References of "Pierard, Luc"
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See detailDeterminant and Impact on Outcome of Exercise Pulmonary Hypertension in Asymptomatic Severe Aortic Stenosis.
Magne, Julien ULg; Donal, E; O'Connor, K et al

Conference (2011)

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See detailBrain natriuretic peptide in asymptomatic degenerative mitral regurgitation: determinants and impact on outcome.
Van de Heyning, C; Magne, Julien ULg; Mahjoub, H et al

Conference (2011)

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See detailValvular heart disease: mitral valve disease
LANCELLOTTI, Patrizio ULg; Magne, Julien ULg; O'Connor, K et al

in The EAE textbook of echocardiography (2011)

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See detailPrediction of exercise pulmonary hypertension in asymptomatic degenerative mitral regurgitation
Magne, Julien ULg; Lancellotti, Patrizio ULg; O'Connor, K. et al

in Journal of the American Society of Echocardiography (2011), 24(9), 1004-1012

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See detailAssessment and management of aortic stenosis [Evaluation et traitement de la sténose aortique]
Pirlet, C.; Magne, Julien ULg; Lancellotti, Patrizio ULg et al

in Revue Medicale Suisse (2011), 7(306), 1606-1611

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See detailStress testing in valvular heart disease: Clinical benefit of echocardiographic imaging
Roşca, M.; Lancellotti, Patrizio ULg; Magne, Julien ULg et al

in Expert Review of Cardiovascular Therapy (2011), 9(1), 81-92

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See detailInfluence of thermoelectric coupling on ectopic beats generated by mechano-electric feedback (MEF) in a one-dimensional cardiac fiber model
Collet, Arnaud ULg; Desaive, Thomas ULg; Pierard, Luc ULg et al

in 9th Belgian Day on Biomedical Engineering, Friday November 26th 2010 in the Academy Palace, Hertogstraat 1, 1000 Brussels (2010, November 26)

The influence of thermal processes on electrophysiology has clearly been underlined by Bini et al., using a FitzHugh--Nagumo-type (FHN-type) model. When the temperature is raised, the action potential ... [more ▼]

The influence of thermal processes on electrophysiology has clearly been underlined by Bini et al., using a FitzHugh--Nagumo-type (FHN-type) model. When the temperature is raised, the action potential duration (APD) has been shown to shorten, while the action potential (AP) amplitude decreases, and the conduction velocity increases. In this research, we investigate the effects of thermoelectric coupling on mechano-electric feedback (MEF), and more specifically, on ectopic beats generated by MEF. To investigate these effects, thermoelectric coupling is introduced in a one-dimensional electromechanical model of a cardiac fiber, which considers excitation-contraction coupling (ECC), as well as MEF. [less ▲]

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See detailInfluence of thermoelectric coupling on ectopic beats generated by mechano-electric feedback (MEF) in a one-dimensional cardiac fiber model
Collet, Arnaud ULg; Desaive, Thomas ULg; Pierard, Luc ULg et al

Poster (2010, November 26)

The influence of thermal processes on electrophysiology has clearly been underlined by Bini et al., using a FitzHugh--Nagumo-type (FHN-type) model. When the temperature is raised, the action potential ... [more ▼]

The influence of thermal processes on electrophysiology has clearly been underlined by Bini et al., using a FitzHugh--Nagumo-type (FHN-type) model. When the temperature is raised, the action potential duration (APD) has been shown to shorten, while the action potential (AP) amplitude decreases, and the conduction velocity increases. In this research, we investigate the effects of thermoelectric coupling on mechano-electric feedback (MEF), and more specifically, on ectopic beats generated by MEF. To investigate these effects, thermoelectric coupling is introduced in a one-dimensional electromechanical model of a cardiac fiber, which considers excitation-contraction coupling (ECC), as well as MEF. [less ▲]

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See detailActualités thérapeutiques dans la cardiomyopathie hypertrophique.
Moonen, Marie ULg; Pierard, Luc ULg

in Revue Médicale Suisse (2010), 6(260), 1591-4

The management of patients with hypertrophic cardiomyopathy has largely evolved over the past two decades. One important finding is that medical treatment appears under used. Invasive procedure are ... [more ▼]

The management of patients with hypertrophic cardiomyopathy has largely evolved over the past two decades. One important finding is that medical treatment appears under used. Invasive procedure are reserved to patients with obstructive hypertrophic cardiomyopathy who remain symptomatic despite optimal medical treatment. Indications for implantable cardiac defibrillator are still debated. A global and multidisciplinary approach of the patient and of his family is mandatory. [less ▲]

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See detailRisk stratification in asymptomatic moderate to severe aortic stenosis: the importance of the valvular, arterial and ventricular interplay.
Lancellotti, Patrizio ULg; Donal, Erwan; Magne, Julien ULg et al

in Heart (2010), 96(17), 1364-71

OBJECTIVE: We sought to evaluate prognostic markers of clinical outcome in asymptomatic patients with moderate to severe aortic stenosis (AS). DESIGN: Prospective follow-up of asymptomatic patients with ... [more ▼]

OBJECTIVE: We sought to evaluate prognostic markers of clinical outcome in asymptomatic patients with moderate to severe aortic stenosis (AS). DESIGN: Prospective follow-up of asymptomatic patients with moderate to severe AS. The patients underwent clinical and Doppler echocardiographic evaluation. SETTING: Department of Cardiology. PATIENTS: 163 patients with moderate to severe AS (aortic valve area < or =0.6 cm(2)/m(2)). MAIN OUTCOME MEASURES: Risk stratification. Predefined endpoints for assessing the outcome were the occurrence during follow-up of symptoms, aortic valve replacement or death. RESULTS: During follow-up (mean, 20 (19) months), 11 patients developed symptoms but were not operated on, 57 required aortic valve replacement and six patients died. In multivariable Cox regression analysis, four parameters that were associated with the outcome were identified: peak aortic jet velocity, left ventricular systolic (LV) longitudinal deformation, valvulo-arterial impedance and indexed left atrial area. Using receiver-operator characteristic curve analysis, a peak aortic jet velocity > or =4.4 m/s, a LV longitudinal myocardial deformation < or =15.9%, a valvular-arterial impedance > or =4.9 mm Hg/ml per m(2) and an indexed left atrial area > or =12.2 cm(2)/m(2) were identified as the best cut-off values to be associated with events. CONCLUSIONS: In asymptomatic patients with moderate to severe AS, measurements that integrate the ventricular, vascular and valvular components of the disease improve risk stratification. [less ▲]

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See detailEtude échocardiographique longitudinale chez des patients atteints de prolactinome et traités par cabergoline
Lancellotti, Patrizio ULg; Latta, K.; O'Connor, Kim ULg et al

in Annales d'Endocrinologie (2010, September), 71(5), 399

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See detailEtude échocardiographique longitudinale chez des patients atteints de prolactinome et traités par Cabergoline
Lancellotti, Patrizio ULg; Latta, K.; O'Connor, K. et al

in 27ème Congrès de la Société Française d'Endocrinologie - Deauville, 29 septembre - 2 octobre 2010 (2010, September)

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See detailStress echocardiography for selecting potential responders to cardiac resynchronisation therapy.
Moonen, Marie ULg; O'Connor, Kim; Magne, Julien ULg et al

in Heart (2010), 96(14), 1142-6

In the current ESC/ACC/AHA guidelines, the selection of patients for cardiac resynchronisation therapy (CRT) is based upon the QRS duration, which reflects interventricular dyssynchrony. However, about 30 ... [more ▼]

In the current ESC/ACC/AHA guidelines, the selection of patients for cardiac resynchronisation therapy (CRT) is based upon the QRS duration, which reflects interventricular dyssynchrony. However, about 30% of patients do not respond to CRT. It has previously been demonstrated that the presence of left ventricular mechanical dyssynchrony is predictive of response to CRT after implantation. Most criteria assessing such dyssynchrony were derived from data obtained with resting Doppler echocardiography. The recently published PROSPECT (Predictors of Response to CRT) trial failed to identify echocardiographic measures of dyssynchrony that could routinely be recommended for patient selection before CRT implantation. Therefore, solutions may come from other echocardiographic modalities, such as dobutamine stress echocardiography and exercise echocardiography. The purpose of this review is to evaluate the usefulness of stress echocardiography to predict response to CRT. This review will show how exercise-induced changes in dyssynchrony and severity of mitral regurgitation and the role of preserved contractile reserve may help to better identify potential responders. [less ▲]

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See detailExercise pulmonary hypertension in asymptomatic degenerative mitral regurgitation
Magne, Julien ULg; Lancellotti, Patrizio ULg; Pierard, Luc ULg

in Circulation (2010), 122(1), 33-41

BACKGROUND: Current guidelines recommend mitral valve surgery for asymptomatic patients with severe degenerative mitral regurgitation and preserved left ventricular systolic function when exercise ... [more ▼]

BACKGROUND: Current guidelines recommend mitral valve surgery for asymptomatic patients with severe degenerative mitral regurgitation and preserved left ventricular systolic function when exercise pulmonary hypertension (PHT) is present. However, the determinants of exercise PHT have not been evaluated. The aim of this study was to identify the echocardiographic predictors of exercise PHT and the impact on symptoms. <br /> <br />METHODS AND RESULTS: Comprehensive resting and exercise transthoracic echocardiography was performed in 78 consecutive patients (age, 61+/-13 years; 56% men) with at least moderate degenerative mitral regurgitation (effective regurgitant orifice area =43+/-20 mm(2); regurgitant volume =71+/-27 mL). Exercise PHT was defined as a systolic pulmonary arterial pressure (SPAP) >60 mm Hg. Exercise PHT was present in 46% patients. In multivariable analysis, exercise effective regurgitant orifice was an independent determinant of exercise SPAP (P<0.0001) and exercise PHT (P=0.002). Resting PHT and exercise PHT were associated with markedly reduced 2-year symptom-free survival (36+/-14% versus 59+/-7%, P=0.04; 35+/-8% versus 75+/-7%, P<0.0001). After adjustment, although the impact of resting PHT was no longer significant, exercise PHT was identified as an independent predictor of the occurrence of symptoms (hazard ratio=3.4; P=0.002). Receiver-operating characteristics curves revealed that exercise PHT (SPAP >56 mm Hg) was more accurate than resting PHT (SPAP >36 mm Hg) in predicting the occurrence of symptoms during follow-up (P=0.032). <br /> <br />CONCLUSIONS: Exercise PHT is frequent in patients with asymptomatic degenerative mitral regurgitation. Exercise mitral regurgitation severity is a strong independent predictor of both exercise SPAP and exercise PHT. Exercise PHT is associated with markedly low 2-year symptom-free survival, emphasizing the use of exercise echocardiography. An exercise SPAP >56 mm Hg accurately predicts the occurrence of symptoms. [less ▲]

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See detailDoes echocardiographic stress test induced release of hsTnT and TnI II?
Le Goff, Caroline ULg; Laurent, Terry; Garweg, Christophe ULg et al

in Clinical Chemistry (2010, July), 56(S6), 128

Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury. In this study, cTnT and cTnI were measured by new commercially available high-sensitive ... [more ▼]

Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury. In this study, cTnT and cTnI were measured by new commercially available high-sensitive methods in patients undergoing brief exercise- or pharmacologicinduced stress. Our aim was to compare cTnT and cTnI levels before and after the stress tests, in the patients with or without reversible ischemia. Materials and Methods: Fifty patients (28 men and 22 women) underwent an echographic stress test (ST) for suspected ischemic heart disease. Of these 50 patients, 28 received pharmacological ST (dobutamine injection) and 22 dynamic ST (bicycle exercise). The patients were subdivided into two groups according to the presence or absence of documented transient reversible ischemia: 14 with reversible ischemia ( mean age: 67.71±9.66 y) and 36 without ischemia ( mean age: 63.17±11.72 y). In all patients, cTnT and cTnI concentrations were measured by high sensitive methods (hsTnT, Roche Diagnostics and TnI II, Abbott Diagnostics) on heparin plasma immediately before (T0) and after ST (T1).The lower detection limit of these assays was 0.005μg/L for hsTnT and 0.01μg/L for TnI II. The protocol was approved by the ethics committee of the University of Liège (Belgium). All patients gave informed consent. All statistical analyses were performed using Medcalc version 8.1 for Windows. P value <0.05 was regarded as statistically significant. Results: There was no significant difference between hsTnT concentrations at T0 and T1, neither in the whole patient group, nor in the subgroups of subjects who received pharmacological ST or dynamic ST. The same was true for TnI II. Although there was no change in hsTnT levels during test in ischemic and in non ischemic patients, the latter tend to demonstrate higher median T0 levels (25th, 75th percentiles) than the others [0.011 (0.007, 0.029) vs 0.007 (0.0047, 0.1125) ng/ml, p=0.09]. They also showed higher median T1 levels [0.014 (0.065, 0.03) vs 0.007 (0.003, 0.0102) ng/ml, p=0.08]. Higher TnI II levels were also recorded in ischemic patients as compared to non ischemic patients at T0[ 0.014 (0.0072; 0.0265) vs 0.005 (0.003; 0.01) ng/ml, p=0.08] and T1[ 0.013 (0.0085- 0.03) vs 0.006 (0.0035-0.008) ng/ml, p=0.08]. Also, TnI II levels did not change during test in both subgroups. Conclusions: Measurement of cardiac troponins by high sensitive methods did not allow to detect significant release of biomarkers from the heart during exercise-or pharmacologic-induced ST, even in patients who demonstrated reversible myocardial ischemia. The type of test – pharmacological or dynamic - was without effect. The patients with induced transient ischemia had however higher troponin T and I levels at baseline, this difference remaining during test. [less ▲]

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See detailA moving heart
Moonen, Marie ULg; Davin, Laurent ULg; Lancellotti, Patrizio ULg et al

in European Heart Journal (2010)

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