References of "Pierard-Franchimont, Claudine"
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See detailThe Inflammatory Hypothesis of Ageing: Fascinating Concept or Confusing Dogma?
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg

in Journal of Cosmetic Dermatology (2004), 3(4), 246

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See detailUpdating trends in cutaneous cancers in south-east Belgium.
Uhoda, Isabelle; Quatresooz, Pascale ULg; Fumal, Isabelle et al

in Oncology Reports (2004), 12(1), 111-4

From data collected in a dermatopathology laboratory, the ratios between the numbers of specific cancers represent good markers for identifying any epidemiological shift in their prevalence and incidence ... [more ▼]

From data collected in a dermatopathology laboratory, the ratios between the numbers of specific cancers represent good markers for identifying any epidemiological shift in their prevalence and incidence among the reference population. The objective of the present study was to assess the ratios of the annual incidence of skin cancers in the Mosan region and Ardennes of Belgium over the past 6 years, and to compare the data with previous similar evaluations. A total of 7,640 skin cancers were collected and compared with regard to age and gender. Changes in time show that the trend of the increase in incidence of malignant melanoma (MM) is more impressive than that of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). The age distribution of BCC and SCC confirms the increasing risk with ageing. By contrast, there is a steady decrease over the past decade in the mean age for MM, teenagers and young adults now form an expanding proportion of MM patients. There is an ongoing trend in diagnosing an increased number of skin cancers in our laboratory. This trend is particularly obvious for MM affecting young adults. [less ▲]

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See detailProlonged imiquimod treatment and graft-versus-host reaction: histological mimicry in the skin infiltration pattern of the monocyte-macrophage-dendrocyte lineage.
Hermanns-Lê, Trinh ULg; Paquet, Philippe ULg; Nikkels, Arjen ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 361-365

Factor-XIIIa-positive dendrocytes belong to the monocyte-macrophage-dendrocyte (MMD) lineage which is considered to play a pivotal role in the skin response to the immune response modifier imiquimod. The ... [more ▼]

Factor-XIIIa-positive dendrocytes belong to the monocyte-macrophage-dendrocyte (MMD) lineage which is considered to play a pivotal role in the skin response to the immune response modifier imiquimod. The same cells are also boosted in low-grade graft-versus-host reaction (GVHR) with skin manifestations. Both conditions are characterized by specific epidermal damage. The aim of the present study was to compare them using immunohistochemistry to identify MMD subsets and other inflammatory cells in the dermis. We compared 3 cases of long-term (4, 9 and 11 months) imiquimod topical applications on normal skin, 25 low-grade GVHR controlled by immunosuppressive therapy and 25 control cases with normal skin. Compared to the normal dermis, cells of the MMD lineage were considerably boosted in the dermis of GVHR and at the imiquimod-treated sites. By contrast, only minimal accumulations of lymphocytes and Langerhans cells were disclosed in the dermis. The pattern of dermal infiltration by MMD cells was similar in GVHR and after imiquimod treatment. However, intraindividual differences in densities were obvious irrespective of the skin condition. In conclusion, there is great mimicry in the MMD involvement in the dermis during low-grade GVHR and after chronic applications of imiquimod. [less ▲]

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See detailOnychomycosis under the microscope
PIERARD, Gérald ULg; ARRESE ESTRADA, Jorge ULg; PIERARD-FRANCHIMONT, Claudine ULg et al

Book published by Janssen Pharmaceutica (2003)

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See detailComment je traite ... un herpès labial récurrent
Petit, L.; Braham, C.; Nikkels, Arjen ULg et al

in Information Dentaire (L') (2002), 22

L'herpès labial récurrent est une affection fréquente. Il fait suite à la réactivation du virus herpétique (HSV1 et au plus rarement HSV2) au niveau du ganglion de Gasser. Le traitement et la prévention ... [more ▼]

L'herpès labial récurrent est une affection fréquente. Il fait suite à la réactivation du virus herpétique (HSV1 et au plus rarement HSV2) au niveau du ganglion de Gasser. Le traitement et la prévention de l'herpès labial récurrent font classiquement appel à des agents antiviraux spécifiques. Les résultats spectaculaires obtenus chez les patients immunodéprimés sont beaucoup moins convaincants chez des sujets par ailleurs sains. D'autres voies prospectives de thérapeutique sont à l'étude utilisant des lipopeptides et des moyens physiques induisant une modification du pH cutané. [less ▲]

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See detailL'allergie aux aromes et parfums: anathème sur un attrait épicurien?
Goffin, Véronique ULg; Nikkels, Arjen ULg; Cornil, F. et al

in Revue Médicale de Liège (2002), 57(9), 605-9

Aromas and fragrances are present in many cosmetics, some topical drugs, food and various hygiene, household and industrial products. They can be responsible for contact dermatitis. Multiple ... [more ▼]

Aromas and fragrances are present in many cosmetics, some topical drugs, food and various hygiene, household and industrial products. They can be responsible for contact dermatitis. Multiple sensitizations can even involve in various combinations some fragrance compounds, a given degradation product or a contaminant. The diagnosis relies on clinical examination and oriented anamnesis. A histological examination is sometimes necessary. Specific path testing brings insight on the culprit chemical compounds. [less ▲]

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See detailPerspectives de dialogue entre des neuromédiateurs et les kératinocytes.
Pierard-Franchimont, Claudine ULg; Faska, N.; Nikkels, Arjen ULg et al

in Dermatologie Actualité (2002), 65

Les neuromédiateurs contrôlant l’activité de l’axe hypothalamo-hypophysaire sont aussi exprimés dans la peau. D’autres neuromédiateurs liés au stress le sont également. En fait, près d’une vingtaine de ... [more ▼]

Les neuromédiateurs contrôlant l’activité de l’axe hypothalamo-hypophysaire sont aussi exprimés dans la peau. D’autres neuromédiateurs liés au stress le sont également. En fait, près d’une vingtaine de ces molécules sont synthétisées in situ et sont connues pour avoir des récepteurs spécifiques et exprimer une activité biologique dans cet organe. Certaines exercent un impact fonctionnel sur les kératinocytes. Il s’agit en fait de systèmes paracrines neuro-kératinocytaires et autocrines par lesquels les kératinocytes expriment de nombreux récepteurs pour les neuromédiateurs qu’ils libèrent eux-mêmes. [less ▲]

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See detailComparative effect of hormone replacement therapy on bone mass density and skin tensile properties
Pierard, Gérald ULg; Vanderplaetsen, S.; Pierard-Franchimont, Claudine ULg

in Maturitas (2001), 40(3), 221-227

Objectives: connective tissues constitutive of skin and bones are affected during the climacteric. Hormone replacement therapy (HRT) can help mitigate their atrophy. The aim of this study was to compare ... [more ▼]

Objectives: connective tissues constitutive of skin and bones are affected during the climacteric. Hormone replacement therapy (HRT) can help mitigate their atrophy. The aim of this study was to compare the HRT effect on the skin tensile properties and bone mass density. Methods: a total of 120 postmenopausal women (60 untreated, 60 receiving HRT) were enrolled in the study. Skin tensile properties were assessed on the volar forearm using a computerized suction device. A 500 mbar suction was applied through a 4-mm diameter hollow probe. Two operating modes were applied using a steep and a progressive Suction, respectively. BMD was measured on the hip, femoral neck and lumbar spine using dual X-ray absorptiometry. Results: in both groups of women skin elasticity was correlated with BMD. HRT significantly reduced the climacteric-associated decline in skin elasticity. A trend in better preserved BMD was also found in these women without, however, reaching significance. Conclusions: it is concluded that measures of the skin tensile properties can be sensitive enough to disclose HRT efficacy upon connective tissue atrophy. Any decrease in skin elasticity during the climacteric should prompt to perform a BMD assessment. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailL'image du mois. Un melanome masque chez un joueur de tennis
Fraiture, A. L.; Henry, Frédérique ULg; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2001), 56(11), 737-8

A man presented with a malignant melanoma of the scalp. The lesion reached a large size before being disclosed. Repetitive sunburns during tennis matches could be responsible for this cancer. Indeed, hair ... [more ▼]

A man presented with a malignant melanoma of the scalp. The lesion reached a large size before being disclosed. Repetitive sunburns during tennis matches could be responsible for this cancer. Indeed, hair protects only partially the skin from ultraviolet damages. [less ▲]

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See detailEffets indesirables cutanes des interferons
Paquet, Philippe ULg; Pierard-Franchimont, Claudine ULg; Arrese, J. E. et al

in Revue Médicale de Liège (2001), 56(10), 699-702

The alpha, beta and gamma recombinant interferons are indicated in a growing spectrum of therapeutic indications. Some unwanted side effects occur on the skin. The main clinical presentations include ... [more ▼]

The alpha, beta and gamma recombinant interferons are indicated in a growing spectrum of therapeutic indications. Some unwanted side effects occur on the skin. The main clinical presentations include vesiculo-bullous sometimes infiltrated dermatitis, vasculitis, necrosis, ulceration and alopecia. Exacerbation of dermatoses such as psoriasis is also possible. [less ▲]

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See detailAnthrax et charbon
Arrese, J. E.; Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2001), 56(10), 685-8

Anthrax is a name given in French language to two distinct infectious diseases. One corresponds to carbuncle which is a collection of boils. The other one corresponds to the English term anthrax. This ... [more ▼]

Anthrax is a name given in French language to two distinct infectious diseases. One corresponds to carbuncle which is a collection of boils. The other one corresponds to the English term anthrax. This condition has a clinical presentation and an outcome that vary according to the inoculation site being cutaneous, pulmonary or digestive, and to the bacterial and toxin spread in the body. [less ▲]

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See detailRelationship between bone mass density and tensile strength of the skin in women
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Vanderplaetsen, S. et al

in European Journal of Clinical Investigation (2001), 31(8), 731-735

BACKGROUND: Skin and bone may be affected similarly during the climacteric and during long-term corticotherapy. Little is known about the correlation between the respective alterations in bone mass ... [more ▼]

BACKGROUND: Skin and bone may be affected similarly during the climacteric and during long-term corticotherapy. Little is known about the correlation between the respective alterations in bone mass density (BMD) and tensile strength of the skin. MATERIALS AND METHODS: A total of 100 women aged 19-88 years, receiving, or not, hormone replenishment therapy or systemic corticosteroids, were enrolled in the study. Tensile strength of the inner forearm skin was measured using the suction method operated in both the steep and progressive-force application modes. BMD was measured by dual X-ray absorptiometry at the hip, femoral neck and lumbar spine. RESULTS: Being heterogeneous, the population of volunteers yielded a wide range of BMD and cutaneous tensile strength values. However, significant correlations were found between BMD and tensile skin parameters. In particular, a positive correlation was yielded between the biological elasticity of skin and the BMD of the hip and femoral neck. CONCLUSION: An overall correlation is shown between skin elasticity on a relatively sun-protected area and cortico-trabecular BMD. [less ▲]

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See detailLes toxidermies iatrogenes, une rancon de la quete de la sante
Fumal, I.; Sriha, B.; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2001), 56(8), 583-91

Muco-cutaneous drug reactions are side effects secondary to the intake of various medications. They are quite frequent and diverse in their clinical presentation, pathogeny, histology and prognosis. It is ... [more ▼]

Muco-cutaneous drug reactions are side effects secondary to the intake of various medications. They are quite frequent and diverse in their clinical presentation, pathogeny, histology and prognosis. It is important to diagnose and adequately monitor the disease in its early evolving phase. [less ▲]

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See detailStigmates professionnels chez le musicien instrumentiste
Claessens, N.; Hermanns-Lê, Trinh ULg; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2001), 56(6), 453-5

The frequent practice of a music instrument represents a risk for frictional or allergic contact dermatitis. The localisation and type of lesions are often typical for the musician specialty.

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See detailInfections cutanees contractees a l'occasion d'activites sportives ou de loisirs recreatifs
Ledoux, Didier ULg; Goffin, Véronique ULg; Fumal, I. et al

in Revue Médicale de Liège (2001), 56(5), 339-42

Going in for sports is at increased risk for cutaneous infections that can be viral, bacterial, mycotic and parasitic in nature. The specific conditions of sports practice have a major influence on their ... [more ▼]

Going in for sports is at increased risk for cutaneous infections that can be viral, bacterial, mycotic and parasitic in nature. The specific conditions of sports practice have a major influence on their occurrence. Other factors such as age, gender and genetic predisposition can also play a role. The cutaneous infections should be the target of preventive measures. To assume the worse, they should be recognized and treated without delay in order to avoid the more or less prolonged arrest of the sports activity and the disease transmission to partners. [less ▲]

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See detailL'allergie au latex--quand l'incertitude reste la seule certitude
Goffin, Véronique ULg; Kharfi, M.; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2001), 56(3), 165-9

Latex devices release allergenic proteins which are responsible for immune IgE mediated reactions. Casual surgical gloves are most often responsible for contact urticaria. Other allergic manifestations ... [more ▼]

Latex devices release allergenic proteins which are responsible for immune IgE mediated reactions. Casual surgical gloves are most often responsible for contact urticaria. Other allergic manifestations include conjunctivitis, rhinitis, asthmatiform dyspnoea and diverse gastro-intestinal troubles. Cardiovascular collapse and anaphylactic shock are possible. Physicians and the paramedical staff are particularly affected by the allergy to latex proteins. Multi-operated patients and those under prolonged health care using latex-made medical probes also present a high-risk group for this type of allergy. [less ▲]

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See detailDermal Dendritic Cells in Anogenital Warty Lesions Unresponsive to an Immune-Response Modifier
Arrese, J.; Paquet, Philippe ULg; Claessens, N. et al

in Journal of Cutaneous Pathology (2001), 28(3), 131-4

BACKGROUND: Human papilloma viruses (HPV) are responsible for a variety of proliferative epithelial lesions including anogenital condylomas. These lesions may regress during treatment with an immune ... [more ▼]

BACKGROUND: Human papilloma viruses (HPV) are responsible for a variety of proliferative epithelial lesions including anogenital condylomas. These lesions may regress during treatment with an immune-response modifier such as imiquimod. The release of specific cytokines from the monocyte-macrophage lineage induces a cascade of events abating the HPV replication. METHOD: A total of 14 persistent warty anogenital lesions were excised 4 to 7 weeks after completing a 4-month imiquimod treatment. Another series of 25 untreated condylomas and 8 bowenoid papulosis served as controls. All examined lesions had been excised in otherwise healthy individuals with a normal immune status. Lesions were examined for the presence of Langerhans cells and subpopulations of the monocyte/macrophage/dendrocyte lineage using immunohistochemical detection of L1-protein, CD68, lysozyme and Factor-XIIIa. CD45R0-positive T lymphocytes were also identified. HPV capsid antigens and genotypes were searched for using immunohistochemistry and in situ hybridization, respectively. RESULTS: The persistent although treated anogenital lesions were identified as 10 viral condylomas, 3 bowenoid papulosis and 1 basal cell carcinoma. The inflammatory cell densities and distributions were similar in the untreated and imiquimod-resistant condylomas with the exception of Factor XIIIa-positive dendrocytes. These dermal dendritic cells were slim and rare in all imiquimod-resistant lesions. In contrast, about two-thirds of the untreated condylomas were enriched in these cells. CONCLUSION: As dermal dendritic cells play a role in the immune surveillance, their low densities in some lesions might be a key feature responsible for low cytokine local production and failure of imiquimod treatment. The combined apparent lack of Langerhans cell activation might suggest that both intraepidermal and intradermal compartments of antigen-presenting cells are affected in imiquimod-resistant lesions. [less ▲]

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See detailQuand solaire rime avec scolaire. Une enquete sur les risques de melanome aupres de 3.695 eleves d'ecoles primaires liegeoises
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2001), 56(2), 88-92

An epidemiological survey was performed in pupils from primary schools of Liege in order to better identify risk factors for photobiological alterations prone to induce cutaneous melanoma in adult life ... [more ▼]

An epidemiological survey was performed in pupils from primary schools of Liege in order to better identify risk factors for photobiological alterations prone to induce cutaneous melanoma in adult life. Phenotypic and behavioral factors facing up to sun exposure were considered. In a 4-level risk scale, about half of the Liege children showed a high to severe risk at photobiological alterations. Thus melanoma prevention requires a sustained effort in the Mosan region, particularly by health education programs at school. [less ▲]

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See detailComment j'explore ... le risque metastatique du melanome
Pierard, Gérald ULg; Arrese, J. E.; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2001), 56(2), 120-3

The development of new therapeutic protocols for malignant melanoma calls for an upgraded assessment of the individual risk to develop metastases. The predictive sentinel lymph node method is best ... [more ▼]

The development of new therapeutic protocols for malignant melanoma calls for an upgraded assessment of the individual risk to develop metastases. The predictive sentinel lymph node method is best practiced in a multidisciplinary approach. The selective lymphadenectomy of the first draining lymph node is followed by minutely detailed histologic examination combined with immunohistochemistry. [less ▲]

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See detailOngles sales et mycotoxines
Arrese, J. E.; Goffin, Véronique ULg; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2001), 56(1), 38-40

Some mycotoxins are among the most toxic natural products. They are metabolites produced by food-borne and feed-borne moulds. Dirty and soiled nails, and contaminated or infected onyxis by these specific ... [more ▼]

Some mycotoxins are among the most toxic natural products. They are metabolites produced by food-borne and feed-borne moulds. Dirty and soiled nails, and contaminated or infected onyxis by these specific moulds can be the origin of oral contamination and mycotoxicosis. Hence, nail cleaning, correct hygiene and treatment of mould onychomycosis have a potentially great impact on health. [less ▲]

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