References of "Pirotte, Bernard"
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See detailRésolution préparative du pirlindole
De Tullio, Pascal ULg; Felekidis, Apostolos ULg; Liégeois, Jean-François ULg et al

Poster (1997, May)

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See detailDesign, synthesis and pharmacology of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas
Masereel, B.; Ouedraogo, R.; Dogne, J. M. et al

Poster (1997, May)

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See detailDesign of new potential hypoglycemic drugs
Masereel, B.; De Tullio, Pascal ULg; Dogne, J. M. et al

Poster (1997, May)

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See detailTentatives de synthèse énantiosélective des isomères R et S du pirlindole
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Stachow, M. et al

Poster (1997, May)

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See detailPharmacomodulation of torasemide led to original diuretic, neuroprotective, anticonvulsant and antithrombotic drugs
Masereel, B.; Dogne, J. M.; Damas, J. et al

Conference (1997, April)

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See detailPharmacological analysis of ATP-dependent potassium channels openers on vascular smooth muscle
Ouedraogo, R.; Somers, F.; De Tullio, Pascal ULg et al

Conference (1997, April)

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See detailDesign, synthesis and biological evaluation of sulfonylureas as original non-prostanoid thromboxane receptor antagonists
Dogne, J. M.; Varache-Lembege, M.; Damas, J. et al

Conference (1997, April)

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See detailStudy of the Influence of Both Cyclodextrins and L-Lysine on the Aqueous Solubility of Nimesulide; Isolation and Characterization of Nimesulide-L-Lysine-Cyclodextrin Complexes
Piel, Géraldine ULg; Pirotte, Bernard ULg; Delneuville, Isabelle et al

in Journal of Pharmaceutical Sciences (1997), 86(4), 475-80

Nimesulide is a nonsteroidal antiinflammatory drug that exhibits a very poor water solubility (0.01 mg.mL-1). A nimesulide-beta-cyclodextrin complex prepared according to patent application WO 94/ 02177 ... [more ▼]

Nimesulide is a nonsteroidal antiinflammatory drug that exhibits a very poor water solubility (0.01 mg.mL-1). A nimesulide-beta-cyclodextrin complex prepared according to patent application WO 94/ 02177 has an aqueous solubility of approximately 16 mg.mL-1 of nimesulide. A nimesulide-L-lysine salt has also been prepared and increases the aqueous solubility of nimesulide to approximately 5.0-7.5 mg.mL-1. The purpose of the present study was to investigate the interaction of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide. Nimesulide-L-lysine-beta- or gamma-cyclodextrin complexes were prepared by spray-drying. The inclusion of the nimesulide-L-lysine salt into the cyclodextrin cavity was confirmed by differential scanning calorimetry and proton nuclear magnetic resonance spectroscopy. These complexes offered remarkable aqueous solubility. The incorporation of nimesulide in a nimesulide-L-lysine-beta-cyclodextrin complex increased its water solubility by a factor of 10 at pH 1.5 (0.050 mg.mL-1 for the complex versus 0.005 mg.mL-1 for nimesulide), 160 at pH 6.8 (2.373 mg.mL-1 for the complex versus 0.015 mg.mL-1 for nimesulide), and 3600 in purified water (36.400 mg.mL-1 for the complex versus 0.01 mg.mL-1 for nimesulide). [less ▲]

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See detailVerapamil: an inhibitor of ATP-sensitive K+ channels?
Lebrun, P.; Antoine, M. H.; Ouedraogo, R. et al

Poster (1997, April)

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See detailPharmacologie des canaux K+ATP-dépendants des cellules B pancréatiques: nouveaux développements
Lebrun, P.; Pirotte, Bernard ULg; Antoine, M. H.

Conference (1997, March 08)

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See detailPhysiology, pharmacology of ATP-sensitive K+ channels and insulin release
Lebrun, P.; Pirotte, Bernard ULg; Antoine, M. H.

Poster (1997, February 15)

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See detailPharmacological analysis of ATP-dependent potassium channel openers on the vascular smooth muscle
Fontaine, J.; Pirotte, Bernard ULg; Lebrun, P.

Poster (1997, February 15)

Detailed reference viewed: 4 (0 ULg)