Investigation of cytokine expression in canine idiopathic pulmonary fibrosis

in Proceeding of 29th VCRS Symposium (2011, November 02)

Cardiac troponin and natriuretic peptide in canine emergencies with a systemic inflammatory response syndrome

in Proceedings of 21st ECVIM Meeting (2011, September 06)

High serum transforming growth factor-beta 1 concentration in West Highland white terriers : a key to the breed predisposition in canine idiopathic pulmonary fibrosis

in Proceedings of the 21st ECVIM-CA Congress (2011, September)

Use of expression microarray to identify potential biomarkers of idiopathic pulmonary fibrosis in dogs

in Proceedings of 29th ACVIM Forum (2011, June)

Contribution of CT scan for lesions affecting the spine

Poster (2011, January 22)

Laryngeal diseases

in Tilley, L. P.; Smith, F. W. (Eds.) Blackwell’s Five Minute Veterinary Consult: Canine & Feline, 5th edition (2011)

Serum and bronchoalveolar lavage fluid endothelin-1 concentrations as diagnostic biomarkers of canine idiopathic pulmonary fibrosis

in Journal of Veterinary Internal Medicine (2011)

Background: Diagnosis of canine idiopathic pulmonary fibrosis (IPF) is challenging. Endothelin-1 (ET1) is a biomarker of IPF in humans, but whether ET1 can detect and differentiate IPF from other canine ... [more ▼]

Background: Diagnosis of canine idiopathic pulmonary fibrosis (IPF) is challenging. Endothelin-1 (ET1) is a biomarker of IPF in humans, but whether ET1 can detect and differentiate IPF from other canine respiratory diseases is unknown. Objective: To evaluate whether measurement of the concentration of ET1 in serum and bronchoalveolar lavage fluid (BALF) can be used to distinguish canine IPF from chronic bronchitis (CB) and eosinophilic bronchopneumopathy (EBP). Animals: Twelve dogs with IPF, 10 dogs with CB, 6 dogs with EBP, 13 privately owned healthy West Highland White Terriers (WHWT), and 9 healthy Beagle dogs. Methods: Prospective, case control study. ET1 concentration was determined by ELISA in serum and in BALF. Results: No significant difference in serum ET1 concentration was detected between healthy Beagle dogs and WHWT. Serum ET1 concentration was higher in dogs with IPF (median interquartile range; 2.32 pg/mL, 2.05-3.38) than healthy Beagle dogs (1.28, 1.07-1.53; P < .001), healthy WHWT (1.56, 1.25-1.85; P < .001), dogs with EBP (0.94 0.68-1.01; P = .001), and dogs with CB (1.54 0.74-1.82; P = .005). BALF ET1 concentration was below the detection limit in healthy WHWT and in dogs with CB, whereas it was measurable in all dogs with IPF. A cut-off serum concentration of 1.8 pg/mL had a sensitivity of 100% and a specificity of 81.2% for detection of IPF, with an area under the receiver operating characteristic curve of 0.818. Conclusions and Clinical Importance: Serum ET1 can differentiate dogs with IPF from dogs with EBP or CB. ET1 can be detected in BALF of dogs with IPF. [less ▲]

L’aspergillose naso-sinusale chez le chien

in Monde Vétérinaire (Le) : European Veterinary Magazine (2010), 107

Genetic analysis of a glomerulonephropathy segregating in a pedigree of French Mastiff.

in Proceedings of 32nd Annual Conference of the International Society of Animal Genetics (2010)

Progressive juvenile glomerulonephropathy in 16 related French Mastiff (Bordeaux) Dogs

in Journal of Veterinary Internal Medicine (2010), 24(2), 314-322