References of "Quatresooz, Pascale"
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See detailA four-generation Ehlers-Danlos syndrome with vascular dissections. Skin ultrastructure and biomechanical properties.
Flagothier, Caroline ULg; Goffin, Véronique ULg; Hermanns-Le, Trinh ULg et al

in Journal of Medical Engineering & Technology (2007), 31(3), 175-80

Ehlers-Danlos syndrome (EDS) is heterogenous with regard to genetic traits, clinical manifestation, the biomechanical and microscopic properties of connective tissues, and basic molecular defects. We ... [more ▼]

Ehlers-Danlos syndrome (EDS) is heterogenous with regard to genetic traits, clinical manifestation, the biomechanical and microscopic properties of connective tissues, and basic molecular defects. We report on nine relatives of four generations who suffered from large vessel dissections and cutaneous microscopic changes consistent with EDS. Measurements of the mechanical properties of skin were performed using a computerized suction device (Cutometer). Morphological and biomechanical alterations suggestive of EDS were present in all examined subjects. A loose network of collagen bundles was admixed with clumsy elastic fibres. Factor XIIIa-positive dermal dendrocytes looked almost normal but were slim and rarefied in four subjects. The severity in ultrastructural alterations of the collagen network differed among the subjects. The group with the most prominent changes showed the most striking biomechanical alterations characterized by increased biologic elasticity without any excess in skin extensibility. A positive correlation was found between skin extensibility and elasticity. In conclusion, distinct alterations in the collagen scaffolding were found to be correlated to variable severity in biomechanical alterations of the skin. The predictive value of these changes for large vessel dissections in some families at risk remains to be settled. [less ▲]

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See detailPeaufiner la dermatopathologie fonctionnelle, la dermometrologie et la mecanobiologie.
Pierard, Gérald ULg; Pierard, Claudine ULg; Hermanns-Le, Trinh ULg et al

in Revue Médicale de Liège (2007), 62 Spec No

Dermatopathology is a tool using the microscopic examination for diagnosing cutaneous diseases. The frontiers of its field of interest were extended by exploring the physiopathology of skin functional ... [more ▼]

Dermatopathology is a tool using the microscopic examination for diagnosing cutaneous diseases. The frontiers of its field of interest were extended by exploring the physiopathology of skin functional properties. An example is provided by the evaluation of alterations of skin suppleness in various connective tissue disorders. This approach takes profit from both conventional histology and histochemistry. Immunohistology targeting dermal dendrocytes reveals their various shapes reflecting the modifications in tensegrity under the control of mechanobiology. The latter property is an indicator of the evolution and severity of the connective tissue changes. Electron microscopy is also very instructive in this field. The in vivo examination by dermoscopy highlights a similar mechanism involving the melanocytes. From an engineering point of view, the skin and subcutaneous tissue represent an integrated load-transmitting structure. It is subjected to intrinsic and environmental influences. Some models were offered to explain how skin withstands and transmits loads through deforming appropriately or abnormally according to disorders of the connective tissue structure. We report a brief review of the principles of interpretation of the measurements of the skin biomechanical properties, and the histological presentations of mechanobiology. The applications of such investigations are summarized in the Ehlers-Danlos syndrome, inguinal hernias, gravitational syndrome, diabetes, scleroderma, hemodialysed patients, in case of growth hormone administration and during climacteric. [less ▲]

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See detailPeut-on sortir de l'embrouillamini relatif aux contraceptifs oraux et aux cancers cutanés?
Pierard, Gérald ULg; Pierard, Claudine ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2007), 62(5-6), 463-6

Skin contains various hormonal receptors, particularly those for estrogens, progesterone and androgens. Steroid hormones of oral contraceptives affect the skin, in particular the control of the cell cycle ... [more ▼]

Skin contains various hormonal receptors, particularly those for estrogens, progesterone and androgens. Steroid hormones of oral contraceptives affect the skin, in particular the control of the cell cycle, DNA replication, apoptosis and other cellular functions. Some estrogen-responsive pathways have the potential to promote tumor development. The question of whether oral contraceptives increase the risk for the development of skin cancer, particularly melanoma, remains an area of concern. There is some evidence that steroid hormones present in oral contraceptives do not significantly increase the risk of developing skin cancer when estrogen exposure is not excessive. [less ▲]

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See detailNoninfectious dermatoses of pregnancy
QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg

in Therapeutique dermatologique (2007)

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See detailDermométrologie et mécanobiologie
QUATRESOOZ, Pascale ULg; PIERARD, Gérald ULg

Scientific conference (2007)

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See detailSuccessful therapy of verrucous carcinoma by photodynamic therapy
NIKKELS, Arjen ULg; thirion, L.; QUATRESOOZ, Pascale ULg et al

Poster (2007)

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See detailPhotodynamic therapy for cutaneous carcinoma
NIKKELS, Arjen ULg; thirion, L.; QUATRESOOZ, Pascale ULg et al

Poster (2007)

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See detailDiagnostic challenge of desmoplastic melanoma.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Trends in Cancer Research (2007), 3

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See detailCutaneous spherulosis (myospherulosis).
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2007), 8(2), 117-9

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See detailWhat do you mean by eczema craquele?
Pierard, Gérald ULg; Quatresooz, Pascale ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2007), 215(1), 3-4

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See detailDowngrading skin climacteric aging by hormone replacement therapy.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Expert Review of Dermatology (2007), 2

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See detailRegional variability in stratum corneum reactivity to antiseptic formulations.
Quatresooz, Pascale ULg; Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg et al

in Contact Dermatitis (2007), 56(5), 271-3

Skin does not react in an identical way to the action of chemicals over all anatomic sites. Accordingly, distinct regional differences have been described in relation to irritancy. The present study ... [more ▼]

Skin does not react in an identical way to the action of chemicals over all anatomic sites. Accordingly, distinct regional differences have been described in relation to irritancy. The present study assesses the regional variations of stratum corneum (SC) reactivity to 3 proprietary antiseptic solutions (povidone iodine (PVP-I), 70 mg/ml and 100 mg/ml, and chlorhexidine digluconate 50 mg/ml) using the corneoxenometry (CXM) bioassay. SC was harvested from the volar forearm, the forehead and the back in 30 young adults. Each SC sample was covered by one of the neat test product or deionized water for 2 hr at 20 degrees C. The intrinsic staining property of each antiseptic on SC was assessed by reflectance colorimetry. For the CXM bioassay, samples were then stained by a toluidine blue-basic fuschin solution in order to show protein denaturation induced by the test products. The colorimetric index of mildness (CIM = L*- Chroma C*) was measured by colorimetry. Data show that PVP-I 100 mg/ml was the least reactive antiseptic to the SC. It was significantly milder than the 2 other antiseptics. [less ▲]

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See detailComment j'explore...la piste toxique revisitée des sclérodermies.
Quatresooz, Pascale ULg; Paquet, Philippe ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2007), 62(3), 170-4

The name scleroderma is given to a spectrum of diseases which differ clinically and bear different prognostic risks. The origins of the various forms of the disease are unclear. A toxic influence has been ... [more ▼]

The name scleroderma is given to a spectrum of diseases which differ clinically and bear different prognostic risks. The origins of the various forms of the disease are unclear. A toxic influence has been suggested, particularly for the progressive systemic scleroderma. However, the imputability of the suspected chemicals often remains unsettled. [less ▲]

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See detailSmoothing the mosaic subclinical melanoderma by calcipotriol.
Pierard, Claudine ULg; Paquet, Philippe ULg; Quatresooz, Pascale ULg et al

in Journal of the European Academy of Dermatology & Venereology (2007), 21(5), 657-61

BACKGROUND: The observation of photo-exposed skin under ultraviolet light reveals a mosaic pattern of varying intensity in epidermal melanization. Several patterns of mosaic subclinical melanoderma (MSM ... [more ▼]

BACKGROUND: The observation of photo-exposed skin under ultraviolet light reveals a mosaic pattern of varying intensity in epidermal melanization. Several patterns of mosaic subclinical melanoderma (MSM) have been described using a specially designed CCD camera and the ultraviolet light-enhanced visualization (ULEV) method. Vitamin D(3) and its analogues influence the biology of keratinocytes and melanocytes. OBJECTIVE: To assess the effect of calcipotriol on MSM. METHODS: This randomized split-face study was conducted in 27 men to compare the effect of once daily applications of 5% calcipotriol cream or a moisturizing cream on the heterogeneity of facial MSM. Computerized image analysis of video images was used at 1-month intervals before and during a 2-month treatment, as well as during a 3-month follow-up. RESULTS: At both sites, the average melanin content of the epidermis showed no significant change over time. However, the mottled appearance was smoothened at the calcipotriol site, whereas it was increased at the site receiving the moisturizer. CONCLUSION: The decreased heterogeneity in MSM after calcipotriol applications suggests a control of the epidermal melanocyte unit by the vitamin D(3) derivative. [less ▲]

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See detailFungal thigmotropism in onychomycosis and in a clear hydrogel pad model.
Pierard, Gérald ULg; Pierard, Claudine ULg; Quatresooz, Pascale ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2007), 215(2), 107-13

BACKGROUND: Thigmotropism is a biological characteristic corresponding to the directional growth of cells following topographical guidance cues. This behavior has been shown experimentally with fungal ... [more ▼]

BACKGROUND: Thigmotropism is a biological characteristic corresponding to the directional growth of cells following topographical guidance cues. This behavior has been shown experimentally with fungal hyphae of both dermatophytes and nondermatophyte molds, as well as with the mycelial phase of the dimorphic yeast Candida albicans. OBJECTIVE AND METHODS: We presently document this phenomenon using histomycology in onychomycoses of various fungal origins. RESULTS: This mechanism is involved in the invasive phase of the pathogen or opportunistic fungi, and it probably governs various clinical aspects of onychomycoses. We incidentally disclosed fungal invasions of hydrogel pads. Conclusion: Thigmotropism can in part explain the diversity of orientations and shapes of fungi invading nail plates. The same phenomenon was disclosed inside hydrogel pads. As this material is transparent and easy to cut for microscopic examination, fungal thigmotropism is conveniently explored by this way. [less ▲]

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See detailEmerging therapeutic agents for onychomycosis.
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Expert Opinion on Emerging Drugs (2007), 12(3), 345-53

Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families ... [more ▼]

Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families have been reported to be responsible for onychomycosis. The output from the pharmaceutical industry of new antifungals to treat onychomycosis has been limited over the last decade. Present treatment options include both oral and topical drugs, with oral therapies giving better outcomes. However, neither of these treatment options provides high cure rates that are durable. At present, azoles and allylamines are keeping the pivotal roles. New derivatives with a favorable risk-benefit ratio and new formulations of older azoles seem to be promising. Thus, ongoing drug development activities have focused on novel delivery technologies to facilitate incorporation of existing antifungal drugs inside the nail plate and the discovery of new active antifungals. [less ▲]

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See detailL'image du mois. Onychopathie mycopsoriasique.
Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2007), 62(9), 533

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