Physiology, pharmacology of ATP-sensitive K+ channels and insulin release

Poster (1997, February 15)

Synthèse et évaluation biologique de sulfonylurées en tant qu’antagonistes du thromboxane A2

Conference (1997, January 12)

Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.

in Archives of Physiology & Biochemistry (1997), 105(5), 421-8

The effect of four KATP channel openers (KCOs) on the firing rate of CA1 pyramidal cells and A10 dopaminergic neurons was investigated using extracellular recording techniques in rat brain slices ... [more ▼]

The effect of four KATP channel openers (KCOs) on the firing rate of CA1 pyramidal cells and A10 dopaminergic neurons was investigated using extracellular recording techniques in rat brain slices. Pinacidil, lemakalim, diazoxide and a new compound, BPDZ44, had an inhibitory effect on the electrical activity of CA1 pyramidal cells. They all had a similar potency. Only BPDZ44 and diazoxide inhibited the firing rate of A10 dopamine neurons. The sulfonylurea glipizide (1 microM) antagonized the effect of BPDZ44 and diazoxide on A10 neurons but failed to antagonize the effect of KCOs on CA1 pyramidal cells. These results show that differences exist among KCOs in their ability to decrease the electrical activity of various populations of central neurons. [less ▲]

Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro

in Archives of Physiology & Biochemistry (1997), 105

The chemistry of 3-phthalimidomethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides and their use in the synthesis of potential cholecystokinin/gastrin receptor ligands

in Bulletin des Sociétés Chimiques Belges (1997), 106

Synthesis and biological evaluation of new 3-aralkylamino-2-aryl-2H-1,2,4-pyridothiadiazine 1,1-dioxides as potential CCK receptor ligands

in Journal of Pharmacy & Pharmacology (1997), 49

Ligand effects in the hydrogenation of methacycline to doxycycline and epi-doxycycline catalysed by rhodium complexes. Molecular structure of the key catalyst [closo-3,3-(η2,3-C7H7CH2)-3,1,2-Rh C2B9H11]

in Journal of Organometallic Chemistry (1997), 536-537

Synthesis and design of potential ATP-sensitive potassium channel openers bearing some structural features of benzopyrans and benzo (pyrido)thiadiazinedioxides52, 2bis

in Journal de Pharmacie de Belgique (1997), 52

Verapamil inhibits ATP-sensitive K+ channel in pancreatic B-cells

Conference (1996, December 07)

Progress towards coumarinic derivatives as protease inhibitors

Poster (1996, September)