References of "Quatresooz, Pascale"
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See detailFacing towards epidermal stem cells (Review).
Schreder, Anelaure; Pierard, Gérald ULg; Paquet, Philippe ULg et al

in International Journal of Molecular Medicine (2010), 26(2), 171-4

Skin contains somatic stem cells that generate keratinocyte, melanocyte and mesenchymal cell lineages. These somatic stem cells have traditionally been thought to be restricted in their differentiation ... [more ▼]

Skin contains somatic stem cells that generate keratinocyte, melanocyte and mesenchymal cell lineages. These somatic stem cells have traditionally been thought to be restricted in their differentiation and regeneration potential to the tissues in which they reside. This review focused on epidermal stem cells (ESCs). These cells are distinguished from transitory amplifier cells and post-mitotic cells. ESC are found in the interadnexal epidermis and in the bulge region of hair follicles. A series of ESCs markers are available, but increased sensitivity and specificity require further development. [less ▲]

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See detailThe therapeutic potential of TNF-alpha antagonists for skin psoriasis comorbidities.
Pierard, Gérald ULg; Pierard, Claudine ULg; Szepetiuk, Grégory ULg et al

in Expert Opinion on Biological Therapy (2010), 10(8), 1197-208

IMPORTANCE OF THE FIELD: Alopecia, psoriatic arthritis, the metabolic syndrome, inflammatory bowel diseases and cardiovascular diseases may occur as skin psoriatic comorbidities. TNF-alpha antagonists are ... [more ▼]

IMPORTANCE OF THE FIELD: Alopecia, psoriatic arthritis, the metabolic syndrome, inflammatory bowel diseases and cardiovascular diseases may occur as skin psoriatic comorbidities. TNF-alpha antagonists are used to treat psoriasis. Adalimumab is one of the recognized active agents for this indication. AREAS COVERED IN THIS REVIEW: The current peer-reviewed publications and presentation of original findings. WHAT THE READER WILL GAIN: Adalimumab is active on recalcitrant psoriasis and some of its comorbidities, particularly arthropathies and Crohn's disease. However, the progression of the radiological alterations is limited with regression of the bony erosions. Psoriatic enthesopathy also regresses. Mortality associated with psoriasis arthropathy is on the decline. Crohn's disease, the most frequent inflammatory bowel comorbidity of psoriasis, is responsive to adalimumab. The effect of adalimumab on the metabolic syndrome and cardiovascular involvement is more erratic. The spectacular effects of adalimumab may be associated with some adverse effects. In particular, despite a marked reduction in the psoriasis area-and-severity index (PASI) score some new acute lesions of cutaneous psoriasis may develop corresponding to paradoxical psoriasis. Other potential adverse effects include infections, granulomas, rapid growth of cancers and occurrence of lymphomas. TAKE HOME MESSAGE: Adalimumab frequently controls moderate-to-severe forms of cutaneous psoriasis and some of its comorbidities. [less ▲]

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See detailGaïa, le stress géoclimatique et la peau.
Pierard, Sébastien ULg; Noel, Fanchon; Franchimont, Claudine ULg et al

in Dermo'Sphère (2010), 2

Le Soleil est à l’origine de la vie sur Terre. Le grand ensemble d’interactions biogéochimiques entre la vie, le sol, l’atmosphère et l’océan n’est pas sans rappeler la physiologie d’un grand organisme ... [more ▼]

Le Soleil est à l’origine de la vie sur Terre. Le grand ensemble d’interactions biogéochimiques entre la vie, le sol, l’atmosphère et l’océan n’est pas sans rappeler la physiologie d’un grand organisme unique. Ce dernier a reçu le nom de Gaïa. Tout le fonctionnement de la biosphère qui en fait partie est largement dépendant de l’apport énergétique solaire. Celui-ci est diversifié car le spectre des rayonnements électromagnétiques est large et variable en intensité et en nature. Le réchauffement global de la Terre et le « trou d’ozone » sont sous les feux de l’actualité. De tels bouleversements sont-ils la préfiguration d’une apocalypse ? L’écologie et la dérive géoclimatique vont-elles influencer la dermatologie de demain ? [less ▲]

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See detailUpdating corneofungimetry: a bioassay exploring dermatomycoses and antifungal susceptibility.
Pierard, Gérald ULg; Franchimont, Claudine ULg; Quatresooz, Pascale ULg

in Mycopathologia (2010), 169(1), 27-35

Superficial dermatomycoses are frequent conditions in humans and animals. Specific treatment modalities have been designed using a variety of different antifungal compounds. The need for antifungal ... [more ▼]

Superficial dermatomycoses are frequent conditions in humans and animals. Specific treatment modalities have been designed using a variety of different antifungal compounds. The need for antifungal susceptibility testing (AST) has been growing steadily over the last two decades due to the extending number of newer antifungal agents. Objective inter- and intraindividual comparisons of their respective efficacies are nearly impossible to perform in vivo. Currently, a series of standardized AST methods and interpretative guidelines have been designed. However, their clinical relevance for dermatomycoses is not consistent. The corneofungimetry bioassay was designed to test comparatively a series of antifungals on pathogenic fungi growing on sheets of human stratum corneum. Computerized morphometric assessments bring numerical values allowing statistical comparisons. Variants of corneofungimetry address more specific aspects related to fungal cell adhesion, fungitoxicity and lipid-dependent fungi. [less ▲]

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See detailComplications des comblements de rides et de volumateurs faciaux.
Paquet, Philippe ULg; Uhoda, Emmanuelle ULg; Quatresooz, Pascale ULg et al

in Dermatologie Actualité (2010), 119

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See detailThe skin landscape following nonoptical capacitance imaging.
Xhauflaire, Emmanuelle ULg; Pierard, Gérald ULg; Quatresooz, Pascale ULg

in American Journal of Clinical Dermatology (2010), 11(2), 89-94

Skin capacitance is an electrical property measurable at the level of the stratum corneum. Values are related to the moisture content of the tissue. Using the silicon image sensor technology, it has ... [more ▼]

Skin capacitance is an electrical property measurable at the level of the stratum corneum. Values are related to the moisture content of the tissue. Using the silicon image sensor technology, it has recently become possible to measure capacitance at 50 microm intervals on the skin surface. The resulting nonoptical picture corresponds to skin capacitance imaging. This novel tool for dermatologists highlights with precision the hollow skin surface patterns, including dermatoglyphics, the patterns of the shallow skin lines, and wrinkles. The topographic heterogeneity in skin surface hydration is made visible. In addition, the sweat gland and follicular openings are disclosed. Skin disorders induced by surfactants or presenting as hyperkeratotic areas, including some neoplasms, may show typical aspects. It is concluded that skin capacitance imaging brings added value to the clinical assessment performed by dermatologists. [less ▲]

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See detailLe pilomatricome unique ou multifocal et son pendant malin.
Reginster, Marie-Annick ULg; Quatresooz, Pascale ULg; Franchimont, Claudine ULg et al

in Dermatologie Actualité (2010), 121

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See detailA docetaxel-induced rash on a radiotherapy port.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2010), 11(5), 367-9

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See detailWeathering of the hairless scalp: a study using skin capacitance imaging and ultraviolet light-enhanced visualization.
Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg; Pierard, Gérald ULg et al

in Clinical & Experimental Dermatology (2010), 35(1), 83-5

The balding scalp is particularly exposed to sunlight, hence, the overall ageing process modulated by ultraviolet and near-infrared light may be increased at this location. The induced changes are better ... [more ▼]

The balding scalp is particularly exposed to sunlight, hence, the overall ageing process modulated by ultraviolet and near-infrared light may be increased at this location. The induced changes are better revealed under ultraviolet light examination. Any alteration in the epidermal maturation is potentially reflected by stratum corneum changes observed as disturbances on skin-capacitance imaging. [less ▲]

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See detailEnvironmental dew point and skin and lip weathering.
Devillers, C.; Pierard, Gérald ULg; Quatresooz, Pascale ULg et al

in Journal of the European Academy of Dermatology & Venereology (2010), 24(5), 513-7

Xerosis represents a physiological response of the stratum corneum (SC) to environmental threats. The influence of the environmental dew point (DP) is not fully understood. This parameter is the air ... [more ▼]

Xerosis represents a physiological response of the stratum corneum (SC) to environmental threats. The influence of the environmental dew point (DP) is not fully understood. This parameter is the air temperature at which the relative humidity is maximum. This study aimed to assess the relationship between the environmental DP and the water-holding capacity of the skin and lower lip vermilion. For comparison, SC property was evaluated after occlusive application of cooled and uncooled hydrogel pads. Electrometric measurements using a dermal phase meter (DPM) device were performed on the back of the hands, the cheeks and the lower lip of 40 healthy menopausal women. Assessments were performed in the outdoor conditions during winter and spring. The same measurements were recorded after hydrogel pads, at room temperature or cooled to 4 degrees C, were placed for 15 min on the test sites. The environmental DP was recorded at each evaluation time. The SC water-holding capacity was discretely influenced by the DP. In the open-air environmental conditions, a positive linear relationship was found on the cheeks between the DP and DPM values. The relationship was weaker on the lips. Conversely, a consistent increase in DPM values was recorded immediately after removal of the cooled and uncooled hydrogel pads. The observations made in the open-air testing conditions are consistent with the predicted events following the Arrhenius law. By contrast, the combination of cooling and occlusion by the hydrogel pads is responsible for the reverse effect on the SC. [less ▲]

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See detailAngiogenic fast-growing melanomas and their micrometastases.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Paquet, Philippe ULg et al

in European Journal of Dermatology (2010), 20(3), 302-7

Malignant melanoma (MM), particularly its fast-growing type, is prone to interstitial, intravascular and extravascular migratory metastases. There is no information linking their growth fraction, the ... [more ▼]

Malignant melanoma (MM), particularly its fast-growing type, is prone to interstitial, intravascular and extravascular migratory metastases. There is no information linking their growth fraction, the configuration of the MM advancing edge, the extent in vascularity and the propensity to metastatic progression. The objective of this study was to determine the growth fraction, the size of vascularity and the contours of the progression border of 32 fast-growing MM with regard to the presence or absence of a micrometastatic spread inside the skin and overt metastases in the sentinel lymph nodes. In vivo high resolution colorimetry was performed as a clinical estimate of MM vascularity. Euclidean geometry and fractal analysis were used on immunohistochemical sections. The relative microvasculature profile area beneath MM, and the fractal dimension D of the MM frontline were assessed. The MIB/Ki-67 index was determined in MM cells. Value a* of colorimetry was similarly increased in the presence or absence of micro-metastases. No difference in growth fraction was revealed between these neoplasms. Correlations were found between vascularity and angiotropism, and between the micrometastatic process and the sentinel lymph node involvement. By contrast, no correlation was shown between vascularity and the fractal D dimension of the MM advancing edge. In sum, this study establishes a link between the extent of MM growth fraction, vascularity and the presence of dermal and nodal micrometastases in fast-growing MM. [less ▲]

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See detailRevisiting biothermal effects on erythematous hypertrophic scars during pregnancy
NIZET, Jean-Luc ULg; Pierard, Gérald ULg; Quatresooz, Pascale ULg

in Journal of Cosmetic Dermatology (2009), 8(1), 27-31

BACKGROUND: Pregnancy is possibly associated with altered wound healing including the development of hypertrophic or keloidal scarring. The management of these lesions may prove to be difficult, and there ... [more ▼]

BACKGROUND: Pregnancy is possibly associated with altered wound healing including the development of hypertrophic or keloidal scarring. The management of these lesions may prove to be difficult, and there are no universally accepted treatment protocols. Objective To assess erythema fading of hypertrophic scars following cold applications. METHODS: Skin color was assessed using the Visi-Chroma VC100 technology following validation of the method. We compared the effects of freezing or cooling hypertrophic scars developed in 45 Caucasian pregnant women. The effects of liquid nitrogen spray cryotherapy, hydrogel cooling pads, and thermal contact cushions were compared. RESULT: This pilot study showed that the three treatment modalities substantially decreased erythema. The thermal contact cushion appeared to be the most effective biothermal means for achieving this effect. CONCLUSION: Freezing or cooling hypertrophic scars helps reducing erythema of hypertrophic scars. This effect probably results from an inhibitory action exerted on the microvasculature. Data suggest that repeat applications of mild cooling might be more effective than a few short freezing sessions. [less ▲]

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See detailSkin homing of Treponema pallidum in early syphilis: an immunohistochemical study
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Applied Immunohistochemistry & Molecular Morphology (2009), 17(1), 47-50

The incidence of syphilis is increasing in most parts of the world including some major European cities. The lesions developing during secondary syphilis may be difficult to diagnose clinically. Similarly ... [more ▼]

The incidence of syphilis is increasing in most parts of the world including some major European cities. The lesions developing during secondary syphilis may be difficult to diagnose clinically. Similarly, the histopathologic changes do not always fulfill the typical diagnostic criteria. The objective of this study was to assess the contribution of immunohistochemistry for the identification and localization of Treponema pallidum on the skin. We retrieved from our files 12 paraffin-embedded biopsies of skin lesions, which had posed diagnostic problems in the past. Only a serologic test had proven that the patients had syphilis. Controls consisted of lichenoid dermatoses unrelated to syphilis and borreliosis. Immunohistochemistry using an antispirochete (T. pallidum and Borrelia) antibody was performed retrospectively. In all samples from primary and secondary syphilis, T. pallidum was highlighted, but none of the control lesions unrelated to syphilis showed positivity. Interestingly enough, T. pallidum present in the lower mid-part of the epidermis often outnumbered that in the dermis. This difference was more striking in secondary syphilis compared with primary syphilis. Immunohistochemistry for T. pallidum considerably increased the sensitivity and the specificity of the histologic diagnosis. The strong epidermal homing of T. pallidum is highlighted in early syphilis. [less ▲]

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See detailKératoses actiniques sous la loupe.
PIERARD, Gérald ULg; BASSET-SEGUIN, N.; HENGGE, U. et al

Book published by Publ. Artoos (2009)

Actinic keratoses are common lesions caused by the cumulative action of the sun’s rays on the skin of predisposed individuals. They generally develop in seniors, but they may be earlier in those who have ... [more ▼]

Actinic keratoses are common lesions caused by the cumulative action of the sun’s rays on the skin of predisposed individuals. They generally develop in seniors, but they may be earlier in those who have an occupational activity outside or who spend a lot of spare time under the sun. The depletion of the ozone layer might also be involved. [less ▲]

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See detailSécrétion sudorale et sébacée
PIERARD, Gérald ULg; QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg

in Expertise médicale continue (2009)

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See detailActinic keartosis under scrutiny: 20 questions and answers
PIERARD, Gérald ULg; BASSET-SEGUIN, N.; HENGGE, U. et al

Book published by Artoos (2009)

Detailed reference viewed: 17 (2 ULg)
See detailLe diagnostic précoce des cancers de la peau est primordial
PIERARD, Gérald ULg; ANDRE, J.; BROCHEZ, L. et al

Book published by bioderma (2009)

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See detailCancers cutanés photo induits en 3D, version spécialiste
PIERARD, Gérald ULg; Andre, J.; Brochez, L. et al

Book (2009)

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See detailmycoses
PIERARD, Gérald ULg; QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg

in Dermatologie et infections sexuellement transmissibles (2009)

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See detailInfections of the nail unit
PIERARD, Gérald ULg; PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg

in Skin infections (2009)

Detailed reference viewed: 7 (3 ULg)