Space-time clustering and seasonality in diagnosing skin cancers in Wallonia (south-east Belgium).
Quatresooz, Pascale ; Pierard, Claudine ; Pierard, Gérald
in Dermatology : International Journal for Clinical & Investigative Dermatology (2008), 217(1), 48-51
BACKGROUND: In Westernized populations, the number of diagnosed cases of primary cutaneous cancers, particularly malignant melanomas and basal cell carcinomas (BCC), has been previously shown to fluctuate ... [more ▼]
BACKGROUND: In Westernized populations, the number of diagnosed cases of primary cutaneous cancers, particularly malignant melanomas and basal cell carcinomas (BCC), has been previously shown to fluctuate during specific periods of the year. OBJECTIVE AND METHOD: The aim of the present 6-year study was to explore the seasonality if any in skin cancer detection in Wallonia (south-east Belgium). RESULTS: For both malignant melanomas and BCC late spring/early summer and mid-autumn were the periods of highest diagnosis prevalence irrespective of gender. The amplitude of this bimodal evolution remained within the range of 2 standard deviations around the monthly means. Similar seasonal variations were also found in non-neoplastic controls consisting of laboratory samplings of onychomycoses and non-infectious onychodystrophies. CONCLUSION: There is reason to believe that this timing and rhythm is unrelated to any specific cancer chronomics. Rather, the present findings suggest unspecific seasonality in diagnosing skin disorders including malignancies. A variable patient awareness of changing aspects of the skin according to seasons probably represents the major influence of the described space-time clustering of skin cancer diagnosis. [less ▲]Detailed reference viewed: 18 (1 ULg)
Skin fungal biocontamination and the skin hydrogel pad test.
Paquet, Philippe ; Pierard, Claudine ; Pierard, Gérald et al
in Archives of Dermatological Research (2008), 300(4), 167-71
Previous observations have revealed that environmental nondermatophyte molds (NDM) can grow inside specific hydrogel pads (LaserAid). Some of these NDM might be responsible for superficial and invasive ... [more ▼]
Previous observations have revealed that environmental nondermatophyte molds (NDM) can grow inside specific hydrogel pads (LaserAid). Some of these NDM might be responsible for superficial and invasive mycoses as well as for allergic respiratory and cutaneous disorders. The load of NDM propagules in the environment is considered to be an important risk factor for all these diseases. It is postulated that the quantification of the responsible fungi deposited at the skin surface may be an indicator of a recent exposure to environmental fungi. The aim of the present study was to assess using the LaserAid hydrogel pads, the density of living NDM adhering to the skin surface of healthy subjects. Sterile hydrogel pads were applied in a repeat procedure onto the normal-looking skin of the palms and face of 35 healthcare workers who were active in low exposure areas. Similar samplings were performed after washing the skin with a regular skin cleanser, or after applying an alcohol solution or a povidone iodine solution. As controls, 20 sterile pads were exposed for a few minutes to ambient air of the laboratory without any contact with the skin. Each of these samples was stored for 2 weeks at room temperature in a clean protected environment. After that period, visual inspection of the pads was followed by microscopic examination of PAS-stained 6 microm-thick sections. In addition, mycological cultures were performed from pieces of the pads deposited onto Sabouraud agar plates. While 19/20 air-exposed samples were not contaminated by environmental air-borne fungi, 61/70 of the initial skin samplings and 6/70 of the repeat skin samplings showed foci of fungal colonization confirmed by microscopic examination. No specific differences were disclosed between the face and palm samplings. Cultures revealed the presence of NDM in the majority (64/67) of the colonized pads, and a few Candida albicans contaminations (3/67) were also disclosed. The cleansing with a non-antimicrobial product as well as disinfecting procedures performed before sampling markedly decreased the mycoflora without, however, clearing the skin of NDM and yeasts. In conclusion, the hydrogel pad procedure brings information about potential environmental skin contamination by NDM and commensal yeasts. The regular cleansing and disinfecting procedures do not eradicate these fungi from the skin surface. [less ▲]Detailed reference viewed: 35 (2 ULg)
Crossroads between actinic keratosis and squamous cell carcinoma, and novel pharmacological issues.
Quatresooz, Pascale ; Pierard, Claudine ; Paquet, Philippe et al
in European Journal of Dermatology (2008), 18(1), 6-10
Actinic keratoses (AKs) and their derived squamous cell carcinomas are distinctive lesions forming a continuum in a multi-step carcinogenesis process. They are typically found on chronically sun exposed ... [more ▼]
Actinic keratoses (AKs) and their derived squamous cell carcinomas are distinctive lesions forming a continuum in a multi-step carcinogenesis process. They are typically found on chronically sun exposed skin. AKs merit to be recognized as such and to be distinguished from squamous cell carcinomas both conceptually and for therapeutic implications. The histological differences between these lesions are well defined and should not be blurred. A brief review is presented about the biological features responsible for AKs and the clinicopathologically distinctive aspects of these lesions. In addition, recent findings are presented about pharmacotherapy using anti-epidermal growth factor receptors, imidazoquinolines, diclofenac-hyaluronan, and methyl aminolevulinate photodynamic therapy. [less ▲]Detailed reference viewed: 64 (4 ULg)
Comment j'explore le témoignage cutané de quelques affections neuro-musculaires par la dermatopathologie.
Quatresooz, Pascale ; Hermanns-Lê, Trinh ; Arrese Estrada, Jorge et al
in Skin (2007), 10Detailed reference viewed: 16 (2 ULg)
A four-generation Ehlers-Danlos syndrome with vascular dissections. Skin ultrastructure and biomechanical properties.
Flagothier, Caroline ; Goffin, Véronique ; Hermanns-Lê, Trinh et al
in Journal of Medical Engineering & Technology (2007), 31(3), 175-80
Ehlers-Danlos syndrome (EDS) is heterogenous with regard to genetic traits, clinical manifestation, the biomechanical and microscopic properties of connective tissues, and basic molecular defects. We ... [more ▼]
Ehlers-Danlos syndrome (EDS) is heterogenous with regard to genetic traits, clinical manifestation, the biomechanical and microscopic properties of connective tissues, and basic molecular defects. We report on nine relatives of four generations who suffered from large vessel dissections and cutaneous microscopic changes consistent with EDS. Measurements of the mechanical properties of skin were performed using a computerized suction device (Cutometer). Morphological and biomechanical alterations suggestive of EDS were present in all examined subjects. A loose network of collagen bundles was admixed with clumsy elastic fibres. Factor XIIIa-positive dermal dendrocytes looked almost normal but were slim and rarefied in four subjects. The severity in ultrastructural alterations of the collagen network differed among the subjects. The group with the most prominent changes showed the most striking biomechanical alterations characterized by increased biologic elasticity without any excess in skin extensibility. A positive correlation was found between skin extensibility and elasticity. In conclusion, distinct alterations in the collagen scaffolding were found to be correlated to variable severity in biomechanical alterations of the skin. The predictive value of these changes for large vessel dissections in some families at risk remains to be settled. [less ▲]Detailed reference viewed: 45 (3 ULg)
Peaufiner la dermatopathologie fonctionnelle, la dermometrologie et la mecanobiologie.
Pierard, Gérald ; Pierard, Claudine ; Hermanns-Lê, Trinh et al
in Revue Médicale de Liège (2007), 62 Spec No
Dermatopathology is a tool using the microscopic examination for diagnosing cutaneous diseases. The frontiers of its field of interest were extended by exploring the physiopathology of skin functional ... [more ▼]
Dermatopathology is a tool using the microscopic examination for diagnosing cutaneous diseases. The frontiers of its field of interest were extended by exploring the physiopathology of skin functional properties. An example is provided by the evaluation of alterations of skin suppleness in various connective tissue disorders. This approach takes profit from both conventional histology and histochemistry. Immunohistology targeting dermal dendrocytes reveals their various shapes reflecting the modifications in tensegrity under the control of mechanobiology. The latter property is an indicator of the evolution and severity of the connective tissue changes. Electron microscopy is also very instructive in this field. The in vivo examination by dermoscopy highlights a similar mechanism involving the melanocytes. From an engineering point of view, the skin and subcutaneous tissue represent an integrated load-transmitting structure. It is subjected to intrinsic and environmental influences. Some models were offered to explain how skin withstands and transmits loads through deforming appropriately or abnormally according to disorders of the connective tissue structure. We report a brief review of the principles of interpretation of the measurements of the skin biomechanical properties, and the histological presentations of mechanobiology. The applications of such investigations are summarized in the Ehlers-Danlos syndrome, inguinal hernias, gravitational syndrome, diabetes, scleroderma, hemodialysed patients, in case of growth hormone administration and during climacteric. [less ▲]Detailed reference viewed: 61 (7 ULg)
Peut-on sortir de l'embrouillamini relatif aux contraceptifs oraux et aux cancers cutanés?
Pierard, Gérald ; Pierard, Claudine ; Quatresooz, Pascale et al
in Revue Médicale de Liège (2007), 62(5-6), 463-6
Skin contains various hormonal receptors, particularly those for estrogens, progesterone and androgens. Steroid hormones of oral contraceptives affect the skin, in particular the control of the cell cycle ... [more ▼]
Skin contains various hormonal receptors, particularly those for estrogens, progesterone and androgens. Steroid hormones of oral contraceptives affect the skin, in particular the control of the cell cycle, DNA replication, apoptosis and other cellular functions. Some estrogen-responsive pathways have the potential to promote tumor development. The question of whether oral contraceptives increase the risk for the development of skin cancer, particularly melanoma, remains an area of concern. There is some evidence that steroid hormones present in oral contraceptives do not significantly increase the risk of developing skin cancer when estrogen exposure is not excessive. [less ▲]Detailed reference viewed: 24 (4 ULg)
Mosaic subclinical melanoderma determined by ULEV method and skin cancers
QUATRESOOZ, Pascale ; PIERARD, Gérald
Poster (2007)Detailed reference viewed: 2 (0 ULg)
Successful therapy of verrucous carcinoma by photodynamic therapy
NIKKELS, Arjen ; ; QUATRESOOZ, Pascale et al
Poster (2007)Detailed reference viewed: 4 (0 ULg)
Avancées physiopathologiques dans la dermatite séborrhéique de l'adulte.
Pierard, Gérald ; Franchimont, Claudine ; Quatresooz, Pascale
in Keratin (2007), 12Detailed reference viewed: 53 (1 ULg)
Downgrading skin climacteric aging by hormone replacement therapy.
Quatresooz, Pascale ; Pierard, Gérald
in Expert Review of Dermatology (2007), 2Detailed reference viewed: 8 (2 ULg)
Regional variability in stratum corneum reactivity to antiseptic formulations.
Quatresooz, Pascale ; Xhauflaire, Emmanuelle ; Pierard, Claudine et al
in Contact Dermatitis (2007), 56(5), 271-3
Skin does not react in an identical way to the action of chemicals over all anatomic sites. Accordingly, distinct regional differences have been described in relation to irritancy. The present study ... [more ▼]
Skin does not react in an identical way to the action of chemicals over all anatomic sites. Accordingly, distinct regional differences have been described in relation to irritancy. The present study assesses the regional variations of stratum corneum (SC) reactivity to 3 proprietary antiseptic solutions (povidone iodine (PVP-I), 70 mg/ml and 100 mg/ml, and chlorhexidine digluconate 50 mg/ml) using the corneoxenometry (CXM) bioassay. SC was harvested from the volar forearm, the forehead and the back in 30 young adults. Each SC sample was covered by one of the neat test product or deionized water for 2 hr at 20 degrees C. The intrinsic staining property of each antiseptic on SC was assessed by reflectance colorimetry. For the CXM bioassay, samples were then stained by a toluidine blue-basic fuschin solution in order to show protein denaturation induced by the test products. The colorimetric index of mildness (CIM = L*- Chroma C*) was measured by colorimetry. Data show that PVP-I 100 mg/ml was the least reactive antiseptic to the SC. It was significantly milder than the 2 other antiseptics. [less ▲]Detailed reference viewed: 22 (1 ULg)
Comment j'explore...la piste toxique revisitée des sclérodermies.
Quatresooz, Pascale ; Paquet, Philippe ; Pierard, Claudine et al
in Revue Médicale de Liège (2007), 62(3), 170-4
The name scleroderma is given to a spectrum of diseases which differ clinically and bear different prognostic risks. The origins of the various forms of the disease are unclear. A toxic influence has been ... [more ▼]
The name scleroderma is given to a spectrum of diseases which differ clinically and bear different prognostic risks. The origins of the various forms of the disease are unclear. A toxic influence has been suggested, particularly for the progressive systemic scleroderma. However, the imputability of the suspected chemicals often remains unsettled. [less ▲]Detailed reference viewed: 18 (0 ULg)
Smoothing the mosaic subclinical melanoderma by calcipotriol.
Pierard, Claudine ; Paquet, Philippe ; Quatresooz, Pascale et al
in Journal of the European Academy of Dermatology & Venereology (2007), 21(5), 657-61
BACKGROUND: The observation of photo-exposed skin under ultraviolet light reveals a mosaic pattern of varying intensity in epidermal melanization. Several patterns of mosaic subclinical melanoderma (MSM ... [more ▼]
BACKGROUND: The observation of photo-exposed skin under ultraviolet light reveals a mosaic pattern of varying intensity in epidermal melanization. Several patterns of mosaic subclinical melanoderma (MSM) have been described using a specially designed CCD camera and the ultraviolet light-enhanced visualization (ULEV) method. Vitamin D(3) and its analogues influence the biology of keratinocytes and melanocytes. OBJECTIVE: To assess the effect of calcipotriol on MSM. METHODS: This randomized split-face study was conducted in 27 men to compare the effect of once daily applications of 5% calcipotriol cream or a moisturizing cream on the heterogeneity of facial MSM. Computerized image analysis of video images was used at 1-month intervals before and during a 2-month treatment, as well as during a 3-month follow-up. RESULTS: At both sites, the average melanin content of the epidermis showed no significant change over time. However, the mottled appearance was smoothened at the calcipotriol site, whereas it was increased at the site receiving the moisturizer. CONCLUSION: The decreased heterogeneity in MSM after calcipotriol applications suggests a control of the epidermal melanocyte unit by the vitamin D(3) derivative. [less ▲]Detailed reference viewed: 16 (2 ULg)