References of "Petrossians, Patrick"
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See detailLes patients acromégales sont-il mal pris en charge? De la mauvaise utilisation des bases de données
Petrossians, Patrick ULg; Tichomirova, M.; Daly, Adrian ULg et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailThe Liège Acromegaly Survey
Tichomirova, M.; Daly, Adrian ULg; Petrossians, Patrick ULg et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailPathologie inflammatoire de l'hypophyse et grossesse
Hansen, Isabelle ULg; Vroonen, Laurent ULg; Tichomirova, M. et al

in Pathologie hypophysaire et grossesse (2006)

Les affections hypophysaires, tumorales ou non tumorales, sont classiquement responsables d'infertilité. Grâce aux progrès des traitements médicaux et chirurgicaux développés pour le traitement de ces ... [more ▼]

Les affections hypophysaires, tumorales ou non tumorales, sont classiquement responsables d'infertilité. Grâce aux progrès des traitements médicaux et chirurgicaux développés pour le traitement de ces affections hypophysaires, les grossesses sont de plus en plus fréquentes chez les patientes ayant en particulier un adénome hypophysaire sécrétant ou une insuffisance anté-hypophysaire ou un diabète insipide central. Cependant, les conséquences de l'affection hypophysaire et des traitements pour la mère ou le f¿tus sont toujours discutés par les endocrinologues, les gynécologues, les obstétriciens et les pédiatres. Le but de cet ouvrage unique en français est une mise au point de nos connaissances sur le sujet, et tout particulièrement sur le diagnostic hormonal et radiologique d'un syndrome d'hypersécrétion ou d'une insuffisance hypophysaire au cours d'une grossesse, ainsi que sur la prise en charge des patientes présentant une pathologie hypophysaire tumorale ou non tumorale, désirant ou présentant une grossesse. [less ▲]

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See detailNodules de la thyroide
Borges-Martins, L.; Betea, Daniela ULg; Thiry, Anne-Marie ULg et al

in Revue Médicale de Liège (2006), 61(5-6, May-Jun), 309-16

Thyroid nodules are commonly encountered in clinical practice. They are present in 4 to 7% of the population by neck palpation and 30 to 50% by ultrasonography. Most are benign and could be neglected by ... [more ▼]

Thyroid nodules are commonly encountered in clinical practice. They are present in 4 to 7% of the population by neck palpation and 30 to 50% by ultrasonography. Most are benign and could be neglected by the clinician and his patient. However, 5% of nodules are malignant, requiring surgical treatment; therefore, an exhaustive evaluation is needed. The diagnostic approach includes physical examination, laboratory analysis, ultrasonography, radioisotope imaging, and fine needle aspiration. This article, based on the literature and the authors'experience, provides recommandations for thyroid nodule management. [less ▲]

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See detailA multicenter collaborative study to measure the prevalence of pituitary disease : methodology and preliminary findings
Tikhomirova, M.; Daly, Adrian ULg; Petrossians, Patrick ULg et al

in 15th Meeting of the Belgian Endocrine Society : Bruxelles, 26 novembre 2005 (2005, November)

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See detailMale Hypogonadism caused by isolated luteinizing hormone deficiency
Daly, Adrian ULg; Salvi, R.; Petrossians, Patrick ULg et al

in 37th International symposium - GH and Growth Factors in Endocrinology and Metabolism (Athènes Symposium) (2005)

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See detailGross total resection or debulking of pituitary adenomas improves hormonal control of acromegaly by somatostatin analogs
Petrossians, Patrick ULg; Borges-Martins, L.; Espinoza, C. et al

in European Journal of Endocrinology (2005), 152(1), 61-66

Introduction: Invasive GH-secreting pituitary adenomas are rarely cured by surgery and although long-term therapy with somatostatin analogs (SSAs) may be employed, hormonal control is achieved in only 60 ... [more ▼]

Introduction: Invasive GH-secreting pituitary adenomas are rarely cured by surgery and although long-term therapy with somatostatin analogs (SSAs) may be employed, hormonal control is achieved in only 60% of cases. The impact of tumor debulking on subsequent control of acromegaly with SSAs has not been studied previously. Methods: We studied retrospectively the response to SSA therapy in acromegalic patients before and after incomplete surgical tumor excision. A case review identified 24 acromegalic patients who had received SSA therapy for 1 month before and after gross total resection or debulking of adenomas. No patient received radiotherapy or combination treatment with SSAs and dopamine agonists during the study. GH and IGF-I responses to SSAs were recorded pre- and postoperatively. Postoperative SSA therapy was begun after a washout period of 1–3 months to assess the hormonal effects of the surgery alone. Results: Before preoperative SSA treatment, 24/24 (100%) patients had elevated GH levels and IGF-I levels were elevated in 19/21 (90.5%) patients with recorded values. During preoperative SSA treatment, GH and IGF-I levels were normalized in 7/24 (29.2%) and 11/24 (45.8%) patients respectively. Following postoperative washout, GH was controlled in only 3/24 (12.5%) patients, while IGF-I was controlled in 8/19 (42.1%) patients with available data. During the second SSA treatment period, normal GH levels were seen in 13/24 (54.2%) patients, while IGF-I control was noted in 18/23 (78.3%). Conclusion: Gross total tumor resection or debulking increases the likelihood of achieving biochemical disease control with SSAs in acromegalic patients with adenomas that were not amenable to complete surgical resection and in whom primary SSA therapy was unable to achieve good biochemical control. [less ▲]

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See detailAn overview of the epidemiology and genetics of acromegaly.
Daly, Adrian ULg; Petrossians, Patrick ULg; Beckers, Albert ULg

in Journal of Endocrinological Investigation (2005), 28(11 Suppl International), 67-69

Historical data indicate that pituitary tumors represent 10% of intracranial tumors, while adenomas are noted in approximately 14-23% of normal subjects on autopsy or magnetic resonance imaging (MRI ... [more ▼]

Historical data indicate that pituitary tumors represent 10% of intracranial tumors, while adenomas are noted in approximately 14-23% of normal subjects on autopsy or magnetic resonance imaging (MRI). About 2.5% of these tumors stain positive for GH in histopathologic studies. In contrast, the prevalence of clinically diagnosed acromegaly is lower at 36-69 per million population. Ongoing studies indicate that the actual prevalence of acromegaly in the community may be higher than previous epidemiologic data suggest. Acromegaly can occur both sporadically and in the setting of familial conditions, such as multiple endocrine neoplasia type 1 (MEN1) and Carney complex (CNC). Isolated familial somatotropinoma has been described and newer data suggest that acromegaly may also occur in non-MEN1/CNC families in combination with other pituitary tumor phenotypes. [less ▲]

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See detailControl of tumor size and hormonal hypersecretion in acromegaly : a large single-center experience
Daly, Adrian ULg; Tikhomirova, M.; Petrossians, Patrick ULg et al

in European Congress of Endocrinology - Abstract book (2005)

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See detailA multicenter collaborative study to measure the prevalence of pituitary disease : methodology and preliminary findings
Daly, Adrian ULg; Petrossians, Patrick ULg; Murat, A. et al

in 9th International Pituitary Congress - Abstract book (2005)

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See detailDiagnosis of active acromegaly : is it time to amend the consensus of opinions?
Beckers, Albert ULg; Daly, Adrian ULg; Petrossians, Patrick ULg et al

in International Novartis Workshop - somatostatin and its natural and synthetic analogues - Update from basic to clinical aspects - Abstract book (2005)

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See detailApproaching the true prevalence of pituitary tumors
Beckers, Albert ULg; Adam, C.; Ciccarelli, A. et al

in ENEA congress : Napoli, April 2004 (2004, April)

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See detailSurgical debulking of GH secreting pituitary adenomas improves GH control of acromegaly by somatostatin analogs
Beckers, Albert ULg; Petrossians, Patrick ULg; Borges Martins, L. et al

in ENEA congress : Napoli, April 2004 (2004, April)

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See detailGonadotropin secreting tumors
Beckers, Albert ULg; Ciccarelli, A.; Valdes Socin, Hernan Gonzalo ULg et al

in The Encyclopedia of Endocrinology and Endocrine Diseases (2004)

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See detailApproaching the true prevalence of pituitary tumors
Beckers, Albert ULg; Ciccarelli, A.; Daly, Adrian ULg et al

in 12th International Congress of Endocrinology - Abstract book (2004)

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See detailUne approche de la vraie prévalence des tumeurs hypophysaires
Beckers, Albert ULg; Ciccarelli, A.; Daly, Adrian ULg et al

in XXIème Congrès de la Société Française d'Endocrinologie - Abstract book (2004)

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See detailLa réduction chirurgicale de la masse tumorale des adénomes hypophysaires améliore le contrôle médical de l'acromégalie par les analogues de la Somatostatine
Petrossians, Patrick ULg; Borges-Martins, L.; Espinoza, C. et al

in XXIème Congrès de la Société Française d'Endocrinologie - Abstract book (2004)

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See detailExtensive inflammatory pseudotumor of the pituitary.
Hansen, Isabelle ULg; Petrossians, Patrick ULg; Thiry, Albert ULg et al

in Journal of Clinical Endocrinology and Metabolism (2001), 86(10), 4603-4610

A 40-yr-old female presented with an extensive lesion of the sellar area and the sphenoid sinus, spreading to the optic nerves and associated with pachymeningitis. Histological findings were consistent ... [more ▼]

A 40-yr-old female presented with an extensive lesion of the sellar area and the sphenoid sinus, spreading to the optic nerves and associated with pachymeningitis. Histological findings were consistent with an inflammatory pseudotumor, and steroid treatment allowed the disappearance of all the lesions. Inflammatory pseudotumors of the pituitary are very rare. This case appears unique with regard to the extension of the lesions and the dramatic response to medical treatment. The differential diagnosis of inflammatory lesions of the pituitary is difficult. It relies mainly on histological analysis and includes sarcoidosis, Wegener's granulomatosis, histiocytosis (Langerhans, Rosai-Dorfman, and Erdheim-Chester diseases) and lymphocytic hypophysitis. [less ▲]

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See detailACTH silent adenoma shrinking under cabergoline.
Petrossians, Patrick ULg; Ronci, N.; Valdes Socin, Hernan Gonzalo ULg et al

in European Journal of Endocrinology (2001), 144(1), 51-57

OBJECTIVES: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically non ... [more ▼]

OBJECTIVES: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically non-functioning pituitary adenomas. DESIGN: Following the clinical and radiological improvement of a recurrent silent ACTH adenoma in a 77-year-old patient treated with cabergoline (0.5 mg every 2 days for 2 years), in vitro studies of the original tumor were performed. METHODS: The original tumor from the patient was studied by in situ hybridization and dopamine D2 receptor autoradiography. It was compared with four macroprolactinomas and two macroadenomas from patients with Cushing's disease. RESULTS: The D2 receptor mRNA signal of the reported case was intense and of the same order of magnitude as that observed in control prolactinomas. Dopamine D2 receptor autoradiography was twice that of control corticotroph adenomas and was close to that observed in prolactinomas. CONCLUSIONS: This is the first description of an in vivo shrinkage of an ACTH silent adenoma under cabergoline. We demonstrate in vitro, the presence of D2 receptors in the primitive tumor in concentrations similar to those found in control prolactinomas. These results suggest that therapeutic trials with cabergoline might be undertaken in recurring cases of ACTH silent tumors and more generally, non-functioning pituitary adenomas. [less ▲]

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