Showing results 21 to 40 of 76
  Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivativesVolvert, Marie-Laure  ; Seyen, Sandrine ; Piette, Marie et alin BMC Pharmacology (2008), 8 Detailed reference viewed: 88 (37 ULg)Assessment of motor and cognitive deficits in mice after cerebral ischemia and therapeutic benefit of intrastriatal transplantation of mesenchymal stem cells following transient cerebral ischemia; Ferrara, André ; et alPoster (2007) Detailed reference viewed: 1 (0 ULg)Gender-specific developmental neurotoxicity of cholinesterase inhibitor Phosalone in miceBraquenier, Jean-Baptiste ; Plumier, Jean-Christophe Poster (2007) Detailed reference viewed: 1 (0 ULg)Transcriptional regulation of the mouse doublecortin gene in differentiating neurons; Muller, Marc ; ROGISTER, Bernard et alPoster (2007) Detailed reference viewed: 1 (0 ULg) Transcriptional regulation of the mouse doublecortin gene in differentiating neuronsPlumier, Jean-Christophe ; Muller, Marc ; Rogister, Bernard et alin International Journal of Developmental Neuroscience (2006, December), 24(8), 535 Detailed reference viewed: 54 (24 ULg)Transcriptional regulation of the mouse doublecortin gene in differentiating neuronsPlumier, Jean-Christophe ; Muller, Marc ; Rogister, Bernard et alin International Journal of Developmental Neuroscience (2006), 24 Detailed reference viewed: 2 (2 ULg)Physiologie Animale; ; et al Book published by De Boeck Université (2006) Detailed reference viewed: 12 (0 ULg)Analysis of the mouse doublecortin gene promoter in neurons; Muller, Marc ; Lion, Michelle et alPoster (2005) Detailed reference viewed: 1 (0 ULg)Effects of hypoxia on stress proteins in the piglet brain at birth; ; Plumier, Jean-Christophe et alin Pediatric Research (2004), 56(5), 775-782 Newborn piglets were submitted to normobaric hypoxia (5% O-2, 95% N-2) for either 1 or 4 h. The effects of hypoxia on the neonatal brain were characterized through a time-course analysis of levels of ... [more ▼] Newborn piglets were submitted to normobaric hypoxia (5% O-2, 95% N-2) for either 1 or 4 h. The effects of hypoxia on the neonatal brain were characterized through a time-course analysis of levels of various proteins such as heat shock proteins (HSP27, 70, and 90), hypoxia inducible factor-1alpha (HIF-1alpha), neuronal nitric oxide synthase (nNOS), hemeoxygenase-2 (HO-2), and caspase-3. The expression of these proteins was determined at different stages of recovery up to 72 h in cerebellum, cortex, and hippocampus by Western blot analysis in hypoxic maintained animals that were made hypoxic at either 20 or 37degreesC. In all regions of the brain, HIF-1alpha and HSP27 expression were strongly increased until 22 h of recovery. No significant changes were observed for HSP70, HSP90, and HO-2. A small elevation of expression of nNOS was observed at early stages in the cerebellum and the cortex with no change in the hippocampus. Expression of caspase 3 was strongly increased in the cortex 24 and 48 h after hypoxia but unchanged in the hippocampus. These results are presented in terms of the porcine model of nonischemic hypoxia and its delayed neuronal effects on the cerebral outcome. Because of their recently established biochemical and functional interactions, the expression of the main HSPs, HIF-1alpha, OS, and caspase-3 after hypoxia are delineated. [less ▲] Detailed reference viewed: 21 (6 ULg)Neurogenesis and neural stem cells as therapeutic strategies for Parkinson's diseasePlumier, Jean-Christophe Scientific conference (2004) EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia.; ; Plumier, Jean-Christophe et alin Journal of Clinical Investigation (2003), 111(8), 1125-32 EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that ... [more ▼] EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that intraventricular administration of EGF and albumin augments 100-fold neuronal replacement in the injured adult mouse striatum after cerebral ischemia. Newly born immature neurons migrate into the ischemic lesion and differentiate into mature parvalbumin-expressing neurons, replacing more than 20% of the interneurons lost by 13 weeks after ischemia and representing 2% of the total BrdU-labeled cells. These data suggest that administration of EGF and albumin could be used to manipulate endogenous neurogenesis in the injured brain and to promote brain self-repair. [less ▲] Detailed reference viewed: 26 (12 ULg)EGF amplifies the replacement of parvalbumin-expressing striatal neurons after ischemia; ; Plumier, Jean-Christophe et alPoster (2003) Detailed reference viewed: 1 (0 ULg)Effects of hypoxia on stress proteins of the piglet brain at birth; ; Plumier, Jean-Christophe et alPoster (2003) Detailed reference viewed: 1 (0 ULg)Epidermal growth factor amplifies the replacement of parvalbumin-expressing striatal neurons after ischemiaPlumier, Jean-Christophe ; ; et alPoster (2003) Detailed reference viewed: 1 (0 ULg)Enhanced susceptibility of focal ischemic in jury in mice lacking prostacyclin receptors; ; et al Poster (2002) |
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