References of "Pierard, Gérald"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailScleroderma: skin stiffness assessment using the stress-strain relationship under progressive suction.
PIERARD, Gérald ULg; Hermanns-Lê, Trinh ULg; Franchimont, Claudine ULg

in Expert Opinion on Medical Diagnostics (2013), 7(2), 119-25

Introduction: A few non-invasive biometrological methods are available for monitoring skin stiffening in systemic scleroderma. Among them, the Cutometer(R) is used for years by several clinical teams ... [more ▼]

Introduction: A few non-invasive biometrological methods are available for monitoring skin stiffening in systemic scleroderma. Among them, the Cutometer(R) is used for years by several clinical teams. Objectives: To revisit the microscopic structure of the dermal fibrous networks in scleroderma and the relationship with changes in viscoelasticity. Methods: The suction method delivered by the Cutometer(R) was applied following the progressive stress-vs-strain modality. Results: The test procedure was sensitive enough to document the initial progression steps of acroscleroderma. Four stages were thus identified including i) the incipient, ii) the progressive, iii) the overt, and iv) the regressive acroscleroderma. Conclusion: The non-invasive determination of skin biomechanical functions is relevant both in routine clinical practice and in antisclerotic drug development. It is complementary although not a substitute for the determination of selected serum biomarkers. [less ▲]

Detailed reference viewed: 31 (8 ULg)
Full Text
Peer Reviewed
See detailComment je traite un état pelliculaire.
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2013), 68(9), 436-9

Dandruff and seborrheic dermatitis form a continuum of desquamative conditions associated with the excessive colonization of the stratum corneum by yeasts of the genus Malassezia spp. Such colonization is ... [more ▼]

Dandruff and seborrheic dermatitis form a continuum of desquamative conditions associated with the excessive colonization of the stratum corneum by yeasts of the genus Malassezia spp. Such colonization is heterogeneous in density, ranging from discrete to abundant according to the fungal ability to adhere to individual corneocytes. The rate of action of antidandruff shampoos shed some doubts about a direct antifungal effect, but rather suggests the involvement of innate immune defenses and the chemical alteration of molecular adhesion modalities between Malassezia and corneocytes. [less ▲]

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailAlterations in hair follicle dynamics in women.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in BioMed Research International (2013), 2013(957432),

Detailed reference viewed: 20 (9 ULg)
Full Text
Peer Reviewed
See detailImmunohistochemical patterns in the interfollicular Caucasian scalps. Influence of age-, gender- and alopecia.
Franchimont, Claudine ULg; Loussouarn, Genevière; Panhard, Ségolène et al

in BioMed Research International (2013), 2013(769489),

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailImmunohistochemical sweat gland profiles.
Noel, Fanchon; Pierard, Gérald ULg; Delvenne, Philippe ULg et al

in Journal of Cosmetic Dermatology (2013), 12

Abstract BACKGROUND: Human sweat glands are heterogeneous in their structures and functions. Accordingly, eccrine, apocrine, and apoeccrine glands are distinguished. AIMS: Some immunohistochemical markers ... [more ▼]

Abstract BACKGROUND: Human sweat glands are heterogeneous in their structures and functions. Accordingly, eccrine, apocrine, and apoeccrine glands are distinguished. AIMS: Some immunohistochemical markers are expected to distinguish the sweat gland types in their secretory and excretory parts. METHODS: This study used two sets of antibodies. The first panel was composed of antibodies directed to well-defined sweat gland structures. The molecular targets included the low-molecular-weight cytokeratins CAM 5.2, the S100-B protein, the epithelial membrane antigen (EMA), the carcinoembryonic antigen (CEA), and the lectin Ulex europaeus agglutinin-1 (UEA-1). A second exploratory panel of antibodies targeted syndecan-1 (CD138), NKI-C3 (CD63), and CD68. They were used to disclose some undescribed antigen expressions in human sweat glands. RESULTS: The first set of antibodies confirmed previous findings. The immunoreactivities of the three sweat gland types were similar in the excretory ducts. By contrast, they were distinguished in the deeper coiled secretory portions of the glands. CONCLUSION: Clues supporting their distinction and probably their functional activity were obtained by immunohistochemistry using the S100-B protein, CEA and CD63 antibodies. The immunoreactivity to the S100-B protein, CEA and CD63 possibly help identifying apoeccrine sweat glands or a peculiar functional activity of eccrine sweat glands. [less ▲]

Detailed reference viewed: 17 (4 ULg)
Full Text
Peer Reviewed
See detailIn vivo evaluation of the skin tensile strength by the suction method: pilot study coping with hysteresis and creep extension.
PIERARD, Gérald ULg; Pierard, Sébastien ULg; Delvenne, Philippe ULg et al

in ISRN dermatology (2013), 2013

From an engineering standpoint, both the skin and subcutaneous tissue act as interconnected load-transmitting structures. They are subject to a variety of intrinsic and environmental influences. Changes ... [more ▼]

From an engineering standpoint, both the skin and subcutaneous tissue act as interconnected load-transmitting structures. They are subject to a variety of intrinsic and environmental influences. Changes in the cutaneous viscoelasticity represent an important aspect in a series of skin conditions. The aim of this work was to explore the methodology of biomechanical measurements in order to better appreciate the evolution and severity of some connective tissue diseases. The Cutometer MPA 580 (C+K electronic) was used in the steep and progressive suction procedures. Adapting measurement modalities was explored in order to mitigate any variability in data collection. The repeat steep suction procedure conveniently reveals the creep phenomenon. By contrast, the progressive suction procedure highlights the hysteresis phenomenon. These viscoelastic characteristics are presently described using the 2 and 4 mm probes on normal skin and in scleroderma, acromegaly, corticosteroid-induced dermatoporosis, and Ehlers-Danlos syndrome. The apposition of an additional outer contention on the skin altered differently the manifestations of the creep extension and hysteresis among the tested skin conditions. Any change in the mechanical test procedure affects the data. In clinical and experimental settings, it is mandatory to adhere to a strict and controlled protocol. [less ▲]

Detailed reference viewed: 7 (2 ULg)
Full Text
Peer Reviewed
See detailScrutinizing skinfield melanin patterns in young Caucasian women.
Hermanns-Lê, Trinh ULg; Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Expert Opinion on Medical Diagnostics (2013)

Introduction: When using adequate wavelength illumination and high resolution recordings, Caucasian skin color appears uneven. The patterns of faint mosaic melanoderma (FMM) are diverse and possibly ... [more ▼]

Introduction: When using adequate wavelength illumination and high resolution recordings, Caucasian skin color appears uneven. The patterns of faint mosaic melanoderma (FMM) are diverse and possibly related to the risk of skin cancer development. Areas covered: The current peer-reviewed publications about objective methods quantifying FMM are revisited. The images from the Visioscan(R) and Visioface(R) Quick devices are computerized in order to record the ultraviolet light-enhanced visualization (ULEV) and the color-enhanced visualization (CEV) of the skin. Previously published data regarding the FMM are gathered in 20 odd Caucasian women. Seven FMM patterns are distinguished. They appear expressed differently according to body regions, but the mean gray level appears more uniform. Expert opinion: The combination of larger subclinical melanotic macules and ivory spots during early adulthood is apparently associated with an increased risk for non-melanoma skin cancers. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
See detailThe thousand and one facets of actinic keratosis.
PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg; DELVENNE, Philippe ULg

Book published by Nova Science Publishers (2013)

Detailed reference viewed: 21 (3 ULg)
Full Text
See detailRegard sur la peau diabétique et ses méhins.
PIERARD, Gérald ULg; RADERMECKER, Régis ULg; SCHEEN, André ULg

in Revue de l'Association Belge du Diabète (2013), 56

La peau exprime certains changements qui sont souvent proportionnels à la durée et la sévérité du diabète. La plupart des composants de la peau sont affectés à des degrés divers, parfois cliniquement ... [more ▼]

La peau exprime certains changements qui sont souvent proportionnels à la durée et la sévérité du diabète. La plupart des composants de la peau sont affectés à des degrés divers, parfois cliniquement imperceptibles, parfois très sévères et invalidants. [less ▲]

Detailed reference viewed: 16 (4 ULg)
Full Text
Peer Reviewed
See detailRisquer sa peau pour quelques "joints".
Hermanns-Lê, Trinh ULg; DELVENNE, Philippe ULg; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 311-314

Detailed reference viewed: 15 (6 ULg)
Full Text
See detailSensory irritation to surfactant-based products.
PIERARD, Gérald ULg

in The International Society of Stratum Corneum Research Newsletter. (2013), 6

Detailed reference viewed: 5 (2 ULg)
Full Text
Peer Reviewed
See detailCritical assessment of diabetic xerosis.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Scheen, André ULg

in Expert Opinion on Medical Diagnostics (2013), 7(2), 201-7

Introduction: Diabetes mellitus is commonly responsible for skin changes including discrete to mild xerosis. Areas covered: This review focuses on some selected relevant bioinstrumental methods assessing ... [more ▼]

Introduction: Diabetes mellitus is commonly responsible for skin changes including discrete to mild xerosis. Areas covered: This review focuses on some selected relevant bioinstrumental methods assessing diabetes xerosis. Peer-reviewed articles on objective non-invasive methods were scrutinized. The reviewed methods address i) the xerosis severity grading scale, ii) corneodynamics referring to the desquamation rate, iii) electrometric assessment of skin hydration including skin capacitance mapping and iv) implication of the imperceptible perspiration. The subjective clinical assessment often fails to disclose diabetic xerosis with confidence and precision. By contrast, a multipronged biometrological approach identifies a cluster of diabetic patients who experience alterations in the structural and functional maturation of the stratum corneum. Expert opinion: A multipronged biometrological approach helps identifying the changes in the stratum corneum of diabetic xerosis. There is a continuum between the 'dry skin' feeling, xerosis and ichthyosiform presentations, particularly on the shins and feet of diabetic patients. [less ▲]

Detailed reference viewed: 25 (3 ULg)
Full Text
Peer Reviewed
See detailCharacterization of spontaneous collagen fibrillogenesis in a cell-free and tension-free environment.
PIERARD, Gérald ULg; Hermanns-Lê, Trinh ULg; Delvenne, Philippe ULg et al

in Clinical & Experimental Dermatology (2013)

The collagen fibril packing that forms threads and bundles is poorly defined, despite the fact that it is important for distinct aspects of the adventitial and reticular dermis. The present study explored ... [more ▼]

The collagen fibril packing that forms threads and bundles is poorly defined, despite the fact that it is important for distinct aspects of the adventitial and reticular dermis. The present study explored an in vitro fibrillogenesis model using the property of heat polymerization. The process was performed on glass slides with mixtures of collagen I and III, and the material was viewed by scanning electron microscopy. In all instances, collagen I and III formed fibrils with regular sizes. The formation of threads was influenced by the relative proportions of collagen I and III; increasing the relative proportion of collagen I resulted in the formation of threads showing increasing variations in thickness. These findings are in line with the differential presentation and compositions of the different parts of the dermis. The possible interventions of stromal cells and of other macromoleules of the extracellular matrix were not considered in this study. [less ▲]

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailComprehensive clinical and molecular analysis of 12 families with type 1 recessive cutis laxa.
Callewaert, Bert; Su, Chi-Ting; Van Damme, Tim et al

in Human Mutation (2013), 34(1), 111-21

Autosomal recessive cutis laxa type I (ARCL type I) is characterized by generalized cutis laxa with pulmonary emphysema and/or vascular complications. Rarely, mutations can be identified in FBLN4 or FBLN5 ... [more ▼]

Autosomal recessive cutis laxa type I (ARCL type I) is characterized by generalized cutis laxa with pulmonary emphysema and/or vascular complications. Rarely, mutations can be identified in FBLN4 or FBLN5. Recently, LTBP4 mutations have been implicated in a similar phenotype. Studying FBLN4, FBLN5, and LTBP4 in 12 families with ARCL type I, we found bi-allelic FBLN5 mutations in two probands, whereas nine probands harbored biallelic mutations in LTBP4. FBLN5 and LTBP4 mutations cause a very similar phenotype associated with severe pulmonary emphysema, in the absence of vascular tortuosity or aneurysms. Gastrointestinal and genitourinary tract involvement seems to be more severe in patients with LTBP4 mutations. Functional studies showed that most premature termination mutations in LTBP4 result in severely reduced mRNA and protein levels. This correlated with increased transforming growth factor-beta (TGFbeta) activity. However, one mutation, c.4127dupC, escaped nonsense-mediated decay. The corresponding mutant protein (p.Arg1377Alafs(*) 27) showed reduced colocalization with fibronectin, leading to an abnormal morphology of microfibrils in fibroblast cultures, while retaining normal TGFbeta activity. We conclude that LTBP4 mutations cause disease through both loss of function and gain of function mechanisms. [less ▲]

Detailed reference viewed: 6 (1 ULg)
Full Text
Peer Reviewed
See detailThe weather-beaten dorsal hand. Clinical rating, shadow casting optical profilometry and skin capacitance mapping.
Delvenne, Marie; FRANCHIMONT, Claudine ULg; SEIDEL, Laurence ULg et al

in BioMed Research International (2013), 2013

Detailed reference viewed: 22 (8 ULg)
Full Text
Peer Reviewed
See detailAnalytic dermoscopy of superficial basal cell carcinoma.
FRANCHIMONT, Claudine ULg; Hermanns, Jean-Francois; Caucanas, Marie et al

in Journal of Case Reports in Medicine (2013), 3

Detailed reference viewed: 21 (6 ULg)
Full Text
See detailParapsoriasis en plaques.
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg

in Thérapeutique Dermatologique (2012)

Detailed reference viewed: 24 (3 ULg)
Full Text
See detailDermatoses non infectieuses de la grossesse.
Hermanns-Lê, Trinh ULg; Franchimont, Claudine ULg; Delvenne, Philippe ULg et al

in Thérapeutique Dermatologique (2012)

Detailed reference viewed: 5 (3 ULg)