References of "QUATRESOOZ, Pascale"
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See detailComment j'explore ... une tache noire au cours de la grossesse. Une tache parfois difficile pour le clinicien.
Uhoda, I.; Pierard, Claudine ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2003), 58(12), 766-9

Cancers rarely coexist with pregnancy. Cutaneous melanoma, however, is one of the most frequently encountered neoplasms during pregnancy. Gestation may also be a period during which the aspect of some ... [more ▼]

Cancers rarely coexist with pregnancy. Cutaneous melanoma, however, is one of the most frequently encountered neoplasms during pregnancy. Gestation may also be a period during which the aspect of some melanocytic naevi can change eventhough the tumor remains benign. Distinction between a benign and a malignant lesion may then be a dilemma. Clinical morphometry, dermoscopy, skin surface biopsy, conventional histology and immunohistochemistry are valuable means that can be used to secure maximum diagnostic confidence. [less ▲]

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See detailIncidental control of rosacea by somatostatin.
Pierard, Claudine ULg; Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(3), 249-51

BACKGROUND: The precise pathomechanism of rosacea remains elusive. The disease commonly requires long-term treatments using topical or oral therapies. OBJECTIVE: This report presents incidental findings ... [more ▼]

BACKGROUND: The precise pathomechanism of rosacea remains elusive. The disease commonly requires long-term treatments using topical or oral therapies. OBJECTIVE: This report presents incidental findings about the possible modulatory role of somatostatin in the outcome of rosacea. METHOD: Four patients presenting long-standing recalcitrant facial rosacea were treated with octreotide for diabetic retinopathy. RESULTS: Rosacea improved rapidly and even cleared without any recurrence in 3 of the patients. CONCLUSION: The beneficial effect might be attributed to inhibitory actions on the sebaceous gland, the neovascularization and/or on the inflammatory process. [less ▲]

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See detailFactor-XIIIa-positive dendrocytes in drug-induced toxic epidermal necrolysis (Lyell's syndrome): paradoxical activation in skin and rarefaction in lymph nodes.
Paquet, Philippe ULg; Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 374-8

BACKGROUND: Drug-induced toxic epidermal necrolysis (TEN) is a rare life-threatening disease characterized by the extensive destruction of the epidermis contrasting with the discreteness of lymphoid cell ... [more ▼]

BACKGROUND: Drug-induced toxic epidermal necrolysis (TEN) is a rare life-threatening disease characterized by the extensive destruction of the epidermis contrasting with the discreteness of lymphoid cell infiltration. The precise pathomechanism of the disease remains unclear. METHODS: Skin specimens and peripheral and thoracic lymph nodes (LNs) were collected from 2 TEN patients. They were examined by conventional histology and immunohistochemistry using antibodies directed to factor XIIIa (dermal dendrocytes), CD1a (Langerhans cells), CD15 (granulocytes), CD20 (B lymphocytes), CD45RO (activated T lymphocytes), CD68 (macrophages) and the proliferation marker Ki-67. LNs from patients with mycosis fungoides, from subjects dead from acute cardiac failure or traumatic injuries, as well as metastasis-free sentinel LNs of cutaneous melanoma served as positive and negative controls. RESULTS: TEN LNs showed absence of germinal centers but a moderate hyperplasia of the paracortical T cell zone. Immunohistochemistry did not reveal any distinctive aspect in LN cellular densities between TEN and other control conditions except for the factor-XIIIa+ dendritic cells which were dramatically reduced in numbers in TEN LNs. This rarefaction in LNs contrasted with the great number of these cells in the skin of the same patients. CONCLUSION: The structure of TEN LNs rules out the involvement of an antibody-mediated response. As dendritic factor-XIIIa+ cells are involved in most cutaneous T-cell-mediated responses, their depletion in TEN LNs could explain the sparse lymphoid cell infiltrate in lesional TEN skin. [less ▲]

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See detailDifferential expression of alpha1 (IV) and alpha5 (IV) collagen chains in basal-cell carcinoma.
Quatresooz, Pascale ULg; Martalo, Oriane; Pierard, Gérald ULg

in Journal of Cutaneous Pathology (2003), 30(9), 548-52

BACKGROUND: Basement membrane alterations are common in malignancies, and they may indicate tumoral aggressiveness. Distinct patterns of tumoral coverage by collagen IV were reported in nodular and ... [more ▼]

BACKGROUND: Basement membrane alterations are common in malignancies, and they may indicate tumoral aggressiveness. Distinct patterns of tumoral coverage by collagen IV were reported in nodular and aggressive basal-cell carcinomas (BCCs). Differential expressions of alpha (IV) collagen chains were also shown on frozen sections. The aim of our work was to document the immunohistochemical expression of alpha1, alpha3, and alpha5 (IV) collagen chains in BCC after routine fixation and processing. METHODS: The patterns of distribution of alpha1 (IV), alpha3 (IV), and alpha5 (IV) collagen chains were studied in 20 formalin-fixed and paraffin-embedded BCCs showing different infiltrative patterns. One trichoblastoma was used as control. RESULTS: In nodular BCCs, the expression of alpha5 (IV) collagen chain was downregulated and uneven. By contrast, alpha1 (IV) collagen chain expression was preserved around these tumors similar to the surrounding skin. However, the alpha1 (IV) collagen chain expression was discontinuous or absent in BCC areas showing an infiltrative pattern of extension. The alpha3 chain was absent both underneath all BCCs and non-neoplastic skin. CONCLUSIONS: The basement membrane alterations around nodular BCCs involved more precisely the alpha5 (IV) collagen chains. Defects in alpha1 (IV) collagen chain expression seemed to be associated with a tumoral invasive and infiltrative pattern. The biological significance of these findings is unclear. [less ▲]

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See detailPercutaneous stereotactic en bloc excision of nonpalpable breast carcinoma: a step in the direction of supraconservative surgery
Lifrange, Eric ULg; Dondelinger, Robert ULg; Foidart, Jean-Michel ULg et al

in Breast (Edinburgh, Scotland ) (2002), 11(6), 501-508

Recently, the advanced breast biopsy instrumentation (ABBI) system has been introduced as an alternative to conventional breast biopsy techniques. This study was prospectively conducted to evaluate the ... [more ▼]

Recently, the advanced breast biopsy instrumentation (ABBI) system has been introduced as an alternative to conventional breast biopsy techniques. This study was prospectively conducted to evaluate the potential of the ABBI method in locoregional management of a consecutive series of patients with nonpalpable mammographically detected breast carcinomas. Sixty-one consecutive patients underwent an ABBI procedure as a first step before possible surgery for nonpalpable breast lesions that would in any case require complete excision. For the 27 patients in whom the ABBI biopsy revealed malignancy further surgery was recommended, including re-excision of the biopsy site and axillary dissection in cases of infiltrating carcinoma. We calculated the probabilities that the ABBI specimen would have tumor-free margins and that a definitely complete excision had been achieved as a function of the mammographic or pathological diameter of the cancer. For cancer with a pathological diameter less than 10 mm, measured on the ABBI specimen, the probability (92%) of obtaining complete resection was significantly better than for larger lesions (P = 0.01, Fisher's exact test). Although the therapeutic perspectives for the ABBI method are limited at present, we suggest that this approach is a first step in the direction of a surgical strategy that is better adapted to the pathological characteristics peculiar to these small tumors, whose incidence is increasing. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailStereotactic breast biopsy with an 8-gauge, directional, vacuum-assisted probe: initial experience
Lifrange, Eric ULg; Dondelinger, Robert ULg; Quatresooz, Pascale ULg et al

in European Radiology (2002), 12(9), 2180-2187

This study was prospectively conducted to assess the feasibility, safety and accuracy of an 8-G directional vacuum-assisted biopsy (DVAB) probe in the diagnostic management of nonpalpable breast lesions ... [more ▼]

This study was prospectively conducted to assess the feasibility, safety and accuracy of an 8-G directional vacuum-assisted biopsy (DVAB) probe in the diagnostic management of nonpalpable breast lesions (NPBL). Of 170 planned procedures which were indicated for investigation of BI-RADS category-3 to category-5 lesions, 153 were performed in 138 consecutive patients. The probe was targeted by the stereotactic unit of a prone table (United States Surgical Corporation, Norwalk, Conn.; and Lorad, Danbury, Conn.). Four to 18 (mean 8) core specimens were obtained for each lesion. In case of complete removal of the lesion, a localizing clip was deployed at the biopsy site. Adequate material for histopathologic examination was obtained in all cases (100%). Four of 138 (3%) patients experienced mild hematomas. We observed 15 of 39 failures (38%) to place the localizing clips. Thirteen of 153 (8%) procedures were inconclusive and required reintervention. Following DVAB, 42 of 138 (30%) patients underwent surgery. Subject to incomplete follow-up of the entire cohort, we observed no false-positive and one false-negative diagnosis. These preliminary results suggest that DVAB using an 8-G probe are feasible, safe and accurate. In our experience, clip placement was problematic. It is probable that increasing the dimensions of DVAB will only be relevant in a limited number of clinical situations, primarily the desire to obtain complete radiologic resections of the target abnormality. [less ▲]

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See detailMultifocal serous cystadenoma of the pancreas synchronous with ampullary adenocarcinoma
Quatresooz, Pascale ULg; Honore, Pierre ULg; Vivario, M. et al

in Annales de Pathologie (2002), 22(4), 317-320

Pancreatic cysts are common, but cystic tumors are uncommon. We report a rare case of serous cystadenoma of the pancreas synchronous with ampullary adenocarcinoma which supports a common etiopathogeny of ... [more ▼]

Pancreatic cysts are common, but cystic tumors are uncommon. We report a rare case of serous cystadenoma of the pancreas synchronous with ampullary adenocarcinoma which supports a common etiopathogeny of these tumors. We discuss the differential diagnosis with mucinous cystadenoma which is potentially malignant and recall the microscopic and radiologic features. [less ▲]

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See detailFluorodeoxyglucose positron emission tomography and somatostatin receptor scintigraphy for diagnosing and staging carcinoid tumours: correlations with the pathological indexes p53 and Ki-67
Belhocine, Tarik; Willems, Jacqueline ULg; Rigo, Pierre ULg et al

in Nuclear Medicine Communications (2002), 23(8), 727-734

We performed this study in order to evaluate the diagnostic accuracy of whole-body fluorodeoxyglucose positron emission tomography (FDG PET) imaging and somatostatin receptor scintigraphy (SRS) for ... [more ▼]

We performed this study in order to evaluate the diagnostic accuracy of whole-body fluorodeoxyglucose positron emission tomography (FDG PET) imaging and somatostatin receptor scintigraphy (SRS) for localizing primary carcinoid tumours and evaluating the extent of the disease. A secondary aim was to correlate those findings with the histological characteristics of the lesions. FDG PET was performed in 17 patients and SRS in 16. All patients had pathologically proven carcinoids. All lesions were verified by histopathological analysis or by follow-up. Ki-67 and p53 expression were assessed as an indicator of the tumours' aggressiveness. FDG PET correctly identified 4/7 primary tumours and 8/11 metastatic spreads, as compared to six and 10 respectively, for SRS. Most tumours were typical carcinoids with low Ki-67 expression. No correlation was found between the histological features and the tracer's uptake. We conclude that SRS remains the modality of choice for evaluating patients with carcinoid tumours, regardless of their proliferative activity. FDG PET should be reserved to patients with negative results on SRS. ((C) 2002 Lippincott Williams Wilkins). [less ▲]

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See detailApercu nosologique du spectre des histiocytoses cutanees. Plus ca change, plus c'est la meme chose.
Quatresooz, Pascale ULg; Hermanns-Lê, Trinh ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2002), 57(11), 715-8

Histiocytes belong to distinct groups of cells. Similarly, histiocytoses represent some pathologic expressions of the various histiocyte lineages recognized by their distinct phenotypes. The recognition ... [more ▼]

Histiocytes belong to distinct groups of cells. Similarly, histiocytoses represent some pathologic expressions of the various histiocyte lineages recognized by their distinct phenotypes. The recognition of four major histiocytosis types relies on the distinction between monocytes-macrophages, dermal dendrocytes, Langerhans cells and the so-called indeterminate cells. Each of these groups exhibits a distinctive clinical and histological presentation. The risk of internal involvement, the prognosis and therapy are different as well. The diagnostic mainly relies on the clinico-pathologic assessment, and more particularly on the combination of histological, immunohistochemical and ultrastructural examinations. [less ▲]

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See detailHyperthyroïdie sur Amiodarone : études complémentaires, traitement et suivi de 32 cas
Valdes Socin, Hernan Gonzalo ULg; Leisteidt, S.; Betea, Daniela ULg et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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See detailEntre dermatoses et entéropathies.
Quatresooz, Pascale ULg; Bourguignon, R.; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2002), 57(8), 528-34

A series of gastro-intestinal diseases exhibits some connection with various cutaneous lesions. Some skin manifestations are clinically or histologically evocative, while others lack specificity. These ... [more ▼]

A series of gastro-intestinal diseases exhibits some connection with various cutaneous lesions. Some skin manifestations are clinically or histologically evocative, while others lack specificity. These manifestations can occur in overt digestive disease or be the clue for a silent one. A careful skin examination can thus reveal some inflammatory or neoplastic diseases of the gastro-intestinal tract, a malabsorption syndrome or food intolerance. [less ▲]

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See detailDes "dermatomycoses banales" qui ne pardonnent pas.
Braham, C.; Fraiture, A. L.; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2002), 57(5), 317-9

Two young adults presented an interdigital intertrigo and a dyschromic nail alteration, respectively. They were adept of intense sport swimming in pools. Lesions had been misdiagnosed as athlete's foot ... [more ▼]

Two young adults presented an interdigital intertrigo and a dyschromic nail alteration, respectively. They were adept of intense sport swimming in pools. Lesions had been misdiagnosed as athlete's foot and onychomycosis, respectively. Several antifungal treatments had been tried without success. After many months of inadequate management, the dermatological examination revealed the presence of two malignant melanomas corresponding to the eroded acrolentiginous and nodular subungueal types, respectively. [less ▲]

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See detailFusariose disséminée chez un patient immunodéprimé
QUATRESOOZ, Pascale ULg; Meiers, I.; ARRESE ESTRADA, Jorge ULg et al

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (2001), 28

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See detailLe cas clinique du mois. Maladie de Von Hippel-Lindau.
Gaspar, Y.; de Leval, Jean ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2001), 56(2), 68-71

VHL disease is a rare genetical disease with a poor long-term prognosis. Clinical features include retineous angiomas, CNS hemangioblastomas, pheochromocytomas and renal cysts. Renal cysts are bilateral ... [more ▼]

VHL disease is a rare genetical disease with a poor long-term prognosis. Clinical features include retineous angiomas, CNS hemangioblastomas, pheochromocytomas and renal cysts. Renal cysts are bilateral and frequently lead to malignant transformation. Surgical treatment of renal cysts is preferably delayed until a minimum of 3 cm diameter has been reached. Treatment has to be as conservative as possible, knowing that uni- or bilateral nephrectomy often has to be carried out later. [less ▲]

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See detailLe cas clinique du mois. Fusariose disseminee chez un patient immunodeprime
Quatresooz, Pascale ULg; Meiers, I.; Arrese, J. E. et al

in Revue Médicale de Liège (2000), 55(11), 974-6

Fusarium spp are ubiquitous soil saprophytes and occasional plant pathogens. Fusariosis in humans is usually limited to superficial mycoses. We report the case of a disseminated fungal infection due to ... [more ▼]

Fusarium spp are ubiquitous soil saprophytes and occasional plant pathogens. Fusariosis in humans is usually limited to superficial mycoses. We report the case of a disseminated fungal infection due to Fusarium spp in an immunosuppressed patient suffering from acute lymphoblastic leukemia. This report and review of the recent literature suggest that Fusarium spp are emerging fungal pathogens in immunosuppressed patients. [less ▲]

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See detailAdenocarcinome pancreatique: role de l'anatomie pathologique
Delvenne, Philippe ULg; Delvenne, Catherine ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2000), 55(3), 135-40

Duct cell adenocarcinoma is by far the most frequent neoplasm of the pancreas, accounting for about 80% of malignant tumors. In this report, we describe the main diagnostic pitfalls of this cancer in ... [more ▼]

Duct cell adenocarcinoma is by far the most frequent neoplasm of the pancreas, accounting for about 80% of malignant tumors. In this report, we describe the main diagnostic pitfalls of this cancer in routine or frozen sections, as well as the help of immunohistology to make the differential diagnosis. We also discuss the potential interest of tumor markers for evaluating the prognosis of these tumors and provide information about the creation of a Web site (URL: http://www.ebm.lib.ulg.ac.be/index.htm) created to help clinicians exploit the laboratory results. [less ▲]

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See detailAssociation adénome toxique thyroïdien et struma ovarii
Valdes Socin, Hernan Gonzalo ULg; Quatresooz, Pascale ULg; Betea, Daniela ULg et al

in XVIIIème Congrès de la Société Française d'Endocrinologie - Abstract book (2000)

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See detailEvaluation pronostique des tumeurs solides humaines par immunohistologie
Delvenne, Philippe ULg; Delvenne, Catherine ULg; Fridman, Viviana ULg et al

in Revue Médicale de Liège (1999), 54(8), 677-82

The aim of this project is to evaluate the interest of new tumor markers in the most frequent solid tumors (breast, colon, prostatic cancers, ...). For each of these tumors, potential prognostic markers ... [more ▼]

The aim of this project is to evaluate the interest of new tumor markers in the most frequent solid tumors (breast, colon, prostatic cancers, ...). For each of these tumors, potential prognostic markers have been selected according to the literature and an immunohistologic technique has been developed to analyse them. We will first discuss the role of pathology in oncology, then briefly describe the analyzed markers and finally give information about a Web site (URL: http:/(/)www.ebm. lib.ulg.ac.be/index.htm) created to help clinicians exploit the laboratory results. [less ▲]

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