References of "Pierard, Gérald"
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See detailFondements physico-biologiques de la fluorescence cutanee - Revue.
SZEPETIUK, Grégory ULg; FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg et al

in Pathologie Biologie (2012), 60

Fluorescence is a peculiar aspect of photoluminescence. Some intrinsic components of the skin are fluorophores. Other synthetic components are metabolized into fluorophores. These characteristics may be ... [more ▼]

Fluorescence is a peculiar aspect of photoluminescence. Some intrinsic components of the skin are fluorophores. Other synthetic components are metabolized into fluorophores. These characteristics may be used for identifying some specific aspects of skin physiopathology. Recent technological evolution has provided new devices bringing sensitive and specific information from the skin. This review presents a synthesis of the progress made in the field of fluorescence and specular reflexion of incident UV light on the skin. [less ▲]

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See detailFibromes cutanés.
PIERARD, Gérald ULg; Franchimont, Claudine ULg

in Fondation René Touraine (Ed.) Thérapeutique Dermatologique (2012)

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See detailProteomic kinetic analysis of blister fluid and serum in a patient with drug-induced toxic epidermal necrolysis. A comparison with skin immunohistochemistry.
Paquet, Philippe; Meuwis, Marie-Alice ULg; Mazzucchelli, Gabriel ULg et al

in Current Drug Safety (2012), 7(5), 339-51

Drug-induced toxic epidermal necrolysis (TEN) is a rare but potentially lethal bullous disease whose complex pathomechanisms remain uncertain. The aim of the study was an exploratory attempt to assess TEN ... [more ▼]

Drug-induced toxic epidermal necrolysis (TEN) is a rare but potentially lethal bullous disease whose complex pathomechanisms remain uncertain. The aim of the study was an exploratory attempt to assess TEN pathobiology using a combination of immunohistochemistry and proteomics. Skin blister fluid (BF) and serum were collected in a patient in the early TEN stage at day (D) +4 of evolution and three days later (D +7). Intravenous cyclosporine A (CsA) treatment was initiated since D +4. Immunohistochemistry was performed on skin blister biopsies. In addition, proteomic analyses compared the BF protein content before and at the issue of the 3-day CsA treatment. Proteins were selected according to their prominent differential abundance in BF between D+4 and D+7, when influenced by lesional skin cells, but not in serum. Among 300 proteins, four were considered. Glutathione transferase pi was related to oxidative stress in TEN epidermis. The monocyte differentiation antigen CD14 and myeloperoxidase indicated macrophage activation. The proinflammatory S100-A8 protein probably originated from activated keratinocytes and/or macrophages. These proteomic findings were in line with immunohistochemistry and supported the prominent involvement of keratinocytes and macrophages in TEN pathomechanism. As opposed to CD14, other proteins were mainly present in BF at D+7, confirming that CsA expressed little effect, if any, on the activity of keratinocytes and macrophages in the present TEN patient. Of note, the present exploratory study using proteomic analyses in a single TEN case supports a pathogenic hypothesis without establishing any firm conclusion. [less ▲]

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See detailEditorial: toxic epidermal necrolysis.
PIERARD, Gérald ULg

in Current Drug Safety (2012), 7(5), 331

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See detailDeciphering supportive treatment strategies for toxic epidermal necrolysis.
Jennes, Serge; PIERARD, Gérald ULg; Paquet, Philippe

in Current Drug Safety (2012), 7(5), 361-6

Toxic epidermal necrolysis (TEN) is a dreadful life-threatening syndrome typically induced by an adverse drug reaction. This condition is characterized by the sudden and extensive destruction of the ... [more ▼]

Toxic epidermal necrolysis (TEN) is a dreadful life-threatening syndrome typically induced by an adverse drug reaction. This condition is characterized by the sudden and extensive destruction of the epidermis. The patient should be promptly addressed to a burn unit where three types of treatment should be administered, namely, (a) specific topical care of the bullous/eroded skin areas, (b) systemic anti-apoptotic/necrotic treatments, and (c) supportive care preventing secondary internal organ failures. This latter aspect is covered by the present review and focuses on (a) early withdrawal of the causative drug, (b) airway management, (c) hydro-electrolytic control, (d) nutritional support, (e) antibiotherapy, (f) prevention of venous thrombosis and gastroduodenal ulcers, and (g) analgesia and anesthesia. [less ▲]

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See detailDrug Interactions with Normal and TEN Epidermal Keratinocytes.
Paquet, Philippe; Delvenne, Philippe ULg; PIERARD, Gérald ULg

in Current Drug Safety (2012), 7(5), 352-6

Human epidermal keratinocytes (EKs) are metabolically involved in various drug transport mechanisms, as well as in detoxification or activation processes. The overall cell mechanisms of drug ... [more ▼]

Human epidermal keratinocytes (EKs) are metabolically involved in various drug transport mechanisms, as well as in detoxification or activation processes. The overall cell mechanisms of drug metabolization, and more specifically drug processing are reviewed in normal EKs. The overall drug metabolism involves different phases corresponding to the uptake, biotransformation and anti-transport steps. In EKs, both the enzymes and transportassociated proteins are different from those involved in the hepatocyte metabolism. Some cytochrome P450 enzymes and the flavin-containing mono-oxygenases are particularly involved in EKs. Basically, EKs represent key cells likely involved during the initial stage of drug-induced toxic epidermal necrolysis (TEN). Only limited advances have been made so far in this field. Nevertheless, mitigating EKs metabolic disturbances in TEN probably represent a promising specific treatment of the disease. [less ▲]

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See detailToxic epidermal necrolysis and antifolate drugs in cancer chemotherapy.
Franchimont, Claudine ULg; Lesuisse, Marianne; Humbert, Philippe et al

in Current Drug Safety (2012), 7(5), 357-60

Folates are one-carbon donors essential for synthesizing purines, pyrimidines, serine, and methionine. They correspond to anionic hydrophilic molecules essential for DNA synthesis in mammalian cells. The ... [more ▼]

Folates are one-carbon donors essential for synthesizing purines, pyrimidines, serine, and methionine. They correspond to anionic hydrophilic molecules essential for DNA synthesis in mammalian cells. The latter cells lack the capacity to synthesize folates. In some patients, high dosages of antifolate drugs (eg: methotrexate, pemetrexed) used in cancer chemotherapy alter the keratinocytes, endothelial cells and Factor XIIIa+ dermal dendrocytes in a range of various severities. Such conditions clinically designed under the heading antifolate cytotoxic skin reaction (ACSR) occasionally resemble the toxic epidermal necrolysis (TEN) / Stevens-Johnson syndrome (SJS) spectrum. Whether or not the TEN/SJS presentation of ACSR is a regular condition similar to that induced by other drugs or a variant condition supported by a unique pathomechanism is unsettled. [less ▲]

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See detailCold injuries.
PIERARD, Gérald ULg; QUATRESOOZ, Pascale ULg; FRANCHIMONT, Claudine ULg

in Goldsmith, L.; Gilchrest, B; Katz, S (Eds.) et al Fitzpatrick's Dermatology in General Medicine (2012)

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See detailHow to manage hair changes in cancer patients.
FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; RORIVE, Andrée ULg et al

in Vereecken, P.; Awada, A. (Eds.) Handbook of skin care in cancer patients. (2012)

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See detailTrancking and treating malignant melanoma metastases.
PIERARD, Gérald ULg; HUMBERT, Philippe; QUATRESOOZ, Pascale ULg

Book published by Hindawi Pub. Corp. - Dermatology Research and Practice - Special Edition (2012)

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See detailImpact climatique sur les ulcères veineux de jambe.
FRANCHIMONT, Claudine ULg; Hermanns-Lê, Trinh ULg; LESUISSE, Marianne et al

in Revue Médicale de Liège (2012), 67

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See detailLa vignette diagnostique de l'étudiant. Le phénomène de Raynaud.
FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg; Hermanns-Lê, Trinh ULg

in Revue Médicale de Liège (2012), 67

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See detailLe melanome cutane: une seule maladie?
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Hermanns-Lê, Trinh ULg et al

in Revue Médicale de Liège (2012), 67(9), 458-60

For the media and the public at large, malignant melanoma is the most dreadful cancer of the skin. This statement is obvious. However, some nuances merit to be considered. The clinical presentations ... [more ▼]

For the media and the public at large, malignant melanoma is the most dreadful cancer of the skin. This statement is obvious. However, some nuances merit to be considered. The clinical presentations, histopathology and molecular genetics point to the fact that malignant melanoma is not a single monolithic pathological condition. Different types of melanomas are distinguished based on distinct origins and contrasted prognoses. The management and information for the patient should be handled individually. [less ▲]

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See detailDeux bacteries et une kyrielle d'infections cutanees communes.
Franchimont, Claudine ULg; Lesuisse, M.; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(10), 513-9

Common bacterial skin infections represent frequent disorders encountered in general practice and in dermatology as well. They encompass a series of infections affecting the epidermis, dermis, hypodermis ... [more ▼]

Common bacterial skin infections represent frequent disorders encountered in general practice and in dermatology as well. They encompass a series of infections affecting the epidermis, dermis, hypodermis and subcutaneous tissues. The two main bacteria involved in these processes are Streptococcus pyogenes and Staphylococcus aureus. The resulting infections show various clinical presentations. Their management must be adapted to their gravity and to the putative or proven nature of the causal microorganism. Searching for any skin ingress possibility and any favouring factor is always of importance in order to stimulate healing and avoid recurrences. Of note, skin possibly allows the ingress way for a secondary septicemic dissemination. Conversely, skin is possibly involved in tissue localisation of septicemia. [less ▲]

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See detailLe melanome metastatique: un vent d'espoir porte par l'ipilimumab et le vemurafenib.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(2), 64-8

Treating a patient with cutaneous malignant melanoma relies on the recognition of a clever stratification of the distinct stages of the disease. The histoprognostic criteria were recently revisited. In ... [more ▼]

Treating a patient with cutaneous malignant melanoma relies on the recognition of a clever stratification of the distinct stages of the disease. The histoprognostic criteria were recently revisited. In addition, translational research fueled the development of new treatments with at last increased efficacy in the metastatic stage. Such therapeutic advance improves the median overall survival for a few months. Some combined treatments could possibly boost the beneficial effects. [less ▲]

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See detailLe "cheetah-look". Le phénotype guépart, face cachée de la pigmentation mélanique innée du visage.
Hermanns-Lê, Trinh ULg; AL RUSTOM, Kamil; FRANCHIMONT, Claudine ULg et al

in Dermatologie Actualité (2012), 131

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See detailUstékinumab (Sterala®), l'axe Th17-IL23 du psoriasis et au-delà.
FRANCHIMONT, Claudine ULg; Hermanns-Lê, Trinh ULg; QUATRESOOZ, Pascale ULg et al

in Dermatologie Actualité (2012), 131

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See detailChallenging regional psoriasis and ustekinumab biotherapy: impact of the patterns of disease.
Hermanns-Lê, Trinh ULg; Berardesca, Enzo; PIERARD, Gérald ULg et al

in Journal of Biomedicine & Biotechnology (2012), 2012

In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar ... [more ▼]

In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations. [less ▲]

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See detailMalignant melanoma and its stromal nonimmune microecosystem.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Delvenne, Philippe ULg

in Journal of Oncology (2012), 2012

In recent years, rapid advances were reached in the understanding of a series of biologic signals influencing cutaneous malignant melanoma (CMM) cells. CMM is in close contact with a peculiar dermal ... [more ▼]

In recent years, rapid advances were reached in the understanding of a series of biologic signals influencing cutaneous malignant melanoma (CMM) cells. CMM is in close contact with a peculiar dermal extracellular matrix (ECM). Stromal cells store and release various structural ECM components. The impact on CMM growth and progression is mediated through strong and long-lasting effects of ECM products. This paper summarizes some peculiar aspects of the peri-CMM stroma showing intracytoplasmic loads in Factor XIIIa, CD34, versican, and alpha (IV) collagen chains. The restricted peri-CMM skin territory exhibiting such changes corresponds to the area showing neoangiogenesis and extravascular unicellular metastatic spread. The latter inconspicuous migratory CMM cells possibly correspond to CMM stem cells or to CMM cells with aberrant HOX gene expression. Their presence is associated with an increased risk for metastases in the regional sentinel lymph nodes. In conclusion, the CMM-stroma connection appears crucial to the growth regulation, invasiveness and initial metastatic spread of CMM cells. Although much remains to be learned in this field, the active intervention of the peri-CMM stroma is likely involved in the inconspicuous early metastatic migration of CMM cells. [less ▲]

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See detailRash de l'ifluenza A H1N1.
PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67

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