References of "Pirotte, Bernard"
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See detailCharacterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig
Dogné, Jean-Michel ULg; Rolin, Stéphanie; Petein, Michel et al

in Thrombosis Research (2005), 116(5), 431-442

Background: Great advances have been made in the prevention of thrombotic disorders by developments of new pharmacological and surgical treatments. Animal models of arterial thrombosis have largely ... [more ▼]

Background: Great advances have been made in the prevention of thrombotic disorders by developments of new pharmacological and surgical treatments. Animal models of arterial thrombosis have largely contributed to the discovery and to the validation of original treatments. The purpose of the present work was to develop and validate an original model of acute myocardial infarction provoked in pig by thrombosis of the left anterior descending (LAD) coronary artery induced by topical application of ferric chloride solution. Methods and results: Myocardial infarction, resulting from an occlusive and adherent mixed thrombus formed in the LAD coronary artery, was examined at macroscopic level using dual staining technique (Evans blue dye; triphenyltetrazolium chloride) and at microscopic level using conventional histological analyses and immunohistochemical detection of desmin. Biochemical markers (troponin T and ATP), platelet reactivity and standard hemodynamic parameters (such as stroke volume, ejection fraction, stroke work and cardiac output) have also been evaluated. From these analyses, it was demonstrated that each pig developed a transmural area of irreversible damage mainly located in the anteroseptal region of the left ventricle. The more progressive development of coronary artery occlusion, as compared to an abrupt Ligation, was accompanied by a correspondingly progressive impairment in hemodynamics. Conclusion: We conclude that this original porcine model of myocardial infarction is quite close to clinical pathophysiological conditions, such as thrombus formation occurring after atherosclerotic plaque rupture. This certainly constitutes a further argument in favour of this model to assess pharmaceutical or mechanical support of an acutely ischemic heart. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailIn vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea]
Hanson, Julien ULg; Rolin, Stéphanie; Reynaud, Denis et al

in Journal of Pharmacology and Experimental Therapeutics (The) (2005), 313

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See detailCrystal structure of 7-chloro-3-isopropylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxide, C10H11CIN2O2S2
Dupont, L.; Boverie, S.; De Tullio, Pascal ULg et al

in Zeitschrift für Kristallographie. New Crystal Structures (2005), NCS 220

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See detailCrystal structure of 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide, C10H12CIN3O2S
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg

in Zeitschrift für Kristallographie. New Crystal Structures (2005), NCS 220

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See detailCrystal structure of 7-chloro-3-isopropoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide monohydrate, C10H13CIN2O4S H2O
Dupont, L.; Boverie, S.; Pirotte, Bernard ULg et al

in Zeitschrift für Kristallographie. New Crystal Structures (2005), NCS 220

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See detailA new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide
Michaux, C.; Charlier, C.; Julémont, F. et al

in European Journal of Medicinal Chemistry (2005), 40

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See detailEffect on KATP channel activation properties and tissue selctivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine
Boverie, S.; Antoine, M.-H.; Somers, F. et al

in Journal of Medicinal Chemistry (2005), 48

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See detailNew insights into the development pf ATP-sensitive potassium channel openers
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Antoine, M.-H. et al

in Expert Opinion on Therapeutic Patents (2005), 15

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See detail3,6-Disubstitued coumarins as mechanism-based inhibitors of thrombin and factor Xa
Frederick, R.; Robert, S.; Charlier, C. et al

in Journal of Medicinal Chemistry (2005), 48

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See detailPharmacophore generation to design new leads for selective cyclooxygenase-2 inhibition
Michaux, C.; Julemont, F.; De Leval, X. et al

Poster (2004, October 07)

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See detailModulation of the arachidonic cascade with omega 3 fatty acids or analogues: Potential therapeutic benefits
Roland, Isabelle ULg; de Leval, X.; Evrard, Brigitte ULg et al

in Mini-Reviews in Medicinal Chemistry (2004), 4(6), 659-668

Increasing interest in the role of omega 3 fatty acids has arisen in these latest years since evidence of their implication in the cardioprotective fish based diet of the Inuit has been demonstrated ... [more ▼]

Increasing interest in the role of omega 3 fatty acids has arisen in these latest years since evidence of their implication in the cardioprotective fish based diet of the Inuit has been demonstrated. Furthermore, several in vitro, in vivo and epidemiological studies support the benefit of this fatty acids intake in various pathological states such as in the cardiovascular, cancer, inflammation, psychiatric, paediatric, pulmonary, dermatological and ophthalmologic fields. This review will focus on metabolism and pharmacological implication of w3 fatty acids intake as well as its interest in the prevention or treatment of the above-mentioned pathologies. [less ▲]

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See detailNew analogues of the potassium channel opener cromakalim : effects on rat pancreatic B-cells and rat aorta rings
Sebille, S.; De Tullio, Pascal ULg; Antoine, M. H. et al

Poster (2004, July)

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See detailRelaxant effects on the rat uterine smooth muscle of putative K+ATP channel openers
Boverie, S.; De Tullio, Pascal ULg; Sebille, S. et al

Poster (2004, July)

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