicites. Toutefois, la nature de cette relation statistique reste controversée. Selon les tenants de « la théorie de la porte d’entrée », le cannabis conduit directement, par des mécanismes biologiques, psychologiques ou sociaux, à une augmentation du risque de consommer des drogues telles que la cocaïne ou l’héroïne. Au contraire, les adeptes de « la théorie du facteur commun » soutiennent que les consommations de cannabis, d’héroïne ou de cocaïne sont expliqués par des facteurs généraux identiques, conduisant ainsi à une relation statistique qui ne serait qu’apparente et en aucun cas de nature causale. A l’heure actuelle, les données expérimentales disponibles ne permettent pas de trancher définitivement entre ces deux théories explicatives. [less ▲]

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See detailEffets du cannabis sur la santé psychologique
Quertemont, Etienne ULg; Blairy, Sylvie ULg; Ansseau, Marc ULg

in Seutin, Vincent; Scuvée, Jacqueline; Quertemont, Etienne (Eds.) Regards croisés sur le cannabis (2010)

Les individus intoxiqués au cannabis rapportent généralement des effets subjectifs plaisants, même si des symptômes désagréables ne sont pas à exclure chez certaines personnes ou à certaines occasions ... [more ▼]

Les individus intoxiqués au cannabis rapportent généralement des effets subjectifs plaisants, même si des symptômes désagréables ne sont pas à exclure chez certaines personnes ou à certaines occasions. L’intoxication cannabique aiguë perturbe différents processus cognitifs plus ou moins intensément. Les effets les plus nets sont probablement les altérations de la mémoire qui surviennent lors de l’intoxication cannabique, et en particulier la perturbation de la consolidation de nouveaux souvenirs. Toutefois, on observe également lors de l’intoxication cannabique une altération de la flexibilité mentale et comportementale rendant les comportements plus rigides et plus impulsifs. Enfin, le cannabis perturbe clairement l’estimation subjective de l’écoulement du temps, donnant ainsi l’impression d’un ralentissement du temps. Ces derniers effets expliquent d’ailleurs en partie l’accroissement lors d’une intoxication cannabique des risques d’accidents de conduite automobile. En conclusion, et compte tenu des difficultés méthodologiques mentionnées précédemment, on peut affirmer que les gros consommateurs de cannabis, surtout ceux qui ont fumé du cannabis quotidiennement pendant de longues périodes couvrant parfois des années, présentent un fonctionnement cognitif légèrement altéré. Les déficits cognitifs identifiés sont plutôt de faible magnitude, touchent généralement la mémoire et disparaissent le plus souvent après quelques semaines d’abstinence. Il semble donc que le cannabis produit des altérations cognitives essentiellement durant les périodes de consommation. Les effets observés dans les semaines qui suivent l’arrêt de la consommation chez les gros consommateurs sont vraisemblablement liés au syndrome de sevrage cannabique ou à la présence résiduelle de cannabis dans l’organisme. Le fait que les déficits cognitifs identifiés chez les consommateurs chroniques de cannabis abstinents ressemblent fortement aux effets de l’intoxication cannabique (légers troubles de la mémoire, réduction de la flexibilité mentale et impulsivité), renforce l’idée qu’il pourrait s’agir d’effets résiduels du cannabis qui mettent plus longtemps à se résorber chez les très gros consommateurs. A ce jour, les études scientifiques n’ont donc pas encore démontré de manière incontestable l’existence de troubles cognitifs persistants, voire permanents, chez les consommateurs réguliers de cannabis devenus abstinents depuis plusieurs mois, mais ils ne les ont pas exclus non plus. Une conclusion prudente serait dès lors que les déficits cognitifs persistants induits par la consommation régulière de grosses quantités de cannabis sont relativement limités et transitoires. Ceci n’exclut pas la survenue d’autres problèmes à long terme, comme par exemple le développement d’une addiction au cannabis, des difficultés sociales ou relationnelles ou d’autres effets sur la santé. D’autres études, méthodologiquement mieux contrôlées, seront cependant nécessaires pour conclure définitivement sur la question de l’existence d’altérations cognitives persistantes suite à la consommation chronique de cannabis. Compte tenu des résultats parfois contradictoires de la littérature scientifique, il n’est pas aisé de tirer des conclusions fermes à propos des effets du cannabis sur la santé psychologique et particulièrement sur les effets persistants susceptibles de se perpétuer au-delà des périodes d’intoxication. Alors que le tableau de l’intoxication/ivresse cannabique est relativement clair, les effets persistants d’une consommation abusive de cannabis sont l’objet d’âpres débats. On peut néanmoins tirer les conclusions suivantes. Les études les plus récentes concordent pour affirmer que l’abus de cannabis, surtout durant l’adolescence, est susceptible de provoquer des troubles psychotiques ou, de manière encore plus évidente, de les précipiter chez des individus fragiles. L’abus chronique de cannabis semble aussi favoriser les troubles de l’humeur, tels que dépression et trouble bipolaire. L’existence d’un syndrome amotivationnel qui serait induit par l’abus chronique de cannabis est plus controversée, même s’il est observé dans certaines études. Ce syndrome amotivationnel supposé est en partie lié à différents troubles cognitifs induits par le cannabis. S’il est avéré que la consommation chronique de cannabis provoque effectivement des altérations du fonctionnement cognitif et tout particulièrement de la mémoire, il reste à déterminer si ces déficits cognitifs persistent au-delà des périodes d’intoxications ou s’ils s’estompent progressivement après l’arrêt de l’abus de cannabis. [less ▲]

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See detailRegards croisés sur le cannabis
Seutin, Vincent ULg; Scuvée-Moreau, Jacqueline ULg; Quertemont, Etienne ULg

Book published by Mardaga (2010)

Multidisciplinary book which presents an up to date review of scientific data available on cannabis (neurobiology, toxicology, epidemiology, public health and treatment options

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See detailPsychostatistique descriptive et inférentielle Partim 1 - Exercices
Quertemont, Etienne ULg

Learning material (2009)

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See detailPsychostatistique descriptive et inférentielle Partim 1 - Théorie
Quertemont, Etienne ULg

Learning material (2009)

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See detailPsychostatistique descriptive et inférentielle Partim 2 - Théorie
Quertemont, Etienne ULg

Learning material (2009)

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See detailPsychostatistique descriptive et inférentielle Partim 2 - Exercices
Quertemont, Etienne ULg

Learning material (2009)

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See detailAcetaldehyde and the hypothermic effects of ethanol in mice.
Closon, Catherine ULg; Didone, Vincent ULg; Tirelli, Ezio ULg et al

in Alcoholism, Clinical & Experimental Research (2009), 33(11), 2005-14

BACKGROUND: Acetaldehyde, the first metabolite of ethanol, has been suggested to be involved in many behavioral effects of ethanol. However, few studies have investigated the hypothermic effects of ... [more ▼]

BACKGROUND: Acetaldehyde, the first metabolite of ethanol, has been suggested to be involved in many behavioral effects of ethanol. However, few studies have investigated the hypothermic effects of acetaldehyde or the contribution of acetaldehyde to ethanol-induced hypothermia. The aim of the present study is to better understand the hypothermic effects of acetaldehyde and the possible contribution of acetaldehyde in ethanol-induced hypothermia, especially under conditions leading to acetaldehyde accumulation. METHODS: Female Swiss mice were injected intraperitoneally with ethanol and acetaldehyde and their rectal temperatures were measured with a digital thermometer at various time points after the injections. Experiment 1 compared the hypothermic effects of various acetaldehyde doses (0 to 300 mg/kg) with a reference dose of ethanol (3 g/kg). Experiment 2 tested the effects of a pretreatment with the aldehyde dehydrogenase (ALDH) inhibitor cyanamide (25 mg/kg) on ethanol- and acetaldehyde-induced hypothermia. In experiments 3 and 4, mice received a combined pretreatment with cyanamide and the alcohol dehydrogenase (ADH) inhibitor 4-Methylpyrazole (10 mg/kg) before the injection of ethanol or acetaldehyde. RESULTS: Acetaldehyde at doses between 100 and 300 mg/kg induced significant hypothermic effects, but of shorter duration than ethanol-induced hypothermia. The inhibition of ALDH enzymes by cyanamide induced a strong potentiation of both ethanol- and acetaldehyde-induced hypothermia. The pretreatment with 4-MP prevented the potentiation of ethanol-induced hypothermia by cyanamide, but slightly increased the potentiation of acetaldehyde-induced hypothermia by cyanamide. CONCLUSIONS: The results of the present study clearly show that acetaldehyde has hypothermic properties in mice at least at relatively high concentrations. Furthermore, the accumulation of acetaldehyde following ALDH inhibition strongly enhanced the hypothermic effects of ethanol. These latter results confirm the hypothermic properties of acetaldehyde and show that acetate, the next step in ethanol metabolism, is not involved in these hypothermic effects. Finally, the experiment with 4-MP indicates that the potentiating effects of cyanamide are mediated by the peripheral accumulation of acetaldehyde, which then reaches the brain to induce a severe hypothermia. [less ▲]

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See detailEffects of the H(3) receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions.
Brabant, Christian ULg; Alleva, Livia ULg; Grisar, Thierry ULg et al

in Psychopharmacology (2009), 202(4), 673-87

RATIONALE: Previous studies have shown that intraperitoneal injections of thioperamide, an imidazole-based H(3) receptor inverse agonist that enhances histamine release in the brain, potentiate cocaine ... [more ▼]

RATIONALE: Previous studies have shown that intraperitoneal injections of thioperamide, an imidazole-based H(3) receptor inverse agonist that enhances histamine release in the brain, potentiate cocaine-induced hyperlocomotion. The present study examined the involvement of the histaminergic system in these effects of thioperamide in mice. MATERIALS AND METHODS: We investigated whether immepip, a selective H(3) agonist, could reverse the potentiating effects of thioperamide. Moreover, the non-imidazole H(3) inverse agonist A-331440 was tested on the locomotor effects of cocaine. Using high-performance liquid chromatography with ultraviolet detection, cocaine plasma concentrations were measured to study potential drug-drug interactions between thioperamide and cocaine. Finally, thioperamide was tested on the locomotor effects of cocaine in histamine-deficient knockout mice in order to determine the contribution of histamine to the modulating effects of thioperamide. RESULTS: Thioperamide potentiated cocaine-induced hyperlocomotion in normal mice, and to a higher extent, in histamine-deficient knockout mice. A-331440 only slightly affected the locomotor effects of cocaine. Immepip did not alter cocaine-induced hyperactivity but significantly reduced the potentiating actions of thioperamide on cocaine's effects. Finally, plasma cocaine concentrations were more elevated in mice treated with thioperamide than in mice that received cocaine alone. CONCLUSIONS: The present results indicate that histamine released by thioperamide through the blockade of H(3) autoreceptors is not involved in the ability of this compound to potentiate cocaine induced-hyperactivity. Our data suggest that thioperamide, at least at 10 mg/kg, increases cocaine-induced locomotion through the combination of pharmacokinetic effects and the blockade of H(3) receptors located on non-histaminergic neurons. [less ▲]

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See detailParametric analysis of the development and expression of ethanol-induced behavioral sensitization in female Swiss mice: effects of dose, injection schedule, and test context.
Didone, Vincent ULg; Quoilin, Caroline ULg; Tirelli, Ezio ULg et al

in Psychopharmacology (2008), 201(2), 249-60

RATIONALE: Repeated administrations of ethanol induce a progressive and enduring increase in its locomotor stimulant effects, a phenomenon termed behavioral sensitization that has not been systematically ... [more ▼]

RATIONALE: Repeated administrations of ethanol induce a progressive and enduring increase in its locomotor stimulant effects, a phenomenon termed behavioral sensitization that has not been systematically characterized. OBJECTIVE: The aim of the present studies was to characterize the development and expression of ethanol sensitization in female Swiss mice by examining (1) the doses of ethanol that induce behavioral sensitization, (2) the doses of acute ethanol challenges that are necessary to express behavioral sensitization, (3) the effects of the intervals between administrations, and (4) the context dependency of ethanol sensitization. MATERIALS AND METHODS: Mice were i.p. injected for 8 days with various ethanol doses, and locomotion was recorded for 5 min. Two days after the last sensitization session, ethanol sensitization was tested in 30-min test sessions. RESULTS: Mice repeatedly injected with 2.5 g/kg ethanol showed a progressive (200-300%) increase in locomotor activity. In response to a 2.5 g/kg ethanol challenge, the mice repeatedly treated with doses above 1.5 g/kg showed a significant sensitization. Following the induction of sensitization with the maximally effective sensitizing dose (2.5 g/kg), mice showed greater activation after challenges with 1.5, 2.0, 2.5, and 3.0 g/kg ethanol. The intervals (24, 48, or 96 h) between ethanol injections did not affect the induction or expression of sensitization. Finally, sensitization to 2.5 g/kg ethanol was expressed regardless of the context in which it was induced. CONCLUSIONS: Female Swiss mice develop a robust context-independent sensitization after repeated ethanol injections at all doses above 1.5 g/kg, including highly sedative doses such as 4 g/kg. [less ▲]

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See detailBehavioral effects of acetaldehyde in mice and rats: From reinforcement to amnesia
Quertemont, Etienne ULg; Didone, Vincent ULg; Closon, Catherine ULg

in Alcoholism, Clinical & Experimental Research (2008), 32(6), 289-289

Whereas human studies keep reporting evidence that acetaldehyde accumulation prevents alcohol drinking and alcoholism, animal studies support a rewarding rather than aversive role for acetaldehyde. In ... [more ▼]

Whereas human studies keep reporting evidence that acetaldehyde accumulation prevents alcohol drinking and alcoholism, animal studies support a rewarding rather than aversive role for acetaldehyde. In recent years, the reinforcing properties of acetaldehyde were demonstrated in various rodent strains and using different experimental methods. These results led to the hypothesis that acetaldehyde might be involved in the addictive properties of alcohol. In addition to its possible role in the reinforcing properties of alcohol, there is also evidence that acetaldehyde is involved in many other behavioral effects of ethanol. Using various behavioral procedures with both mice and rats, we have studied the behavioral effects of direct acetaldehyde injections. Additionally, in independent experiments we have compared the effects of ethanol in mice with or without a pre-treatment with the aldehyde dehydrogenase inhibitor cyanamide, which produces acetaldehyde accumulation. The results of these studies show that acetaldehyde produces a wide spectrum of behavioral effects, including reinforcement, aversion, sedation, ataxia and amnesia. These effects were mainly dependent upon acetaldehyde doses, with some of them showing an inverted U shape dose-response curve. These results also suggest that acetaldehyde might mediate or contribute to many of the behavioral effects of ethanol and especially to alcohol abuse and alcoholism. [less ▲]

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See detailCharacterization of the development of a behavioural sensitization in female Swiss mice
Didone, Vincent ULg; Quertemont, Etienne ULg

in Behavioural Pharmacology (2008), 19(5-6), 30-30

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