References of "Pirotte, Bernard"
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See detailNew dihydrocoumarine derivatives as potential mechanism-based inactivators of serine proteinases
Schynts, M.; Boggetto, N.; Masereel, B. et al

in Pharmaceutisch Weekblad (1992), 14

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See detailDesign, Synthesis and Biological Activity of a Series of Torasemide Derivatives, Potent Blockers of the Na+ 2cl- K+ Co-Transporter: In-Vitro Study
Masereel, B.; Lohrmann, E.; Schynts, M. et al

in Journal of Pharmacy & Pharmacology (1992), 44

Pharmacomodulation of the torasemide molecule, a loop diuretic inhibiting Na+ 2Cl- K+ co-transport in the thick ascending limb of the loop of Henle has been performed in order to obtain new long-acting ... [more ▼]

Pharmacomodulation of the torasemide molecule, a loop diuretic inhibiting Na+ 2Cl- K+ co-transport in the thick ascending limb of the loop of Henle has been performed in order to obtain new long-acting diuretics. The aim of this study was to decrease the metabolism of the drug and to slow down its rate of excretion by increasing its hydrophobicity. The present study describes the synthesis and the inhibitory potency of new torasemide derivatives in the bioassay system of the cortical thick ascending limb of rabbit. A correlation between the lipophilicity (log P') of these substances and their activity as inhibitors of the Na+ Cl- K+ co-transporter was observed. The present design led to compounds more active than torasemide. Structure-activity relationships permit us to propose an interaction model between torasemide derivatives and the Na+ 2Cl- K+ co-transport system of the cortical thick ascending limb. [less ▲]

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See detailSynthèse, étude théorique et évaluation biologique de dérivés du 4-amino-4H-1,2,4-triazole analogues des antibiotiques b-lactamiques
Pirotte, Bernard ULg; Dive, Georges ULg; Delarge, Jacques et al

in European Journal of Medicinal Chemistry (1992), 27(3), 193-205

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See detailNa+,2Cl-,K+ cotransport system as a marker of antihypertensive activity of new torasemide derivatives
Masereel, B.; Ferrari, P.; Ferrandi, M. et al

in European Journal of Pharmacology (1992), 219

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See detailNew relative K+-sparing high ceiling diuretics related to torasemide
Masereel, B.; Schynts, M.; Lohrmann, E. et al

in Journal de Pharmacie de Belgique (1992), 47

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See detailNew relative K+-sparing high ceiling diuretics related to torasemide
Masereel, B.; Schynts, M.; Lorhmann, E. et al

Poster (1991, September)

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See detailLoop diuretics : SAR, molecular interactions and target topography
Masereel, B.; Dupont, L.; Lohrmann, E. et al

Poster (1991, September)

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See detailAntibacterial activity of 5-acylaminothiazole derivatives, synthetic drugs related to β-lactam antibiotics
Pirotte, Bernard ULg; Delarge, Jacques; Coyette, Jacques ULg et al

in Journal of Antibiotics (The) (1991), 44

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See detailInhibiteurs potentiels de proteases à sérine apparentés aux antibiotiques β-lactamiques
Pirotte, Bernard ULg; Vilain, A.-C.; Vergely, I. et al

in Regard sur la Biochimie (1991), 6, 91

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See detailStructure de la bétaïne du carboxyméthyl-1 méthylamino-4 triazolium-1,2,4
Dupont, L.; Englebert, S.; Dideberg, O. et al

in Acta Crystallographica (1991), C47

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See detailStructure de l'acide (tert-butylamino-4 oxo-5 triazol-1,2,4 yle-1)acétique
Dupont, L.; Englebert, S.; Dideberg, O. et al

in Acta Crystallographica (1991), C47

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See detailStructures du cyclohexyl-1[(cycloheptylamino-4 pyridyl-3)sulfonyl]-3 urée et de l'hydrogénonitrate du cyclohexyl-1[(cyclooctylamino-4 pyridyl-3)sulfonyl]-3 urée
Dupont, L.; Dideberg, O.; Masereel, B. et al

in Acta Crystallographica (1991), C47

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See detailLoop diuretics : SAR, molecular interactions and target topography
Masereel, B.; Dupont, L.; Lohrmann, E. et al

in Archiv der Pharmazie (1991), 324

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