References of "Plumier, Jean-Christophe"
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See detailThe usefulness of operant conditioning procedures to assess long-lasting deficits following transient focal ischemia in mice.
Ferrara, André ULg; El Bejaoui, Sophie; Seyen, Sandrine ULg et al

in Behavioural Brain Research (2009), 205(2), 525-34

In this study, we examined a number of short and long-term sensorimotor, behavioural and cognitive consequences of an experimental ischemia induced by a 60-min right middle cerebral artery occlusion (MCAO ... [more ▼]

In this study, we examined a number of short and long-term sensorimotor, behavioural and cognitive consequences of an experimental ischemia induced by a 60-min right middle cerebral artery occlusion (MCAO) in 129S2 mice. During 14 days after surgery, a classical sensorimotor assessment was conducted using hanging wire test, negative geotaxis test, grip strength test, accelerated rotarod test and locomotor activity-meter. In order to provide a technique for the assessment of more resistant consequences of ischemia on fine psychomotor control, the peak procedure (a modified version of the operant fixed-interval schedule of reinforcement) was used. This procedure also helped to objectify temporal perception in mice five weeks following surgery. On several sensorimotor tests, ischemic mice showed some degree of impairment which rapidly tended to improve after stroke, a profile of results substantially consistent with previous studies. Five weeks post-surgery, ischemic mice tested with the peak procedure exhibited a moderate but yet significant temporal regulation impairment along with a reduced response rate compared to control mice. The present results suggest that the peak procedure and other derived operant schedules of reinforcement may provide useful and sensitive tools for the long-term assessment of both behavioural and cognitive aspects of the consequences of an experimental ischemia. [less ▲]

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See detail15th Benelux Congress of Zoology abstract book
Colleye, Orphal ULg; Dauby, Patrick ULg; Fabri, Gregory et al

Book published by Editions de l'université de Liège (2008)

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See detailRole of the transcription factor HNF-6 on doublecortin expression
Degueldre, Julie; Piens, Marie; Plumier, Jean-Christophe ULg

Poster (2007)

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See detailTranscriptional regulation of the mouse doublecortin gene in differentiating neurons
Plumier, Jean-Christophe ULg; Muller, Marc ULg; Rogister, Bernard ULg et al

in International Journal of Developmental Neuroscience (2006, December), 24(8), 535

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See detailTranscriptional regulation of the mouse doublecortin gene in differentiating neurons
Plumier, Jean-Christophe ULg; Muller, Marc ULg; Rogister, Bernard ULg et al

in International Journal of Developmental Neuroscience (2006), 24

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See detailPhysiologie Animale
Ancil, Michel; Baguet, Fernand; Charmantier, Mireille et al

Book published by De Boeck Université (2006)

Detailed reference viewed: 19 (1 ULg)
See detailTranscritional regulation of the mouse doublecortin gene in differentiating neurons
Piens, Marie; Muller, Marc ULg; Lion, Michelle et al

Poster (2005)

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See detailAnalysis of the mouse doublecortin gene promoter in neurons
Piens, Marie; Muller, Marc ULg; Lion, Michelle ULg et al

Poster (2005)

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See detailEffects of hypoxia on stress proteins in the piglet brain at birth
Chiral, M.; Grongnet, J. F.; Plumier, Jean-Christophe ULg et al

in Pediatric Research (2004), 56(5), 775-782

Newborn piglets were submitted to normobaric hypoxia (5% O-2, 95% N-2) for either 1 or 4 h. The effects of hypoxia on the neonatal brain were characterized through a time-course analysis of levels of ... [more ▼]

Newborn piglets were submitted to normobaric hypoxia (5% O-2, 95% N-2) for either 1 or 4 h. The effects of hypoxia on the neonatal brain were characterized through a time-course analysis of levels of various proteins such as heat shock proteins (HSP27, 70, and 90), hypoxia inducible factor-1alpha (HIF-1alpha), neuronal nitric oxide synthase (nNOS), hemeoxygenase-2 (HO-2), and caspase-3. The expression of these proteins was determined at different stages of recovery up to 72 h in cerebellum, cortex, and hippocampus by Western blot analysis in hypoxic maintained animals that were made hypoxic at either 20 or 37degreesC. In all regions of the brain, HIF-1alpha and HSP27 expression were strongly increased until 22 h of recovery. No significant changes were observed for HSP70, HSP90, and HO-2. A small elevation of expression of nNOS was observed at early stages in the cerebellum and the cortex with no change in the hippocampus. Expression of caspase 3 was strongly increased in the cortex 24 and 48 h after hypoxia but unchanged in the hippocampus. These results are presented in terms of the porcine model of nonischemic hypoxia and its delayed neuronal effects on the cerebral outcome. Because of their recently established biochemical and functional interactions, the expression of the main HSPs, HIF-1alpha, OS, and caspase-3 after hypoxia are delineated. [less ▲]

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See detailNeuronal replacement in the ischemic brain
Plumier, Jean-Christophe ULg

Scientific conference (2003)

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See detailEGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia.
Teramoto, Tetsuyuki; Qiu, Jianhua; Plumier, Jean-Christophe ULg et al

in Journal of Clinical Investigation (2003), 111(8), 1125-32

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that ... [more ▼]

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that intraventricular administration of EGF and albumin augments 100-fold neuronal replacement in the injured adult mouse striatum after cerebral ischemia. Newly born immature neurons migrate into the ischemic lesion and differentiate into mature parvalbumin-expressing neurons, replacing more than 20% of the interneurons lost by 13 weeks after ischemia and representing 2% of the total BrdU-labeled cells. These data suggest that administration of EGF and albumin could be used to manipulate endogenous neurogenesis in the injured brain and to promote brain self-repair. [less ▲]

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See detailEGF amplifies the replacement of parvalbumin-expressing striatal neurons after ischemia
Teramoto, Tetsuyuki; Qiu, Jianhua; Plumier, Jean-Christophe ULg et al

Poster (2003)

Detailed reference viewed: 1 (0 ULg)