References of "Pirotte, Bernard"
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See detailNew trends in the design of drugs against Alzheimer's disease
Francotte, Pierre ULg; De Tullio, Pascal ULg; Fraikin, Pierre ULg et al

in Frontiers in Medicinal Chemistry (2006), 3

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See detailThe use of nimesulide and its analogues in cancer chemoprevention
Renard, Jean-François ULg; Julémont, F.; De Leval, X. et al

in Anti-Cancer Agents in Medicinal Chemistry (2006), 6

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See detailStructure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method
Michaux, C.; De Leval, X.; Julémont, F. et al

in European Journal of Medicinal Chemistry (2006), 41

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See detailSynthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2-H-1-benzopyran-4-yl)ureas structurally related to cromakalim
Khelili, S.; Lebrun, P.; De Tullio, Pascal ULg et al

in Bioorganic & Medicinal Chemistry (2006), 14

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See detailIn Search of Novel Ampa Potentiators
Francotte, Pierre ULg; De Tullio, Pascal ULg; Fraikin, Pierre ULg et al

in Recent Patents on CNS Drug Discovery (2006), 1(3), 239-46

Glutamate is the major excitatory neurotransmitter in the brain. Amongst ionotropic receptors responding to glutamate, the AMPA subtype has been considered as essential for the fast excitatory ... [more ▼]

Glutamate is the major excitatory neurotransmitter in the brain. Amongst ionotropic receptors responding to glutamate, the AMPA subtype has been considered as essential for the fast excitatory neurotransmission in the central nervous system and the expression and maintenance of long-term potentiation. As glutamate is known to be involved in many neurological and psychiatric disorders, AMPA receptors seem to represent interesting targets to develop therapeutic drugs. Hence, the enhancement of AMPA signals is an approach currently investigated for the management of Alzheimer's disease, schizophrenia or mood disorders. In particular, many efforts are being conducted in the development of AMPA positive allosteric modulators ("potentiators"), which alter the rate of receptor desensitization. The major chemical families developed as AMPA potentiators are aniracetam derivatives, cyclothiazide derivatives and biarylpropylsulfonamides derivatives. [less ▲]

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See detailBenzopyran derivatives, method of production and use thereof
Sebille, S.; Pirotte, Bernard ULg; Boverie, S. et al

Patent (2005)

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See detailSynthesis and pharmacological effects of opened analogues of benzothiadiazine 1,1-dioxides with sulfonylurea moieties on diuresis and glycemia
Khelili, S.; Bouider, N.; Delarge, J. et al

Poster (2005, May)

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See detailDéveloppement de modulateurs de la voie du thromboxane A2 en tant qu’agents anti-angiogéniques et anti-métastatiques
De Leval, X.; Dassesse, T.; Dogne, J. M. et al

Poster (2005, May)

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