References of "Quatresooz, Pascale"
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See detailCrossroads between actinic keratosis and squamous cell carcinoma, and novel pharmacological issues.
Quatresooz, Pascale ULiege; Pierard, Claudine ULiege; Paquet, Philippe ULiege et al

in European Journal of Dermatology (2008), 18(1), 6-10

Actinic keratoses (AKs) and their derived squamous cell carcinomas are distinctive lesions forming a continuum in a multi-step carcinogenesis process. They are typically found on chronically sun exposed ... [more ▼]

Actinic keratoses (AKs) and their derived squamous cell carcinomas are distinctive lesions forming a continuum in a multi-step carcinogenesis process. They are typically found on chronically sun exposed skin. AKs merit to be recognized as such and to be distinguished from squamous cell carcinomas both conceptually and for therapeutic implications. The histological differences between these lesions are well defined and should not be blurred. A brief review is presented about the biological features responsible for AKs and the clinicopathologically distinctive aspects of these lesions. In addition, recent findings are presented about pharmacotherapy using anti-epidermal growth factor receptors, imidazoquinolines, diclofenac-hyaluronan, and methyl aminolevulinate photodynamic therapy. [less ▲]

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See detailPhotodynamic therapy for cutaneous verrucous carcinoma
Nikkels, Arjen ULiege; Thirion, Laurence; Quatresooz, Pascale ULiege et al

in Journal of the American Academy of Dermatology (2007)

Cutaneous verrucous carcinoma is a low-grade and well-differentiated variant of squamous cell carcinoma. This rare neoplasm follows a seemingly indolent progression and exhibits a low metastatic potential ... [more ▼]

Cutaneous verrucous carcinoma is a low-grade and well-differentiated variant of squamous cell carcinoma. This rare neoplasm follows a seemingly indolent progression and exhibits a low metastatic potential. Photodynamic therapy relies on the selective intratumoral cell accumulation and photoactivation of a photosensitizer, leading to the generation of phototoxic compounds responsible for necrosis and apoptosis of the target cells. An 82-year-old man presenting with a large long-standing verrucous carcinoma on the leg was treated successfully by 6 photodynamic therapy sessions administered at weekly intervals using methyl-aminolevulinate and 57-J/cm2 irradiations at 634-nm wavelength. The use of methyl-aminolevulinate–photodynamic therapy for treating cutaneous verrucous carcinoma had not been reported so far. It may represent a convenient therapeutic alternative in this setting. [less ▲]

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See detailDermatologie et Rhumatologie.
Quatresooz, Pascale ULiege

Scientific conference (2007)

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See detailMosaic subclinical melanoderma and skin cancers.
Quatresooz, Pascale ULiege

Conference (2007)

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See detailA four-generation Ehlers-Danlos syndrome with vascular dissections. Skin ultrastructure and biomechanical properties.
Flagothier, Caroline ULiege; Goffin, Véronique ULiege; Hermanns-Lê, Trinh ULiege et al

in Journal of Medical Engineering & Technology (2007), 31(3), 175-80

Ehlers-Danlos syndrome (EDS) is heterogenous with regard to genetic traits, clinical manifestation, the biomechanical and microscopic properties of connective tissues, and basic molecular defects. We ... [more ▼]

Ehlers-Danlos syndrome (EDS) is heterogenous with regard to genetic traits, clinical manifestation, the biomechanical and microscopic properties of connective tissues, and basic molecular defects. We report on nine relatives of four generations who suffered from large vessel dissections and cutaneous microscopic changes consistent with EDS. Measurements of the mechanical properties of skin were performed using a computerized suction device (Cutometer). Morphological and biomechanical alterations suggestive of EDS were present in all examined subjects. A loose network of collagen bundles was admixed with clumsy elastic fibres. Factor XIIIa-positive dermal dendrocytes looked almost normal but were slim and rarefied in four subjects. The severity in ultrastructural alterations of the collagen network differed among the subjects. The group with the most prominent changes showed the most striking biomechanical alterations characterized by increased biologic elasticity without any excess in skin extensibility. A positive correlation was found between skin extensibility and elasticity. In conclusion, distinct alterations in the collagen scaffolding were found to be correlated to variable severity in biomechanical alterations of the skin. The predictive value of these changes for large vessel dissections in some families at risk remains to be settled. [less ▲]

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See detailPeaufiner la dermatopathologie fonctionnelle, la dermometrologie et la mecanobiologie.
Pierard, Gérald ULiege; Pierard, Claudine ULiege; Hermanns-Lê, Trinh ULiege et al

in Revue Médicale de Liège (2007), 62 Spec No

Dermatopathology is a tool using the microscopic examination for diagnosing cutaneous diseases. The frontiers of its field of interest were extended by exploring the physiopathology of skin functional ... [more ▼]

Dermatopathology is a tool using the microscopic examination for diagnosing cutaneous diseases. The frontiers of its field of interest were extended by exploring the physiopathology of skin functional properties. An example is provided by the evaluation of alterations of skin suppleness in various connective tissue disorders. This approach takes profit from both conventional histology and histochemistry. Immunohistology targeting dermal dendrocytes reveals their various shapes reflecting the modifications in tensegrity under the control of mechanobiology. The latter property is an indicator of the evolution and severity of the connective tissue changes. Electron microscopy is also very instructive in this field. The in vivo examination by dermoscopy highlights a similar mechanism involving the melanocytes. From an engineering point of view, the skin and subcutaneous tissue represent an integrated load-transmitting structure. It is subjected to intrinsic and environmental influences. Some models were offered to explain how skin withstands and transmits loads through deforming appropriately or abnormally according to disorders of the connective tissue structure. We report a brief review of the principles of interpretation of the measurements of the skin biomechanical properties, and the histological presentations of mechanobiology. The applications of such investigations are summarized in the Ehlers-Danlos syndrome, inguinal hernias, gravitational syndrome, diabetes, scleroderma, hemodialysed patients, in case of growth hormone administration and during climacteric. [less ▲]

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See detailPeut-on sortir de l'embrouillamini relatif aux contraceptifs oraux et aux cancers cutanés?
Pierard, Gérald ULiege; Pierard, Claudine ULiege; Quatresooz, Pascale ULiege et al

in Revue Médicale de Liège (2007), 62(5-6), 463-6

Skin contains various hormonal receptors, particularly those for estrogens, progesterone and androgens. Steroid hormones of oral contraceptives affect the skin, in particular the control of the cell cycle ... [more ▼]

Skin contains various hormonal receptors, particularly those for estrogens, progesterone and androgens. Steroid hormones of oral contraceptives affect the skin, in particular the control of the cell cycle, DNA replication, apoptosis and other cellular functions. Some estrogen-responsive pathways have the potential to promote tumor development. The question of whether oral contraceptives increase the risk for the development of skin cancer, particularly melanoma, remains an area of concern. There is some evidence that steroid hormones present in oral contraceptives do not significantly increase the risk of developing skin cancer when estrogen exposure is not excessive. [less ▲]

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See detailNoninfectious dermatoses of pregnancy
QUATRESOOZ, Pascale ULiege; PIERARD-FRANCHIMONT, Claudine ULiege; PIERARD, Gérald ULiege

in Therapeutique dermatologique (2007)

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See detailDermométrologie et mécanobiologie
QUATRESOOZ, Pascale ULiege; PIERARD, Gérald ULiege

Scientific conference (2007)

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See detailSuccessful therapy of verrucous carcinoma by photodynamic therapy
NIKKELS, Arjen ULiege; thirion, L.; QUATRESOOZ, Pascale ULiege et al

Poster (2007)

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See detailPhotodynamic therapy for cutaneous carcinoma
NIKKELS, Arjen ULiege; thirion, L.; QUATRESOOZ, Pascale ULiege et al

Poster (2007)

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See detailDiagnostic challenge of desmoplastic melanoma.
Quatresooz, Pascale ULiege; Franchimont, Claudine ULiege; Pierard, Gérald ULiege

in Trends in Cancer Research (2007), 3

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See detailCutaneous spherulosis (myospherulosis).
Quatresooz, Pascale ULiege; Pierard, Gérald ULiege

in American Journal of Clinical Dermatology (2007), 8(2), 117-9

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See detailWhat do you mean by eczema craquele?
Pierard, Gérald ULiege; Quatresooz, Pascale ULiege

in Dermatology : International Journal for Clinical & Investigative Dermatology (2007), 215(1), 3-4

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See detailDowngrading skin climacteric aging by hormone replacement therapy.
Quatresooz, Pascale ULiege; Pierard, Gérald ULiege

in Expert Review of Dermatology (2007), 2

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See detailRegional variability in stratum corneum reactivity to antiseptic formulations.
Quatresooz, Pascale ULiege; Xhauflaire, Emmanuelle ULiege; Pierard, Claudine ULiege et al

in Contact Dermatitis (2007), 56(5), 271-3

Skin does not react in an identical way to the action of chemicals over all anatomic sites. Accordingly, distinct regional differences have been described in relation to irritancy. The present study ... [more ▼]

Skin does not react in an identical way to the action of chemicals over all anatomic sites. Accordingly, distinct regional differences have been described in relation to irritancy. The present study assesses the regional variations of stratum corneum (SC) reactivity to 3 proprietary antiseptic solutions (povidone iodine (PVP-I), 70 mg/ml and 100 mg/ml, and chlorhexidine digluconate 50 mg/ml) using the corneoxenometry (CXM) bioassay. SC was harvested from the volar forearm, the forehead and the back in 30 young adults. Each SC sample was covered by one of the neat test product or deionized water for 2 hr at 20 degrees C. The intrinsic staining property of each antiseptic on SC was assessed by reflectance colorimetry. For the CXM bioassay, samples were then stained by a toluidine blue-basic fuschin solution in order to show protein denaturation induced by the test products. The colorimetric index of mildness (CIM = L*- Chroma C*) was measured by colorimetry. Data show that PVP-I 100 mg/ml was the least reactive antiseptic to the SC. It was significantly milder than the 2 other antiseptics. [less ▲]

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See detailComment j'explore...la piste toxique revisitée des sclérodermies.
Quatresooz, Pascale ULiege; Paquet, Philippe ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2007), 62(3), 170-4

The name scleroderma is given to a spectrum of diseases which differ clinically and bear different prognostic risks. The origins of the various forms of the disease are unclear. A toxic influence has been ... [more ▼]

The name scleroderma is given to a spectrum of diseases which differ clinically and bear different prognostic risks. The origins of the various forms of the disease are unclear. A toxic influence has been suggested, particularly for the progressive systemic scleroderma. However, the imputability of the suspected chemicals often remains unsettled. [less ▲]

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