References of "Pierard-Franchimont, Claudine"
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See detailHypomelanosis of Ito: pigmentary mosaicism with immature melanosome in keratinocytes.
Devillers, Céline; QUATRESOOZ, Pascale ULg; Hermanns-Lê, Trinh ULg et al

in International Journal of Dermatology (2011), 50(10), 1234-9

BACKGROUND: Hypomelanosis of Ito is a rare genetic disorder characterized by whorled areas of hypomelanosis. The purpose of the present study was to revisit some aspects of Ito's hypomelanosis. METHODS ... [more ▼]

BACKGROUND: Hypomelanosis of Ito is a rare genetic disorder characterized by whorled areas of hypomelanosis. The purpose of the present study was to revisit some aspects of Ito's hypomelanosis. METHODS: Clinical observations included ultraviolet-light-enhanced visualization (ULEV) method. Histochemistry, immunohistochemistry, and electron microscopy were performed on biopsy samples from the hypopigmented areas and the surrounding skin. RESULTS: Both the ULEV and microscopic examinations revealed the heterogeneity of the pigmentation. Hypomelanosis was characterized by a reduction in melanosomes, both in melanocytes and keratinocytes. These organelles were immature and atypical, showing a weak tyrosinase immunoreactivity. Melanosome macroautophagy was prominent in keratinocytes. Some clusters of the same cells exhibited strong immunoreactivity for the Mac 387 antibody (Ca(2+) -dependent calprotectin). Ulex europaeus agglutinin-1 (UEA-1) decorated the superficial layers of the epidermis. Such features are typically found in functionally altered keratinocytes. A number of dermal cells exhibited intense phagocytic activity linked to lysozyme immunoreactivity. CONCLUSIONS: Both the melanosome depletion and macroautophagy of immature melanosomes in keratinocytes appeared to represent prominent aspects of hypomelanosis of Ito. In sum, Ito's hypomelanosis combines structural and functional changes affecting both the melanocytes and keratinocytes in the skin. [less ▲]

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See detailHydroxyacids
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; PIERARD, Gérald ULg

in Cosmeceuticals-drugs vs cosmetics (2011)

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See detailIdentification d'une dermatose provoquée par la lumière
PIERARD-FRANCHIMONT, Claudine ULg; CAUCANAS, Marie ULg; QUATRESOOZ, Pascale ULg et al

in Revue Médicale de Liège (2011), 66

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See detailRevisiting cutaneous adverse reactions to pemetrexed
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; REGINSTER, Marie-Annick ULg et al

in Oncology Letters (2011), (2), 769-772

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See detailFocus on skin cancer association and progression under TNF antagonist therapy.
PIERARD-FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg; QUATRESOOZ, Pascale ULg

in Expert Opinion on Biological Therapy (2011), 11(9), 1215-22

INTRODUCTION: Basal and squamous cell carcinomas are the most common non-melanoma skin cancers (NMSC) in humans. Their prevalence is higher in immunocompromized patients. Results of some animal ... [more ▼]

INTRODUCTION: Basal and squamous cell carcinomas are the most common non-melanoma skin cancers (NMSC) in humans. Their prevalence is higher in immunocompromized patients. Results of some animal experiments have indicated that TNF acts both as a tumour promotor and an inductor of apoptosis. AREAS COVERED: Peer-reviewed articles about human skin cancers possibly related to TNF antagonists. The occurrence and growth kinetics of NMSC are possibly increased in some patients under TNF antagonist therapy. Other issues of such biological treatment suggested include the activation of other distinct skin malignancies, including malignant melanoma. Benign melanocytic tumours appear to be boosted as well. At present, most of the reported findings only represent anecdotal case reports. The influence of cumulative co-factors must not be neglected, particularly the effect of other therapies administered to the patients. The occurrence of antibodies to some TNF antagonists may decrease both the treatment efficacy and the risk of skin cancer progression. EXPERT OPINION: More research needs to be performed in order to firmly establish and understand the risk of anti-TNF biologicals in the area of human skin cancers. At present, NMSC progression appears to be boosted on areas of skin field cancerization. Benign melanocytic naevi may develop as well. [less ▲]

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See detailRecent trends in specular light reflectance beyond clinical fluorescence diagnosis.
Szepetiuk, Gregory; Pierard, Sébastien ULg; PIERARD-FRANCHIMONT, Claudine ULg et al

in European Journal of Dermatology (2011), 21(2), 157-61

Under specific light illumination, particularly ultraviolet (UV) and near-UV light stimulation, the skin produces both specular light reflectance and, possibly, specific fluorescent emission. These ... [more ▼]

Under specific light illumination, particularly ultraviolet (UV) and near-UV light stimulation, the skin produces both specular light reflectance and, possibly, specific fluorescent emission. These properties offer diagnostic clues and disclose some peculiar functions of the skin. A series of superficial infections (erythrasma, some tinea capitis types, tinea/pityriasis versicolor, dermatophytoses, etc.) and pilosebaceous follicles enriched in Propionibacterium spp show fluorescence. This latter characteristic is downgraded or lost while on some anti-acne treatments. A quenching effect of fluorescence is observed following the application of sunscreens. The (pre)neoplastic areas prepared for methylaminolevulinate photodynamic therapy (MAL-PDT) show reddish fluorescence following drug metabolisation producing porphyrins by the abnormal activated cells. Of note, when using a recording sensitive CCD camera instead of casual visual observation, skin fluorescence may be superimposed on the specular reflectance of the incident light. With the current technology, these situations are not distinguished with confidence. Any harsh and scaly lesion appears brighter following yellowish specular light reflectance. Stratum corneum samplings collected on clear self-adhesive discs or cyanoacrylate skin surface strippings are conveniently examined ex vivo, taking advantage of the same optical properties. [less ▲]

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See detailRadionécrose historique
CAUCANAS, Marie ULg; PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg et al

in Revue Médicale de Liège (2011), 66

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See detailComment j'explore ... l'hypothese diagnostique d'une syphilis.
PIERARD-FRANCHIMONT, Claudine ULg; CAUCANAS, Marie ULg; QUATRESOOZ, Pascale ULg et al

in Revue Médicale de Liège (2011), 66(10), 550-4

The versatility of the clinical presentations of syphilis is large. A laboratory diagnosis is required in any case where a clinical assumption is raised. Two main diagnostic methods are available ... [more ▼]

The versatility of the clinical presentations of syphilis is large. A laboratory diagnosis is required in any case where a clinical assumption is raised. Two main diagnostic methods are available according to the lesion aspects and the staging of the disease. They rely on the recognition of the spirochete or on the identification of the immune response using specific and non specific serology tests. [less ▲]

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See detailImputabilite medicamenteuse dans les iatrogenies cutanees.
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; REGINSTER, Marie-Annick ULg et al

in Revue Médicale de Liège (2011), 66(9), 474-7

Drug eruptions are frequently encountered. Their putative diagnosis is based on a set of imputability arguments. The histopathological aspect is often evocative of the nature of the dermatosis. It varies ... [more ▼]

Drug eruptions are frequently encountered. Their putative diagnosis is based on a set of imputability arguments. The histopathological aspect is often evocative of the nature of the dermatosis. It varies according to the type of drug reaction. Some drug eruptions follow a benign course, but others are life-threatening. [less ▲]

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See detailLes coulisses du cancer mammaire.
CAUCANAS, Marie ULg; PIERARD-FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 269-73

A 55 year-old women presented with lesions simulating cysts of the scalp. The dermatopathological examination revealed a metastasis of a breast adenocarcinoma. At the diagnosis disclosure, the patient ... [more ▼]

A 55 year-old women presented with lesions simulating cysts of the scalp. The dermatopathological examination revealed a metastasis of a breast adenocarcinoma. At the diagnosis disclosure, the patient recognized having concealed for 7 years a neoplastic wound replacing one of her breasts. About this case report, we report the astonishing clinical diversity of skin metastases of breast adenocarcinomas. [less ▲]

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See detailLa maladie de Paget mammaire indicatrice d'un adenocarcinome sous-jacent.
REGINSTER, Marie-Annick ULg; QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 265-8

Mammary Paget's disease is an intraepithelial carcinoma present on the nipple and its areola. The tumor typically develops in middle aged women. It is frequently associated or contiguous to an underlying ... [more ▼]

Mammary Paget's disease is an intraepithelial carcinoma present on the nipple and its areola. The tumor typically develops in middle aged women. It is frequently associated or contiguous to an underlying galactophoric adenocarcinoma. The histopathologic and immunopathologic aspects are typical and linked to the presence of Paget's cells. Early diagnosis is required searching for a possible underlying carcinoma. The surgical treatment is directed by the characteristics of the deep mammary carcinoma. [less ▲]

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See detailSpecular light reflectance of flakes in seborrhoeic dermatitis of the scalp: a pilot study.
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; PIERARD, Gérald ULg

in Clinical & Experimental Dermatology (2011), 36(7), 793-6

Seborrhoeic dermatitis and dandruff are common scalp conditions. In this study, we set out to explore a new method for rating both the severity of the scalp condition and the efficacy of scalp-care ... [more ▼]

Seborrhoeic dermatitis and dandruff are common scalp conditions. In this study, we set out to explore a new method for rating both the severity of the scalp condition and the efficacy of scalp-care compounds. Scalp flakiness was sampled for 40 volunteers using adhesive-coated clear discs, with image analysis used to quantify the specular light reflectance (SLR) of the flakes Two ultraviolet (UV)-emitting charge-coupled device cameras (Visioscan VC98 and Visiopor PP34) were used. SLR clearly highlighted the flakiness with high contrast against a black background, and the recorded appearance could be conveniently submitted to the image-analysis system for quantification. In conclusion, SLR under UV illumination highlights scalp flakiness, allowing objective measurements. [less ▲]

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See detailHow to manage hair changes in cancer patients
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; RORIVE, Andrée ULg et al

in Handbook of skin care in cancer patients (2010)

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See detailCyanoacrylate skin surface strippings
PIERARD-FRANCHIMONT, Claudine ULg; ARRESE ESTRADA, Jorge ULg; QUATRESOOZ, Pascale ULg et al

in Textbook of aging skin (2010)

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See detailSebum production
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; PIERARD, Gérald ULg

in Textbook of aging skin (2010)

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See detailComment j'explore...la peau par le photodiagnostic utilisant la fluorescence cutanee et son imagerie fonctionnelle.
Szepetiuk, G.; PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg et al

in Revue Médicale de Liège (2010), 65(9), 521-6

Under specific light illumination, skin produces peculiar fluorescent aspects. Such property can be used to provide diagnostic arguments or to disclose some peculiar functions of the skin. Some ... [more ▼]

Under specific light illumination, skin produces peculiar fluorescent aspects. Such property can be used to provide diagnostic arguments or to disclose some peculiar functions of the skin. Some superficial infections (erythrasma, tinea versicolor, dermatophytic tinea,..) reveal fluorescence that may be intense. The pilosebaceous follicles enriched in Propionibacterium spp show fluorescence. Such property is lost during some anti-acne treatments. A quenching effect is observed after application of sunscreens. The (pre)neoplastic areas prepared for dynamic phototherapy become fluorescent. Pyranine labeling of the stratum corneum exhibits fluorescence allowing the assessment of the renewal activity of the epidermis. [less ▲]

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See detailLes ulceres de jambe. Le dogme "noir, jaune, rouge" mis a mal.
HENRY, Frédérique ULg; QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg et al

in Revue Médicale de Liège (2010), 65(9), 502-5

The medical history of a leg ulcer is spangled with episodes contributing to its chronicity before leading to possible healing. The complexity of the involved biological factors is undisputable. In order ... [more ▼]

The medical history of a leg ulcer is spangled with episodes contributing to its chronicity before leading to possible healing. The complexity of the involved biological factors is undisputable. In order to simplify the management of these lesions, some doctors and nurses summarize the evolution of a leg ulcer in 3 phases according to the colour of the wound bed: black, yellow and red. The latter stage is commonly considered as a favourable condition for skin healing. We criticize such a concept by showing the anatomo-functional heterogeneity of the red wound bed. [less ▲]

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