References of "Pierard, Gérald"
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See detailAnalytic assessment under ultraviolet light of actinic lentigines under bleaching treatment.
PIERARD, Gérald ULg; Seite, Sophie; Rougier, Andre et al

in Journal of Cosmetic Dermatology (2011), 10(2), 104-9

BACKGROUND: Actinic (solar) lentigines are melanotic tumors frequently developed during photoaging on the dorsum of the hands. Bleaching (whitening) agents are commonly offered to fade their darker aspect ... [more ▼]

BACKGROUND: Actinic (solar) lentigines are melanotic tumors frequently developed during photoaging on the dorsum of the hands. Bleaching (whitening) agents are commonly offered to fade their darker aspect. In general, regular colorimetric methods show poor sensitivity to disclose any bleaching effect. METHOD: The present randomized controlled study on 24 women was designed to objectively assess the clinical efficacy of a combination of bleaching agents on actinic lentigines. In the endeavor of improving sensitivity, the ultraviolet light-enhanced visualization (ULEV) method was used to derive analytical measurements of lentigo areas and darkness. The test product was a commercially available formulation associating glycolic acid, kojic acid, lipohydroxyacid, and a Vitreoscilla extract. The Analysis(R) Olympus and Adobe Photoshop(R) quantitative methods were applied to the ULEV pictures. RESULTS: Data indicated a rapid bleaching effect arising as early as after 1 month of daily applications. The effect progressively increased over 3 months of therapy. CONCLUSION: The presently described analytical method appears to be sensitive to document some bleaching effects on actinic lentigines. [less ▲]

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See detailMechanobiology and cell tensegrity: the root of ethnic hair curling?
Pierard-Franchimont, Claudine; PAQUET, Philippe ULg; QUATRESOOZ, Pascale ULg et al

in Journal of Cosmetic Dermatology (2011), 10(2), 163-7

BACKGROUND: The hair shape, either straight, crimp, or curly, is basically under genetic influence. It is possibly altered by some drugs such as cytostatic agents. In addition, specific innate molecular ... [more ▼]

BACKGROUND: The hair shape, either straight, crimp, or curly, is basically under genetic influence. It is possibly altered by some drugs such as cytostatic agents. In addition, specific innate molecular characteristics are modulated by some cosmetic procedures to reshape the hair shafts. AIM: To revisit the possible implication of mechanobiology and cell tensegrity in shaping ethnic hair. MATERIALS AND METHODS: Optical and scanning electron microscopy of hairs. RESULTS: It is generally held that the cross-section shape of hair is related to differences in the global aspect of the hair shaft. A possible biologic link between these features may rely on shaping cell tensegrity at any portion of the hair shaft. Cell tensegrity encompasses all intrinsic and extrinsic forces responsible for the three-dimensional arrangement of intracellular macromolecules. CONCLUSION: We offer as a hypothesis that the hair shape in part depends on the organization of the cell proliferation in the hair matrix. This review gathers observations supporting the involvement of cell tensegrity in shaping the hair shaft. [less ▲]

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See detailRadionécrose historique
CAUCANAS, Marie ULg; PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg et al

in Revue Médicale de Liège (2011), 66

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See detailComment j'explore ... l'hypothese diagnostique d'une syphilis.
PIERARD-FRANCHIMONT, Claudine ULg; CAUCANAS, Marie ULg; QUATRESOOZ, Pascale ULg et al

in Revue Médicale de Liège (2011), 66(10), 550-4

The versatility of the clinical presentations of syphilis is large. A laboratory diagnosis is required in any case where a clinical assumption is raised. Two main diagnostic methods are available ... [more ▼]

The versatility of the clinical presentations of syphilis is large. A laboratory diagnosis is required in any case where a clinical assumption is raised. Two main diagnostic methods are available according to the lesion aspects and the staging of the disease. They rely on the recognition of the spirochete or on the identification of the immune response using specific and non specific serology tests. [less ▲]

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See detailImputabilite medicamenteuse dans les iatrogenies cutanees.
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; REGINSTER, Marie-Annick ULg et al

in Revue Médicale de Liège (2011), 66(9), 474-7

Drug eruptions are frequently encountered. Their putative diagnosis is based on a set of imputability arguments. The histopathological aspect is often evocative of the nature of the dermatosis. It varies ... [more ▼]

Drug eruptions are frequently encountered. Their putative diagnosis is based on a set of imputability arguments. The histopathological aspect is often evocative of the nature of the dermatosis. It varies according to the type of drug reaction. Some drug eruptions follow a benign course, but others are life-threatening. [less ▲]

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See detailLes coulisses du cancer mammaire.
CAUCANAS, Marie ULg; PIERARD-FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 269-73

A 55 year-old women presented with lesions simulating cysts of the scalp. The dermatopathological examination revealed a metastasis of a breast adenocarcinoma. At the diagnosis disclosure, the patient ... [more ▼]

A 55 year-old women presented with lesions simulating cysts of the scalp. The dermatopathological examination revealed a metastasis of a breast adenocarcinoma. At the diagnosis disclosure, the patient recognized having concealed for 7 years a neoplastic wound replacing one of her breasts. About this case report, we report the astonishing clinical diversity of skin metastases of breast adenocarcinomas. [less ▲]

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See detailLa maladie de Paget mammaire indicatrice d'un adenocarcinome sous-jacent.
REGINSTER, Marie-Annick ULg; QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 265-8

Mammary Paget's disease is an intraepithelial carcinoma present on the nipple and its areola. The tumor typically develops in middle aged women. It is frequently associated or contiguous to an underlying ... [more ▼]

Mammary Paget's disease is an intraepithelial carcinoma present on the nipple and its areola. The tumor typically develops in middle aged women. It is frequently associated or contiguous to an underlying galactophoric adenocarcinoma. The histopathologic and immunopathologic aspects are typical and linked to the presence of Paget's cells. Early diagnosis is required searching for a possible underlying carcinoma. The surgical treatment is directed by the characteristics of the deep mammary carcinoma. [less ▲]

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See detailSpecular light reflectance of flakes in seborrhoeic dermatitis of the scalp: a pilot study.
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; PIERARD, Gérald ULg

in Clinical & Experimental Dermatology (2011), 36(7), 793-6

Seborrhoeic dermatitis and dandruff are common scalp conditions. In this study, we set out to explore a new method for rating both the severity of the scalp condition and the efficacy of scalp-care ... [more ▼]

Seborrhoeic dermatitis and dandruff are common scalp conditions. In this study, we set out to explore a new method for rating both the severity of the scalp condition and the efficacy of scalp-care compounds. Scalp flakiness was sampled for 40 volunteers using adhesive-coated clear discs, with image analysis used to quantify the specular light reflectance (SLR) of the flakes Two ultraviolet (UV)-emitting charge-coupled device cameras (Visioscan VC98 and Visiopor PP34) were used. SLR clearly highlighted the flakiness with high contrast against a black background, and the recorded appearance could be conveniently submitted to the image-analysis system for quantification. In conclusion, SLR under UV illumination highlights scalp flakiness, allowing objective measurements. [less ▲]

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See detailL'image du mois. Quand tout va a vau-l'eau: evolution cataclysmique d'un melanome a croissance rapide.
Bourguignon, R.; Lesuisse, M.; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2011), 66(3), 117-20

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See detailPhotoaging under recreational sunbeds.
QUATRESOOZ, Pascale ULg; HENRY, Frédérique ULg; PAQUET, Philippe ULg et al

in Skin Research & Technology (2011)

Background: Artificial sources of restricted light wavelength, particularly tanning beds, are progressively gaining importance in photoaging. Objective: To assess the kinetics and the long-term evolution ... [more ▼]

Background: Artificial sources of restricted light wavelength, particularly tanning beds, are progressively gaining importance in photoaging. Objective: To assess the kinetics and the long-term evolution of skin pigmentation and tensile functions in sunbed worshippers over a period of 8 years. Methods: Photoaging was explored in women who were both sunshine and sunbed worshippers. A series of 65 phototype III women aged 31-46 years completed a 100-month survey. Quarterly assessments were performed on the forearms to measure (a) the skin color individual typology angle (ITA degrees ), (b) the extent in mottled subclinical melanoderma (MSM) using the ultraviolet light-enhanced visualization method and (c) the rheological properties of skin. Results: A progressive increase in both skin extensibility and hysteresis was observed, contrasting with a decrease in biologic elasticity. These rheological changes were correlated with the ITA degrees changes, but not with the MSM extent. The kinetics of evolution of each test variable were distinct over time. Discussion: This work is the first attempt at evaluating the kinetics of changes in physical parameters during a long period of frequent exposures to tanning sunbeds and sunshine for lifestyle purposes. The alterations were quite important in the color, MSM and rheological functions of the skin. [less ▲]

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See detailFacing up to the imperceptible perspiration. Modulatory influences by diabetic neuropathy, physical exercise and antiperspirant.
Xhauflaire-Uhoda, E.; Mayeux, G.; Quatresooz, Pascale ULg et al

in Skin Research & Technology (2011)

Background: Sweating is variably altered by physical exercise, diabetic neuropathy and antiperspirants. Methods: Skin temperature, skin surface water loss (SSWL), the Corneometer((R)) average capacitance ... [more ▼]

Background: Sweating is variably altered by physical exercise, diabetic neuropathy and antiperspirants. Methods: Skin temperature, skin surface water loss (SSWL), the Corneometer((R)) average capacitance (CMAC) and skin capacitance mapping (SCM) were measured before and after moderate physical exercise in 20 healthy subjects. The effect of 5% aluminium chloride hexahydrate (ACH) in a water solution was similarly tested. The same assessments were performed in 20 diabetic patients at rest. Results: Diabetic neuropathy appeared at rest as an increased (compensatory) SCM on the forearms without obvious modification on the hypohidrotic legs. On ACH sites after exercise, SCM revealed both a lowered number of active sweat glands and a lighter stratum corneum (SC) (dryness). In addition, CMAC and SSWL were decreased on ACH sites at rest and at completion of exercise. Conclusion: In diabetic neuropathy, the compensatory hyperhidrosis is more easily disclosed than the hypohidrosis. ACH affects both sweat excretion and the SC hydration. [less ▲]

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See detailComment j'explore...le meli-melo des ichtyoses.
Hermanns-Le, Trinh ULg; REGINSTER, Marie-Annick ULg; QUATRESOOZ, Pascale ULg et al

in Revue Médicale de Liège (2011), 66(2), 102-8

Ichthyoses are hereditary and sometimes acquired diseases of keratinisation. They are heterogeneous according to their clinical and histopathological presentations, as well as to the nature of their ... [more ▼]

Ichthyoses are hereditary and sometimes acquired diseases of keratinisation. They are heterogeneous according to their clinical and histopathological presentations, as well as to the nature of their molecular and genetic alterations. We present the most frequent types of hereditary ichthyoses. [less ▲]

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See detailIntroduction a l'analyse spectrale des reseaux microvasculaires du melanome cutane primitif.
Quatresooz, Pascale ULg; PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg et al

in Pathologie Biologie (2010)

Cutaneous malignant melanoma represents one of the most dramatic skin cancers because its incidence is steadily growing in White populations. Of note, its metastatic risk and mortality dramatically ... [more ▼]

Cutaneous malignant melanoma represents one of the most dramatic skin cancers because its incidence is steadily growing in White populations. Of note, its metastatic risk and mortality dramatically increase when the primary neoplasm reaches about one millimeter thick. It is believed that angiogenesis and lymphangiogenesis associated with cutaneous melanoma potentially influence the neoplastic progression of the primary tumor and its metastases. In some instances, both the intratumoral and peritumoral microvasculature are correlated to booming of the tumoral growth fraction. In addition, the vascular network serves as a migration path for the intravascular and perivascular neoplastic spread. Hence, the quantification of the microvasculature might help establishing a prognostic factor of evolution. Among the available methods, spectral analysis of immunohistochemical sections highlighting vessels helps defining the microvasculature distribution. The benefit of using spectral analysis is discussed and the modalities of application of this analytical method are scrutinized. [less ▲]

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See detailIntroduction a l'analyse spectrale des reseaux microvasculaires du melanome cutane primitif.
Quatresooz, Pascale ULg; Pierard, Gérald ULg; FRANCHIMONT, Claudine ULg et al

in Pathologie Biologie (2010), 60

Cutaneous malignant melanoma represents one of the most dramatic skin cancers because its incidence is steadily growing in White populations. Of note, its metastatic risk and mortality dramatically ... [more ▼]

Cutaneous malignant melanoma represents one of the most dramatic skin cancers because its incidence is steadily growing in White populations. Of note, its metastatic risk and mortality dramatically increase when the primary neoplasm reaches about one millimeter thick. It is believed that angiogenesis and lymphangiogenesis associated with cutaneous melanoma potentially influence the neoplastic progression of the primary tumor and its metastases. In some instances, both the intratumoral and peritumoral microvasculature are correlated to booming of the tumoral growth fraction. In addition, the vascular network serves as a migration path for the intravascular and perivascular neoplastic spread. Hence, the quantification of the microvasculature might help establishing a prognostic factor of evolution. Among the available methods, spectral analysis of immunohistochemical sections highlighting vessels helps defining the microvasculature distribution. The benefit of using spectral analysis is discussed and the modalities of application of this analytical method are scrutinized. [less ▲]

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See detailLe botryomycome.
Wauters, Odile ULg; Sabatiello, Murielle ULg; Nikkels, Nazli ULg et al

in Annales de Dermatologie et de Vénéréologie (2010), 137(3), 238-42237243

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See detailL'image du mois. Calcinose idiopathique du scrotum.
Paquet, Philippe ULg; Devillers, C.; Szepetiuk, Grégory ULg et al

in Revue Médicale de Liège (2010), 65(3), 113-4

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See detailCutaneous papules in a patient with AIDS.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Paquet, Philippe ULg et al

in Dermatology Reports (2010), 2(e2), 4-5

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See detailImagerie de la microcirculation cutanée défaillante.
QUATRESOOZ, Pascale ULg; REGINSTER, Marie-Annick ULg; FRANCHIMONT, Claudine ULg et al

in Dermatologie Actualité (2010), 123

Le réseau microvasculaire de la peau joue des rôles physiologiques majeurs en oxygénant les tissus et en permettant des échanges thermiques finement régulés. Son parcours résistif et capacitif module les ... [more ▼]

Le réseau microvasculaire de la peau joue des rôles physiologiques majeurs en oxygénant les tissus et en permettant des échanges thermiques finement régulés. Son parcours résistif et capacitif module les résistances périphériques au débit sanguin. La microvascularisation est sous l’influence de divers facteurs, mais globalement, elle semble presque immuable dans la peau saine. En revanche, certaines circonstances pathologiques engendrent des hyperplasies ou des hypoplasies vasculaires. Parfois aussi, le réseau semble garder son extension normale, mais sa structure intime est remaniée. Cette revue est un florilège d’aspects microscopiques associés à des perturbations majeures de la fonctionnalité vasculaire cutanée. [less ▲]

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