Analytic quantification of the bleaching effect of a 4-hydroxyanisole-tretinoin combination on actinic lentigines.
Pierard-Franchimont, Claudine ; Henry, Frédérique ; Quatresooz, Pascale et al
in Journal of Drugs in Dermatology (2008), 7Detailed reference viewed: 30 (16 ULg)
Comment je traite... certaines pathologies cutanées par le biais de l'immunité innée.
Pierard-Franchimont, Claudine ; Pierard, Gérald
in Revue Médicale de Liège (2008), 63
L’immunité innée repose sur une organisation biologique complexe qui a des implications certaines dans diverses pathologies, en particulier au niveau de la peau. Son fonctionnement dépend de deux piliers ... [more ▼]
L’immunité innée repose sur une organisation biologique complexe qui a des implications certaines dans diverses pathologies, en particulier au niveau de la peau. Son fonctionnement dépend de deux piliers principaux qui sont les récepteurs PRR (protein recognition receptor) et des peptides antimicrobiens. Chez l’homme, les principaux PRRs sont les Toll-like récepteurs (TLRs) et les peptides antimicrobiens majeurs comprennant les α- et β-défensines, et la cathélicidines. L’expression de ces composants de l’immunité innée est modulée par certains médicaments, ce qui représente un mode d’action qui était resté ignoré par le passé. [less ▲]Detailed reference viewed: 29 (3 ULg)
Diversité des cryothérapies, de la cryochirurgie et d'autres moyens de délivrer le froid.
; Pierard-Franchimont, Claudine ; Pierard, Gérald
in Dermatologie Actualité (2008), 110Detailed reference viewed: 55 (5 ULg)
Traduire la recherche translationnelle autour du pseudoxanthome élastique.
; Pierard-Franchimont, Claudine ; Pierard, Gérald
in Dermatologie Actualité (2008), 108Detailed reference viewed: 35 (6 ULg)
Un contaminant envahissant : nouveau regard sur le thigmotropisme fongique.
; ; Henry, Frédérique et al
in Dermatologie Actualité (2008), 107Detailed reference viewed: 48 (8 ULg)
Epidemiology of onychomycoses assessed by histomycology in psoriatic patients
Pierard-Franchimont, Claudine ; ; Hermanns-Le, Trinh et al
in Journal de Mycologie Medicale (2006), 16(3), 159-162
Onychomycosis is a common condition in the adult population. It has been reported to be more prevalent in association with some specific diseases including psoriasis. This study using combined ... [more ▼]
Onychomycosis is a common condition in the adult population. It has been reported to be more prevalent in association with some specific diseases including psoriasis. This study using combined histomycology and cultures was performed on nail clippings collected from thickened dystrophic toenails in 233 eligible psoriatic patients. Onychopathies associated with psoriasis were more numerous in men. Their prevalence increased up to the age of 40 and remained stable thereafter. A total of 42/233 cases were diagnosed as onychomycoses. These infections were more prevalent in middle-aged men. The identified infectious agents (35/42 cases) frequently corresponded to dermatophytes, but Candida albicans was also implicated, particularly in women. (c) 2006 Elsevier Masson SAS. All rights reserved. [less ▲]Detailed reference viewed: 7 (2 ULg)
Mélanodermie infraclinique et cancers photo-induits
QUATRESOOZ, Pascale ; PIERARD-FRANCHIMONT, Claudine ; HENRY, Frédérique et al
in Actualités en Ingéniérie Cutanée (2006)Detailed reference viewed: 12 (1 ULg)
The activity of R126638, a new triazole antifungal, as assessed by corneofungimetry
; Pierard-Franchimont, Claudine ; et al
in Journal of the American Academy of Dermatology (2005, March), 52(3, Suppl. S), 129Detailed reference viewed: 1 (0 ULg)
Cyanoacrylate biopsy for cytologic evaluation of the epidermis
ARRESE ESTRADA, Jorge ; QUATRESOOZ, Pascale ; PIERARD-FRANCHIMONT, Claudine et al
in Hand-book of non-invasive methods and the skin (2005)Detailed reference viewed: 8 (1 ULg)
Granulomes à corps étrangers exogènes et endogènes
PIERARD, Gérald ; FLAGOTHIER, Caroline ; QUATRESOOZ, Pascale et al
in Encyclopédie médico-chirurgicale Dermatologie (2005)Detailed reference viewed: 11 (1 ULg)
Comment je traite.... Un carcinome basocellulaire par l'imiquimod topique (Aldara).
Pierard-Franchimont, Claudine ; Nikkels, Arjen ; Paquet, Philippe et al
in Revue Médicale de Liège (2005), 60(4), 207-209
Basal cell carcinoma is the most frequent cancer in humans. Several clinical types are distinguished. They are bound to distinct evolutive prognosis. The surgical excision is the treatment of choice which ... [more ▼]
Basal cell carcinoma is the most frequent cancer in humans. Several clinical types are distinguished. They are bound to distinct evolutive prognosis. The surgical excision is the treatment of choice which is rarely followed by recurrence. However, when the lesion is superficial and non aggressive and when the body site is adequate, topical applications of imiquimod can provoke the neoplastic regression. This type of immunotherapy brings 70 to 90% complete remission. A medical follow-up of the treated site is mandatory for a couple of years. [less ▲]Detailed reference viewed: 119 (6 ULg)
Vascularity and fractal dimension of the dermo-epidermal interface in guttate and plaque-type psoriasis.
; Pierard, Gérald ; Pierard-Franchimont, Claudine et al
in Dermatology : International Journal for Clinical & Investigative Dermatology (2005), 210(3), 189-93
BACKGROUND: Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions ... [more ▼]
BACKGROUND: Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions. OBJECTIVE: To determine and compare the variations in shape of the dermo-epidermal junction and the size of the superficial vessels in psoriatic lesions. METHOD: The relative microvasculature area and the fractal dimension D of the dermo-epidermal interface were measured inside and outside growth-stunted guttate lesions (n = 22) and expanding plaques (n = 37) in psoriasis of the trunk. RESULTS: The median D values of the dermo-epidermal interface were significantly larger (p < 0.01) in psoriatic plaques (D = 1.15) than in guttate lesions (D = 1.08), and these D values on lesional skin were significantly larger (p < 0.01) than in the uninvolved skin (D = 1.03). The microvasculature was significantly (p < 0.01) more developed in lesional (plaque: 13%, guttate: 8.20%) than in uninvolved skin (3.60 and 3.85%). No correlations were found between the relative microvasculature areas and the D values of the dermo-epidermal interface, both in the uninvolved and lesional skins of each psoriatic type. CONCLUSION: The absence of a relationship between modulations of the dermo-epidermal junction and vascular hyperplasia, both in expanding and stable psoriasis lesions, suggests that these events are regulated by different mechanisms and do not depend on each other. [less ▲]Detailed reference viewed: 29 (5 ULg)
Photodynamic therapy and imiquimod immunotherapy for basal cell carcinomas
Nikkels, Arjen ; Pierard-Franchimont, Claudine ; Tassoudji, Nazli et al
in Acta Clinica Belgica (2005), 60(5, Sep-Oct), 227-234
Photodynamic therapy (PDT) and topical imiquimod immunotherapy (TII) are two recently introduced treatment modalities for certain types of basal cell carcinomas (BCC). We present a review of the relevant ... [more ▼]
Photodynamic therapy (PDT) and topical imiquimod immunotherapy (TII) are two recently introduced treatment modalities for certain types of basal cell carcinomas (BCC). We present a review of the relevant literature and report our own findings regarding the efficacy and tolerance of PDT and TII in the treatment of BCCs. According to published studies, the cure rates range from 75-95% for PDT and 42-100% for TII, depending on treatment modalities and BCC type. In our observations, 13 patients with nodular or superficial BCCs were treated by PDT using two courses of 3-hour topical application of methyl aminolevulinate, followed by 8 minutes illumination (lambda = 634 rim, e = 37J/cm(2)). Biopsies were taken before and one month after PDT. Side effects including pain and crusting were assessed. Eight patients with superficial BCC were treated by TII using 3 monthly courses each consisting of 3 weekly applications for 3 weeks followed by one week out of treatment. Biopsies were taken before and after 3 months of TII. Adverse reactions including erythema, oozing, ulceration, and crusting were recorded. Clinico-histological cure was obtained in 12/13 PDT cases as assessed after I month, and in 6/8 TII cases after 3 months. Minimal pain during illumination and crust formation were observed in 7/13 and 3/13 PDT cases, respectively. Variable erythema, oozing, ulceration, and crusting were observed in all TII-treated lesions. It is concluded that PDT represents an active and well tolerated alternative treatment for both nodular and superficial BCCs. TII also shows activity, although the tolerance may be poor and cure needs a longer time to be obtained. The final cosmetic appearance was fine following both PDT and TII procedures. Both PDT and TII may leave intact neoplastic aggregates inside the skin. They cannot be clinically perceived, leading to unexpected recurrences. It is stressed that the currently available efficacy information about PDT and TII deals with short term follow-up periods. A 5-year follow-up must be awaited before drawing firm conclusions. [less ▲]Detailed reference viewed: 39 (3 ULg)
The Inflammatory Hypothesis of Ageing: Fascinating Concept or Confusing Dogma?
Pierard, Gérald ; Pierard-Franchimont, Claudine
in Journal of Cosmetic Dermatology (2004), 3(4), 246Detailed reference viewed: 6 (0 ULg)
Updating trends in cutaneous cancers in south-east Belgium.
; Quatresooz, Pascale ; et al
in Oncology Reports (2004), 12(1), 111-4
From data collected in a dermatopathology laboratory, the ratios between the numbers of specific cancers represent good markers for identifying any epidemiological shift in their prevalence and incidence ... [more ▼]
From data collected in a dermatopathology laboratory, the ratios between the numbers of specific cancers represent good markers for identifying any epidemiological shift in their prevalence and incidence among the reference population. The objective of the present study was to assess the ratios of the annual incidence of skin cancers in the Mosan region and Ardennes of Belgium over the past 6 years, and to compare the data with previous similar evaluations. A total of 7,640 skin cancers were collected and compared with regard to age and gender. Changes in time show that the trend of the increase in incidence of malignant melanoma (MM) is more impressive than that of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). The age distribution of BCC and SCC confirms the increasing risk with ageing. By contrast, there is a steady decrease over the past decade in the mean age for MM, teenagers and young adults now form an expanding proportion of MM patients. There is an ongoing trend in diagnosing an increased number of skin cancers in our laboratory. This trend is particularly obvious for MM affecting young adults. [less ▲]Detailed reference viewed: 33 (8 ULg)
Prolonged imiquimod treatment and graft-versus-host reaction: histological mimicry in the skin infiltration pattern of the monocyte-macrophage-dendrocyte lineage.
Hermanns-Le, Trinh ; Paquet, Philippe ; Nikkels, Arjen et al
in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 361-365
Factor-XIIIa-positive dendrocytes belong to the monocyte-macrophage-dendrocyte (MMD) lineage which is considered to play a pivotal role in the skin response to the immune response modifier imiquimod. The ... [more ▼]
Factor-XIIIa-positive dendrocytes belong to the monocyte-macrophage-dendrocyte (MMD) lineage which is considered to play a pivotal role in the skin response to the immune response modifier imiquimod. The same cells are also boosted in low-grade graft-versus-host reaction (GVHR) with skin manifestations. Both conditions are characterized by specific epidermal damage. The aim of the present study was to compare them using immunohistochemistry to identify MMD subsets and other inflammatory cells in the dermis. We compared 3 cases of long-term (4, 9 and 11 months) imiquimod topical applications on normal skin, 25 low-grade GVHR controlled by immunosuppressive therapy and 25 control cases with normal skin. Compared to the normal dermis, cells of the MMD lineage were considerably boosted in the dermis of GVHR and at the imiquimod-treated sites. By contrast, only minimal accumulations of lymphocytes and Langerhans cells were disclosed in the dermis. The pattern of dermal infiltration by MMD cells was similar in GVHR and after imiquimod treatment. However, intraindividual differences in densities were obvious irrespective of the skin condition. In conclusion, there is great mimicry in the MMD involvement in the dermis during low-grade GVHR and after chronic applications of imiquimod. [less ▲]Detailed reference viewed: 34 (7 ULg)