References of "Pierard, Claudine"
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See detailThe riddle of genuine skin microrelief and wrinkles.
Quatresooz, Pascale ULg; Thirion, L.; Pierard, Claudine ULg et al

in International Journal of Cosmetic Science (2006), 28(6), 389-95

Wrinkles result from distinct structural changes occurring in specific parts of the dermis and subcutaneous tissue. There is a need for evidenced-based cosmetology identifying and quantifying the ... [more ▼]

Wrinkles result from distinct structural changes occurring in specific parts of the dermis and subcutaneous tissue. There is a need for evidenced-based cosmetology identifying and quantifying the different aspects of wrinkling. Histology allows to detect specific changes associated with particular types of wrinkles. Four main types of wrinkles can thus be recognized, including the atrophic crinkling rhytids, the permanent elastotic creases, the dynamic expression lines, and the gravitational folds. Each type usually develops on specific skin regions exhibiting distinct microanatomical characteristics. Whereas skin microrelief, expression lines and skin folds appear clearly marked at the histological level, only little dermal changes are identified under other reducible or permanent wrinkles compared with the skin immediately adjacent to them. Distinguishing different types of wrinkles brings more precision to the clinical practice. This is of importance because the different types of wrinkles respond differently to cosmetic, dermatological and surgical treatments. [less ▲]

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See detailL'image du mois. Carcinome basocellulaire chez un patient psoriasique.
Thirion, L.; Pierard, Claudine ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2006), 61(12), 795-6

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See detailManifestations cutanées des pathologies endocriniennes
Quatresooz, Pascale ULg; Thirion, Laurence; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2006), 61(2), 104-8

Some cutaneous lesions accompany or reveal endocrine disorders. Identifying the endocrinopathy is very important because it sometimes allows corrective rather than symptomatic treatment. The most ... [more ▼]

Some cutaneous lesions accompany or reveal endocrine disorders. Identifying the endocrinopathy is very important because it sometimes allows corrective rather than symptomatic treatment. The most frequenly involved diseases include thyrotoxicosis, hypothyroidism, the auto-immune disorders of thyroid, Cushing syndrome, Addison disease, acromegaly, androgen-dependent disorders, hypopituitarism, hypoparathyroidism, pseudohypoparathyroidism and diabetes mellitus. [less ▲]

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See detailComment j'explore ... un patient atteint de mélanome: actualisation d'un algorithme.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(12), 837-43

Cutaneous melanoma is a cancer affecting an ever growing proportion of young adults. Currently, the best approach for a prolonged remission or cure relies on early detection of the primary neoplasm and of ... [more ▼]

Cutaneous melanoma is a cancer affecting an ever growing proportion of young adults. Currently, the best approach for a prolonged remission or cure relies on early detection of the primary neoplasm and of its first possible metastases. Some therapies can bring much hope at this stage of the disease. The early detection of lymph node metastases is therefore essential in the global management strategy. The excision and the microscopic examination of the sentinel lymph node are important in this evaluation. Echography of the draining lymph nodes is a non invasive procedure which may also prove to be informative. PET-scan brings additional information, particularly when the dissemination risk is beyond the first group of lymph nodes. [less ▲]

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See detailComment je traite...un patient atteint de mycosis fongoide.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(11), 740-6

Primary lymphomas of the skin exhibit singular clinical, histological and prognostic features that are not shared by lymphomas originating from the lymphoid tissues. This review is an update of the ... [more ▼]

Primary lymphomas of the skin exhibit singular clinical, histological and prognostic features that are not shared by lymphomas originating from the lymphoid tissues. This review is an update of the current concepts about the diagnosis and treatment of mycosis fungoides, the most frequent entity among the primary cutaneous lymphomas. [less ▲]

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See detailSkin capacitance mapping of psoriasis.
Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Journal of the European Academy of Dermatology & Venereology (2006), 20(10), 1261-5

BACKGROUND: The pathobiological dynamics of psoriatic lesions are complex and difficult to perceive by clinical inspection alone. Non-invasive bioengineering methods may prove to be useful in this field ... [more ▼]

BACKGROUND: The pathobiological dynamics of psoriatic lesions are complex and difficult to perceive by clinical inspection alone. Non-invasive bioengineering methods may prove to be useful in this field. OBJECTIVE: To identify some subtle capacitance variations in the stratum corneum of chronic psoriasis lesions. METHOD: The newly developed method of skin capacitance imaging was used to provide non-optical images of the hydration of the superficial layers of the stratum corneum. RESULTS: Compared to the uninvolved skin, psoriatic lesions usually showed an overall lowered capacitance, admixed with foci of moderately higher capacitance. Still other sharply circumscribed blotches with higher capacitance were present. The latter aspect corresponded to inflammatory areas. Sweating appeared markedly impaired inside the lesions. The fingerprint of some patients was altered, thus potentially interfering with the current biometric security procedures using the same method. CONCLUSION: Skin capacitance imaging is a non-invasive, non-optical method that distinguishes three contrasting levels of stratum corneum hydration in psoriatic lesions. The lowest capacitance level probably corresponded to xerotic orthokeratosis. The medium capacitance level presumably identified foci of parakeratosis and clumps of neutrophils. The highest capacitance level suggested exsudation at the site of prominent vessel dilation and dermal inflammation. Impaired sweating in the psoriatic lesions may potentially interfere with body thermoregulation. [less ▲]

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See detailComment je traite...l'acné de l'adolescent: un algorithme stratégique sans antibiotique.
Xhauflaire, Emmanuelle ULg; Goffin, Véronique ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2006), 61(10), 667-70

Acne is a multifaceted disorder. Its clinical presentation differs according to the age and gender of the subjects. Acne of the adolescent is a frequent disorder. Some topical and oral antibiotics have ... [more ▼]

Acne is a multifaceted disorder. Its clinical presentation differs according to the age and gender of the subjects. Acne of the adolescent is a frequent disorder. Some topical and oral antibiotics have proven their efficacy. However, the risk of bacterial resistance may be a concern for the clinicians and their patients. Hence, a therapeutic strategy without antibiotics merits to be considered. Retinoids have a place of choice in this therapeutic strategy. Benzoyl peroxide and miconazole are also active and valuable agents in this therapeutic algorithm. [less ▲]

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See detailRevisiting dandruff.
Pierard, Claudine ULg; Xhauflaire, Emmanuelle ULg; Pierard, Gérald ULg

in International Journal of Cosmetic Science (2006), 28(5), 311-8

Dandruff is a common scalp disorder affecting almost half of the postpubertal population of any ethnicity and both genders. It may, however, represent a stubborn esthetical disturbance often source of ... [more ▼]

Dandruff is a common scalp disorder affecting almost half of the postpubertal population of any ethnicity and both genders. It may, however, represent a stubborn esthetical disturbance often source of pruritus. Skin biocenosis, in particular the Malassezia spp. flora, plays a key aetiologic role, in combination with the unusual capacity of some corneocytes to be coated by these yeasts. Substantial evidence indicates that keratinocytes play an active role in the generation and expression of immunopathological reactions. This is probably the case in dandruff. Upon stimulation of a critical colonization of corneocytes by Malassezia yeasts, the release of pro-inflammatory mediators is increased. This could lead to the subclinical microinflammation present in dandruff. In seborrheic dermatitis, local deposits of immunoglobulins and the release of lymphokines are responsible for the recruitment and local activation of leukocytes leading to the eventual amplification of the inflammatory reaction. Some ancillary non-microbial causes of dandruff may operate through physical or chemical irritants. Many methods have been described for rating dandruff. Our favourite tools are clinical examination and squamometry. Dandruff can precipitate telogen effluvium and exacerbate androgenic alopecia. Antidandruff formulations exhibiting some direct or indirect anti-inflammatory activity can improve both dandruff and its subsequent hair cycle disturbance. [less ▲]

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See detailTreatment of pyogenic granulomas with the Nd-YAG laser.
Bourguignon, Raphael; Paquet, Philippe ULg; Pierard, Claudine ULg et al

in Journal of Dermatological Treatment (2006), 17(4), 247-9

Pyogenic granuloma is a common vascular tumour that can be treated by various means. However, some large lesions and those located on some difficult-to-treat body sites may represent a difficult challenge ... [more ▼]

Pyogenic granuloma is a common vascular tumour that can be treated by various means. However, some large lesions and those located on some difficult-to-treat body sites may represent a difficult challenge to the clinician (residual pain after treatment, difficult to cover with a dressing, or risk of sequelae). We report the successful treatment of such lesions in three patients using the Nd-YAG laser. [less ▲]

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See detailSyndrome DRESS à la sulfasalazine.
Bourguignon, Raphaël; Pierard, Claudine ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2006), 61(9), 643-8

We report a case of drug hypersensibility syndrome (DRESS syndrome) developed one month after initiation of a treatment by sulfasalazine. Due to the severity of the cytolytic hepatic damages as observed ... [more ▼]

We report a case of drug hypersensibility syndrome (DRESS syndrome) developed one month after initiation of a treatment by sulfasalazine. Due to the severity of the cytolytic hepatic damages as observed in this case, we emphasize the importance of suggesting this diagnosis in any patient developing a cutaneous rash and an alteration of the general health status after initiation of a new treatment. The hematologic alterations which represent a key feature for the diagnosis may rash. develop only a few days after the cutaneous rash. [less ▲]

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See detailL'image du mois: Maladie de Kaposi chez un sidéen africain.
Thirion, L.; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(9), 609-10

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See detailComment je previens...une exacerbation de la dermatite atopique.
Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg; Nikkels, Arjen ULg et al

in Revue Médicale de Liège (2006), 61(7-8), 600-3

Atopic dermatitis is under the influence of series of environmental factors. The contact with unsuited cleaning agents and rough textiles can exacerbate pruritus and inflammation. Preventive and adjuvant ... [more ▼]

Atopic dermatitis is under the influence of series of environmental factors. The contact with unsuited cleaning agents and rough textiles can exacerbate pruritus and inflammation. Preventive and adjuvant measures can thus help the care procedures of the disease. Appropriate hygiene measures and the use of emollients are particularly helpful. Clothing measures are also in place. Undergarments and pyjamas made of knitted natural silk are available. Other measures, sometimes corresponding to anecdotal claims--antihistamines, thermal cures, unconventional medicine, probiotics, chinese herbals, essential fatty acids--have not proven their preventive efficacy in atopic dermatitis. [less ▲]

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See detailL'image du mois. Ecthyma de l'adulte révélateur d'un diabète.
Thirion, L.; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(7-8), 543-4

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See detailL'eau déshydrate : l'antinomie de la xérose.
Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Dermatologie Actualité (2006), 97

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See detailHighlighting the rim of the perifollicular epidermal unit.
Xhauflaire, Emmanuelle ULg; Hermanns, Jean-Francois; Pierard, Claudine ULg et al

in European Journal of Dermatology (2006), 16(3), 225-9

The perifollicular and interfollicular areas of normal skin may look similar. However, some physiological and pathological processes may specifically involve a thin perifollicular rim. This review ... [more ▼]

The perifollicular and interfollicular areas of normal skin may look similar. However, some physiological and pathological processes may specifically involve a thin perifollicular rim. This review illustrates some of the methods available for highlighting the rim of the perifollicular epidermal unit. Non invasive methods rely on dermoscopy, ultraviolet light enhanced visualization (ULEV), skin capacitance imaging and cyanoacrylate skin surface strippings (CSSS). Conventional histology and immunohistochemistry may also show specific perifollicular features without, however, revealing the aspects highlighted by the specific non invasive methods. The clinically relevant modifications consist of pigmentary and hyperkeratotic perifollicular changes. [less ▲]

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See detailQualite de vie, emollients et agents hydratants.
Xhauflaire, Emmanuelle ULg; Haubrechts, C.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2006), 61(4), 233-6

So-called dry skin is a quite common and annoying condition. This skin may affect individuals that are otherwise healthy. It may be particularly severe and unpleasant in cases of ichthyosis, atopic ... [more ▼]

So-called dry skin is a quite common and annoying condition. This skin may affect individuals that are otherwise healthy. It may be particularly severe and unpleasant in cases of ichthyosis, atopic dermatitis or psoriasis. The inductive effects of the environment must not be ignored. Emollients and hydrating agents for the stratum corneum can help relieve the clinical manifestations. [less ▲]

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See detailThe key role of corneocytes in pityrosporoses.
Pierard, Gérald ULg; Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2006), 212(1), 23-6

Pityrosporoses encompass various Malassezia-driven conditions. Dandruff and seborrheic dermatitis are members of this family of disorders. Their precise pathomechanisms have not been completely elucidated ... [more ▼]

Pityrosporoses encompass various Malassezia-driven conditions. Dandruff and seborrheic dermatitis are members of this family of disorders. Their precise pathomechanisms have not been completely elucidated so far. This review focuses on the role of corneocytes in these disorders. Malassezia yeasts are not evenly distributed at the surface of the stratum corneum. Rather, they are clumped on some corneocytes while other corneocytes in their vicinity are almost free of these microorganisms. The corneocytes heavily coated by yeasts suggest a cell-related defect in the mechanisms controlling the skin biocene including the natural antimicrobial peptides and nitric oxide. Most environmental factors influencing pityrosporoses indeed affect the natural human defenses against certain microorganisms. We frame as a hypothesis that the primary defect in some Malassezia-driven disorders resides in the corneocytes and their precursor keratinocytes. [less ▲]

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See detailDandruff-associated smouldering alopecia: a chronobiological assessment over 5 years.
Pierard, Claudine ULg; Xhauflaire, Emmanuelle ULg; Loussouarn, G. et al

in Clinical & Experimental Dermatology (2006), 31(1), 23-6

BACKGROUND: In some individuals, dandruff may be recurrent and even chronic. This represents a difficult-to-treat condition. Excessive hair shedding and diffuse alopecia may develop. OBJECTIVES: To ... [more ▼]

BACKGROUND: In some individuals, dandruff may be recurrent and even chronic. This represents a difficult-to-treat condition. Excessive hair shedding and diffuse alopecia may develop. OBJECTIVES: To evaluate the chronobiological aspects of dandruff, hair shedding and alopecia. METHODS: This study was performed in eight men suffering from such a scalp condition. They were examined 40 times at regular intervals for five consecutive years. Hair-density assessments and trichograms were performed at least twice per trimester on the parietal region of the scalp, corresponding to an area where dandruff was present. RESULTS: A positive correlation was found between the percentage of telogen hairs and dandruff severity as assessed by the squamometry index. Bimodal yearly biorhythms were found for dandruff severity, telogen counts and hair loss between two consecutive visits. The chronobiological fluctuations were prominent in some study participants, but remained inconspicuous in others. The biorhythms were almost synchronized in all participants, showing variations over the year. CONCLUSIONS: The biorhythms on the hair cycle in dandruff are not fundamentally different from those previously reported in subjects without dandruff. The periodicity may be an intrinsic feature of human skin. [less ▲]

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See detailActivity of the triazole antifungal r126638 as assessed by corneofungimetry.
Pierard, Claudine ULg; Ausma, Jannie; Wouters, Luc et al

in Skin Pharmacology & Physiology (2006), 19(1), 50-6

BACKGROUND: R126638 is a novel triazole exhibiting potent in vitro and in vivo antifungal activity against fungal pathogens including dermatophytes and yeasts. OBJECTIVE: To determine the antifungal ... [more ▼]

BACKGROUND: R126638 is a novel triazole exhibiting potent in vitro and in vivo antifungal activity against fungal pathogens including dermatophytes and yeasts. OBJECTIVE: To determine the antifungal activity in time in the stratum corneum of healthy volunteers after oral intake of R126638 at a daily dose of 100 or 200 mg for 1 week. METHOD: Sixteen male volunteers were randomly allocated to oral treatment with either 100 or 200 mg of R126638 once daily for 1 week. Five cyanoacrylate skin surface strippings (CSSS) were obtained from the forearm of each subject before drug intake at day 1. CSSS were also collected during treatment at day 2 (24 h after the first drug intake, before the second drug intake), at day 4 (before the fourth drug intake) and at day 7 (10 h after the last drug intake). The post-treatment lingering effect was assessed at day 10 (3 days after treatment) and at day 14 (7 days after treatment). The corneofungimetry bioassay was performed on these CSSS to assess the antifungal profile of R126638. Cells of different fungal species (Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, Candida albicans and Malassezia globosa) were deposited and cultured for 10 days on CSSS in a sterile and controlled environment. The extent of fungal growth on the stratum corneum was determined using computerized image analysis. RESULTS: R126638 clearly reduced the growth of all tested fungal species. The onset of effects of R126638 was evidenced at day 4 when it reached statistical significance for 3 of 5 species. At day 7, significance was reached for 4 of 5 species. During the posttreatment period, R126638 remained effective for 4 of 5 species at day 10, and this activity persisted until day 14 for 2 of 5 species. CONCLUSION: A broad spectrum antifungal activity was rapidly expressed in the stratum corneum after oral intake of R126638. The drug likely reached the upper layers of the stratum corneum by diffusion and persisted in this location for at least 7 days after treatment. [less ▲]

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