References of "Plenevaux, Alain"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailNCA asymmetric synthesis of 6-[18F]fluoro-L-dopa.
Lemaire, Christian ULg; Guillaume, M.; Cantineau, R. et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1991), 30

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detail18F-substituted aromatic aldehydes, key intermediates for nca radiosyntheses.
Lemaire, Christian ULg; Guillaume, M.; Plenevaux, Alain ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1991), 30

Detailed reference viewed: 20 (0 ULg)
Full Text
Peer Reviewed
See detailSynthesis and preliminary animal studies of [131I]iodotropapride: a cerebral dopamine D2 receptor ligand.
Cantineau, R.; Damhaut, Ph.; Plenevaux, Alain ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1991), 30

Detailed reference viewed: 9 (1 ULg)
Peer Reviewed
See detailAsymmetric synthesis of 4-[18F]fluoro-L-m-tyrosine via aromatic fluorination.
Lemaire, Christian ULg; Damhaut, Ph.; Plenevaux, Alain ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1991), 32

Detailed reference viewed: 15 (1 ULg)
Peer Reviewed
See detailSerotonine-S2 receptor imaging with [18F]altanserin and PET. Results in young normal controls.
Sadzot, Bernard ULg; Lemaire, Christian ULg; Cantineau, R. et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1991), 32

Detailed reference viewed: 16 (1 ULg)
Peer Reviewed
See detail4-[18F]Fluorotropapride, a specific D2 receptor ligand for PET.
Damhaut, Ph.; Cantineau, R.; Lemaire, Christian ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1991), 32

Detailed reference viewed: 6 (1 ULg)
Peer Reviewed
See detail2 and 4-[18F]fluorotropapride, two specific D2 receptor ligand for PET.
Damhaut, Ph.; Cantineau, R.; Lemaire, Christian ULg et al

in European Journal of Nuclear Medicine (1991), 18

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailAN APPROACH TO THE ASYMMETRIC-SYNTHESIS OF L-6-[F-18]FLUORODOPA VIA NCA NUCLEOPHILIC FLUORINATION
Lemaire, Christian ULg; Guillaume, Marcel; Cantineau, Robert et al

in Applied Radiation & Isotopes (1991), 42(7), 629-635

The NCA asymmetric synthesis of L-6-[F-18]fluorodopa starting from (1R,2R,5R)-[(+)-2-hydroxypinanyl-3-idene]glycine t-butyl ester as chiral agent has been developed. After F-18-fluorination of the two ... [more ▼]

The NCA asymmetric synthesis of L-6-[F-18]fluorodopa starting from (1R,2R,5R)-[(+)-2-hydroxypinanyl-3-idene]glycine t-butyl ester as chiral agent has been developed. After F-18-fluorination of the two commercially available aldehydes either 6-nitroveratraldehyde or 6-nitropiperonal, the required alkylating [F-18]fluorobenzyl bromide derivative can be easily prepared by treatment with NaBH4 followed by SOBr2. Alkylation of the Schiff base was carried out with the lithium salt of 2,2,6,6-tetramethylpiperidine as base in anhydrous THF at -78-degrees-C. Following hydrolysis of the protecting groups with hydroxylamine and Hl, the L-amino acid was obtained in 75% L form (ee 50%) with a 10% decay corrected (120 min) radiochemical yield. [less ▲]

Detailed reference viewed: 28 (2 ULg)
Full Text
Peer Reviewed
See detailThe synthesis of no-carrier-added DL-4-[18F]fluorodeprenyl via the nucleophilic aromatic substitution reaction.
Plenevaux, Alain ULg; Fowler, Joanna S.; Dewey, Stephen L. et al

in International Journal of Radiation Applications and Instrumentation. Part A : Applied Radiation and Isotopes (1991), 42(2), 121-7

No-carrier-added DL-alpha-methyl-beta-4-[18F]fluorophenyl-N-methyl-N-propynylethylamin e (DL-4-[18F]fluorodeprenyl) was synthesized via the following 3-step procedure: (1) nucleophilic aromatic ... [more ▼]

No-carrier-added DL-alpha-methyl-beta-4-[18F]fluorophenyl-N-methyl-N-propynylethylamin e (DL-4-[18F]fluorodeprenyl) was synthesized via the following 3-step procedure: (1) nucleophilic aromatic substitution by [18F]fluoride on 4-nitrobenzaldehyde to produce 4-[18F]fluorobenzaldehyde (yield 65%); (2) the reaction of 4-[18F]fluorobenzaldehyde with (1-chloro-1-(trimethylsilyl)ethyl)lithium followed by hydrolysis to give 4-[18F]fluorophenylacetone (yield 50%); and (3) reductive alkylation of 4-[18F]fluorophenylacetone with N-methyl-propynylamine in the presence of NaBH3CN (yield 35%) followed by HPLC purification to give a racemic mixture of 4-[18F]fluorodeprenyl. The overall yield was 11% (EOB corrected), the synthesis time was 90 min and the specific activity greater than 0.57 Ci/mumol (end of synthesis). This synthesis approach, the conversion of an aromatic aldehyde to a homologous methyl ketone, extends the flexibility of the nucleophilic aromatic substitution reaction by applying it to the synthesis of radiotracers which do not bear electron-withdrawing activating groups on the aromatic ring. The tissue distribution of DL-4-[18F]fluorodeprenyl in mice at 1, 10 and 60 min was also measured and showed that metabolic defluorination was not significant. Clearance of radioactivity from brain after injection of DL-4-[18F]fluorodeprenyl was more rapid than that previously observed for [11C]L-deprenyl. [less ▲]

Detailed reference viewed: 27 (3 ULg)
Full Text
Peer Reviewed
See detailFluorine-18-altanserin: a radioligand for the study of serotonin receptors with PET: radiolabeling and in vivo biologic behavior in rats.
Lemaire, Christian ULg; Cantineau, Robert; Guillaume, Marcel et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1991), 32(12), 2266-72

No-carrier-added [18F]altanserin was synthesized by nucleophilic substitution of the corresponding nitro compound with [18F]fluoride in the presence of kryptofix 222 and K2CO3. After purification by ... [more ▼]

No-carrier-added [18F]altanserin was synthesized by nucleophilic substitution of the corresponding nitro compound with [18F]fluoride in the presence of kryptofix 222 and K2CO3. After purification by preparative HPLC, [18F]altanserin was produced in less than 2 hr with a radiochemical yield of 10% (EOS) and a specific activity of 0.8-1.3 Ci/mumol. In rats, the tracer localized rapidly in the whole brain (0.5% ID/g organ) with a high binding to the frontal cortex. The frontal cortex/cerebellum ratio increased with time and reached a plateau of 11 at 2 hr postinjection. This uptake in S2 receptor regions was saturable and could be blocked by pretreatment with various S2 antagonists. This radiopharmaceutical appears to be more selective for S2 receptor sites than other ligands available today and allows the study of S2 receptors under in vivo conditions. [less ▲]

Detailed reference viewed: 18 (4 ULg)
Peer Reviewed
See detail[131I]iodotropapride: a cerebral dopamine D2 receptor ligand.
Cantineau, R.; Damhaut, Ph; Plenevaux, Alain ULg et al

Poster (1990, August 26)

Detailed reference viewed: 12 (3 ULg)
Peer Reviewed
See detailImaging serotonin-S2 receptors in humans with PET and the selective S2 antagonist [18F]altanserin. Preliminary results.
Sadzot, Bernard ULg; Lemaire, Christian ULg; Cantineau, R. et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1990, June 19), 31

Detailed reference viewed: 11 (2 ULg)
Full Text
Peer Reviewed
See detailSynthesis and tissue distribution of four Se-labeled tertiary amines, potential brain pH imaging agents.
Plenevaux, Alain ULg; Cantineau, Robert; Brihaye, Claude et al

in International Journal of Radiation Applications and Instrumentation. Part B : Nuclear Medicine and Biology (1990), 17(6), 601-7

Four new tertiary amines: bis(3-N,N-dimethyl aminopropyl)selenide (PROMOSE), bis(3-N-(morpholino)propyl)selenide, N-methyl-selenomorpholine and N-phenyl-selenomorpholine structurally related to MOSE ... [more ▼]

Four new tertiary amines: bis(3-N,N-dimethyl aminopropyl)selenide (PROMOSE), bis(3-N-(morpholino)propyl)selenide, N-methyl-selenomorpholine and N-phenyl-selenomorpholine structurally related to MOSE proposed by Kung and Blau, have been labeled through a radiochemical procedure suitable for both 75Se and 73Se. The radiochemical yields of the carrier added synthesis ranged between 64 and 85% for the four 75Se labelings and was 64% EOB time corrected for [73Se]PROMOSE. The chemical and radiochemical purities were higher than 99% after chromatographic purifications. The n-octanol/phosphate buffer partition coefficients (P) were measured at various pH (6.5-8) for each compound and the tissue distributions of PROMOSE in rats were also carried out. The experimental results showed a good correlation between the P = f(pH) function and the in vivo behaviour of the considered compound. PROMOSE was selected for further investigations as a brain pH indicator. [less ▲]

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailNO-CARRIER-ADDED (NCA) ARYL [F-18] FLUORIDES VIA THE NUCLEOPHILIC AROMATIC-SUBSTITUTION OF ELECTRON-RICH AROMATIC RINGS
DING, Y. S.; SHIUE, C. Y.; FOWLER, J. S. et al

in Journal of Fluorine Chemistry (1990), 48(2), 189-205

Nucleophilic aromatic substitution by [18F]fluoride ion has been demonstrated on rings containing electron donating groups in addition to the necessary electron withdrawing and leaving groups.

Detailed reference viewed: 21 (1 ULg)
Full Text
Peer Reviewed
See detailChemical processing for production of no-carrier-added selenium-73 from germanium and arsenic targets and synthesis of L-2-amino-4-([73Se]methylseleno) butyric acid (L-[73Se]selenomethionine).
Plenevaux, Alain ULg; Guillaume, Marcel; Brihaye, Claude et al

in International Journal of Radiation Applications and Instrumentation. Part A : Applied Radiation and Isotopes (1990), 41(9), 829-38

The Ge(4He, xn) and 75As(p, 3n) reactions were compared as the best potential routes for routine production of selenium-73 (73Se) for medical applications. With 26 MeV alpha particles, available with ... [more ▼]

The Ge(4He, xn) and 75As(p, 3n) reactions were compared as the best potential routes for routine production of selenium-73 (73Se) for medical applications. With 26 MeV alpha particles, available with compact cyclotrons, the first reaction required an enriched 70Ge target of sodium metagermanate to give a production yield of 1 mCi/microAh (0.037 GBq/microAh) in a 105 mg/cm2 target. With 55 MeV protons the As(p, 3n) reaction on natural arsenic yielded 20 mCi/microAh (0.74 GBq/microAh) in a 685 mg/cm2 target. A simple method was developed and optimized for both targets in order to isolate and purify the no-carrier-added selenium in the elemental form with a radiochemical yield greater than 75% in less than 90 min. An automated radiochemical processing unit has been designed for the routine production of 100-150 mCi (3.7-5.5 GBq) batches of carrier-free 73Se ready for radiopharmaceutical labeling. 30 mCi (1.11 GBq) (EOS) of L-2-amino-4-([73Se]methylseleno) butyric acid (L-[73Se]selenomethionine) ready for injection with a specific activity of 5 Ci/mmol (185 GBq/mmol) (EOS) were obtained through a fast chemical synthesis. Radiation absorbed dose estimates for L-[73Se]selenomethionine have been determined. A value of 0.70 rem/mCi (0.19 mSv/MBq) administered was calculated for the risk from irradiation in man. The first human PET investigation with [73Se]selenomethionine showed a very good delineation between liver and pancreas. [less ▲]

Detailed reference viewed: 39 (7 ULg)
Full Text
Peer Reviewed
See detailSynthesis of (R)-(-)- and (S)-(+)-4-fluorodeprenyl and (R)-(-)- and (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl and positron emission tomography studies in baboon brain.
Plenevaux, Alain ULg; Dewey, Stephen L.; Fowler, Joanna S. et al

in Journal of Medicinal Chemistry (1990), 33(7), 2015-9

(R)-(-)- and (S)-(+)-alpha-methyl-beta-4-(fluorophenyl)-N-methyl-N- propynylethylamine [R)-(-)- and (S)-(+)-4-fluorodeprenyl) were synthesized via the reaction of 4-fluorobenzaldehyde with nitroethane ... [more ▼]

(R)-(-)- and (S)-(+)-alpha-methyl-beta-4-(fluorophenyl)-N-methyl-N- propynylethylamine [R)-(-)- and (S)-(+)-4-fluorodeprenyl) were synthesized via the reaction of 4-fluorobenzaldehyde with nitroethane followed by reduction with lithium aluminum hydride to produce racemic 4-fluoroamphetamine, which was resolved by recrystallization with L- or D-N-acetylleucine to yield (R)-(-)-4-fluoroamphetamine or (S)-(+)-4-fluoroamphetamine in greater than 96% enantiomeric excesses and in yields of 42 and 39%, respectively. Alkylation with propargyl bromide gave (R)-(-)- or (S)-(+)-4-fluoronordeprenyl which was reductively methylated (Borch conditions) to produce (R)-(-)- or (S)-(+)-4-fluorodeprenyl. Alkylation of (R)-(-)- or (S)-(+)-4-fluoronordeprenyl with carbon-11 labeled methyl iodide gave (R)-(-)- or (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl in a radiochemical yield of 30-40%. Comparative PET studies of the two labeled enantiomers in baboons showed a significantly lower retention of radioactivity in the striatum for the (S)-(+) enantiomer relative to the (R)-(-) enantiomer. [less ▲]

Detailed reference viewed: 33 (2 ULg)
Peer Reviewed
See detailDevelopment of a new in vivo tracer of the cerebral pH.
Plenevaux, Alain ULg; Demonceau, G.; Cantineau, R. et al

in Journal of Cerebral Blood Flow & Metabolism (1989), 9S1

Detailed reference viewed: 5 (2 ULg)
Peer Reviewed
See detailSynthesis of carbon-11 and fluorine-18 labeled 4-fluorodeprenyl as probes for functional monoamine oxidase.
Plenevaux, Alain ULg; Dewey, S. L.; Fowler, J. S. et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1989), 30

Detailed reference viewed: 9 (2 ULg)