References of "Quatresooz, Pascale"
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See detailSkin ageprint: the causative factors
PIERARD, Gérald ULg; PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg

in Handbook of cosmetic science and technology (2009)

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See detailTe Visioscan driven ULEV and SELS methods
QUATRESOOZ, Pascale ULg; PIERARD, Gérald ULg

in Handbook of cosmetic science and technology (2009)

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See detailImmunohistochemical clues at aging of the skin microvascular unit.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Journal of Cutaneous Pathology (2009), 36(1), 39-43

BACKGROUND: Skin aging is a multifaceted process influenced by various factors affecting at variable degree at different body sites. This study focused on the aging process affecting dermal dendrocytes ... [more ▼]

BACKGROUND: Skin aging is a multifaceted process influenced by various factors affecting at variable degree at different body sites. This study focused on the aging process affecting dermal dendrocytes and the microvasculature. We also explored the effect of substance P released by capsaicin because this neuropeptide is known to affect the microvasculature environment. METHODS: The first part of the present study was undertaken in two groups of 35 men who were younger than 30 years and older than 65 years, respectively. A skin biopsy was taken from the intact skin of a thigh during orthopedic surgical intervention after road accident. The second part of the study was performed on 30 men aged 65-68 years. They applied once daily a 0.05% capsaicin gel and the vehicle in a randomized design on the volar forearms. A skin biopsy was taken at inclusion and after a 5-month treatment phase. Immunohistochemistry was performed using a panel of antibodies. Dermal cells were distinguished according to the presence of factor XIIIa, CD34 or thrombomodulin. Blood and lymphatic vessels were studied by Ulex europaeus agglutinin-1, human podoplanin, human vascular endothelial growth factor-C (H-VEGF-C) and alpha-actin immunoreactivities. RESULTS: In the study phase 1, a significant decrease in thrombomodulin-positive cells and vascularity were evidenced in the aged group. In the study phase 2, capsaicin appeared to boost the factor XIIIa-positive dendrocytes, the thrombomodulin-positive cells and the blood vessel network as well. CONCLUSIONS: Specific subsets of the dermal dendrocyte populations and the blood microvasculature appear affected by aging. Capsaicin may limit these aging effects. [less ▲]

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See detailPerivascular cuff and spread of Treponema pallidum.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2009), 219(3), 259-62

BACKGROUND: The incidence of syphilis is on the rise in many cities worldwide. Both the clinical and histopathological changes do not always fulfil the typical diagnostic criteria. Immunohistochemistry is ... [more ▼]

BACKGROUND: The incidence of syphilis is on the rise in many cities worldwide. Both the clinical and histopathological changes do not always fulfil the typical diagnostic criteria. Immunohistochemistry is available to identify and localize Treponema pallidum. Two main patterns of T. pallidum distribution were described in the skin, namely heavy intraepidermal infiltration and scattered pattern inside the lichenoid cell infiltrate. OBJECTIVE: To search for a third pattern consistent with dissemination of the disease. METHODS: Immunohistochemistry using an antispirochete (T. pallidum and Borrelia) antibody was used in all cases of syphilis submitted to our laboratory. In addition, deposits of immunoglobulins and complement indicative of immune complexes were searched for. RESULTS: According to the cases, T. pallidum was disclosed in a combination of three patterns. The previously described epidermal and lichenoid patterns were confirmed, and a third pattern predominating in a perivascular location throughout the dermis was clearly identified in primary syphilis. The microorganisms were abundant in extracellular and intracellular locations, particularly inside endothelial cells. No deposits of immunoglobulins and complement were disclosed. CONCLUSION: The perivascular cuff of T. pallidum throughout the dermis might be representative of the dissemination phase of T. pallidum. [less ▲]

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See detailImpact de l'infection par le VIH sur les cancers cutanes.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2009), 64(1), 37-40

A series of skin cancers are more frequent or show a worsened course and outcome in HIV-treated patients. The leading neoplasms correspond to basal and squamous cell carcinomas, some primary cutaneous ... [more ▼]

A series of skin cancers are more frequent or show a worsened course and outcome in HIV-treated patients. The leading neoplasms correspond to basal and squamous cell carcinomas, some primary cutaneous lymphomas and malignant melanomas. In theses patients, early diagnosis and radical treatment on sight should be considered. [less ▲]

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See detailLa couche cornée, le point de rosée et l'eau-comme-de-la-glace.
Uhoda, Emmanuelle ULg; Franchimont, Claudine ULg; Quatresooz, Pascale ULg et al

in Dermatologie Actualité (2009), 112

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See detailEpidermal field carcinogenesis in bald-headed. An attempt at finetuning early noninvasive detection.
Quatresooz, Pascale ULg; Uhoda, Emmanuelle ULg; Franchimont, Claudine ULg et al

in Oncology Reports (2009), 21

Skin weathering and photoaging of the balding scalp have not attracted much investigative attention so far. However, the concept of field cancerization, in particular actinic field carcinogenesis, is ... [more ▼]

Skin weathering and photoaging of the balding scalp have not attracted much investigative attention so far. However, the concept of field cancerization, in particular actinic field carcinogenesis, is likely applicable to this body region. The aim of the study was to finetune the epidermal actinic changes present on hairlessness scalp. The ultraviolet light-enhanced visualization (ULEV) method was used to assess a series of 50 healthy men older than 50 years with documented baldness for over 15 years. They were scrutenized looking for altered epidermal structures corresponding to photoaging-associated changes. Attention was focused on the faint mosaic melanoderma (FMM) and atypical scaliness. Observations were made on the scalp and forehead. FMM was recognized in each case. It presented either as a single manifestation of photoaging or it was associated with an unusual pattern of discrete rimmed scaliness. In this latter case histology and morphometry disclosed keratinocyte dysplasia. A similar scaly pattern was not seen on the forehead. Subtle skin surface changes were disclosed on long-standing sun-exposed balding scalps. The scaly aspect was distinct from dandruff, seborrheic dermatitis or any other common inflammatory scalp dermatosis. The presently described changes had not previously been described during early balding. It is suggested that the presently described condition may be associated with or indicative for actinic field carcinogenesis and incipient keratinocyte dysplasia. [less ▲]

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See detailVulnerability of reactive skin to electric current perception--a pilot study implicating mast cells and the lymphatic microvasculature.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Journal of Cosmetic Dermatology (2009), 8(3), 186-9

BACKGROUND/OBJECTIVE: Sensitive/reactive skin is regarded as a manifestation of sensory irritation. This susceptibility condition to various exogenous factors suggests the intervention of some ... [more ▼]

BACKGROUND/OBJECTIVE: Sensitive/reactive skin is regarded as a manifestation of sensory irritation. This susceptibility condition to various exogenous factors suggests the intervention of some neuropeptides and other neurobiological mediators. Mast cells are among the putative implicated cells. METHOD: The present immunohistochemical and morphometric study was performed on two groups of 36 gender- and age-matched subjects complaining or not from reactive skin as determined by electric current perception. In the mid upper part of the dermis, the numerical density in mast cells and the size of the microvasculature were assessed distinguishing the blood and lymphatic vessels. RESULTS: Globally, the distributions of data were large in reactive skin. This condition was characterized by a prominent increase in both the numerical density in mast cells and the overall size of the lymphatics. By contrast, no difference was found in the size of cutaneous blood vessels. More precisely, it appeared that a subgroup of people with reactive skin exhibited these changes contrasting with some other individuals whose data remained close to the normal range. CONCLUSION: Mast cells and lymphatics are probably involved in the process of sensory irritation affecting a subgroup of the population. [less ▲]

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See detailMolecular histology on the diagnostic cutting edge between malignant melanomas and cutaneous melanocytomas (Review).
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Oncology Reports (2009), 22(6), 1263-7

In recent years, the screening accuracy of clinical dermoscopy has increased in the early detection of evolving atypical melanocytic neoplasms. However, the most dramatic cases of human malignant ... [more ▼]

In recent years, the screening accuracy of clinical dermoscopy has increased in the early detection of evolving atypical melanocytic neoplasms. However, the most dramatic cases of human malignant melanomas (MM), i.e. the fast-growing neoplasms, usually escape the classical clinical criteria of MM. As a result, a number of puzzling cases exhibit uncertain clues for MM. Thus, the risk of microscopic misdiagnosis is likely on the rise if the histological criteria are not fine-tuned. This review summarizes a conceptual classification of atypical melanocytic neoplasms grouped under the heading of melanocytomas. Some immunohistochemical markers are tentatively used as discriminators between fast-growing MM and melanocytomas. However, some differences seem to be more statistically significant than clinically useful due to extensive overlap in immunoreactivity from any case to case. A multipronged immunohistological screening is therefore welcome. [less ▲]

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See detailPseudolymphomes cutanés et pseudoclonalité des infiltrats lymphoïdes.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Devillers, Céline ULg et al

in Revue Médicale de Liège (2009), 64

Cutaneous pseudolymphomas represent an heterogeneous group of tumours resembling lymphomas by some clinical and histological aspects. They are distinguished, in particular, by their benign evolution. The ... [more ▼]

Cutaneous pseudolymphomas represent an heterogeneous group of tumours resembling lymphomas by some clinical and histological aspects. They are distinguished, in particular, by their benign evolution. The histological and immunohistological examinations combined with molecular biology help to elucidate any diagnostic uncertainty. In these diseases, monoclonality and pseudoclonality must be distinguished in the lymphoid infiltrates. Searching for any specific etiology is important because removing the cause is likely to clear the lesions. [less ▲]

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See detailLe cosméceutique, oxymoron de la quête d'une efficacité cosmétique?
Pierard, Gérald ULg; Meunier, J.; Franchimont, Claudine ULg et al

in Dermatologie Actualité (2009), 113

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See detailComment j'explore... des lésions cutanées chez un toxicomane adepte de la cocaïne ou du crack.
Devillers, Céline ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg et al

in Revue Médicale de Liège (2009), 64

Both cocaine and crack exert sympathetic and prothrombotic effects. The induced lesion may affect the skin, and other organ systems as well. Various types of vasculitis and infectious dermatoses are the ... [more ▼]

Both cocaine and crack exert sympathetic and prothrombotic effects. The induced lesion may affect the skin, and other organ systems as well. Various types of vasculitis and infectious dermatoses are the predominant issues. In addition, tactile and visual hallucinations may occur suggesting insect crawling underneath the skin. [less ▲]

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See detailPanoplies des therapies ciblees par anticorps monoclonaux en dermatologie. Actualite et prospectives.
Pierard, Claudine ULg; Quatresooz, Pascale ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2009), 64(5-6), 334-8

Targeted therapies are focused on one or a few molecules particularly involved in specific diseases. Some inflammatory dermatoses and cutaneous neoplasia potentially benefit from these approaches. Nine ... [more ▼]

Targeted therapies are focused on one or a few molecules particularly involved in specific diseases. Some inflammatory dermatoses and cutaneous neoplasia potentially benefit from these approaches. Nine monoclonal antibodies of interest in dermatology are presented according to the disorders where they have proven their efficacy. Biotherapies extend beyond monoclonal antibodies. A given effect, such as TNF-alpha antagonism, is indeed obtained by distinct drug classes. The interindividual differences in the therapeutic responses remain unpredictable, and there is no criteria of selection of patients who could benefit the most from these targeted medications. [less ▲]

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See detailLe paradoxe des effets cutanes indesirables, mais predictifs de l'efficacite des therapies ciblees anticancereuses.
Quatresooz, Pascale ULg; Rorive, Andrée ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2009), 64(5-6), 347-50

A series of medical disciplines benefit from the emergence of diverse targeted therapies using monoclonal antibodies. Skin is affected by adverse events of such therapies primarily targeting internal ... [more ▼]

A series of medical disciplines benefit from the emergence of diverse targeted therapies using monoclonal antibodies. Skin is affected by adverse events of such therapies primarily targeting internal cancers. As a unique event in medicine, some of the skin adverse effects are predictive markers of the therapeutic antineoplastic activity. This fact concerns the paroxismal acneiform eruption and the inflammatory flare-up of actinic keratoses. Such a situation is linked to the fact that these specific "unwanted" effects are not really side effects but rather represent the direct pharmacological consequence of the activity directed to the EGF receptors which are particularly abundant in the follicular ostium and in precursor lesions to skin carcinomas. [less ▲]

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See detailChildhood cutaneous leiomyosarcoma.
Blaise, Géraldine ULg; Nikkels, Arjen ULg; Quatresooz, Pascale ULg et al

in Pediatric Dermatology (2009), 26(4), 477-9

Cutaneous leiomyosarcoma is a soft tissue neoplasm exhibiting an aggressive local behavior and a potential for distant metastases. It is rare during childhood and diagnosis can be challenging both ... [more ▼]

Cutaneous leiomyosarcoma is a soft tissue neoplasm exhibiting an aggressive local behavior and a potential for distant metastases. It is rare during childhood and diagnosis can be challenging both clinically and histologically. Surgical excision with wide lateral and deep margins is the treatment of choice, whereas radiotherapy and chemotherapy are contraindicated. Long-term follow-up is necessary as recurrences are not infrequent. [less ▲]

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See detailSyndrome de Birt-Hogg-Dube sporadique.
Vandenbossche, Géraldine; Franchimont, Claudine ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2009), 64(7-8), 358-60

Birt-Hogg-Dube is a rare syndrome which is sporadic or hereditary with a dominant autosomal transmission. Various organs, in particular the skin, can be affected. In the presently reported case, skin was ... [more ▼]

Birt-Hogg-Dube is a rare syndrome which is sporadic or hereditary with a dominant autosomal transmission. Various organs, in particular the skin, can be affected. In the presently reported case, skin was covered by hundreds of small molluscoid papules corresponding to trichodiscomas, fibrofolliculomas and skin tags. [less ▲]

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See detailMolecular pathways supporting the proliferation staging of malignant melanoma (review).
Quatresooz, Pascale ULg; Pierard, Gérald ULg; Franchimont, Claudine ULg et al

in International Journal of Molecular Medicine (2009), 24(3), 295-301

The clinical diagnosis of cutaneous melanoma always calls for histological confirmation. In addition to the recognition of the classic aspects of the neoplasm, immunohistochemistry is determinant, in ... [more ▼]

The clinical diagnosis of cutaneous melanoma always calls for histological confirmation. In addition to the recognition of the classic aspects of the neoplasm, immunohistochemistry is determinant, in particular in the assessment of the size of the replicative compartment. Generally, the proliferation rate is indicative of the neoplastic progression and is related to the clinical growth rate of the neoplasm. It allows to distinguish high risk melanomas showing a high growth rate from those of lower malignancy associated with a restricted growth rate. In melanoma, the recruitment and progression of neoplastic cells in the cell cycle of proliferation have lost some of their controls that are normally processed by a series of key regulatory molecules. In addition, the apoptotic pathway counteracting any hyperproliferative activity is released of the dependency of specific regulated molecular mechanisms. This review summarizes the current knowledge on key molecular components involved in the deregulation of the growth fraction, cell proliferation and apoptosis in melanocytic neoplasms. The implication of cyclins and of the mitogen-activated protein kinase pathways are scrutinized. The involvement of neoplastic stem cells in the metastatic process is also discussed. [less ▲]

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See detailL'image du mois. Melanome a croissance rapide.
Bourguignon, Raphaël; Giet-Lesuisse, Marianne; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2009), 64(9), 429-31

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See detailEn chemin vers les cancers photo-induits.
Pierard, Gérald ULg; André, J.; Brochez, L. et al

in Skin (2009), 12

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See detailSpotlight on adapalene.
Pierard, Gérald ULg; Franchimont, Claudine ULg; Paquet, Philippe ULg et al

in Expert opinion on drug metabolism & toxicology (2009), 5(12), 1565-75

BACKGROUND: In the field of dermatology, topical retinoids represent a mainstay in acne treatment. Adapalene is a naphthoic acid derivative showing some pharmacological activities similar to the regular ... [more ▼]

BACKGROUND: In the field of dermatology, topical retinoids represent a mainstay in acne treatment. Adapalene is a naphthoic acid derivative showing some pharmacological activities similar to the regular retinoids. The drug is used singly or in combination for treating acne and a few other miscellaneous skin disorders. OBJECTIVE: To critically review the pharmacokinetic, pharmacologic aspects and clinical benefits and adverse effects associated with topical adapalene. METHOD: A systematic literature review was conducted primarily based on PubMed citations. RESULTS/CONCLUSIONS: Adapalene shares some biological activities in common with retinoic acid. However, it exhibits distinct physicochemical and binding properties for selective retinoic acid receptors. In acne, adapalene is expected to reduce comedogenesis, expel mature comedones and exert some anti-inflammatory effects. The drug is effective as monotherapy in mild comedonal acne and in combination with benzoyl peroxide for mild-to-moderate inflammatory acne. The safety profile of adapalene is good. Indeed, only discrete to moderate adverse events including erytheme, xerosis, itching and stinging may develop during the early treatment phase. Clinical experience has established that adapalene represents a valuable addition to the other current treatments for acne. [less ▲]

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