Traitement par anti-TNF-alpha et cancers de la peau
Pierard, Claudine ; Pierard, Gérald ; Quatresooz, Pascale et al
in ONCO-HEMATO (2011), 5Detailed reference viewed: 18 (2 ULg)
''Malignant melanoma microecosystem'': Immunohistopathological insights into the stromal cell phenotype (Review)
QUATRESOOZ, Pascale ; REGINSTER, Marie-Annick ; PIERARD, Gérald
in Experimental and Therapeutic Medicine (2011), 2Detailed reference viewed: 25 (9 ULg)
Traitement par anti-TNF-alpha et cancers de la peau.
FRANCHIMONT, Claudine ; PIERARD, Gérald ; QUATRESOOZ, Pascale et al
in Onco-Hémato (2011), 5Detailed reference viewed: 32 (1 ULg)
Le cornéocyte immature et fragile, un phénotype marqueur d'un environnement hostile.
QUATRESOOZ, Pascale ; PIERARD, Gérald ; FRANCHIMONT, Claudine
in Dermatologie Actualité (2011), 126Detailed reference viewed: 14 (0 ULg)
Predictive methods exploring sensory irritation to surfactant-based products.
Pierard, Gérald ; ; QUATRESOOZ, Pascale
in Household and Personal Care (2011), 7Detailed reference viewed: 19 (1 ULg)
Identification d'une dermatose provoquée par la lumière
PIERARD-FRANCHIMONT, Claudine ; CAUCANAS, Marie ; QUATRESOOZ, Pascale et al
in Revue Médicale de Liège (2011), 66Detailed reference viewed: 26 (0 ULg)
Revisiting cutaneous adverse reactions to pemetrexed
PIERARD-FRANCHIMONT, Claudine ; QUATRESOOZ, Pascale ; REGINSTER, Marie-Annick et al
in Oncology Letters (2011), (2), 769-772Detailed reference viewed: 22 (2 ULg)
Micropapules paroxysmales prurigineuses tronculaires.
CAUCANAS, Marie ; PIERARD, Gérald ; FRANCHIMONT, Claudine et al
in Dermatologie Actualité (2011), 127Detailed reference viewed: 45 (0 ULg)
La peau du patient sous chimiothérapie anticancéreuse.
PIERARD, Gérald ; PAQUET, Philippe ; FRANCHIMONT, Claudine et al
in Dermatologie Actualité (2011), 124
Des effets cutanés indésirables peuvent survenir lors de chimiothérapies anticancéreuses. La morbidité peut être handicapante à des degrés divers. Certaines manifestations sont graves comme celles ... [more ▼]
Des effets cutanés indésirables peuvent survenir lors de chimiothérapies anticancéreuses. La morbidité peut être handicapante à des degrés divers. Certaines manifestations sont graves comme celles rencontrées lors de nécroses épithéliales et/ou vasculaires étendues. D’autres sont spécifiques à l’agent administré. Tel est le cas pour des éruptions acnéiformes induites par les antagonistes de l’EGFR. Dans la grande majorité des cas, les altérations de la structure de la couche cornée et de ses fonctions se résument seulement à un état de xérose. Parfois aussi, les altérations ne se décèlent qu’à l’examen histopathologique sans répercussion clinique manifeste. Pour chaque patient concerné, il convient d’identifier avec précision les effets indésirables de la chimiothérapie anticancéreuse afin de choisir les moyens les plus adéquats pour prévenir leur aggravation et les traiter au mieux. L’apport de l’examen dermatopathologique standard et fonctionnel est précieux au stade du diagnostic. [less ▲]Detailed reference viewed: 68 (5 ULg)
Malignant melanoma: from cell kinetics to micrometastases.
QUATRESOOZ, Pascale ; PIERARD, Gérald
in American Journal of Clinical Dermatology (2011), 12(2), 77-86
Malignant melanoma (MM) micrometastases are basically seen in three locations inside the peritumoral dermis. They are localized (i) inside the interstitial sector of the dermal stroma; (ii) abutted to the ... [more ▼]
Malignant melanoma (MM) micrometastases are basically seen in three locations inside the peritumoral dermis. They are localized (i) inside the interstitial sector of the dermal stroma; (ii) abutted to the external surface of the microvasculature; and (iii) more rarely present inside vascular channels. Single-cell and paucicellular micrometastases may be disclosed using immunohistochemistry even in the absence of larger microsatellites, which represent micronodular nests of metastatic cells. The presence of microsatellites is frequently tied to markers of MM aggressiveness including thickness and the Ki-67 index. Micrometastases may be present in the same conditions, but even as early as thin MM showing a small growth fraction. Microsatellites as well as micrometastases appear to predict locoregional extension and decreased relapse-free interval, but not distant metastasis and overall survival. These considerations have implications for patient care since patients with microsatellites and micrometastases are now included in the clinical stage III category of the disease. Their implication as a prognostic factor is not fully dependent on or linked to other markers of MM aggressiveness. [less ▲]Detailed reference viewed: 22 (3 ULg)
Dynamics of skin barrier repair following preconditioning by a biotechnology-driven extract from samphire (Crithmum maritimum) stem cells.
CAUCANAS, Marie ; ; Pierard, Gérald et al
in Journal of Cosmetic Dermatology (2011), 10(4), 288-93
Background With aging, the barrier repair kinetics following any weakening of the epidermal permeability barrier function is commonly slowed down. Objective To assess the recovery rate of the epidermal ... [more ▼]
Background With aging, the barrier repair kinetics following any weakening of the epidermal permeability barrier function is commonly slowed down. Objective To assess the recovery rate of the epidermal permeability barrier function following controlled stripping and applications of samphire and control formulations. Method In 12 healthy subjects older than 50 years, controlled stratum corneum (SC) strippings were used to increase the transepidermal water loss (TEWL) just above 15 g/m(2) /h. This procedure followed a 14-day skin preconditioning by daily applications of formulations enriched or not with a samphire (Crithmum maritimum) biomass. An untreated skin site served as control. The epidermal permeability repair kinetics was assessed for 14 days by daily measurements of both TEWL and the colorimetric value a*. Results A rapid (96 h) recovery to lower TEWL values was obtained at each of the samphire-preconditioned sites (0.1% serum, 0.05% cream, the serum-cream association, and 0.5% silicone oil). This process was significantly (P < 0.001) faster than that on both the placebo-preconditioned (silicone oil) and the untreated sites. No adverse inflammatory and sensory reactions were recorded. At the sites preconditioned by samphire formulations, the SC moisture (capacitance) was higher at completion of the study compared to inclusion. Conclusions The present experimental pilot study brings some clues supporting a beneficial boosting effect of samphire cell biomass on the kinetics of epidermal permeability barrier repair. [less ▲]Detailed reference viewed: 19 (2 ULg)
Pattern granulomateux dans les pathologies inflammatoires cutanées
Scientific conference (2011)Detailed reference viewed: 15 (2 ULg)
Focus on skin cancer association and progression under TNF antagonist therapy.
PIERARD-FRANCHIMONT, Claudine ; PIERARD, Gérald ; QUATRESOOZ, Pascale
in Expert Opinion on Biological Therapy (2011), 11(9), 1215-22
INTRODUCTION: Basal and squamous cell carcinomas are the most common non-melanoma skin cancers (NMSC) in humans. Their prevalence is higher in immunocompromized patients. Results of some animal ... [more ▼]
INTRODUCTION: Basal and squamous cell carcinomas are the most common non-melanoma skin cancers (NMSC) in humans. Their prevalence is higher in immunocompromized patients. Results of some animal experiments have indicated that TNF acts both as a tumour promotor and an inductor of apoptosis. AREAS COVERED: Peer-reviewed articles about human skin cancers possibly related to TNF antagonists. The occurrence and growth kinetics of NMSC are possibly increased in some patients under TNF antagonist therapy. Other issues of such biological treatment suggested include the activation of other distinct skin malignancies, including malignant melanoma. Benign melanocytic tumours appear to be boosted as well. At present, most of the reported findings only represent anecdotal case reports. The influence of cumulative co-factors must not be neglected, particularly the effect of other therapies administered to the patients. The occurrence of antibodies to some TNF antagonists may decrease both the treatment efficacy and the risk of skin cancer progression. EXPERT OPINION: More research needs to be performed in order to firmly establish and understand the risk of anti-TNF biologicals in the area of human skin cancers. At present, NMSC progression appears to be boosted on areas of skin field cancerization. Benign melanocytic naevi may develop as well. [less ▲]Detailed reference viewed: 62 (2 ULg)
Recent trends in specular light reflectance beyond clinical fluorescence diagnosis.
; Pierard, Sébastien ; PIERARD-FRANCHIMONT, Claudine et al
in European Journal of Dermatology (2011), 21(2), 157-61
Under specific light illumination, particularly ultraviolet (UV) and near-UV light stimulation, the skin produces both specular light reflectance and, possibly, specific fluorescent emission. These ... [more ▼]
Under specific light illumination, particularly ultraviolet (UV) and near-UV light stimulation, the skin produces both specular light reflectance and, possibly, specific fluorescent emission. These properties offer diagnostic clues and disclose some peculiar functions of the skin. A series of superficial infections (erythrasma, some tinea capitis types, tinea/pityriasis versicolor, dermatophytoses, etc.) and pilosebaceous follicles enriched in Propionibacterium spp show fluorescence. This latter characteristic is downgraded or lost while on some anti-acne treatments. A quenching effect of fluorescence is observed following the application of sunscreens. The (pre)neoplastic areas prepared for methylaminolevulinate photodynamic therapy (MAL-PDT) show reddish fluorescence following drug metabolisation producing porphyrins by the abnormal activated cells. Of note, when using a recording sensitive CCD camera instead of casual visual observation, skin fluorescence may be superimposed on the specular reflectance of the incident light. With the current technology, these situations are not distinguished with confidence. Any harsh and scaly lesion appears brighter following yellowish specular light reflectance. Stratum corneum samplings collected on clear self-adhesive discs or cyanoacrylate skin surface strippings are conveniently examined ex vivo, taking advantage of the same optical properties. [less ▲]Detailed reference viewed: 59 (0 ULg)
Analytic assessment under ultraviolet light of actinic lentigines under bleaching treatment.
PIERARD, Gérald ; ; et al
in Journal of Cosmetic Dermatology (2011), 10(2), 104-9
BACKGROUND: Actinic (solar) lentigines are melanotic tumors frequently developed during photoaging on the dorsum of the hands. Bleaching (whitening) agents are commonly offered to fade their darker aspect ... [more ▼]
BACKGROUND: Actinic (solar) lentigines are melanotic tumors frequently developed during photoaging on the dorsum of the hands. Bleaching (whitening) agents are commonly offered to fade their darker aspect. In general, regular colorimetric methods show poor sensitivity to disclose any bleaching effect. METHOD: The present randomized controlled study on 24 women was designed to objectively assess the clinical efficacy of a combination of bleaching agents on actinic lentigines. In the endeavor of improving sensitivity, the ultraviolet light-enhanced visualization (ULEV) method was used to derive analytical measurements of lentigo areas and darkness. The test product was a commercially available formulation associating glycolic acid, kojic acid, lipohydroxyacid, and a Vitreoscilla extract. The Analysis(R) Olympus and Adobe Photoshop(R) quantitative methods were applied to the ULEV pictures. RESULTS: Data indicated a rapid bleaching effect arising as early as after 1 month of daily applications. The effect progressively increased over 3 months of therapy. CONCLUSION: The presently described analytical method appears to be sensitive to document some bleaching effects on actinic lentigines. [less ▲]Detailed reference viewed: 19 (0 ULg)
Mechanobiology and cell tensegrity: the root of ethnic hair curling?
; PAQUET, Philippe ; QUATRESOOZ, Pascale et al
in Journal of Cosmetic Dermatology (2011), 10(2), 163-7
BACKGROUND: The hair shape, either straight, crimp, or curly, is basically under genetic influence. It is possibly altered by some drugs such as cytostatic agents. In addition, specific innate molecular ... [more ▼]
BACKGROUND: The hair shape, either straight, crimp, or curly, is basically under genetic influence. It is possibly altered by some drugs such as cytostatic agents. In addition, specific innate molecular characteristics are modulated by some cosmetic procedures to reshape the hair shafts. AIM: To revisit the possible implication of mechanobiology and cell tensegrity in shaping ethnic hair. MATERIALS AND METHODS: Optical and scanning electron microscopy of hairs. RESULTS: It is generally held that the cross-section shape of hair is related to differences in the global aspect of the hair shaft. A possible biologic link between these features may rely on shaping cell tensegrity at any portion of the hair shaft. Cell tensegrity encompasses all intrinsic and extrinsic forces responsible for the three-dimensional arrangement of intracellular macromolecules. CONCLUSION: We offer as a hypothesis that the hair shape in part depends on the organization of the cell proliferation in the hair matrix. This review gathers observations supporting the involvement of cell tensegrity in shaping the hair shaft. [less ▲]Detailed reference viewed: 36 (1 ULg)
Les champignons des villes et des champ, les animaux de compagnie et leurs propriétaires.
Noël, Fanchon ; PIERARD-FRANCHIMONT, Claudine ; PIERARD, Gérald et al
in Revue Médicale de Liège (2011), 66Detailed reference viewed: 13 (1 ULg)