References of "Pierard, Claudine"
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See detailNew insights into the effect of amorolfine nail lacquer.
Flagothier, Caroline ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Mycoses (2005), 48(2), 91-4

Despite improvements in antifungal strategies, the outcome of treating onychomycoses often remains uncertain. Several factors account for treatment failure, of which the pharmacokinetics and ... [more ▼]

Despite improvements in antifungal strategies, the outcome of treating onychomycoses often remains uncertain. Several factors account for treatment failure, of which the pharmacokinetics and pharmacodynamics of the antifungal are of importance. The taxonomic nature and ungual location of the fungus cannot be neglected, besides the type of nail and its growth rate. In addition, the biological cycle of the fungus and the metabolic activity of the pathogen likely play a marked influence in drug response. The presence of natural antimicrobial peptides in the nail is also probably a key feature controlling the cure rates. There are many outstanding publications that cover the full spectrum of the field. The purpose of this review is to put in perspective some facets of activity of the topical treatment using amorolfine nail laquer. The antifungal activity of the drug is likely less pronounced in onychomycosis than that expected from conventional in vitro studies. However, the nail laquer formulation should reduce the propensity to form antifungal-resistant spores and limit the risk of reinfection. [less ▲]

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See detailTraitements par lasers et lumière pulsée.
Paquet, Philippe ULg; Pierard, Claudine ULg; Henry, Frédérique ULg et al

in Revue Médicale de Liège (2005), 60 Suppl 1

Numerous types of lasers can exert different and specific effects in the skin. Devices delivering high intensity of pulsed light can exert similar effect.

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See detailTraitements par la lumière.
Pierard, Claudine ULg; Henry, Frédérique ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60 Suppl 1

Some cutaneous disorders can be treated by light under specific modalities. Balneotherapy, UVA phototherapy, PUVAtherapy, TL 01 phototherapy, extracorporeal photochemotherapy and external photodynamic ... [more ▼]

Some cutaneous disorders can be treated by light under specific modalities. Balneotherapy, UVA phototherapy, PUVAtherapy, TL 01 phototherapy, extracorporeal photochemotherapy and external photodynamic therapy are representatives of this group of treatment modalities. [less ▲]

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See detailPhotoprotection cutanée.
Henry, Frédérique ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60 Suppl 1

Physical or chemical photoprotection is mandatory in order to prevent some of the negative effects of ultraviolet light exposure.

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See detailLucites par photosensibilisation.
Claessens, Nadine; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60 Suppl 1

There exists a series of photodermatoses due to phototoxic or photoallergic reactions. Anamnestic and clinical clues supplemented by dermatopathological examination and photobiological tests are key ... [more ▼]

There exists a series of photodermatoses due to phototoxic or photoallergic reactions. Anamnestic and clinical clues supplemented by dermatopathological examination and photobiological tests are key features for reaching the correct diagnosis and the adequate choice of therapy. [less ▲]

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See detailLa peau et ses nuances ethniques.
Flagothier, Caroline ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60 Suppl 1

Ethnic (racial) differences exist for a series of physiological skin characteristics. Colour is responsible for typology and resistance to ultraviolet irradiations. Other differences have also been ... [more ▼]

Ethnic (racial) differences exist for a series of physiological skin characteristics. Colour is responsible for typology and resistance to ultraviolet irradiations. Other differences have also been reported for the transepidermal water loss, the size and cohesion of corneocytes, the vascular reactiviy, the biomechanical properties, the pH, the lipidic content, the superficial microflora and the structure of mast cell granules. [less ▲]

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See detailPhotobiologie moléculaire.
Nikkels, Arjen ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60 Suppl 1

Photochemical reactions are numerous in the skin. They generate reactive oxygen species and other biochemical alterations as well. According to their nature, the molecular components of the skin which ... [more ▼]

Photochemical reactions are numerous in the skin. They generate reactive oxygen species and other biochemical alterations as well. According to their nature, the molecular components of the skin which have been altered by these mechanisms can be repaired with various degrees of efficacy. [less ▲]

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See detailSources artificielles de lumière.
Pierard, Claudine ULg; Paquet, Philippe ULg; Henry, Frédérique ULg et al

in Revue Médicale de Liège (2005), 60 Suppl 1

The artificial light sources are numerous. They emit a more or less delimited spectrum of wavelengths. Ultraviolet light dosimetry allows to control the amount of delivered energy.

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See detailLe cas clinique du mois. Mycobacteries atypiques et mésothérapie.
Henry, Frédérique ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60(1), 7-10

Cutaneous infections due to atypical mycobacteria are varied. Their prevalence appears on the rise. The contamination comes from the environment following a breaking, even minimal, of the cutaneous ... [more ▼]

Cutaneous infections due to atypical mycobacteria are varied. Their prevalence appears on the rise. The contamination comes from the environment following a breaking, even minimal, of the cutaneous barrier. Mesotherapy, particularly when performed using a mechanical device, is a well recognized iatrogenic origin of this type of microorganism inoculation [less ▲]

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See detailQuantification of dandruff adherence to hair.
Pierard, Claudine ULg; Uhoda, Emmanuelle ULg; Pierard, Gérald ULg

in International Journal of Cosmetic Science (2005), 27(5), 279-82

Dandruff adherence to hair shafts is a visible annoying phenomenon. The aspect can be recorded by different means including the ultraviolet light-enhanced visualization (ULEV) method and microscopy. We ... [more ▼]

Dandruff adherence to hair shafts is a visible annoying phenomenon. The aspect can be recorded by different means including the ultraviolet light-enhanced visualization (ULEV) method and microscopy. We present another quantitative method. Hairs were clipped from the parietal scalp area of 25 volunteers complaining of dandruff. They were firmly applied onto cyanoacrylate-coated microscopic slides. Hairs were lifted up after 15-20 s leaving a cast in the adhesive coat. Dandruff were thus harvested from the hair shafts and remained attached to the cyanoacrylate coat. After staining, the material was submitted to image analysis to derive the dandruff density per unit length of hairs. In 11/25 subjects, a correlation was found between the width of the hair casts and the dandruff density. This method does not collect all dandruff along hair shafts, but data are likely representative of the whole corneocyte load. [less ▲]

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See detailComment je préviens ... par des soins dermo-cosmetiques, l'expression d'une acné qui couve.
Pierard, Gérald ULg; Pierard, Claudine ULg

in Revue Médicale de Liège (2005), 60(9), 741-3

Acne is a disorder affecting the majority of subjects during adolescence that may persist at various grades of severity during adulthood. This disorder may manifest itself at different levels of severity ... [more ▼]

Acne is a disorder affecting the majority of subjects during adolescence that may persist at various grades of severity during adulthood. This disorder may manifest itself at different levels of severity ranging from discrete to severe. The lesions may be sporadic or follow a wild course. The therapeutic strategy depends on these progression characteristics and must fit to each individual patient. This review focuses on the minor but the most frequent types of acne that may benefit from dermocosmetic treatments. [less ▲]

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See detailThe nail under fungal siege in patients with type II diabetes mellitus.
Pierard, Gérald ULg; Pierard, Claudine ULg

in Mycoses (2005), 48(5), 339-42

Few studies have examined the prevalence of onychomycosis among diabetic patients. Given the morbidity linked to onychomycosis, and the ever-growing size of the diabetic population, a better recognition ... [more ▼]

Few studies have examined the prevalence of onychomycosis among diabetic patients. Given the morbidity linked to onychomycosis, and the ever-growing size of the diabetic population, a better recognition of this nail infection is welcome. To revisit the relative prevalence of dermatophyte, yeast and non-dermatophytic mould onychomycoses in diabetic adults in a prospective study using combined histomycology and cultures. Toenail clippings were collected for 3 years in 190 type II diabetic patients (136 men and 54 women) and from an age- and gender-matched group of non-diabetic subjects. All sampled nails showed clinical alterations reminiscent of onychomycosis. Histomycology and cultures were performed on each sample to distinguish onychomycosis from non-infectious onychodystrophy. Compared to non-diabetic subjects with nail alterations, diabetics showed a higher proportion of onychomycosis relative to non-fungal onychodystrophy. Diabetic men suffered more frequently from onychomycosis and onychodystrophy than diabetic women. When considering the nature of the fungal pathogens, dermatophytes predominated largely over yeast and non-dermatophytic moulds, both in diabetic and non-diabetic patients. Diabetic patients, particularly men, are at increased risk of developing onychomycosis. The morbidity linked to this disorder, and its impact on the foot status in diabetic subjects merit to be better appreciated by clinicians. [less ▲]

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See detailComment j'explore ... une grosse jambe rouge.
Goffin, Véronique ULg; Hermanns-Lê, Trinh ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(3), 155-7

A consultation motivated by an enlarged red leg is a common situation. The causes are multiple and the diagnosis primarily relies on case history and physical examination distinguishing inflammatory red ... [more ▼]

A consultation motivated by an enlarged red leg is a common situation. The causes are multiple and the diagnosis primarily relies on case history and physical examination distinguishing inflammatory red legs from erythemato-violaceous presentations. Additional diagnostic search cannot be described as a single standardized procedure. Each disease calls for specific and different paraclinical investigations. The most frequent cause is erysipelas or a thrombophlebitis. Some vascular malformations and some functional circulatory disturbances are also possible, as well as sequelae of panniculitis or borreliosis. [less ▲]

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See detailComment je traite.... la colonisation bactérienne critique d'un ulcère de jambe. Le Yin et le Yang des pansements argentiques.
Pierard, Claudine ULg; Quatresooz, Pascale ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2004), 59(6), 403-6

The critical bacterial colonizaion of leg ulcers can impair their healing rate, aggravate the patient discomfort and increase the medical and nursing costs. In recent times, the dressings designed for leg ... [more ▼]

The critical bacterial colonizaion of leg ulcers can impair their healing rate, aggravate the patient discomfort and increase the medical and nursing costs. In recent times, the dressings designed for leg ulcers have followed a pace of conceptual revolution. Some of them are now offered containing an antiseptic of the silver salt family. The silver concentraton delivered into the wound bed is important to consider when assessing treatment efficacy. The diversity of the silver-based dressings currently on the European market is as large as their differences in activity. Only a minority of these dressings adequately control the wound biocenosis. Their cost which is high for the patient, must be compared to that of nursing care that may become less important. The expected beneficit is a reduction in healing time. [less ▲]

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See detailRevisiting the gender-linked melanoma burden.
Quatresooz, Pascale ULg; Uhoda, Isabelle; Fumal, Isabelle et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2004), 209(3), 197-201

BACKGROUND: Much is known about the worldwide rising incidence of skin cancers in the white populations. However, contradictory reports have been presented about a gender-linked risk for malignant ... [more ▼]

BACKGROUND: Much is known about the worldwide rising incidence of skin cancers in the white populations. However, contradictory reports have been presented about a gender-linked risk for malignant melanoma (MM). OBJECTIVE: To review the recent epidemiological information about primary and metastatic MM in south-east Belgium. METHODS: Laboratory records of primary MM according to age and gender were compared per 3-year periods from 1988 to 2002. The numbers of MM per decade of patient age were corrected with regard to the number of citizens in the defined periods of age. This led to the calculation of the rate of estimated prevalence (REP). The same assessments were performed on 187 sentinel lymph node biopsies collected during the last 3-year period. RESULTS: A total of 1,051 primary MM in women and 594 primary MM in men were diagnosed over the 15-year period. The female-to-male ratio rose by 24% over time, with a mean value of 1.77. The most recent years showed a marked increase both in the numbers and REP of primary MM. This situation was present in both genders, although it was most prominent in women of the reproductive age. MM metastases were found in 38/187 sentinel lymph nodes with a female-to-male ratio of 2.17. The age distribution for all sentinel lymph node biopsies copied that of primary MM, but the vast majority of the nodal metastatic MM was found in patients older than 50 years. The ratio between MM metastases and primary MM reached 6.1% (12/198) in men and 6.9% (26/378) in women. CONCLUSION: A recent increase in primary MM incidence was observed in our laboratory. The most likely cause is ascribed to more sensitive MM detection using the combination of clinical dermoscopy and laboratory immunohistochemistry. During the past 15 years, women were more affected than men by both primary and metastatic MM. The gender difference in incidence of primary MM has progressively widened due to an increased incidence in young and middle-aged women. By contrast, nodal metastatic MM mostly affected postmenopausal women. [less ▲]

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See detailMosaic subclinical melanoderma: an Achilles heel for UV-related epidermal carcinogenesis?
Quatresooz, Pascale ULg; Petit, Ludivine; Uhoda, Isabelle et al

in International Journal of Oncology (2004), 25(6), 1763-7

Cutaneous cancers are not uncommon on the face of elderly patients. Melanin should protect, at least in part, against the ultraviolet (UV)-induced neoplastic damage. However, the density in melanin ... [more ▼]

Cutaneous cancers are not uncommon on the face of elderly patients. Melanin should protect, at least in part, against the ultraviolet (UV)-induced neoplastic damage. However, the density in melanin chromatophores is heterogeneous in the epidermis of Caucasian adults. The computerized UV light-enhanced visualization (ULEV) method is a sensitive tool to assess non-invasively this mosaic pattern of intra-epidermal melanin load. In this study, the combination of ULEV pattern analysis and image analysis were performed involving four groups of phototype III Caucasian subjects. The first group was composed of 55 patients aged from 65 to 75 years who suffered from several malignancies of facial skin. The second control group of 55 patients who never had developed skin cancers were matched with the first group for age, sex and phototype. The third group was composed of 80 patients aged from 49 to 59 years who had developed a single basal cell carcinoma. The fourth group comprised 80 age, sex and phototype-matched healthy control subjects. Irrespective of the groups of subjects, a correlation was found between the pattern grading and the objectively determined relative area of subclinical melanoderma. Patients with multiple skin cancers differed from the other groups by the fact that a significantly higher proportion of them exhibited an extensive type of subclinical melanoderma. This feature was also seen in a minority of patients with a single basal cell carcinoma. The extensive subclinical melanoderma pattern is interpreted as a clue for risk, but not as a cause of UV-induced skin carcinogenesis. [less ▲]

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See detailImmunohistochemical aid at risk stratification of melanocytic neoplasms.
Quatresooz, Pascale ULg; Arrese Estrada, Jorge ULg; Pierard, Claudine ULg et al

in International Journal of Oncology (2004), 24(1), 211-6

There is increasing awareness of the population about the risk of cutaneous melanoma. In recent years, some improvement was gained in the early recognition of clinical warning signs using dermoscopy. As a ... [more ▼]

There is increasing awareness of the population about the risk of cutaneous melanoma. In recent years, some improvement was gained in the early recognition of clinical warning signs using dermoscopy. As a result, the number of puzzling cases exhibiting limited classical clues for malignancy are submitted to the dermatopathologist. Thus, the risk of microscopic uncertainty or misdiagnosis may be increasing. The aim of the study was to assess retrospectively the contribution of immunohistochemistry in establishing the histological diagnosis of 520 melanocytic neoplasms. According to the disease evolution and the histological presentation, 6 profiles of phenotypical expressions were distinguished. [less ▲]

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See detailLe cas clinique du mois. Purpura révélateur d'un rhumatisme articulaire aigu.
Fumal, I.; Henry, Frédérique ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(11), 630-2

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for ... [more ▼]

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for identifying the disease. [less ▲]

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See detailCoping with mild inflammatory catamenial acne: a clinical and bioinstrumental split-face assessment.
Petit, Ludivine; Pierard, Claudine ULg; Uhoda, Emmanuelle ULg et al

in Skin Research & Technology (2004), 10(4), 278-82

BACKGROUND: Acne is a multifactorial disease exhibiting distinct clinical presentations. Among them, the catamenial type is a matter of concern for young women. Some oral contraceptives may help without ... [more ▼]

BACKGROUND: Acne is a multifactorial disease exhibiting distinct clinical presentations. Among them, the catamenial type is a matter of concern for young women. Some oral contraceptives may help without, however, clearing the skin condition. AIM: The present open study aimed at evaluating the effect of overnight applications of a paste made of petrolatum,15% zinc oxide and 0.25% miconazole nitrate. METHOD: The split-face trial was conducted in 35 women. A non-medicated cream was used as control. Clinical evaluations and biometrological assessments on cyanoacrylate follicular biopsies were performed monthly for 3 months. Comedometry and the density in autofluorescent follicular casts were used as analytical parameters. In addition, the five most severe cases at inclusion were tested at the completion of the study for follicular bacterial viability using dual flow cytometry. RESULTS: Compared with baseline and to the control hemi-face, the medicated paste brought significant improvement of acne. The number of papules and their redness were reduced beginning with the first treatment phase. A reduction in the follicular fluorescence was yielded beginning with the second treatment phase. The ratios between injured and dead bacteria, on the one hand, and live bacteria, on the other hand were significantly increased at completion of the study. CONCLUSION: A miconazole paste applied for 1 week at the end of the ovarian cycle has a beneficial effect on catamenial acne. [less ▲]

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See detailComment j'explore... une perte de cheveux chez un patient cancéreux.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2004), 59(9), 525-9

Increased hair loss followed, in some instances by an acute focal or total alopecia, can develop in some cancer patients. The surgical stress or procedure, radiotherapy and some chemotherapy regimens can ... [more ▼]

Increased hair loss followed, in some instances by an acute focal or total alopecia, can develop in some cancer patients. The surgical stress or procedure, radiotherapy and some chemotherapy regimens can be responsible for these disturbing events. The alopecia is transient or permanent according to its origin. Diverse diagnostic and prognostic methods are available for assessing alopecias. The trichogram is a rewarding one. [less ▲]

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