References of "Pierard, Gérald"
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See detailSkin ultrastructural similarities between fibromyalgia and Ehlers-Danlos syndrome hypermobility type
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg

in Journal of osteoarthritis (2015), 1(1),

Fibromyalgia (FM) and hypermobility type Ehlers-Danlos syndrome (EDSH) share a series of common clinical signs. A clinical distinction between both diseases is occasionally difficult to be established ... [more ▼]

Fibromyalgia (FM) and hypermobility type Ehlers-Danlos syndrome (EDSH) share a series of common clinical signs. A clinical distinction between both diseases is occasionally difficult to be established. The physical changes observed in the mechanical properties of skin and joints do not distinctly distinguish these disorders. In addition, similar ultrastructural dermal changes are observed in both EDSH and some FM cases. The molecular alterations remain largely undisclosed in both diseases. As a result, EDSH remains undiagnosed in some FM patients. This condition deteriorates quality of life and possibly leads to prominent health problems. [less ▲]

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See detailHedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas.
FRANCHIMONT, Claudine ULg; Hermanns-Lê, Trinh ULg; PAQUET, Philippe ULg et al

in Future Oncology (2015), 11

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in patched homologue 1 (PTCH 1) or smoothened (SMO), two conducting proteins of the Hedgehog (Hh ... [more ▼]

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in patched homologue 1 (PTCH 1) or smoothened (SMO), two conducting proteins of the Hedgehog (Hh) pathway. They rarely progress deeply and metastasize; however, if they do, these advanced BCC become amenable to treatment by inhibiting the Hedgehog and the P13K–mTOR pathways. Such innovative drugs include vismodegib, cyclopamine, itraconazole, everolimus and a few other agents that are in early clinical development. [less ▲]

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See detailCOSMÉTIQUES, SANTÉ ET ENVIRONNEMENT Actualisation d’une diatribe justifiée ou exagérée ?
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Lesuisse, Marianne et al

in Revue Médicale de Liège (2015), 70

In recent years, the population and producers of consumer products became aware of deleterious effects of some substances on human health and environment. Cosmetic products are part of such concern. What ... [more ▼]

In recent years, the population and producers of consumer products became aware of deleterious effects of some substances on human health and environment. Cosmetic products are part of such concern. What are the risks currently involved? The so-called «natural», «bio» or «green» products, do they represent an ideal panacea ? This topic has a complex issue because documents available for the general public are of unequal quality, and objective scientifc publications remain rare and prone to controversies. [less ▲]

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See detailSweat Gland Awakening on Physical Training: A Skin Capacitance Mapping Observation
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Clinical Research in Dermatology : Open Access (2015), 2

Skin capacitance mapping (SCM) is an established real-time noninvasive method useful in the assessment of sweat production. We presently review and explore the sweat gland production following a mild 10 ... [more ▼]

Skin capacitance mapping (SCM) is an established real-time noninvasive method useful in the assessment of sweat production. We presently review and explore the sweat gland production following a mild 10-min physical training on a cycloergometer. Sprouts of sweat vapor are progressively increased by recruiting increasing numbers of active sweat pores. An overall moisturization of the stratum corneum ensues, and liquid sweat appears in a further step. These aspects are conveniently assessed using SCM while blind assessments of the skin surface water loss cannot distinguish these functional features. [less ▲]

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See detailSimulants of malignant melanoma
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Delvenne, Philippe ULg

in Oncology Reviews (2015), 9

During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains ... [more ▼]

During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further suggested such as MELTUMP (after melanocytic tumor of uncertain malignant potential) and STUMP (after Spitzoid melanocytic tumor of uncertain malignant potential). In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM) variants, are grouped under the tentative broad heading skin melanocytoma. Such set of AMN frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas), and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and MM remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any malignancy risk if present. [less ▲]

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See detailCutaneous Melanocytomas: Variants and Caveats
Pierard, Gérald ULg; Franchimont, Claudine ULg

in Austin Journal of Cancer and Clinical Research (2015), 2(3), 1035

There is a regular improvement in the early clinical disclosure of various atypical melanocytic neoplasms (AMN). The histopathological examination of AMN remains mandatory for establishing their diagnosis ... [more ▼]

There is a regular improvement in the early clinical disclosure of various atypical melanocytic neoplasms (AMN). The histopathological examination of AMN remains mandatory for establishing their diagnosis and proper management. Panels of experts in AMN diagnosis report only moderate agreement in a diversity of puzzling cases. Some AMN have been differently designated in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus and pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further offered such as MELTUMP (after “melanocytic tumor of uncertain malignant potential”) and STUMP (after “Spitzoid melanocytic tumor of uncertain malignant potential”). In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM) variants, are grouped under the tentative broad heading cutaneous melanocytoma. These lesions typically follow an indolent course, although they exhibit an atypical and sometimes worrisome patterns or cytologic aspects. Rare cases of cutaneous melanocytomas progress to locoregional clusters of lesions (agminate lesions), and even to regional lymph nodes. At times, the distinction between a cutaneous melanocytoma and MM remains problematic and even proves to be merely impossible. However, multipronged immunohistochemistry helps assessing the malignancy risk. [less ▲]

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See detailRegarder dans une boule de cristal et dépister des sujets à risque pour le mélanome cutané
Pierard, Gérald ULg; Franchimont, Claudine ULg; Hermanns-Lê, Trinh ULg et al

in Revue Médicale de Liège (2015), 70

Cutaneous melanoma is the deadliest skin cancer showing an increasingly growing incidence in white populations of Europe and United States. Intensive research in recent years has begun to unlock its ... [more ▼]

Cutaneous melanoma is the deadliest skin cancer showing an increasingly growing incidence in white populations of Europe and United States. Intensive research in recent years has begun to unlock its molecular pathogenesis. Screening the neoplasm at an early stage remains primordial. Hence, targeting populations at risk is likely efficient. In such an attempt, the regular clinical examination benefits from a series of non invasive procedures such as skin surface biopsies, in vivo confocal microscopy, dermoscopy and specular fluorescent light reflectance. [less ▲]

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See detailProtomyofibroblast Pathway in Early Thermal Burn Healing
Hermanns-Lê, Trinh ULg; Pierard, Gérald ULg; jennes, Serge et al

in Skin Pharmacology & Physiology (2015), 28

Wound healing following partial thickness thermal burns is commonly hampered by the risk of hypertrophic scarring. Skin myofibroblast (MF) density is commonly increased in postburn healing. The transition ... [more ▼]

Wound healing following partial thickness thermal burns is commonly hampered by the risk of hypertrophic scarring. Skin myofibroblast (MF) density is commonly increased in postburn healing. The transition between fibroblast-like cells and α-smooth muscle actin (SMA)+ MF possibly begins with CD14+ monocytes, evolving to CD14+ CD34+ fibrocytes, followed by β-SMA+ protomyofibroblast (PMF) maturation. Skin biopsies from 25 burn patients were collected about 1 and 4 weeks after injury. Immunohistochemistry was performed using monoclonal antibodies to α-SMA, β-SMA, factor XIIIa, lysozyme, Mac 387, CD14, CD117 and Ulex europaeus agglutinin-1 (UEA-1). The set of Mac 387+ and CD14+ monocytes was accompanied by both CD34+ fibrocytes and factor XIIIa+ dendrocytes. By contrast, β-SMA+ PMF were rare. Of note, α-SMA+ MF were more abundant at week 4 than at week 1 (p < 0.01). The UEA-1+ endothelial cells showed marked variations in their dermal distribution, irrespective of the densities in the other scrutinized cells. In conclusion, healing of partial thickness thermal burns involves a diversity of cell types including PMF. In the present samples, the PMF density remained low. [less ▲]

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See detailSyndrome d'Ehlers-Danlos de type hypermobile: une atteinte multisystémique. Apport de l'ultrastructure cutanée pour une prise en charge personnalisée
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg; PIERARD-FRANCHIMONT, Claudine ULg et al

in Revue Médicale de Liège (2015), 70(5-6), 325-330

Ehlers-Danlos syndrome (EDS) represents a heterogenous group of disorders of the connective tissue structure. Currently, several types are distinguish following a limited set of clinical signs and genetic ... [more ▼]

Ehlers-Danlos syndrome (EDS) represents a heterogenous group of disorders of the connective tissue structure. Currently, several types are distinguish following a limited set of clinical signs and genetic mutations. However, there is a lack of specificity of most recognized genetic alterations with the current clinical typing. In addition, the criteria from dermatopathology, ultrastructure and biomechanics are not considered. In addition, the establish frontiers are hazardous because a series of anatomo-clinical signs are not considered in the classical EDS concept. The hypermobile type EDS represents an example of the diagnostic uncertainties. It results that guidelines based on evidence-based medecine cannot be established. Only an individual management can be offerted to the concerned patients. [less ▲]

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See detailLe mélanome cutané sporadique au-delà de sa classification normative. Plaidoyer prenant en compte son particularisme évolutif
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg

in Revue Médicale de Liège (2015), 70(5-6), 277-281

For aeons, cutaneous sporadic melanoma, exhibiting either a slow or rapid growth rate, is identified using a set of well defined histopathological criteria. Such diagnostic step is greatly appreciated ... [more ▼]

For aeons, cutaneous sporadic melanoma, exhibiting either a slow or rapid growth rate, is identified using a set of well defined histopathological criteria. Such diagnostic step is greatly appreciated, and it brings a rough estimate of the probable evolution of the cancer. Some additional assessments try to improve the progressive prognosis of cutaneous melanoma. In this scope, fractals and spectral analyses expect to better perceive the individual progressive characteristics of each tumor. The extent in the tumoral germinative compartment and the peritumoral microvascular network are explored and should in a near future make clear the progressive potential of cutaneous melanoma. The possible tumoral regression and the immune reaction should be better perceived. [less ▲]

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See detailThe conundrum of toxic epidermal necrolysis
Pierard, Gérald ULg; PAQUET, Philippe ULg; Jennes, Serge et al

Book published by Novapublishers - Nova Biomedical (2015)

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See detailFrom observational to analytical morphology of the stratum corner: progress avoiding hazardous animal and human testings.
PIERARD, Gérald ULg; Courtois, J.; Ritacco, C. et al

in Clinical, Cosmetic and Investigational Dermatology (2015), 8

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See detailComment j'explore ... le "cheetah-look". Regard sur la peau sous des longueurs d'ondes particulieres de la lumiere.
Pierard-Franchimont, Claudine ULg; Hermanns-Lê, Trinh ULg; Pierard, Gérald ULg et al

in Revue medicale de Liege (2015), 70(4), 204-6

The melanotic facial pigmentation of each individual is frequently heterogeneous, even when this condition remains imperceptible under natural ambient light. However, with aging, this aspect may appear to ... [more ▼]

The melanotic facial pigmentation of each individual is frequently heterogeneous, even when this condition remains imperceptible under natural ambient light. However, with aging, this aspect may appear to everybody. The melanin heterochromia has various origins including ethnicity, the hormonal impact, the influence of various inflammatory, toxic and drug-induced disorders, as well as the impact of photoaging. The cheetah-look aspect is thus established and well identified under ultraviolet light or using an ingenious trick selecting some wavelengths of visible light. [less ▲]

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See detailLes cheveux et leur environnement.
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue medicale de Liege (2015), 70(2), 70-2

Hair is influenced by the effects of the daily environment. Some toxic xenobiotics slow down or block the cell renewal of the hair matrix, thus inhibiting hair growth. The ultraviolet light obviously ... [more ▼]

Hair is influenced by the effects of the daily environment. Some toxic xenobiotics slow down or block the cell renewal of the hair matrix, thus inhibiting hair growth. The ultraviolet light obviously influences the physical structure and physiology of the hair follicle. Tobacco is similarly responsible for negative influences on the evolution of various alopecias. Several cosmetic procedures for maintaining and making hair more attractive are not always harmless, and they occasionally represent a possible origin for alopecia. [less ▲]

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See detailComment je traite... une onychomycose par voie topique.
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg

in Revue medicale de Liege (2015), 70(1), 5-11

Onychomycosis is a frequent and challenging disease to treat. Well conducted oral therapies are commonly quite effective for a short term period. However, recurrences are frequent. Topical therapies ... [more ▼]

Onychomycosis is a frequent and challenging disease to treat. Well conducted oral therapies are commonly quite effective for a short term period. However, recurrences are frequent. Topical therapies appear globally less active. Studies in this field are rare, although the promotional advertisements to the general public abound nowadays. Various microscopic fungi (dermatophytes, yeasts, molds) should be targeted by the treatment, In addition, the distinct activity conditions of both growth and quiescence of the pathogen fungi should be influenced by the treatments. This is not frequently considered by drug companies and encountered in practice. The antifungal drug penetration inside all the nail layers is important to be performed. [less ▲]

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See detailIn vivo skin fluorescence imaging in young Caucasian adults with early malignant melanomas
PIERARD, Gérald ULg; Hermanns-Lê, Trinh ULg; Pierard, Sébastien ULg et al

in Clinical, Cosmetic and Investigational Dermatology (2014), 7

Background: Human cutaneous malignant melanoma (CMM) is an aggressive cancer showing a dramatic worldwide increase in incidence over the past few decades. The most prominent relative epidemiological ... [more ▼]

Background: Human cutaneous malignant melanoma (CMM) is an aggressive cancer showing a dramatic worldwide increase in incidence over the past few decades. The most prominent relative epidemiological increase has been disclosed in young women. The aim of the study was to assess the effects of chronic sun exposures in order to rate the extend of melanocytic stimulations in the vicinity of CMM. Methods: The study was designed to evaluate the melanin distribution and density using ultraviolet light illumination. The present study was performed on surgical excision specimens of thin CMM lesion removed from the upper limbs of 55 Caucasian adults (37 women and 18 men). Two control groups comprised 23 men and 21 women of similar ages who had medium-size congenital melanocytic nevi, also present on the upper limbs. The peritumoral skin was scrutinized using a Visioscan® VC98 device, revealing the faint mosaic melanoderma (FMM) pattern that grossly indicates early signs of chronic photodamage in epidermal melanin units. Results: The median extent of relative FMM was significantly higher in the CMM male group. By contrast, the CMM female group showed a reverse bimodal distribution in FMM size. Only 12/37 (32.5%) of the CMM female group had an increased FMM size, whereas 25/37 (67.5%) of females with CMM had a global FMM extent in the normal range, relative to the controls. Conclusion: Thin CMM supervening in young women appear unrelated to repeat photoexposure. Other mechanisms are possibly involved. [less ▲]

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See detailEffect of gamma-hydroxybutyrate on keratinocytes proliferation: a preliminary prospective controlled study in severe burn patients.
ROUSSEAU, Anne-Françoise ULg; BARGUES, Laurent; LE BEVER, Hervé et al

in International Journal of Critical Illness and Injury Science (2014), 4(2), 108-113

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See detailChangements climatiques et l'antinomie de l'eau qui déshydrate.
Franchimont, Claudine ULg; Hermanns-Lê, Trinh ULg; Pierard, Sébastien ULg et al

in Revue Médicale de Liège (2014), 69

The stratum corneum materializes the interface <br />between the body and its environment. Such a structure is <br />influenced by the climate and seasons. A series of physicochemical <br />parameters are ... [more ▼]

The stratum corneum materializes the interface <br />between the body and its environment. Such a structure is <br />influenced by the climate and seasons. A series of physicochemical <br />parameters are involved in this relationship. Among <br />them, the relative humidity, the dew point, the insensible loss <br />of water and the concepts of water-as-ice and the higgledypiggledy- <br />water. [less ▲]

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See detailComment j'explore ... Votre patient se plaint d’une perte de cheveux Contribution de la biopsie cutanée dans le diagnostic des alopécies non cicatricielles
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue medicale de Liege (2014), 69(12), 686-91

The diagnosis of most alopecia problems is based on the clinical history and a well conducted clinical examination. The additional contributions of dermoscopy, trichoscopy and trichogram are helpful ... [more ▼]

The diagnosis of most alopecia problems is based on the clinical history and a well conducted clinical examination. The additional contributions of dermoscopy, trichoscopy and trichogram are helpful. However, a scalp biopsy is occasionally necessary to establish the correct diagnosis. The main noncicatricial alopecias are represented by androgenetic alopecia, alopecia areata, trichotillomania, traction and pressure alopecia, temporal triangular alopecia, ageing alopecia, loose anagen syndrome, telogen effluvium and anagen effluvium. [less ▲]

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