References of "Quatresooz, Pascale"
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See detailLe melanome cutane: innovations conceptuelles et therapeutiques, fruit de la recherche translationnelle.
Pierard, Gérald ULg; Quatresooz, Pascale ULg; Rorive, Andrée ULg et al

in Revue Médicale de Liège (2008), 63(10), 579-84

The scientific information about melanoma is on the rise. It has a direct impact on the diagnostic acuteness and on the therapeutic management. The most recent aspects of the utmost importance are ... [more ▼]

The scientific information about melanoma is on the rise. It has a direct impact on the diagnostic acuteness and on the therapeutic management. The most recent aspects of the utmost importance are presented. The concept of the duality between fast-growing (high malignancy) and slow-growing (reduced malignancy) melanoma is stressed. A new international multicentric approach using adjuvant therapy for stage III melanomas involves the clinical oncology department of the CHU of Liege. It concerns a targeted immunotherapy directed to the Mage A3 protein. [less ▲]

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See detailComment j'explore... une metastase cutanee. Qui es-tu, d'ou viens-tu?
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Rorive, Andrée ULg et al

in Revue Médicale de Liège (2008), 63(9), 559-63

Cutaneous metastases may accompany up to 3 to 10% of all malignancies. They are usually identified after diagnosing the primary neoplasm. However, their disclosure can be synchronous, or the metastasis ... [more ▼]

Cutaneous metastases may accompany up to 3 to 10% of all malignancies. They are usually identified after diagnosing the primary neoplasm. However, their disclosure can be synchronous, or the metastasis may be the initial finding qualified as "precocious". The identification of the primary neoplasm sometimes proves to be difficult. Gender of the patient, the aspect and distribution of the metastases, as well as the histological and immunohistological examinations help establishing the diagnosis. The prognosis of the metastatic disease is often poor. [less ▲]

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See detailLe cas clinique du mois. Pemphigoide bulleuse apres brulure thermique.
Blaise, G.; Pierard, Claudine ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2008), 63(4), 182-3

In rare instances, some injuring physical factors such as thermal burns can be at the origin of bullous pemphigoid lesions. The early lesions are most often restricted to the injured skin area. Secondary ... [more ▼]

In rare instances, some injuring physical factors such as thermal burns can be at the origin of bullous pemphigoid lesions. The early lesions are most often restricted to the injured skin area. Secondary generalization is the natural evolution to be expected. However, once the episode is resolved, recurrence is exceptional. When the natural history of bullous pemphigoid differs from the regular type, the peculiar condition of development of these lesions does not change any of the diagnostic clinical and histological criteria, as well as the therapeutic procedures to follow. [less ▲]

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See detailLa peau et ses principales neurocristopathies.
Quatresooz, Pascale ULg; Vandenbossche, Géraldine ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 354-8

The neurocristopathies encompass genetic disorders targeting some structures originating from the neural crest development. Hence, skin is affected by some clinical manifestations of these disorders. This ... [more ▼]

The neurocristopathies encompass genetic disorders targeting some structures originating from the neural crest development. Hence, skin is affected by some clinical manifestations of these disorders. This review covers the main aspects found in neurofibromatosis, tuberous sclerosis, incontinentia pigmenti, neurocutaneous melanoblastosis, basal cell naevomatosis and the epidermal naevus syndrome. [less ▲]

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See detailComment j'explore... un lymphome T cutane. Nouveaux horizons.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2008), 63(4), 208-12

Although cutaneous T cell lymphomas remain rare, their incidence seems progressively on the rise. The main diagnostic criteria are issued from the clinico-pathological confrontation. Other methods help ... [more ▼]

Although cutaneous T cell lymphomas remain rare, their incidence seems progressively on the rise. The main diagnostic criteria are issued from the clinico-pathological confrontation. Other methods help support the diagnosis and establish a prognosis. [less ▲]

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See detailL'image du mois. Tinea incognito.
Vandenbossche, Géraldine ULg; Legrain, A.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2008), 63(7-8), 463-4

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See detailComment j'explore...Un patient avec un erytheme palmaire.
Vandenbossche, Géraldine ULg; Pierard, Claudine ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2008), 63(2), 101-4

Palmar erythema occurs in a series of physiological and pathological conditions. The first group encompasses hereditary and idiopathic conditions, as well as the time of pregnancy and ageing. The ... [more ▼]

Palmar erythema occurs in a series of physiological and pathological conditions. The first group encompasses hereditary and idiopathic conditions, as well as the time of pregnancy and ageing. The pathological states include some dermatoses as well as hepatic, autoimmune, infectious and paraneoplastic conditions. Medications may also be responsible for palmar erythema, in particular some chemotherapy agents. [less ▲]

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See detailBiometrology of physical properties of skin in thyroid dysfunction.
Szepetiuk, Grégory ULg; Pierard, Gérald ULg; Betea, Daniela ULg et al

in Journal of the European Academy of Dermatology & Venereology (2008), 22(10), 1173-1177

OBJECTIVE: There is ample clinical evidence that skin is responsive to physiopathological levels of circulating thyroid hormones. The aim of the study was to assess some physical changes of the skin in ... [more ▼]

OBJECTIVE: There is ample clinical evidence that skin is responsive to physiopathological levels of circulating thyroid hormones. The aim of the study was to assess some physical changes of the skin in the presence of moderate thyroid dysfunction. SETTING: University Hospital. PATIENTS AND METHODS: A total of 119 adults suffering from hypothyroidism or hyperthyroidism and 60 healthy controls were enrolled in this study. Hormonal dosages (TSH, fT3, fT4) were assessed in the serum. A series of biometrological assessments were also performed on the volar and dorsal aspects of the forearms. These included electrometric assessments (Nova Dermal Phase Meter, Corneometer), evaporimetry (Tewameter)), colorimetry (Mexameter), ultrasound shear wave propagation (Reviscometer) and squamometry X. Correlations were searched between each of the serum hormonal dosages and each of the biometrological parameters. RESULTS: The hormonal changes in the untreated patients with thyroid dysfunction were modest in intensity. A few outlier values with regard to the normal range were found for each biometrological parameter. No correlations were found between fT3 or fT4 and each of the physical parameters. By contrast, significant negative linear correlations were found between thyroid-stimulating hormone (TSH) and skin hydration measured by the Corneometer and the Nova DPM. CONCLUSION: This multipronged exploratory study shows that direct or indirect effects of TSH may influence the stratum corneum hydration. This correlation seemed very sensitive, as no other specific biophysical parameter was significantly correlated with the thyroid hormonal concentrations in the serum. However, our findings do not exclude the possibility of some other skin changes supervening in case of more severe thyroid dysfunction. The mechanism by which TSH alters the stratum corneum hydration is yet unknown. [less ▲]

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See detailUrgences dermatologiques de première ligne
Pierard-Franchimont, Claudine ULg; Devillers, Céline; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2008), 63

Les urgences dermatologiques couvrent de nombreuses affections, en particulier celles d’origine infectieuse, auto-immune et environnementale. Elles sont fréquemment responsables de consultations chez le ... [more ▼]

Les urgences dermatologiques couvrent de nombreuses affections, en particulier celles d’origine infectieuse, auto-immune et environnementale. Elles sont fréquemment responsables de consultations chez le médecin généraliste et auprès d’unités de médecine d’urgence hospitalière. Les praticiens concernés se retrouvent alors en première ligne pour gérer des situations potentiellement dramatiques. Nous discutons les affections les plus fréquentes incluant l’urticaire, l’angioedème, la cellulite infectieuse, les lucites aiguës, le syndrome de Lyell, d’autres réactions médicamenteuses paroxystiques indésirables, les brûlures, l’état d’érythrodermie et l’éruption varicelliforme de Kaposi-Juliusberg. [less ▲]

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See detailNovelties in the multifaceted miconazole effects on skin disorders.
Quatresooz, Pascale ULg; Vroome, Valérie; Borgers, Marcel et al

in Expert Opinion on Pharmacotherapy (2008), 9(11), 1927-34

BACKGROUND: Miconazole nitrate is a time-honored antifungal of the imidazole class. OBJECTIVE: To revisit the various aspects of action of the drug in a dermatologic setting. METHOD: Review of the current ... [more ▼]

BACKGROUND: Miconazole nitrate is a time-honored antifungal of the imidazole class. OBJECTIVE: To revisit the various aspects of action of the drug in a dermatologic setting. METHOD: Review of the current peer-reviewed publications. RESULTS/CONCLUSION: Miconazole essentially inhibits 14alpha-demethylase, an enzyme required for the biosynthesis of ergosterol, which is the main sterol constituent of fungal cell membranes. Hence, toxic methylated sterols accumulate. Synthesis of triglycerides and phospholipids is also affected. In addition, miconazole also exhibits other ancillary mechanisms of action that probably participate in the therapeutic efficacy of the drug. The oxidative and peroxidative enzyme activities are altered leading to an intracellular build up of a toxic concentration of hydrogen peroxide. This may contribute to the deterioration of subcellular organelles and to cell necrosis. Farnesol synthesis is stimulated in Candida spp. leading to the prevention of yeast-to-mycelium formation. Overall, miconazole is fungistatic through its effect on ergosterol biosynthesis, but it may also have a fungicidal effect against a number of fungal species due to its effect on hydrogen peroxide accumulation. In addition, miconazole is active against a series of Gram-positive bacteria and has been shown to help the repair of the skin barrier function and to help mitigate some inflammatory cell reactions (such as in acne). To conclude, miconazole exerts multi-pronged effects both against pathogenic fungi and on skin physiology. [less ▲]

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See detailSpectre anatomo-clinique des lésions cutanées radio-induites
Quatresooz, Pascale ULg; Henry, Frédérique ULg; Hermanns-Lê, Trinh ULg et al

in Skin (2008), 11

La radiothérapie est un outil important en cancérologie. Des effets indésirables peuvent cependant apparaître au niveau de la peau irradiée. Ces complications sont variables, tant par leur nature que par ... [more ▼]

La radiothérapie est un outil important en cancérologie. Des effets indésirables peuvent cependant apparaître au niveau de la peau irradiée. Ces complications sont variables, tant par leur nature que par leur intensité. Le type d’équipement de radiothérapie et les modalités d’irradiation influencent ce risque. Tous les types cellulaires de l’épiderme et du derme sont concernés. Le risque majeur est la cancérogenèse en champs qui est potentialisée par l’exposition solaire. [less ▲]

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See detailL'agonie du taratata auprès du clinicien.
Xhauflaire-Uhoda, Emmanuelle; Quatresooz, Pascale ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2008), 63

Le clinicien est à la croisée des chemins entre la rigueur scientifique et le taratata d’une certaine communication bien moins sérieuse. Dans ce contexte, la recherche de l’objectivité est primordiale ... [more ▼]

Le clinicien est à la croisée des chemins entre la rigueur scientifique et le taratata d’une certaine communication bien moins sérieuse. Dans ce contexte, la recherche de l’objectivité est primordiale dans les études cliniques. Nous résumons les aspects principaux des méthodes de dénombrement, de classement, de mesures paramétriques et d’évaluations sur échelles structurée ou non structurée. [less ▲]

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See detailClinicopathologic presentations of dermatomycoses in cancer patients.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Arrese Estrada, Jorge ULg et al

in Journal of the European Academy of Dermatology & Venereology (2008)

Many of the skin fungal infections in cancer patients may look similar to those infections in non-cancer patients. However, in some cases, they become more extensive and even life threatening. Prolonged ... [more ▼]

Many of the skin fungal infections in cancer patients may look similar to those infections in non-cancer patients. However, in some cases, they become more extensive and even life threatening. Prolonged and severe neutropenia is the main risk factor for the dramatic issue of fungal infections. The dermatomycoses in cancer patients can be classified in four broad groups: primary superficial dermatophytoses, primary superficial yeast infections, opportunistic mold infections with distinct potential for dissemination and secondary cutaneous manifestations of fungaemia. Occasionally, more than one fungus are found inside a given skin lesion. A special condition is represented by the mycotic colonization of mucosal squamous cell carcinomas. Angio-invasion by fungi accounts for the frequency of disseminated infections prevailing in immunocompromised cancer patients. In case of skin involvement, the dermatologist may assist by recognizing subtle semiological signs and performing biopsies for swift histological examination, molecular biology and/or culture. [less ▲]

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See detailHighlighting the immunohistochemical profile of melanocytomas: review.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Oncology Reports (2008), 19(6), 1367-72

The histological assessment of atypical melanocytic neoplasms is mandatory to ensure proper diagnosis and treatment. However, for some atypical lesions, expert pathologists report only moderate ... [more ▼]

The histological assessment of atypical melanocytic neoplasms is mandatory to ensure proper diagnosis and treatment. However, for some atypical lesions, expert pathologists report only moderate concordance in the diagnosis. In addition, certain atypical neoplasms have been coined differently in the literature. These designations include among others atypical and metastasizing Spitz tumor, malignant Spitz naevus, borderline and intermediate melanocytic tumor, and melanocytic tumor of uncertain malignant potential (MELTUMP) or Spitzoid melanocytic tumor of uncertain malignant potential (STUMP). These neoplasms are grouped here under the heading melanocytoma. Such melanocytic lesions have a benign outcome but exhibit an atypical and worrisome aspect. Rare individual cases of melanocytomas can progress to locoregional disease (agminate melanocytomas), and even beyond. At times, the distinction between melanocytoma and melanoma is difficult and may even be impossible. However, multipronged immunohistochemistry can help define malignancy risk stratification and therapeutic guidelines. [less ▲]

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See detailSpace-time clustering and seasonality in diagnosing skin cancers in Wallonia (south-east Belgium).
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2008), 217(1), 48-51

BACKGROUND: In Westernized populations, the number of diagnosed cases of primary cutaneous cancers, particularly malignant melanomas and basal cell carcinomas (BCC), has been previously shown to fluctuate ... [more ▼]

BACKGROUND: In Westernized populations, the number of diagnosed cases of primary cutaneous cancers, particularly malignant melanomas and basal cell carcinomas (BCC), has been previously shown to fluctuate during specific periods of the year. OBJECTIVE AND METHOD: The aim of the present 6-year study was to explore the seasonality if any in skin cancer detection in Wallonia (south-east Belgium). RESULTS: For both malignant melanomas and BCC late spring/early summer and mid-autumn were the periods of highest diagnosis prevalence irrespective of gender. The amplitude of this bimodal evolution remained within the range of 2 standard deviations around the monthly means. Similar seasonal variations were also found in non-neoplastic controls consisting of laboratory samplings of onychomycoses and non-infectious onychodystrophies. CONCLUSION: There is reason to believe that this timing and rhythm is unrelated to any specific cancer chronomics. Rather, the present findings suggest unspecific seasonality in diagnosing skin disorders including malignancies. A variable patient awareness of changing aspects of the skin according to seasons probably represents the major influence of the described space-time clustering of skin cancer diagnosis. [less ▲]

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See detailSkin fungal biocontamination and the skin hydrogel pad test.
Paquet, Philippe ULg; Pierard, Claudine ULg; Pierard, Gérald ULg et al

in Archives of Dermatological Research (2008), 300(4), 167-71

Previous observations have revealed that environmental nondermatophyte molds (NDM) can grow inside specific hydrogel pads (LaserAid). Some of these NDM might be responsible for superficial and invasive ... [more ▼]

Previous observations have revealed that environmental nondermatophyte molds (NDM) can grow inside specific hydrogel pads (LaserAid). Some of these NDM might be responsible for superficial and invasive mycoses as well as for allergic respiratory and cutaneous disorders. The load of NDM propagules in the environment is considered to be an important risk factor for all these diseases. It is postulated that the quantification of the responsible fungi deposited at the skin surface may be an indicator of a recent exposure to environmental fungi. The aim of the present study was to assess using the LaserAid hydrogel pads, the density of living NDM adhering to the skin surface of healthy subjects. Sterile hydrogel pads were applied in a repeat procedure onto the normal-looking skin of the palms and face of 35 healthcare workers who were active in low exposure areas. Similar samplings were performed after washing the skin with a regular skin cleanser, or after applying an alcohol solution or a povidone iodine solution. As controls, 20 sterile pads were exposed for a few minutes to ambient air of the laboratory without any contact with the skin. Each of these samples was stored for 2 weeks at room temperature in a clean protected environment. After that period, visual inspection of the pads was followed by microscopic examination of PAS-stained 6 microm-thick sections. In addition, mycological cultures were performed from pieces of the pads deposited onto Sabouraud agar plates. While 19/20 air-exposed samples were not contaminated by environmental air-borne fungi, 61/70 of the initial skin samplings and 6/70 of the repeat skin samplings showed foci of fungal colonization confirmed by microscopic examination. No specific differences were disclosed between the face and palm samplings. Cultures revealed the presence of NDM in the majority (64/67) of the colonized pads, and a few Candida albicans contaminations (3/67) were also disclosed. The cleansing with a non-antimicrobial product as well as disinfecting procedures performed before sampling markedly decreased the mycoflora without, however, clearing the skin of NDM and yeasts. In conclusion, the hydrogel pad procedure brings information about potential environmental skin contamination by NDM and commensal yeasts. The regular cleansing and disinfecting procedures do not eradicate these fungi from the skin surface. [less ▲]

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See detailCrossroads between actinic keratosis and squamous cell carcinoma, and novel pharmacological issues.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Paquet, Philippe ULg et al

in European Journal of Dermatology (2008), 18(1), 6-10

Actinic keratoses (AKs) and their derived squamous cell carcinomas are distinctive lesions forming a continuum in a multi-step carcinogenesis process. They are typically found on chronically sun exposed ... [more ▼]

Actinic keratoses (AKs) and their derived squamous cell carcinomas are distinctive lesions forming a continuum in a multi-step carcinogenesis process. They are typically found on chronically sun exposed skin. AKs merit to be recognized as such and to be distinguished from squamous cell carcinomas both conceptually and for therapeutic implications. The histological differences between these lesions are well defined and should not be blurred. A brief review is presented about the biological features responsible for AKs and the clinicopathologically distinctive aspects of these lesions. In addition, recent findings are presented about pharmacotherapy using anti-epidermal growth factor receptors, imidazoquinolines, diclofenac-hyaluronan, and methyl aminolevulinate photodynamic therapy. [less ▲]

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