References of "Pierard, Gérald"
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See detailHedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas.
FRANCHIMONT, Claudine ULg; Hermanns-Lê, Trinh ULg; PAQUET, Philippe ULg et al

in Current approaches to basal cell carcinoma (2014)

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in patched homologue 1 (PTCH 1) or smoothened (SMO), two conducting proteins of the Hedgehog (Hh ... [more ▼]

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in patched homologue 1 (PTCH 1) or smoothened (SMO), two conducting proteins of the Hedgehog (Hh) pathway. They rarely progress deeply and metastasize; however, if they do, these advanced BCC become amenable to treatment by inhibiting the Hedgehog and the P13K–mTOR pathways. Such innovative drugs include vismodegib, cyclopamine, itraconazole, everolimus and a few other agents that are in early clinical development. [less ▲]

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See detailNail surface topography and onychochronobiology.
PIERARD, Gérald ULg; Franchimont, Claudine ULg

in Berardesca, E.; Wilhelm, K.P.; Maibach, H.I. (Eds.) Non invasive diagnostic techniques in clinical dermatology. (2014)

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See detailCorneosurfametry and corneoxenometry.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; REGINSTER, Marie-Annick ULg

in Berardesca, Enzo; Wilhelm, K.P.; Maibach, H.I. (Eds.) Non invasive diagnostic techniques in clinical dermatology. (2014)

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See detailCyanoacrylate skin surface / follicular stripping.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Delvenne, Philippe ULg et al

in Berardesca, Enzo; Wilhelm, KP; Maibach, H.I. (Eds.) Non invasive diagnostic techniques in clinical dermatology. (2014)

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See detailVisioscan-driven ULEV method.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Pierard, Sébastien ULg

in Berardesca, Enzo (Ed.) Non invasive diagnostic techniques in clinical dermatology. (2014)

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See detailSkin Cancer
Lian, C.G.; Mihm, M.C.; PIERARD, Gérald ULg et al

in Stewart, B.W.; Wild, C.P. (Eds.) World Cancer Report 2014. (2014)

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See detailLa cascade des MAP kinases : traitements ciblés en cancérologie cutanée.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; LEONARD, Boris ULg et al

in Revue Médicale de Liège (2013), 68(12), 650-654

Résumé : Les «Mitogen-Activated Protein Kinases» (MAPK) forment un ensemble coordonné de protéines cellulaires impliquées dans la prolifération, la différenciation, la migration et l’apoptose des cellules ... [more ▼]

Résumé : Les «Mitogen-Activated Protein Kinases» (MAPK) forment un ensemble coordonné de protéines cellulaires impliquées dans la prolifération, la différenciation, la migration et l’apoptose des cellules. Elles sont particulièrement activées, par certaines cytokines, hormones, le stress environnemental, ainsi que dans des cancers cutanés. Des agents pharmacologiques ciblés contre la cascade MAPK révolutionnent actuellement la cancérologie cutanée, du moins dans une phase transitoire du processus métastatique. Des traitements combinés sont susceptibles d’améliorer la survie médiane. [less ▲]

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See detailDermal ultrastructure in collagen VI myopathy.
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg; Franchimont, Claudine ULg et al

in Ultrastructural Pathology (2013)

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See detailEhlers-Danlos syndrome.
Hermanns-Lê, Trinh ULg; REGINSTER, Marie-Annick ULg; Franchimont, Claudine ULg et al

in Stirling, J; Curry, A; Eyden, B (Eds.) Diagnostic electron microscopy (2013)

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See detailRevisiting the cutaneous impact of oral hormone replacement therapy.
PIERARD, Gérald ULg; Humbert, Philippe; Berardesca, Enzo et al

in BioMed Research International (2013), 2013(971760),

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See detailLa vignette diagnostique de l'etudiant. Le spectre des toxidermies.
Hermanns-Lê, Trinh ULg; Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2013), 68(1), 44-50

Drug eruptions are frequently encountered and they represent "diseases of medical progress". They are expected in about 2% of treated patients. Their putative diagnosis is based on a set of imputability ... [more ▼]

Drug eruptions are frequently encountered and they represent "diseases of medical progress". They are expected in about 2% of treated patients. Their putative diagnosis is based on a set of imputability factors. Several distinct drug-induced skin disorders are identified. They are initially recognized from personal experience, but the implication to a specific drug derives from the collective experience of published evidence. Their histopathological aspect is often evocative or demonstrative for the nature of the dermatosis. Some drug eruptions follow an indolent course, while others are life-threatening. [less ▲]

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See detailSkin viscoelasticity during hormone replacement therapy for climacteric ageing.
Pierard, Gérald ULg; Hermanns-Lê, Trinh ULg; PAQUET, Philippe ULg et al

in International journal of cosmetic science (2013), 36

BACKGROUND: Climacteric ageing refers to the period of women's life centred by the perimenopause. This step of life is responsible for initiating skin atrophic withering and slackness responsible for ... [more ▼]

BACKGROUND: Climacteric ageing refers to the period of women's life centred by the perimenopause. This step of life is responsible for initiating skin atrophic withering and slackness responsible for changes in the viscoelasticity of the dermal connective tissue. Some women benefit from hormone replacement therapy (HRT) for controlling some unpleasant internal climacteric changes (osteoporosis, vasomotor instability, ...). OBJECTIVE: To investigate some corrective effects of HRT on the functional damages in the dermal tensile strength. PATIENTS AND METHODS: This study was performed on 200 healthy Caucasian women. In vivo skin viscoelasticity was assessed using the suction method. RESULTS: Skin distensibility and hysteresis appeared increased at menopause with or without HRT. By contrast, the biological elasticity significantly decreased out of HRT. CONCLUSION: Some drugs and cosmetics might attempt at improving such viscoelastic attributes of the skin at menopause. [less ▲]

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See detailFibromyalgie: un syndrome d'Ehlers-Danlos de type hypermobile qui s'ignore?
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg; Angenot, Ph

in Revue Médicale de Liège (2013), 68(1), 22-4

Some patients suffering from fibromyalgia present with clinical signs and alterations in the histopathology, immunohistochemistry and ultrastructure of the dermis similar to the Ehlers-Danlos syndrome ... [more ▼]

Some patients suffering from fibromyalgia present with clinical signs and alterations in the histopathology, immunohistochemistry and ultrastructure of the dermis similar to the Ehlers-Danlos syndrome, hypermobile type (EDSH). Some types of fibromyalgia possibly represent an undiagnosed EDSH. [less ▲]

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See detailCyclic catamenial dermatoses.
Hermanns-Lê, Trinh ULg; Hermanns, Jean François; Lesuisse, Marianne et al

in BioMed Research International (2013), 2013

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See detailL'addiction au Soleil, son estocade et la parade des crèmes solaires.
FRANCHIMONT, Claudine ULg; Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 321-325

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See detailEhlers-Danlos syndrome type VIII: a rare cause of leg ulcers in young patients.
Ronceray, Sophie; Miquel, J.; Lucas, A. et al

in Case Reports in Dermatological Medicine (2013), 2013

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See detailThe skin landscape in diabetes mellitus. Focus on dermocosmetic management.
PIERARD, Gérald ULg; Seite, Sophie; Hermanns-Lê, Trinh ULg et al

in Clinical, Cosmetic and Investigational Dermatology (2013), 6

BACKGROUND: Some relationships are established between diabetes mellitus (DM) and a series of cutaneous disorders. Specific dermatoses are markers for undiagnosed DM. Other disorders represent supervening ... [more ▼]

BACKGROUND: Some relationships are established between diabetes mellitus (DM) and a series of cutaneous disorders. Specific dermatoses are markers for undiagnosed DM. Other disorders represent supervening complications in an already treated DM patient. OBJECTIVE: To review the information about dermocosmetic care products and their appropriate use in the management and prevention of dermatoses related to DM. METHOD: The peer-reviewed literature and empiric findings are covered. Owing to the limited clinical evidence available for the use of dermocosmetics, a review of the routine practices and common therapies in DM-related dermatoses was conducted. RESULTS: Some DM-related dermatoses (acanthosis nigricans, pigmented purpuric dermatosis) are markers of macrovascular complications. The same disorders and some others (xerosis, Dupuytren's disease) have been found to be more frequently associated with microangiopathy. Other skin diseases (alopecia areata, vitiligo) were found to be markers of autoimmunity, particularly in type 1 DM. Unsurprisingly, using dermocosmetics and appropriate skin care has shown objective improvements of some DM-related dermatoses, such effects improve the quality of life. The most common skin manifestations of DM fall along continuum between "dry skin," xerosis, and acquired ichthyosis, occurring predominately on the shins and feet. Dermocosmetic products improve the feeling of well-being for DM patients. [less ▲]

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See detailComment j'explore ... l'atteinte fonctionnelle cutanee d'une sclerodermie.
Hermanns-Lê, Trinh ULg; Franchimont, Claudine ULg; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2013), 68(3), 141-7

Scleroderma refers to distinct clinical presentations sharing in common a sclerotic process most often clinically obvious on the skin. The involvement possibly affects the skin alone in morphea or in ... [more ▼]

Scleroderma refers to distinct clinical presentations sharing in common a sclerotic process most often clinically obvious on the skin. The involvement possibly affects the skin alone in morphea or in combination with internal lesions in systemic sclerosis. Some objective and non-invasive functional assessments are useful for better appreciating the severity and evolution of the disease, as well as to monitor the therapeutic efficacy. In this endeavour, in vivo measurements of the skin mechanical properties are unsurprisingly informative. [less ▲]

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