References of "Pierard, Gérald"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailLa vignette diagnostique de l'étudiant. Diagnostic et évolution d'une chéloïde.
FRANCHIMONT, Claudine ULg; Hermanns-Lê, Trinh ULg; NIZET, Jean-Luc ULg et al

in Revue Médicale de Liège (2014), 69

Une chéloïde est une formation saillante, fibreuse hypertrophique du derme. Elle est très ferme au toucher. Il en existe deux types cliniques qui correspondent, d’une part, à une évolution particulière ... [more ▼]

Une chéloïde est une formation saillante, fibreuse hypertrophique du derme. Elle est très ferme au toucher. Il en existe deux types cliniques qui correspondent, d’une part, à une évolution particulière d’une cicatrice et, d’autre part, à une apparition présumée spontanée. Cette lésion est caractérisée par des dépôts massifs de faisceaux de collagène. Cet aspect la distingue de la cicatrice hypertrophique qui représente, de manière primordiale, une accumulation de fibroblastes et de petits vaisseaux. [less ▲]

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailSkin ageprint: the causative factors.
PIERARD, Gérald ULg; Hermanns-Lê, Trinh ULg; Delvenne, Philippe ULg et al

in Paye, M.; Maibach, H.I.; Barel, A.O. (Eds.) Handbook of Cosmetic Science and Technology (2014)

Detailed reference viewed: 32 (9 ULg)
Full Text
Peer Reviewed
See detailAsymmetric facial skin viscoelasticity during climacteric aging.
Pierard, Gérald ULg; Hermanns-Lê, Trinh ULg; Gaspard, Ulysse ULg et al

in Clinical, cosmetic and investigational dermatology (2014), 7

BACKGROUND: Climacteric skin aging affects certain biophysical characteristics of facial skin. The purpose of the present study was to assess the symmetric involvement of the cheeks in this stage of the ... [more ▼]

BACKGROUND: Climacteric skin aging affects certain biophysical characteristics of facial skin. The purpose of the present study was to assess the symmetric involvement of the cheeks in this stage of the aging process. METHODS: Skin viscoelasticity was compared on both cheeks in premenopausal and post-menopausal women with indoor occupational activities somewhat limiting the influence of chronic sun exposure. Eighty-four healthy women comprising 36 premenopausal women and 48 early post-menopausal women off hormone replacement therapy were enrolled in two groups. The tensile characteristics of both cheeks were tested and compared in each group. A computerized suction device equipped with a 2 mm diameter hollow probe was used to derive viscoelasticity parameters during a five-cycle procedure of 2 seconds each. Skin unfolding, intrinsic distensibility, biological elasticity, and creep extension were measured. RESULTS: Both biological elasticity and creep extension were asymmetric on the cheeks of the post-menopausal women. In contrast, these differences were more discrete in the premenopausal women. CONCLUSION: Facial skin viscoelasticity appeared to be asymmetric following menopause. The possibility of asymmetry should be taken into account in future studies of the effects of hormone replacement therapy and any antiaging procedure on the face in menopausal women. [less ▲]

Detailed reference viewed: 9 (2 ULg)
Full Text
Peer Reviewed
See detailCyanoacrylate skin surface strippings and the 3S-Bioket advent in tropical dermatology. A look from Liège.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; PAQUET, Philippe ULg et al

in Scientific World Journal (The) (2014), 2014

In the dermatopathology field, some simple available laboratory tests require minimum equipment for establishing a diagnosis. Among them, the cyanoacrylate skin surface stripping (CSSS), formerly named ... [more ▼]

In the dermatopathology field, some simple available laboratory tests require minimum equipment for establishing a diagnosis. Among them, the cyanoacrylate skin surface stripping (CSSS), formerly named skin surface biopsy or follicular biopsy, represents a convenient low cost procedure. It is a minimally invasive method collecting a continuous sheet of stratum corneum and horny follicular casts. In the vast majority of cases, it is painless and is unassociated with adverse events. CSSS can be performed in subjects of any age. The method has a number of applications in diagnostic dermatopathology and cosmetology, as well as in experimental dermatology settings. A series of derived analytic procedures include xerosis grading, comedometry, corneofungimetry, corneodynamics of stratum corneum renewal, corneomelametry, corneosurfametry, and corneoxenometry. [less ▲]

Detailed reference viewed: 13 (5 ULg)
Full Text
Peer Reviewed
See detailFaites vos jeux, rien ne va plus ... la peau a l'age de la retraite, aujourd'hui et demain.
Pierard, Gérald ULg; Lesuisse, M.; Saint-Leger, D. et al

in Revue medicale de Liege (2014), 69(5-6), 366-71

Senescence of people represents a global expression of obsolescence of their organs, tissues, cells and constitutive molecules. Skin, similarly to any other organ, is ageing in particular ways. Over the ... [more ▼]

Senescence of people represents a global expression of obsolescence of their organs, tissues, cells and constitutive molecules. Skin, similarly to any other organ, is ageing in particular ways. Over the past century, the time effects on skin have been expressed differently. Skin of any individual presently engaged in the Third Age looks different from that of his/her line ancestral. What is the expected future? The Third Age population is expanding and skin problems call for a variety of management procedures. Prevention of the diverse types of skin ageing has made tremendous progresses particularly in the field of preventive and corrective dermocosmetology. The future should further speed up such trends. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailNeonatal progeroid variant of Marfan syndrome with congenital lipodystrophy results from mutations at the 3' end of FBN1 gene.
Jacquinet, Adeline ULg; Verloes, Alain; Callewaert, Bert et al

in European journal of medical genetics (2014), 57(5), 230-4

We report a 16-year-old girl with neonatal progeroid features and congenital lipodystrophy who was considered at birth as a possible variant of Wiedemann-Rautenstrauch syndrome. The emergence of ... [more ▼]

We report a 16-year-old girl with neonatal progeroid features and congenital lipodystrophy who was considered at birth as a possible variant of Wiedemann-Rautenstrauch syndrome. The emergence of additional clinical signs (marfanoid habitus, severe myopia and dilatation of the aortic bulb) lead to consider the diagnosis of the progeroid variant of Marfan syndrome. A de novo donor splice-site mutation (c.8226+1G>A) was identified in FBN1. We show that this mutation leads to exon 64 skipping and to the production of a stable mRNA that should allow synthesis of a truncated profibrillin-1, in which the C-terminal furin cleavage site is altered. FBN1 mutations associated with a similar phenotype have only been reported in four other patients. We confirm the correlation between marfanoid phenotype with congenital lipodystrophy and neonatal progeroid features (marfanoid-progeroid-lipodystrophy syndrome) and frameshift mutations at the 3' end of FBN1. This syndrome should be considered in differential diagnosis of neonatal progeroid syndromes. [less ▲]

Detailed reference viewed: 29 (8 ULg)
Full Text
Peer Reviewed
See detailLa dermatoporose, un "vintage" de l'atrophodermie et de la "peau transparente".
FRANCHIMONT, Claudine ULg; Hermanns, J.F.; Hermanns-Lê, Trinh ULg et al

in Revue Médicale de Liège (2014), 69

Le vieillissement de la peau se marque à terme par une atrophodermie, parfois sévère. La corticothérapie, qu’elle soit systémique ou topique, exerce un effet atrophiant qui copie l’effet du grand âge. Cet ... [more ▼]

Le vieillissement de la peau se marque à terme par une atrophodermie, parfois sévère. La corticothérapie, qu’elle soit systémique ou topique, exerce un effet atrophiant qui copie l’effet du grand âge. Cet état d’atrophodermie a été décrit comme la «peau transparente» il y a une quarantaine d’années, et il a reçu plus récemment la nouvelle dénomination de dermatoporose. Il est connu de longue date que cet état entraîne des conséquences cliniques parfois majeures qui conduisent à des lésions diverses sous forme de purpura de Bateman, de cicatrices stellaires, et de plaies faisant suite à des traumatismes mineurs. [less ▲]

Detailed reference viewed: 26 (0 ULg)
Full Text
See detailGynecologic and obstetric impact of the Ehlers-Danlos syndrome: clues from scrutinizing dermal ultrastructural alterations.
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg et al

in Gynecology (2014), 2(1),

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective ... [more ▼]

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective tissue fragility. Each EDS type corresponds to a multisystemic disorder with widespread implications. Physicians evoke the EDS diagnosis in presence of some typical cutaneous signs, such as atrophic scars and frequent hematomas. Methods: To revisit the transmission electron microscopy support from skin biopsies when screening EDS in gynecology-obstetrics. Results: EDS women commonly suffer from a series of gynecologic and obstetric disorders. Dermal ultrastructural changes are keynote features suggesting some EDS types. Conclusion: Gene mutations are mostly identified in the classic and vascular EDS types, but only in sporadic cases of the hypermobile EDS type which apparently represents the most frequent type. Dermal ultrastructural changes represent relevant diagnostic clues for the practitioner. Preconception counseling about possible complications is welcome. Management requires precise diagnosis of the EDS type. [less ▲]

Detailed reference viewed: 34 (4 ULg)
Full Text
Peer Reviewed
See detailEffect of N-acetylcysteine combined with infliximab on toxic epidermal necrolysis. A proof-of-concept study.
PAQUET, Philippe ULg; JENNES, Serge; ROUSSEAU, Anne-Françoise ULg et al

in Burns : Journal of the International Society for Burn Injuries (2014)

Detailed reference viewed: 23 (4 ULg)
Full Text
Peer Reviewed
See detailIntense pulsed light in infantile hemangiomas.
PAQUET, Philippe ULg; Caucanas, Marie; FRANCHIMONT, Claudine ULg et al

in Open Access Journal of Science and Technology (2014), 2

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of ... [more ▼]

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of well-suited beta-blockers, as well as noncoherent light and laser therapies. The aim of this work was to revisit the effect of intense pulsed light (IPL) therapy on infantile hemangioma. Information was collected from the peer-reviewed literature and illustrated by personal cases. When applied early in the evolution of infantile hemangiomas, IPL treatment stops the growth phase and induces regression with minimal cosmetic adverse effects and psychological damage. Initiating an adequate treatment is important because damage due to hemangiomas can be diminished by a timely and adequate approach. Beta-blockers have revolutionized the therapeutic strategy of infantile hemangiomas. The flash light therapy (IPL) represents an alternative therapy for some patients. [less ▲]

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailLes vergetures, leurs couleurs et leur mécanobiologie.
FRANCHIMONT, Claudine ULg; Peters, S.; Hermanns, J.F. et al

in Revue Médicale de Liège (2014), 69

Detailed reference viewed: 14 (3 ULg)
Full Text
Peer Reviewed
See detailWomen's skin throughout lifetime.
PIERARD, Gérald ULg; CHARLIER, Corinne ULg; Delvenne, Philippe ULg et al

in BioMed Research International (2014), 2014

Detailed reference viewed: 25 (8 ULg)
Full Text
Peer Reviewed
See detailLe point de rosée en berne et la couche cornée hivernale.
PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg; Delvenne, Philippe ULg

in Revue Médicale de Liège (2014), 69(2), 68-71

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed ... [more ▼]

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed individuals during winter season. The reductions in the outdoor temperature, ambient moisture and dew point are the main physical factors involved in this process. We present the aspects seen under ultraviolet light and scanning electron microscopy. Keywords : Stratum corneum - Dew point [less ▲]

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailLa dermocosmétique en appui de traitements oncologiques ciblés.
FRANCHIMONT, Claudine ULg; Lesuisse, Marianne; PIERARD, Gérald ULg

in Revue Médicale de Liège (2014), 69(1), 35-37

Some recently introduced targeted treatments in cancerology are responsible for adverse effects on the skin. These events alter the patient well-being. Adequate dermocosmetic management allows to curb the ... [more ▼]

Some recently introduced targeted treatments in cancerology are responsible for adverse effects on the skin. These events alter the patient well-being. Adequate dermocosmetic management allows to curb the unwanted skin conditions without interfering with the targeted therapeutic effects. However, evidence-based support for using dermocosmetic products as adjunctive cancer treatment remains scarce. It remains nonetheless that the clinical perception is unanimously favourable for such procedure. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
See detailHand dermometrology
PIERARD, Gérald ULg; Pierard, Sébastien ULg; Franchimont, Claudine ULg et al

in Alikhan, A.; Lachapelle, J.M.; Maibach, M.I. (Eds.) Textbook of hand eczema. (2014)

Detailed reference viewed: 15 (0 ULg)
Peer Reviewed
See detailHedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas.
FRANCHIMONT, Claudine ULg; Hermanns-Lê, Trinh ULg; PAQUET, Philippe ULg et al

in Current approaches to basal cell carcinoma (2014)

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in patched homologue 1 (PTCH 1) or smoothened (SMO), two conducting proteins of the Hedgehog (Hh ... [more ▼]

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in patched homologue 1 (PTCH 1) or smoothened (SMO), two conducting proteins of the Hedgehog (Hh) pathway. They rarely progress deeply and metastasize; however, if they do, these advanced BCC become amenable to treatment by inhibiting the Hedgehog and the P13K–mTOR pathways. Such innovative drugs include vismodegib, cyclopamine, itraconazole, everolimus and a few other agents that are in early clinical development. [less ▲]

Detailed reference viewed: 83 (9 ULg)
Full Text
Peer Reviewed
See detailNail surface topography and onychochronobiology.
PIERARD, Gérald ULg; Franchimont, Claudine ULg

in Berardesca, E.; Wilhelm, K.P.; Maibach, H.I. (Eds.) Non invasive diagnostic techniques in clinical dermatology. (2014)

Detailed reference viewed: 24 (8 ULg)
Full Text
Peer Reviewed
See detailCorneosurfametry and corneoxenometry.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; REGINSTER, Marie-Annick ULg

in Berardesca, Enzo; Wilhelm, K.P.; Maibach, H.I. (Eds.) Non invasive diagnostic techniques in clinical dermatology. (2014)

Detailed reference viewed: 23 (7 ULg)
Full Text
Peer Reviewed
See detailCyanoacrylate skin surface / follicular stripping.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Delvenne, Philippe ULg et al

in Berardesca, Enzo; Wilhelm, KP; Maibach, H.I. (Eds.) Non invasive diagnostic techniques in clinical dermatology. (2014)

Detailed reference viewed: 30 (14 ULg)
Full Text
Peer Reviewed
See detailVisioscan-driven ULEV method.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Pierard, Sébastien ULg

in Berardesca, Enzo (Ed.) Non invasive diagnostic techniques in clinical dermatology. (2014)

Detailed reference viewed: 12 (1 ULg)