Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats

in Brain Research (1996), 735

The extracellular changes of amino acids glutamate, taurine and GABA in the nucleus accumbens of freely moving rats were estimated using the microdialysis technique following acute and chronic ethanol ... [more ▼]

The extracellular changes of amino acids glutamate, taurine and GABA in the nucleus accumbens of freely moving rats were estimated using the microdialysis technique following acute and chronic ethanol injections (1, 2, and 3 g/kg body weight). Compared to baseline values, taurine increased by 154%, 142% and 162%, 20 min after the acute injection of, respectively, 1, 2 and 3 g/kg body weight ethanol, while 40 min after ethanol injection, taurine had increased by 124%, 146% and 168%. No changes in either glutamate or GABA were detected at any time points assayed. In the rats which had received chronic ethanol administration prior to a further acute ethanol injection (1, 2, and 3 g/kg body weight), taurine increased by 138%, 144% and 180%, 20 min after the ethanol injection, and at 40 min post ethanol injection taurine had increased by 134%, 160% and 158%, compared to the basal baseline value. No significant changes were observed in either glutamate or GABA microdialysate content in these chronic studies. The biological role played by taurine after acute ethanol injection in the nucleus accumbens remains unclear but may be associated with a yet, undefined mechanism, in reducing the cytotoxicity of ethanol. [less ▲]

Acute ethanol increases extracellular taurine in the accumbens, amygdala, hippocampus and cerebellum but glutamate only into the hippocampus

in Alcoholism, Clinical & Experimental Research (1996), 20

Extracellular amygdala taurine can be conditioned to stimuli associated with ethanol

in Alcoholism, Clinical & Experimental Research (1996), 20

Extracellular amygdala excitatory and inhibitory amino acids change after acute ethanol administration

in Alcohol & Alcoholism (1995), 30

Ethanol increases taurine but not glutamate nor GABA in the nucleus accumbens using microdialysis

in Society for Neuroscience Abstracts (1994)

Acute ethanol increases taurine but neither GABA nor glutamate in the nucleus accumbens: a microdialysis study in male rat

in Pflügers Archiv : European Journal of Physiology (1994), 427(3-4), 61-61