References of "Pirotte, Bernard"
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See detailPharmacological analysis of ATP-dependent potassium channels openers on vascular smooth muscle
Ouedraogo, R.; Somers, F.; De Tullio, Pascal ULg et al

Conference (1997, April)

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See detailDesign, synthesis and biological evaluation of sulfonylureas as original non-prostanoid thromboxane receptor antagonists
Dogne, J. M.; Varache-Lembege, M.; Damas, J. et al

Conference (1997, April)

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See detailStudy of the Influence of Both Cyclodextrins and L-Lysine on the Aqueous Solubility of Nimesulide; Isolation and Characterization of Nimesulide-L-Lysine-Cyclodextrin Complexes
Piel, Géraldine ULg; Pirotte, Bernard ULg; Delneuville, Isabelle et al

in Journal of Pharmaceutical Sciences (1997), 86(4), 475-80

Nimesulide is a nonsteroidal antiinflammatory drug that exhibits a very poor water solubility (0.01 mg.mL-1). A nimesulide-beta-cyclodextrin complex prepared according to patent application WO 94/ 02177 ... [more ▼]

Nimesulide is a nonsteroidal antiinflammatory drug that exhibits a very poor water solubility (0.01 mg.mL-1). A nimesulide-beta-cyclodextrin complex prepared according to patent application WO 94/ 02177 has an aqueous solubility of approximately 16 mg.mL-1 of nimesulide. A nimesulide-L-lysine salt has also been prepared and increases the aqueous solubility of nimesulide to approximately 5.0-7.5 mg.mL-1. The purpose of the present study was to investigate the interaction of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide. Nimesulide-L-lysine-beta- or gamma-cyclodextrin complexes were prepared by spray-drying. The inclusion of the nimesulide-L-lysine salt into the cyclodextrin cavity was confirmed by differential scanning calorimetry and proton nuclear magnetic resonance spectroscopy. These complexes offered remarkable aqueous solubility. The incorporation of nimesulide in a nimesulide-L-lysine-beta-cyclodextrin complex increased its water solubility by a factor of 10 at pH 1.5 (0.050 mg.mL-1 for the complex versus 0.005 mg.mL-1 for nimesulide), 160 at pH 6.8 (2.373 mg.mL-1 for the complex versus 0.015 mg.mL-1 for nimesulide), and 3600 in purified water (36.400 mg.mL-1 for the complex versus 0.01 mg.mL-1 for nimesulide). [less ▲]

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See detailVerapamil: an inhibitor of ATP-sensitive K+ channels?
Lebrun, P.; Antoine, M. H.; Ouedraogo, R. et al

Poster (1997, April)

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See detailPharmacologie des canaux K+ATP-dépendants des cellules B pancréatiques: nouveaux développements
Lebrun, P.; Pirotte, Bernard ULg; Antoine, M. H.

Conference (1997, March 08)

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See detailPhysiology, pharmacology of ATP-sensitive K+ channels and insulin release
Lebrun, P.; Pirotte, Bernard ULg; Antoine, M. H.

Poster (1997, February 15)

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See detailPharmacological analysis of ATP-dependent potassium channel openers on the vascular smooth muscle
Fontaine, J.; Pirotte, Bernard ULg; Lebrun, P.

Poster (1997, February 15)

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See detailSynthèse et évaluation biologique de sulfonylurées en tant qu’antagonistes du thromboxane A2
Dogne, J. M.; Varache-Lembeche, M.; Damas, J. et al

Conference (1997, January 12)

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See detailEffect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.
Scuvée-Moreau, Jacqueline ULg; Seutin, Vincent ULg; Vrijens, Bernard ULg et al

in Archives of Physiology & Biochemistry (1997), 105(5), 421-8

The effect of four KATP channel openers (KCOs) on the firing rate of CA1 pyramidal cells and A10 dopaminergic neurons was investigated using extracellular recording techniques in rat brain slices ... [more ▼]

The effect of four KATP channel openers (KCOs) on the firing rate of CA1 pyramidal cells and A10 dopaminergic neurons was investigated using extracellular recording techniques in rat brain slices. Pinacidil, lemakalim, diazoxide and a new compound, BPDZ44, had an inhibitory effect on the electrical activity of CA1 pyramidal cells. They all had a similar potency. Only BPDZ44 and diazoxide inhibited the firing rate of A10 dopamine neurons. The sulfonylurea glipizide (1 microM) antagonized the effect of BPDZ44 and diazoxide on A10 neurons but failed to antagonize the effect of KCOs on CA1 pyramidal cells. These results show that differences exist among KCOs in their ability to decrease the electrical activity of various populations of central neurons. [less ▲]

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See detailEffect of activators and inhibitors of K+-channels on insulin secretion in the amphibian pancreas
Francini, F.; Pirotte, Bernard ULg; Gagliardino, J. J.

in Archives of Physiology & Biochemistry (1997), 105

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See detailPyridothiadiazines as potent inhibitors of glucose-induced insulin release
Lebrun, P.; Antoine, M.-H.; Ouedraogo, R. et al

in Physiology and Pathophysiology of the Islets of Langerhans (1997)

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See detailSynthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas
Masereel, B.; Ouedraogo, R.; Dogne, J.-M. et al

in European Journal of Medicinal Chemistry (1997), 32

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See detailVerapamil, a phenylalkylamine Ca2+ channel blocker, inhibits ATP-sensitive K+ channels in insulin-secreting cells
Lebrun, P.; Antoine, M.-H.; Ouedraogo, R. et al

in Diabetologia (1997), 40

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