References of "Piel, Géraldine"
     in
Bookmark and Share    
See detailPOLYMERIC NANOVECTORS: Actual developments and perspectives
Piel, Géraldine ULg

Scientific conference (2013)

Detailed reference viewed: 29 (4 ULg)
Full Text
Peer Reviewed
See detailEvaluation of a new biocompatible poly(N-(morpholino ethyl methacrylate)-based copolymer for the delivery of ruthenium oligonucleotides, targeting HPV16 E6 oncogene
Reschner, Anca ULg; Shim, Yong Ho; Dubois, Philippe et al

in Journal of Biomedical Nanotechnology (2013), 9

This study investigates the use of a new biocompatible block copolymer poly(2-(dimethylamino)ethyl methacrylate-N-(morpholino)ethyl methacrylate (PDMAEMA-b-PMEMA) for the delivery of a particular ... [more ▼]

This study investigates the use of a new biocompatible block copolymer poly(2-(dimethylamino)ethyl methacrylate-N-(morpholino)ethyl methacrylate (PDMAEMA-b-PMEMA) for the delivery of a particular antisense oligonucleotide targeting E6 gene from human papilloma virus. This antisense oligonucleotide was derivatized with a polyazaaromatic RuII complex which, under visible illumination, is able to produce an irreversible crosslink with the complementary targeted sequence. The purpose of this study is to determine whether by the use of a suitable transfection agent, it is possible to increase the efficiency of the antisense oligonucleotide targeting E6 gene, named Ru-P-4. In a recent study, we showed that Oligofectamine® transfected Ru-P-4 antisense oligonucleotide failed to inhibit efficiently the growth of cervical cancer cell line SiHa, contrarily to the Ru-P-6 antisense oligonucleotide, another sequence also targeting the E6 gene. The ability of PDMAEMA-b-PMEMA to form polyplexes with optimal physicochemical characteristics was investigated first. Then the ability of the PDMAEMA-b-PMEMA/Ru-P-4 antisense oligonucleotide polyplexes to transfect two keratinocyte cell lines (SiHa and HaCat) and the capacity of polyplexes to inhibit HPV16 + cervical cancer cell growth was evaluated. PDMAEMA-b-PMEMA base polyplexes at the optimal molar ratio of polymer nitrogen atoms to DNA phosphates (N/P), were able to deliver Ru-P-4 antisense oligonucleotide and to induce a higher growth inhibition in human cervical cancer SiHa cells, compared to other formulations based on Oligofectamine®. [less ▲]

Detailed reference viewed: 92 (27 ULg)
See detailLe double défi de la nanomédecine
Piel, Géraldine ULg; Evrard, Brigitte ULg

Scientific conference (2012, November 29)

Detailed reference viewed: 19 (2 ULg)
Full Text
See detailCharacterization and transfection experiments of polyplexes targeting HDAC7
Frère, Antoine ULg; Kawalec, Michal; Collard, Laurence ULg et al

Poster (2012, October 22)

Detailed reference viewed: 27 (15 ULg)
Full Text
Peer Reviewed
See detailUNDERSTANDING THE INTERACTIONS BETWEEN ARTEMISININ AND CYCLODEXTRINS: SPECTROSCOPIC STUDIES AND MOLECULAR MODELING
Zime Diawara, Hermine; Dive, Georges ULg; Piel, Géraldine ULg et al

in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry (2012), 74(1), 305-315

Detailed reference viewed: 26 (12 ULg)
Full Text
Peer Reviewed
See detailAssessment of new biocompatible Poly(N-(morpholino)ethyl methacrylate)-based copolymers by transfection of immortalized keratinoc
Van Overstraeten-Schlögel, Nancy; Shim, Yong Ho; Tevel, Virginie et al

in Drug Delivery (2012), 16(2), 102-111

Detailed reference viewed: 26 (12 ULg)
Peer Reviewed
See detailNUCLEAR DELIVERY OF A THERAPEUTIC PEPTIDE BY LONG CIRCULATING pH-SENSITIVE LIPOSOMES: BENEFITS OVER CLASSICAL VESICLES
Ducat, Emilie; Deprez, Juile; Noël, Agnès ULg et al

Poster (2011, December 06)

Detailed reference viewed: 26 (12 ULg)
Full Text
Peer Reviewed
See detailLiposome surface charge influence on skin penetration behaviour
Gillet, Aline ULg; Compère, Philippe ULg; Lecomte, Frédéric ULg et al

in International Journal of Pharmaceutics (2011), 411(1-2), 223-231

Detailed reference viewed: 57 (21 ULg)
Full Text
See detailNanotechnology based anti-cancer drug delivery systems: current developments and perspectives
Piel, Géraldine ULg

Scientific conference (2011, May 20)

Detailed reference viewed: 89 (7 ULg)
Full Text
Peer Reviewed
See detailLiposomes and parameters affecting their skin penetration behaviour
Gillet, Aline ULg; Evrard, Brigitte ULg; Piel, Géraldine ULg

in Journal of Drug Delivery Science and Technology [=JDDST] (2011), 21

Detailed reference viewed: 94 (27 ULg)