References of "Quertemont, Etienne"
     in
Bookmark and Share    
Peer Reviewed
See detailAre expectancies and peers involved in the relation between depressive mood, anxiety and cannabis use in adolescence?
Schmits, Emilie ULg; Quertemont, Etienne ULg; Boulard, Aurore ULg

Poster (2014, July 15)

Background: Cannabis is the most commonly used illicit drug among teenagers and depression is one of the most common psychopathologies in adolescence. The specific symptom of depressive mood is present in ... [more ▼]

Background: Cannabis is the most commonly used illicit drug among teenagers and depression is one of the most common psychopathologies in adolescence. The specific symptom of depressive mood is present in 30% to 40% of adolescents in regular school settings. Links between cannabis use and depression have been highlighted, especially in adolescence. But questions remain about the strength of the association between lifetime cannabis use, depressive mood and anxiety, and about the mechanism underpinning the link. Aim: The aim of this study was to clarify the relationship between depressive mood and lifetime cannabis use in adolescents, particularly through the mediating role of anxiety and cannabis use effect expectancies, and the moderating role of peer cannabis use. Methods: A questionnaire was administered to 1,246 Belgian teenagers aged 16–17 years. ANOVA, chi-square, logistic regressions and mediation/moderation analyses were carried out to model lifetime cannabis use. Results: Depressive mood was positively correlated with lifetime cannabis use. Social anxiety, trait-anxiety and cognitive impairment effect expectancies mediated the effect of depression on lifetime cannabis use. The direct effect of depression on lifetime cannabis use increased when mediators were introduced into the relation, revealing their suppressive effects. The number of peer cannabis users moderated this model. Conclusion: Findings are discussed in terms of potential risk factors (depressive mood) or protective factors (anxiety and expectancies) for lifetime cannabis use, including the self-medication hypothesis. [less ▲]

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailStimulant and motivational effects of alcohol: Lessons from rodent and primate models
Brabant, Christian ULg; Guarnieri, Douglas J.; Quertemont, Etienne ULg

in Pharmacology, Biochemistry & Behavior (2014), 122

In several animal species including humans, the acute administration of low doses of alcohol increasesmotor activity. Different theories have postulated that alcohol-induced hyperactivity is causally ... [more ▼]

In several animal species including humans, the acute administration of low doses of alcohol increasesmotor activity. Different theories have postulated that alcohol-induced hyperactivity is causally related to alcoholism.Moreover, a common biological mechanism in the mesolimbic dopamine system has been proposed to mediate the stimulant and motivational effects of alcohol. Numerous studies have examined whether alcohol-induced hyperactivity is related to alcoholism using a great variety of animal models and several animal species. However, there is no review that has summarized this extensive literature. In this article, we present the various experimental models that have been used to study the relationship between the stimulant and motivational effects of alcohol in rodents and primates. Furthermore, we discuss whether the theories hypothesizing a causal link between alcohol-induced hyperactivity and alcoholism are supported by published results. The reviewed findings indicate that animal species that are stimulated by alcohol also exhibit alcohol preference. Additionally, the role of dopamine in alcohol-induced hyperactivity is well established since blocking dopaminergic activity suppresses the stimulant effects of alcohol. However, dopamine transmission plays a much more complex function in the motivational properties of alcohol and the neuronal mechanisms involved in alcohol stimulation and reward are distinct. Overall, the current review provides mixed support for theories suggesting that the stimulant effects of alcohol are related to alcoholism and highlights the importance of animal models as a way to gain insight into alcoholism. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailThe self-report Version of the LSAS-CA: Psychometric Properties of the French Version in a non-clinical adolescent sample
Schmits, Emilie ULg; Heeren, Alexandre; Quertemont, Etienne ULg

in Psychologica Belgica (2014), 54(2), 181-198

The Liebowitz Social Anxiety Scale (LSAS) is one of the most popular measures of social anxiety in adults. The LSAS has been adapted for clinical assessment of children and adolescents (LSAS-CA). The ... [more ▼]

The Liebowitz Social Anxiety Scale (LSAS) is one of the most popular measures of social anxiety in adults. The LSAS has been adapted for clinical assessment of children and adolescents (LSAS-CA). The psychometric properties of the self-report version of the LSAS-CA (LSAS-CA-SR) have been investigated in a Spanish population. However, no study to date has adapted and validated this scale in French. The purpose of this study was to develop a French version of the LSAS-CA-SR and to assess its score reliability and structural validity in a French-speaking community sample. The sample was made up of 1,343 teenagers from secondary schools, aged between 14 and 18 years. Confirmatory factor analyses established the structural validity of the French version of the LSAS-CA-SR and good psychometric properties, including reliable internal consistency, were observed. [less ▲]

Detailed reference viewed: 32 (3 ULg)
Full Text
Peer Reviewed
See detailHigher long-lasting ethanol sensitization after adolescent ethanol exposure in mice
Quoilin, Caroline; Didone, Vincent ULg; Tirelli, Ezio ULg et al

in Psychopharmacology (2014), 231

Rationale. Due to their maturing brain, adolescents are suggested to be more vulnerable to the long-term consequences of chronic alcohol use. Increased sensitization to the stimulant effects of ethanol is ... [more ▼]

Rationale. Due to their maturing brain, adolescents are suggested to be more vulnerable to the long-term consequences of chronic alcohol use. Increased sensitization to the stimulant effects of ethanol is a possible consequence of ethanol exposure during adolescence. Objectives. The aim of this study was to characterize the long-term alterations in the stimulant effects of ethanol and in the rate of ethanol sensitization in mice pre-exposed to ethanol during adolescence in comparison to mice pre-exposed to ethanol in adulthood. Methods. Adolescent and adult female SWISS mice were injected with saline or ethanol (2.5 or 4 g/kg) during 14 consecutive days. After a three weeks period of ethanol abstinence, mice were tested as adults before and after a second exposure to daily repeated ethanol injections. Results. All mice pre-exposed to ethanol as adults or adolescents showed higher stimulant effects when re-exposed to ethanol three weeks later. However, this enhanced sensitivity to the stimulant effects of ethanol was of significantly higher magnitude in mice repeatedly injected with high ethanol doses (4g/kg) during adolescence. Furthermore, the increased expression of ethanol stimulant effects in these mice was maintained even after a second procedure of ethanol sensitization. Conclusions. Adolescence is a critical period for the development of a sensitization to ethanol stimulant properties providing that high intermittent ethanol doses are administered. These results might contribute to explain the relationship between age at first alcohol use and risks of later alcohol problems and highlight the dangers of repeated consumption of high alcohol amounts in young adolescents. [less ▲]

Detailed reference viewed: 22 (7 ULg)
Full Text
See detailProjet TADAM: RAPPORT FINAL 2007-2013
Demaret, Isabelle ULg; Litran, Géraldine; Magoga, Cécile et al

Report (2013)

Background: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts resistant to other treatment. A new trial compared HAT and methadone treatment with HAT limited to 12 months in ... [more ▼]

Background: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts resistant to other treatment. A new trial compared HAT and methadone treatment with HAT limited to 12 months in order to assess its feasibility and efficacy in Belgium. Methods: TADAM (Treatment Assisted by Diacetylmorphine) was an open label randomised controlled trial. The experimental treatment was based upon the Swiss model of HAT developed in 1994. The primary efficacy criterion was determined by an improvement in street heroin use or in (physical or mental) health or a decrease in criminal involvement. Participants were assessed every 3 months. Self-reported data were complemented with toxicological analyses and criminal proceedings. Findings: 74 participants were randomised in the trial: 36 in the experimental group and 38 in the control group. The experimental group counted 30% of responders more than the control group at 3 months (p<0.05), 6 months (p<0.05), and 9 months (p<0.01). At 12 months, the number of responders was still higher in the experimental group (11%) but the difference was no longer significant (p=0.35). Street heroin use increased in the experimental group at the 12-month assessment just before the end of HAT. Conclusion: HAT is feasible and effective. However, HAT should not have a predetermined duration for heroin users for which heroin addiction became a chronic relapsing disease. Other data: In addition to the outcomes of the randomised controlled trial, the report contains other exploratory data and analysis: satisfaction of in treatment, criminological data, opinion of heroin users not included in the trial, opinion of caregivers and field workers (in the HAT centre, in the partner centres, and in other centres in the addiction field), impact of the HAT centre on its neighbourhood and a socio-economic evaluation. Funding: The TADAM trial was funded at 80% by the Federal Minister of Social Affairs and Public Health. It was also funded the City and the University of Liège. [less ▲]

Detailed reference viewed: 95 (34 ULg)
Peer Reviewed
See detailRetirement and the onset of Alzheimer's disease: The ICTUS study
Grotz, Catherine ULg; Letenneur, luc; Bonsang, Eric et al

Conference (2013, October 03)

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailAssessing the stimulant and sedative effects of alcohol with explicit and implicit measures in a balanced placebo design
Kreusch, Fanny ULg; Vilenne, Aurélie ULg; Quertemont, Etienne ULg

in Journal of Studies on Alcohol and Drugs (2013), 74(6), 923-930

Objective: Alcohol consumption is characterized by biphasic stimulant and sedative effects. In previous studies, various tools were used to assess these effects, including expectancy questionnaires ... [more ▼]

Objective: Alcohol consumption is characterized by biphasic stimulant and sedative effects. In previous studies, various tools were used to assess these effects, including expectancy questionnaires, implicit association tests, and self-report scales. The present study was aimed at clarifying the relationships between these measures. Method: Three different measures were used to directly or indirectly assess the stimulant and sedative effects of alcohol in 61 undergraduate students. The participants completed the Alcohol Expectancy Questionnaire (AEQ) and performed two unipolar Implicit Association Tasks to assess implicit associations between alcohol and the concepts of “stimulation” and “sedation.” The levels of alcohol consumption also were recorded by means of the Alcohol Use Disorders Identifi cation Test. An alcohol (0.4 g/kg) or placebo challenge was then administered using a balanced placebo design. After alcohol/placebo administration, the participants completed the Biphasic Alcohol Effects Scale (BAES). Results: Alcohol consumption signifi cantly correlated with AEQ alcohol explicit expectancies of arousal and relaxation, whereas no signifi cant correlations were obtained with the implicit associations. There were positive correlations between AEQ and BAES subscales, especially for the arousal subscale of the AEQ. Self-reported sedation recorded with the BAES was signifi cantly affected by what the participants believed that they had drunk but not by the actual consumption of alcohol. Conclusions: These fi ndings indicate that alcohol explicit expectancies of arousal measured with the AEQ best predict current alcohol consumption. Regarding explicit measures of alcohol-induced stimulation and sedation, BAES subscales seem to be more affected by alcohol drinking expectations than by actual alcohol consumption. [less ▲]

Detailed reference viewed: 21 (8 ULg)