References of "Penning, Sophie"
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See detailInsulin Kinetics during Hyper-Insulinemia Euglycemia Therapy (HIET)
Penning, Sophie ULg; MASSION, Paul ULg; Le Compte, Aaron J. et al

Conference (2012, August)

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See detailDevelopment and Pilot Trial Results of Stochastic Targeted (STAR) Glycemic Control in a Medical ICU
Fisk, Liam M.; Le Compte, Aaron J.; Shaw, Geoffrey M. et al

in Proceedings of the 8th IFAC Symposium on Biological and Medical Systems (2012, August)

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See detailVariability of insulin sensitivity during the first 4 days of critical illness: implications for tight glycemic control
Pretty, Christopher ULg; Le Compte, Aaron J.; Chase, J. Geoffrey et al

in Annals of Intensive Care (2012)

Introduction: Effective tight glycaemic control (TGC) can improve outcomes in critical care patients, but is difficult to achieve consistently. Insulin sensitivity defines the metabolic balance between ... [more ▼]

Introduction: Effective tight glycaemic control (TGC) can improve outcomes in critical care patients, but is difficult to achieve consistently. Insulin sensitivity defines the metabolic balance between insulin concentration and insulin mediated glucose disposal. Hence, variability of insulin sensitivity can cause variable glycaemia. This study quantifies and compares the daily evolution of insulin sensitivity level and variability for critical care patients receiving TGC. <br /> <br />Methods: A retrospective analysis of data from the SPRINT TGC study involving patients admitted to a mixed medical-surgical ICU between August 2005 and May 2007. Only patients who commenced TGC within 12 hours of ICU admission and spent at least 24 hours on the SPRINT protocol were included (N=164). Model-based insulin sensitivity (SI) was identified each hour. Absolute level and hour-to-hour percent changes in SI were assessed on cohort and per-patient bases. Levels and variability of SI were compared over time on 24-hour and 6-hour timescales for the first 4 days of ICU stay. <br /> <br />Results: Cohort and per-patient median SI levels increased by 34% and 33% (p<0.001) between days 1 and 2 of ICU stay. Concomitantly, cohort and per-patient SI variability decreased by 32% and 36% (p<0.001). For 72% of the cohort, median SI on day 2 was higher than on day 1. The day 1-2 results are the only clear, statistically significant trends across both analyses. <br /> <br />Analysis of the first 24 hours using 6-hour blocks of SI data showed that most of the improvement in insulin sensitivity level and variability seen between days 1 and 2 occurred during the first 12-18 hours of day 1. <br /> <br />Conclusions: Critically ill patients have significantly lower and more variable insulin sensitivity on day 1 than later in their ICU stay and particularly during the first 12 hours. This rapid improvement is likely due to the decline of counter-regulatory hormones as the acute phase of critical illness progresses. Clinically, these results suggest that while using TGC protocols with patients during their first few days of ICU stay, extra care should be afforded. Increased measurement frequency, higher target glycaemic bands, conservative insulin dosing and modulation of carbohydrate nutrition should be considered to safely minimize outcome glycaemic variability and reduce the risk of hypoglycaemia. [less ▲]

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See detailDoes Tight Glycemic Control positively impact on patient mortality?
Penning, Sophie ULg; Le Compte, Aaron J.; Signal, Matthew et al

Poster (2012, March 20)

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See detailDoes Tight Glycemic Control positively impact on patient mortality?
Penning, Sophie ULg; Le Compte, Aaron J.; Signal, Matthew et al

in Critical Care (2012, March 20)

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See detailLe contrôle de la glycémie
Penning, Sophie ULg; Massion, Paul

Scientific conference (2012, March 16)

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See detailPilot Trial of STAR in Medical ICU
Fisk, Liam M.; Le Compte, Aaron J.; Shaw, Geoffrey M. et al

Poster (2012, March)

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See detailVariability of insulin sensitivity during the first 4 days of critical illness
Pretty, Christopher ULg; Le Compte, A; Chase, JG et al

in Critical Care (2012), 16 (Suppl 1)

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See detailCumulative time in band (cTIB): glycemic level, variability and patient outcome vs mortality
Penning, Sophie ULg; Signal, M; Preiser, JC et al

in Proceedings of ANZICS 2012 (2012)

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See detailPilot Trial of STAR in Medical ICU
Fisk, LM; Le Compte, A; Shaw, GM et al

in Critical Care (2012), 16 (Suppl 1)

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See detailEvolution de l’insulino-résistance au cours de l’hypothermie thérapeutique
Moermans, A; Taccone, F; Penning, Sophie ULg et al

in Proceedings des journees francophone de nutrition 2012 (2012)

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See detailSTAR Development and Protocol Comparison
Fisk, Liam M.; Le Compte, Aaron J.; Shaw, Geoffrey M. et al

in IEEE Transactions on Biomedical Engineering (2012)

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See detailInterface Design and Human Factors Consideration for Model-Based Tight Glycemic Control in Critical Care
Ward, Logan; Steel, James; Le Compte, Aaron et al

in Journal of Diabetes Science and Technology (2012)

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See detailStochastic Targeted (STAR) Glycemic Control - Design, Safety and Performance
Evans, Alicia; Le Compte, Aaron; Tan, Chian-Siong et al

in Journal of Diabetes Science and Technology (2012)

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See detailData Entry Errors and Design for Model-Based Tight Glycemic Control in Critical Care
Ward, Logan; Steel, James; Le Compte, Aaron et al

in Journal of Diabetes Science and Technology (2012)

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See detailGlycemic Variability, Hypoglycemia and Organ Failure in the Glucontrol Study
Penning, Sophie ULg; Le Compte, Aaron J.; Preiser, Jean-Charles et al

Poster (2011, December)

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See detailEnhanced insulin sensitivity variability in the first 3 days of ICU stay: Implications for TGC
Chase, J. Geoffrey; Le Compte, Aaron; Penning, Sophie ULg et al

in Critical Care (2011, March)

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See detailValidation of a virtual patient and virtual trials method for accurate prediction of TGC protocol performance
Suhaimi, Fatanah; Le Compte, Aaron; Penning, Sophie ULg et al

in Critical Care (2011, March)

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