References of "Pierard-Franchimont, Claudine"
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See detailInfections cutanées virales récurrentes et le syndrome de Wiskott-Aldrich.
Vandenbossche, Géraldine; Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg et al

in Dermatologie Actualité (2008), 109

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See detailLes MRSA et la peau. Nouveaux visages des HAMRSA, des CAMRSA et des PAMRSA.
Devillers, Céline; Pierard-Franchimont, Claudine ULg; Henry, Frédérique ULg et al

in Skin (2008), 11

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See detailDécimer les carcinomes basocellulaires peu agressifs et les kératoses actiniques par l'imiquimod.
Pierard-Franchimont, Claudine ULg; Henry, Frédérique ULg; Bourguignon, Raphaël et al

in Dermatologie Actualité (2008), 106

Les indications thérapeutiques émergentes de l’IRM (« immune response modifier ») imiquimod 5% en crème (Aldara®) sont des carcinomes basocellulaires peu agressifs et les kératoses actiniques. La maladie ... [more ▼]

Les indications thérapeutiques émergentes de l’IRM (« immune response modifier ») imiquimod 5% en crème (Aldara®) sont des carcinomes basocellulaires peu agressifs et les kératoses actiniques. La maladie de Bowen est un autre candidat potentiel pour une telle option thérapeutique innovatrice. Cet IRM peut s’avérer particulièrement précieux, sous supervision dermatologique, tant en milieu hospitalier qu’en dehors, et ce, particulièrement chez des patients à mobilité réduite et chez ceux refusant toute intervention chirurgicale, de même que dans le cadre de lésions cutanées multiples et/ou difficilement accessibles à d’autres thérapeutiques. L’imiquimod s’affirme à la fois comme un traitement non-invasif et comme une alternative à d’autres techniques utilisées en cancérologie cutanée (cryothérapie, curetage, exérèse chirurgicale, radiothérapie, 5-fluorouracile topique, photothérapie dynamique, …). [less ▲]

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See detailComment je traite... certaines pathologies cutanées par le biais de l'immunité innée.
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2008), 63

L’immunité innée repose sur une organisation biologique complexe qui a des implications certaines dans diverses pathologies, en particulier au niveau de la peau. Son fonctionnement dépend de deux piliers ... [more ▼]

L’immunité innée repose sur une organisation biologique complexe qui a des implications certaines dans diverses pathologies, en particulier au niveau de la peau. Son fonctionnement dépend de deux piliers principaux qui sont les récepteurs PRR (protein recognition receptor) et des peptides antimicrobiens. Chez l’homme, les principaux PRRs sont les Toll-like récepteurs (TLRs) et les peptides antimicrobiens majeurs comprennant les α- et β-défensines, et la cathélicidines. L’expression de ces composants de l’immunité innée est modulée par certains médicaments, ce qui représente un mode d’action qui était resté ignoré par le passé. [less ▲]

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See detailDiversité des cryothérapies, de la cryochirurgie et d'autres moyens de délivrer le froid.
Xhauflaire-Uhoda, Emmanuelle; Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatologie Actualité (2008), 110

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See detailTraduire la recherche translationnelle autour du pseudoxanthome élastique.
Blaise, Géraldine; Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatologie Actualité (2008), 108

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See detailUn contaminant envahissant : nouveau regard sur le thigmotropisme fongique.
Quatresooz, Pascale; Blaise, Géraldine; Henry, Frédérique ULg et al

in Dermatologie Actualité (2008), 107

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See detailNoninfectious dermatoses of pregnancy
QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg

in Therapeutique dermatologique (2007)

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See detailEpidemiology of onychomycoses assessed by histomycology in psoriatic patients
Pierard-Franchimont, Claudine ULg; Arrese, J. E.; Hermanns-Lê, Trinh ULg et al

in Journal de Mycologie Medicale (2006), 16(3), 159-162

Onychomycosis is a common condition in the adult population. It has been reported to be more prevalent in association with some specific diseases including psoriasis. This study using combined ... [more ▼]

Onychomycosis is a common condition in the adult population. It has been reported to be more prevalent in association with some specific diseases including psoriasis. This study using combined histomycology and cultures was performed on nail clippings collected from thickened dystrophic toenails in 233 eligible psoriatic patients. Onychopathies associated with psoriasis were more numerous in men. Their prevalence increased up to the age of 40 and remained stable thereafter. A total of 42/233 cases were diagnosed as onychomycoses. These infections were more prevalent in middle-aged men. The identified infectious agents (35/42 cases) frequently corresponded to dermatophytes, but Candida albicans was also implicated, particularly in women. (c) 2006 Elsevier Masson SAS. All rights reserved. [less ▲]

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See detailMélanodermie infraclinique et cancers photo-induits
QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg; HENRY, Frédérique ULg et al

in Actualités en Ingéniérie Cutanée (2006)

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See detailDéterminisme multifactoriel de l'héliodermie
QUATRESOOZ, Pascale ULg; uhoda, I.; PIERARD-FRANCHIMONT, Claudine ULg et al

in Actualités en Ingéniérie Cutanée (2006)

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See detailThe activity of R126638, a new triazole antifungal, as assessed by corneofungimetry
Ausma, J.; Pierard-Franchimont, Claudine ULg; Borgers, M. et al

in Journal of the American Academy of Dermatology (2005, March), 52(3, Suppl. S), 129

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See detailCyanoacrylate biopsy for cytologic evaluation of the epidermis
ARRESE ESTRADA, Jorge ULg; QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg et al

in Hand-book of non-invasive methods and the skin (2005)

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See detailGranulomes à corps étrangers exogènes et endogènes
PIERARD, Gérald ULg; FLAGOTHIER, Caroline ULg; QUATRESOOZ, Pascale ULg et al

in Encyclopédie médico-chirurgicale Dermatologie (2005)

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See detailEnvironmental hazards and the skin
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; Berardesca, E. et al

in European Dermatology Forum White Book (2005)

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See detailComment je traite.... Un carcinome basocellulaire par l'imiquimod topique (Aldara).
Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2005), 60(4), 207-209

Basal cell carcinoma is the most frequent cancer in humans. Several clinical types are distinguished. They are bound to distinct evolutive prognosis. The surgical excision is the treatment of choice which ... [more ▼]

Basal cell carcinoma is the most frequent cancer in humans. Several clinical types are distinguished. They are bound to distinct evolutive prognosis. The surgical excision is the treatment of choice which is rarely followed by recurrence. However, when the lesion is superficial and non aggressive and when the body site is adequate, topical applications of imiquimod can provoke the neoplastic regression. This type of immunotherapy brings 70 to 90% complete remission. A medical follow-up of the treated site is mandatory for a couple of years. [less ▲]

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See detailVascularity and fractal dimension of the dermo-epidermal interface in guttate and plaque-type psoriasis.
Uhoda, Isabelle; Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2005), 210(3), 189-93

BACKGROUND: Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions ... [more ▼]

BACKGROUND: Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions. OBJECTIVE: To determine and compare the variations in shape of the dermo-epidermal junction and the size of the superficial vessels in psoriatic lesions. METHOD: The relative microvasculature area and the fractal dimension D of the dermo-epidermal interface were measured inside and outside growth-stunted guttate lesions (n = 22) and expanding plaques (n = 37) in psoriasis of the trunk. RESULTS: The median D values of the dermo-epidermal interface were significantly larger (p < 0.01) in psoriatic plaques (D = 1.15) than in guttate lesions (D = 1.08), and these D values on lesional skin were significantly larger (p < 0.01) than in the uninvolved skin (D = 1.03). The microvasculature was significantly (p < 0.01) more developed in lesional (plaque: 13%, guttate: 8.20%) than in uninvolved skin (3.60 and 3.85%). No correlations were found between the relative microvasculature areas and the D values of the dermo-epidermal interface, both in the uninvolved and lesional skins of each psoriatic type. CONCLUSION: The absence of a relationship between modulations of the dermo-epidermal junction and vascular hyperplasia, both in expanding and stable psoriasis lesions, suggests that these events are regulated by different mechanisms and do not depend on each other. [less ▲]

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See detailPhotodynamic therapy and imiquimod immunotherapy for basal cell carcinomas
Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg; Tassoudji, Nazli ULg et al

in Acta Clinica Belgica (2005), 60(5, Sep-Oct), 227-234

Photodynamic therapy (PDT) and topical imiquimod immunotherapy (TII) are two recently introduced treatment modalities for certain types of basal cell carcinomas (BCC). We present a review of the relevant ... [more ▼]

Photodynamic therapy (PDT) and topical imiquimod immunotherapy (TII) are two recently introduced treatment modalities for certain types of basal cell carcinomas (BCC). We present a review of the relevant literature and report our own findings regarding the efficacy and tolerance of PDT and TII in the treatment of BCCs. According to published studies, the cure rates range from 75-95% for PDT and 42-100% for TII, depending on treatment modalities and BCC type. In our observations, 13 patients with nodular or superficial BCCs were treated by PDT using two courses of 3-hour topical application of methyl aminolevulinate, followed by 8 minutes illumination (lambda = 634 rim, e = 37J/cm(2)). Biopsies were taken before and one month after PDT. Side effects including pain and crusting were assessed. Eight patients with superficial BCC were treated by TII using 3 monthly courses each consisting of 3 weekly applications for 3 weeks followed by one week out of treatment. Biopsies were taken before and after 3 months of TII. Adverse reactions including erythema, oozing, ulceration, and crusting were recorded. Clinico-histological cure was obtained in 12/13 PDT cases as assessed after I month, and in 6/8 TII cases after 3 months. Minimal pain during illumination and crust formation were observed in 7/13 and 3/13 PDT cases, respectively. Variable erythema, oozing, ulceration, and crusting were observed in all TII-treated lesions. It is concluded that PDT represents an active and well tolerated alternative treatment for both nodular and superficial BCCs. TII also shows activity, although the tolerance may be poor and cure needs a longer time to be obtained. The final cosmetic appearance was fine following both PDT and TII procedures. Both PDT and TII may leave intact neoplastic aggregates inside the skin. They cannot be clinically perceived, leading to unexpected recurrences. It is stressed that the currently available efficacy information about PDT and TII deals with short term follow-up periods. A 5-year follow-up must be awaited before drawing firm conclusions. [less ▲]

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