References of "Quatresooz, Pascale"
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See detailCutaneous spherulosis (myospherulosis).
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2007), 8(2), 117-9

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See detailWhat do you mean by eczema craquele?
Pierard, Gérald ULg; Quatresooz, Pascale ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2007), 215(1), 3-4

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See detailDowngrading skin climacteric aging by hormone replacement therapy.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Expert Review of Dermatology (2007), 2

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See detailRegional variability in stratum corneum reactivity to antiseptic formulations.
Quatresooz, Pascale ULg; Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg et al

in Contact Dermatitis (2007), 56(5), 271-3

Skin does not react in an identical way to the action of chemicals over all anatomic sites. Accordingly, distinct regional differences have been described in relation to irritancy. The present study ... [more ▼]

Skin does not react in an identical way to the action of chemicals over all anatomic sites. Accordingly, distinct regional differences have been described in relation to irritancy. The present study assesses the regional variations of stratum corneum (SC) reactivity to 3 proprietary antiseptic solutions (povidone iodine (PVP-I), 70 mg/ml and 100 mg/ml, and chlorhexidine digluconate 50 mg/ml) using the corneoxenometry (CXM) bioassay. SC was harvested from the volar forearm, the forehead and the back in 30 young adults. Each SC sample was covered by one of the neat test product or deionized water for 2 hr at 20 degrees C. The intrinsic staining property of each antiseptic on SC was assessed by reflectance colorimetry. For the CXM bioassay, samples were then stained by a toluidine blue-basic fuschin solution in order to show protein denaturation induced by the test products. The colorimetric index of mildness (CIM = L*- Chroma C*) was measured by colorimetry. Data show that PVP-I 100 mg/ml was the least reactive antiseptic to the SC. It was significantly milder than the 2 other antiseptics. [less ▲]

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See detailComment j'explore...la piste toxique revisitée des sclérodermies.
Quatresooz, Pascale ULg; Paquet, Philippe ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2007), 62(3), 170-4

The name scleroderma is given to a spectrum of diseases which differ clinically and bear different prognostic risks. The origins of the various forms of the disease are unclear. A toxic influence has been ... [more ▼]

The name scleroderma is given to a spectrum of diseases which differ clinically and bear different prognostic risks. The origins of the various forms of the disease are unclear. A toxic influence has been suggested, particularly for the progressive systemic scleroderma. However, the imputability of the suspected chemicals often remains unsettled. [less ▲]

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See detailSmoothing the mosaic subclinical melanoderma by calcipotriol.
Pierard, Claudine ULg; Paquet, Philippe ULg; Quatresooz, Pascale ULg et al

in Journal of the European Academy of Dermatology & Venereology (2007), 21(5), 657-61

BACKGROUND: The observation of photo-exposed skin under ultraviolet light reveals a mosaic pattern of varying intensity in epidermal melanization. Several patterns of mosaic subclinical melanoderma (MSM ... [more ▼]

BACKGROUND: The observation of photo-exposed skin under ultraviolet light reveals a mosaic pattern of varying intensity in epidermal melanization. Several patterns of mosaic subclinical melanoderma (MSM) have been described using a specially designed CCD camera and the ultraviolet light-enhanced visualization (ULEV) method. Vitamin D(3) and its analogues influence the biology of keratinocytes and melanocytes. OBJECTIVE: To assess the effect of calcipotriol on MSM. METHODS: This randomized split-face study was conducted in 27 men to compare the effect of once daily applications of 5% calcipotriol cream or a moisturizing cream on the heterogeneity of facial MSM. Computerized image analysis of video images was used at 1-month intervals before and during a 2-month treatment, as well as during a 3-month follow-up. RESULTS: At both sites, the average melanin content of the epidermis showed no significant change over time. However, the mottled appearance was smoothened at the calcipotriol site, whereas it was increased at the site receiving the moisturizer. CONCLUSION: The decreased heterogeneity in MSM after calcipotriol applications suggests a control of the epidermal melanocyte unit by the vitamin D(3) derivative. [less ▲]

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See detailFungal thigmotropism in onychomycosis and in a clear hydrogel pad model.
Pierard, Gérald ULg; Pierard, Claudine ULg; Quatresooz, Pascale ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2007), 215(2), 107-13

BACKGROUND: Thigmotropism is a biological characteristic corresponding to the directional growth of cells following topographical guidance cues. This behavior has been shown experimentally with fungal ... [more ▼]

BACKGROUND: Thigmotropism is a biological characteristic corresponding to the directional growth of cells following topographical guidance cues. This behavior has been shown experimentally with fungal hyphae of both dermatophytes and nondermatophyte molds, as well as with the mycelial phase of the dimorphic yeast Candida albicans. OBJECTIVE AND METHODS: We presently document this phenomenon using histomycology in onychomycoses of various fungal origins. RESULTS: This mechanism is involved in the invasive phase of the pathogen or opportunistic fungi, and it probably governs various clinical aspects of onychomycoses. We incidentally disclosed fungal invasions of hydrogel pads. Conclusion: Thigmotropism can in part explain the diversity of orientations and shapes of fungi invading nail plates. The same phenomenon was disclosed inside hydrogel pads. As this material is transparent and easy to cut for microscopic examination, fungal thigmotropism is conveniently explored by this way. [less ▲]

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See detailEmerging therapeutic agents for onychomycosis.
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Expert Opinion on Emerging Drugs (2007), 12(3), 345-53

Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families ... [more ▼]

Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families have been reported to be responsible for onychomycosis. The output from the pharmaceutical industry of new antifungals to treat onychomycosis has been limited over the last decade. Present treatment options include both oral and topical drugs, with oral therapies giving better outcomes. However, neither of these treatment options provides high cure rates that are durable. At present, azoles and allylamines are keeping the pivotal roles. New derivatives with a favorable risk-benefit ratio and new formulations of older azoles seem to be promising. Thus, ongoing drug development activities have focused on novel delivery technologies to facilitate incorporation of existing antifungal drugs inside the nail plate and the discovery of new active antifungals. [less ▲]

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See detailL'image du mois. Onychopathie mycopsoriasique.
Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2007), 62(9), 533

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See detailLe mélanome cutané dans une perspective liégeoise. Actualisation de son épidémiologie et avancées diagnostiques.
Quatresooz, Pascale ULg; Hustinx, Roland ULg; Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2007), 62(Supplément), 52-55

Cutaneous melanoma is one of the research poles at the University Hospital of Liège. Since 20 years or so, the dermatopathology laboratory with the contribution of the Mosan Study Group of Pigmented ... [more ▼]

Cutaneous melanoma is one of the research poles at the University Hospital of Liège. Since 20 years or so, the dermatopathology laboratory with the contribution of the Mosan Study Group of Pigmented Neoplasms have scrutenised the epidemiological evolution of this cancer. We have disclosed a sharp increase in the global incidence of melanoma, more particularly in women in the age of procreation. We have also contributed and innovated in terms of clinical diagnosis by introducing dermoscopy and initiating both the ULEV method and the cyanoacrylate skin surface stripping. In the field of dermatopathology we have developed an immunohistological panel allowing to fine tune the diagnosis and to define some histoprognostic criteria. For the checkup of the disease extension, the PET scan method has been particularly refined. [less ▲]

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See detailMaladie de Darier zostériforme et infection herpétique.
Blaise, Géraldine; Franchimont, Claudine ULg; Quatresooz, Pascale ULg et al

in Dermatologie Actualité (2007), 102

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See detailLa syphilis, la grande simulatrice démasquée.
Quatresooz, Pascale ULg; Blaise, Géraldine; Franchimont, Claudine ULg et al

in Dermatologie Actualité (2007), 104

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See detailErlotinib-responsive actinic keratoses.
Hermanns, Jean-Francois; Pierard, Gérald ULg; Quatresooz, Pascale ULg

in Oncology Reports (2007), 18(3), 581-4

Erlotinib is an inhibitor of the tyrosine-kinase domain of the epidermal growth factor receptor-1 (EGFR). This drug is used to treat some solid cancers, particularly advanced non-small-cell lung carcinoma ... [more ▼]

Erlotinib is an inhibitor of the tyrosine-kinase domain of the epidermal growth factor receptor-1 (EGFR). This drug is used to treat some solid cancers, particularly advanced non-small-cell lung carcinoma. Similar to other EGFR inhibitors, erlotinib is responsible for a series of skin adverse reactions, particularly acneiform lesions. We described the incidental effect of erlotinib on actinic keratoses which became markedly inflamed and showed partial regression. Inflammation appeared to spontaneously decrease while on erlotinib treatment. This reaction in the skin neoplasm is perhaps a visible and accessible model for predicting the effect in the deep-seated neoplasm targeted by the drug. [less ▲]

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See detailLe syndrome d'Ehlers-Danlos. Qu'y a-t-il sous la pointe émergée de l'iceberg?
Quatresooz, Pascale ULg; Blaise, Géraldine; Franchimont, Claudine ULg et al

in Dermatologie Actualité (2007), 105

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See detailCancers cutanés après transplantation d'organe, un revers de médaille.
Quatresooz, Pascale ULg; Pierard, Gérald ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2007), 62(11), 663-8

Drug-induced immunosuppression is the necessary corollary of organ transplantation. This situation is responsible for an increased risk of both infection and neoplasia. Cutaneous carcinomas are the most ... [more ▼]

Drug-induced immunosuppression is the necessary corollary of organ transplantation. This situation is responsible for an increased risk of both infection and neoplasia. Cutaneous carcinomas are the most frequent malignancies developing after organ transplantation. The usual squamous to basal cell carcinoma ratio is increased and reversed compared to the general population. Carcinomas primarily result from the combination of cumulative sun exposure, fair skin phototype and effects of immunosuppressive drugs. These treatments impair the systemic immunosurveillance and may exert a direct carcinogenic effect. The severity of these carcinomas is due to their multiplicity and to the occurrence of more aggressive lesions. Prevention relies on a strict adherence to sun protection after transplantation, and on refined immunosuppressive strategies. The treatment of the neoplastic lesions is based on their early and complete excision with histological control of the nature of the neoplasm, the safety surgical margins, and the determination of prognostic factors. [less ▲]

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See detailTour d'horizon des dermatoses prurigineuses chez la femme enceinte.
Szepetiuk, Grégory; Melotte, Chantal ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2007), 62(12), 719-24

Any pruritus occurring in pregnant women may represent a sensorial manifestation unrelated to pregnancy, but it may represent the consequence of a pregnancy-specific dermatosis. This latter group ... [more ▼]

Any pruritus occurring in pregnant women may represent a sensorial manifestation unrelated to pregnancy, but it may represent the consequence of a pregnancy-specific dermatosis. This latter group encompass pruritus gravidarum with or without intrahepatic cholestasis, pemphigoid gestationis, polymorphic eruption of pregnancy, prurigo gestationis, acute folliculitis of pregnancy, impetigo herpetiformis and the progesterone auto-immune dermatitis. Fetal risk of morbidity is recognized for pruritus gravidarum with intrahepatic cholestasis, pemphigoid gestationis and impetigo herpetiformis. [less ▲]

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See detailConfrontation anatomo-clinique. Le cancer cutané a-t-il été éradique?
Arrese Estrada, Jorge ULg; Pierard, Gérald ULg; Ruiz Ballon, M. et al

in Revue Médicale de Liège (2007), 62(9), 582-4

Distinguishing complete removal of a skin cancer and its partial destruction is frequently requested by the clinicians and their patients. The information is awaited from the laboratory, but it is not ... [more ▼]

Distinguishing complete removal of a skin cancer and its partial destruction is frequently requested by the clinicians and their patients. The information is awaited from the laboratory, but it is not always correctly interpreted by the information-seekers. The factors influencing this assessment include the combination of the nature of the antineoplastic therapy, the sampling modality of the area to be examined, and the quality of the dermatopathology procedure. In addition, the possibility of neoplastic regression linked to scarring or, conversely, the existence of a possible field cancerisation should be taken into consideration. [less ▲]

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