References of "Peeters, Dominique"
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See detailAn immunohistochemical study of canine nasal aspergillosis
Peeters, Dominique ULg; Day, M. J.; Clercx, Cécile ULg

in Journal of Comparative Pathology (2005), 132(4), 283-288

In this study, histochemistry and immunohistochemistry were used to characterize the phenotype and distribution of leucocytes in the distal nasal mucosa of 15 dogs with nasal aspergillosis. The most ... [more ▼]

In this study, histochemistry and immunohistochemistry were used to characterize the phenotype and distribution of leucocytes in the distal nasal mucosa of 15 dogs with nasal aspergillosis. The most consistent histopathological finding was a severe, predominantly lymphoplasmacytic, inflammatory infiltration of the lamina propria. Fungal hyphae were not observed to invade the mucosa but were found at the mucosal surface and within material collected from the nasal cavity. The main immunohistochemical findings were (1) a predominance of IgG(+) plasma cells over IgA(+) and IgM(+) plasma cells, (2) significant numbers of macrophages and dendritic cells expressing MHC class 11 molecules, (3) macrophages and neutrophils expressing L1 antigen and (4) a mixture of CD4(+) and CD8(+) T cells. These findings are consistent with a dominant Th1-regulated cell-mediated immune response. The nature of the inflammatory infiltrate and the lack of invasiveness of the mucosa by the fungus, together with the clinical course of the disease and the apparent immunocompetence of the affected dogs, suggest that canine nasal aspergillosis resembles the chronic erosive non-invasive fungal sinusitis described in human patients. © 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailReal-time RT-PCR quantification of mRNA encoding cytokines and chemokines in histologically normal canine nasal, bronchial and pulmonary tissue
Peeters, Dominique ULg; Peters, I. R.; Farnir, Frédéric ULg et al

in Veterinary Immunology and Immunopathology (2005), 104(3-4), 195-204

Cytokines and chemokines are likely to be involved in the pathogenesis of inflammatory diseases of the canine respiratory tract. The roles and relative amounts of these molecules have not yet been defined ... [more ▼]

Cytokines and chemokines are likely to be involved in the pathogenesis of inflammatory diseases of the canine respiratory tract. The roles and relative amounts of these molecules have not yet been defined in the respiratory mucosa of normal dogs or dogs with naturally acquired respiratory inflammation. In the present study, real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays were employed to quantify messenger RNA (mRNA) encoding the chemokines monocyte chernotactic protein (MCP)-2, eotaxin-2 and eotaxin-3, and the cytokines interleukin-4 (IL-4), IL-5, IL-6, IL-10, IL-12p40, IL-18, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta) in normal nasal, bronchial and pulmonary tissues from puppies (n = 4) and from adult dogs (n = 7). There was no significant difference in the expression of any transcript between puppies and adult dogs at any of the anatomical sites examined. The expression of mRNA encoding eotaxin-2 and eotaxin-3 increased significantly with progression from the nasal mucosa to pulmonary parenchyma but expression of MCP-2 mRNA did not show this trend. At all levels of the respiratory mucosa, the most abundant transcripts were those encoding IL-18 and TGF-beta. Transcripts encoding IL-6, IL-10, IL-12 and TNF-alpha were approximately ten-fold less abundant, and IL-4, IL-5 and IFN-gamma were the least abundant templates. There was significantly different amount of mRNA encoding IL-5, IL- 18 and TNF-alpha between particular anatomical levels of the respiratory mucosa while the mRNA expression of the other cytokines was similar at all anatomical sites. The results of the present study will enable comparisons to be made with results obtained from similar samples obtained from dogs with nasal, bronchial or pulmonary diseases. (c) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailDistribution of leucocyte subsets in the canine respiratory tract
Peeters, Dominique ULg; Day, M. J.; Farnir, Frédéric ULg et al

in Journal of Comparative Pathology (2005), 132(4), 261-272

Histochemistry and immunohistochemistry were used to characterize leucocyte subsets in the respiratory tract of 15 outbred dogs (five aged <6 months and 10 aged >1 year) that had no evidence of ... [more ▼]

Histochemistry and immunohistochemistry were used to characterize leucocyte subsets in the respiratory tract of 15 outbred dogs (five aged <6 months and 10 aged >1 year) that had no evidence of respiratory disease. No organized nose- or bronchus-associated lymphoid tissue was observed in any of the sections examined. IgA(+) plasma cells predominated in nasal mucosa and in all parts of the bronchial tree, with fewer IgG(+) and IgM(+) plasma cells. The numbers of IgA(+) and IgM(+) cells were significantly greater in the nasal mucosa than in any other part of the respiratory mucosa. There were significantly fewer IgA(+), IgG(+) and IgM(+) cells in all parts of the respiratory tract in the puppies than in the adults. The number and distribution of mast cells and cells expressing MHC class II, L1 or CD1c were recorded. Mast cells were mainly found in the subepithelial lamina propria of nasal and bronchial mucosa and in the alveolar interstitium, and cells expressing IgE had a similar distribution. Mast cells were also present within muscle layers of the bronchial tree. The numbers of mast cells and MHC class II(+) cells were significantly greater in the nasal mucosa than in any other part of the respiratory mucosa. In the nose, carina and primary and secondary bronchus, there were significantly more mast cells and MHC class II(+) cells in puppies than in adult dogs, whereas the numbers of L1(+) cells and CD1c(+) cells in most sites were significantly greater in older dogs. There were significantly more CD3(+) and CD8(+) cells in the nasal mucosa than in any part of the bronchial mucosa. In most parts of the respiratory mucosa, CD4(+), CD8(+) and TCR alphabeta(+) cells were present in significantly greater numbers in adults than in puppies. All parts of the respiratory tract had similar numbers of mucosal CD4(+) and CD8(+) T lymphocytes. TCR gammadelta(+) cells were absent or sparse in all samples. These data, obtained from dogs without respiratory disease, will enable comparisons to be made with dogs suffering from infectious or inflammatory nasal, bronchial and pulmonary diseases. [less ▲]

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See detailDistribution of leucocyte subsets in bronchial mucosa from dogs with eosinophilic bronchopneumopathy
Peeters, Dominique ULg; Day, M. J.; Clercx, Cécile ULg

in Journal of Comparative Pathology (2005), 133(2-3, Aug-Oct), 128-135

Immunohistochemistry was used to characterize the distribution of leucocyte subsets in the bronchial mucosa of 11 dogs with idiopathic eosinophilic bronchopneumopathy (EBP). Formalin-fixed tissues from ... [more ▼]

Immunohistochemistry was used to characterize the distribution of leucocyte subsets in the bronchial mucosa of 11 dogs with idiopathic eosinophilic bronchopneumopathy (EBP). Formalin-fixed tissues from all dogs were included in the study, but frozen tissue from only one dog was available. MHC class II(+) cells were found in moderate numbers in the lamina propria (LP). These cells were morphologically either dendritic-like cells or macrophages, but many macrophages did not express MHC class II. Such molecules were expressed by occasional fibroblasts. L1(+) cells, which formed a relatively small component of the LP inflammatory infiltrate, were morphologically either macrophages or polymorphonuclear cells (probably eosinophils). IgA(+) plasma cells were found in varying numbers in the LP, mostly in association with glandular tissue. IgG(+) plasma cells were less common, and IgM(+) plasma cells were present in low numbers. Many CD3(+) cells were present in the LP. In the single case from which frozen tissue was available, most of the lymphocytes were labelled with CD4 marker, while smaller numbers were CD8(+) T cells. Most of the lymphocytes in this case were positively labelled with T-cell receptor (TCR)-alphabeta marker. TCR-gammadelta(+) cells, although less common, were present in significant numbers throughout the LP. CDlc(+) dendritic cells were numerous in the epithelium and in the LP, immediately beneath the basement membrane. These findings, which were similar to those described in human asthma, are suggestive of a Th2 dominant immune response in canine EBP. As in human asthma, this provides a possible basis for new forms of treatment in canine EBP. [less ▲]

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See detailTraitement d’une obésité associée à une hypercholestérolémie chez une chienne.
Jeusette, Isabelle; Peeters, Dominique ULg; Diez, Marianne ULg

in Le nouveau praticien vétérinaire (2004)

Cas clinique

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See detailL’aspergillose naso-sinusale dans l’espèce canine
Peeters, Dominique ULg; Clercx, Cécile ULg

in Annales de Médecine Vétérinaire (2004), 148(4), 168-173

Canine sino-nasal aspergillosis is a common cause of chronic nasal discharge. The pathogenesis of the disease is not well understood but factors associated to the fungus and to the host are implicated ... [more ▼]

Canine sino-nasal aspergillosis is a common cause of chronic nasal discharge. The pathogenesis of the disease is not well understood but factors associated to the fungus and to the host are implicated. Even if computed tomography and magnetic resonance imaging have been proved valuable in differentiating sino-nasal aspergillosis from neoplasia, the definitive diagnosis of the disease requires visualisation of the fungus either by rhinoscopy, cytology or histology. The best treatment involves topical administration of antifungal drugs. The long-term prognosis is guarded to good. [less ▲]

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See detailLa bronchopneumopathie éosinophilique idiopathique canine : revue de la littérature
Peeters, Dominique ULg; Clercx, Cécile ULg

in Annales de Médecine Vétérinaire (2004), 148(3), 115-120

Several diseases characterized by pulmonary eosinophilic infiltrates are described in the dog, but a clear and accepted classification of these disorders is lacking. In the present paper, we briefly ... [more ▼]

Several diseases characterized by pulmonary eosinophilic infiltrates are described in the dog, but a clear and accepted classification of these disorders is lacking. In the present paper, we briefly review most of these conditions through a classification based on the cause of the eosinophilic infiltrate. A complete literature review of canine idiopathic eosinophilic bronchopneumopathy is also included in the paper. [less ▲]

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See detailAn immunohistochemical study of eosinophilic bronchopneumopathy in dogs.
Peeters, Dominique ULg; Day, M. J.; Clercx, Cécile ULg

in Proceedings of the 14th Annual Congress of the ECVIM-CA (2004)

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See detailAn immunohistochemical study of canine nasal aspergillosis.
Peeters, Dominique ULg; day, M. J.; Moore, Peter et al

in Proceedings of The 14th Annual Congress of the ECVIM-CA (2004)

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See detailClinical comparison between nasopharyngeal, oropharyngeal and laryngopharyngeal disorders in dogs and cats: a review of 80 cases.
Billen, Frédéric ULg; Peeters, Dominique ULg; Day, Michael et al

in Proceedings of the 13th ECVIM-CA Congress (4-6/09/2003), Uppsala, Sweden (2003, September)

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See detailRhinitis/Bronchopneumonia syndrome in Irish Wolfhounds.
Clercx, Cécile ULg; Reichler, I.; Peeters, Dominique ULg et al

in Journal of Veterinary Internal Medicine (2003), 17(6), 843-9

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK ... [more ▼]

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK, Canada, Germany, and Switzerland. Signs included transient to persistent mucoid or mucopurulent rhinorrhea, cough, and respiratory dyspnea. Radiographic, rhinoscopic, and bronchoscopic findings were variable. Analysis of ciliary ultrastructure was performed in 5 affected dogs, but no characteristic primary ciliary defects (primary ciliary dyskinesia) were detected. Serum and bronchoalveolar lavage fluid (BALF) concentrations of IgA, IgG, and IgM were determined in some affected dogs and clinically normal Irish Wolfhounds. Serum IgA concentration was below the reference range in 5 of 8 affected dogs tested, whereas BALF IgA concentration was above the normal range in 2 affected adult dogs. The CD4 to CD8 lymphocyte subset ratio (CD4:CD8) in peripheral blood was tested in 3 affected dogs and was within the normal range. BALF CD4:CD8 was tested in 1 affected dog and was higher than the normal range. Decreased neutrophil phagocytosis was observed in 1 of the 4 dogs tested. Analysis of pedigrees of the Belgian, Canadian, German, and Swiss dogs revealed common ancestry, suggesting a heritable syndrome. [less ▲]

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See detailT cell subsets in the respiratory tract of dogs without respiratory disease : preliminary results.
Peeters, Dominique ULg; Day, M. J.; Moore, P. et al

in Proceedings of the 13th Annual Congress of the ECVIM-CA (2003)

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See detailDrug-induced destructive cholangitis and total ductopenia in a young dog.
gabriel, Alexandra; Heimann, M.; van den ingh, T. et al

in Proceedings of the 13th Annual Congress of the ECVIM-CA (2003)

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See detailResolution of chylothorax after resection of rib chondroma in a dog
Watine, Séverin; Hamaide, Annick ULg; Peeters, Dominique ULg et al

in Journal of Small Animal Practice (2003), 44(12), 546-549

A six-year-old, male dobermann was presented with a history of dyspnoea and bouts of coughing. Radiography and computed tomography of the thorax showed pleural effusion and a well-circumscribed, calcified ... [more ▼]

A six-year-old, male dobermann was presented with a history of dyspnoea and bouts of coughing. Radiography and computed tomography of the thorax showed pleural effusion and a well-circumscribed, calcified mass of 10 cm in diameter, appearing to originate from the left first rib. Thoracocentesis revealed that the pleural fluid was chylous in nature. An inclsional biopsy was performed, which gave a histological diagnosis of chondroma. Resolution of the chylothorax after en-bloc surgical removal of the tumour suggested that the rib tumour was the initiating cause of the chylothorax. Seventeen months later, rib neoplasia recurred without pleural effusion, and was removed successfully. To the authors' knowledge, rib chondroma, which is an unusual tumour in dogs, has not been previously documented as a cause of chylothorax. [less ▲]

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See detailLeucocyte subsets in the respiratory tract of dogs without respiratory disease : preliminary results.
Peeters, Dominique ULg; Day, M. J.; Laurent, A. et al

in Proceedings of the 12th Annual Congress of the ECVIM-CA (2002)

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See detailAn Immunologic investigation of canine eosinophilic bronchopneumopathy.
Clercx, Cécile ULg; Peeters, Dominique ULg; German, Alex et al

in Journal of Veterinary Internal Medicine (2002), 16

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See detailUltrasonographic findings in 5 dogs with gallbladder disease
Benvenuti, Luca; Busoni, Valeria ULg; Peeters, Dominique ULg et al

Poster (2002)

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See detailPathologies surrénaliennes
Peeters, Dominique ULg; Remy, Isabelle ULg

in Proceedings du congrès CNVSPA-SAVAB (2001, November)

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See detailL’anémie : approche diagnostique et cas cliniques
Peeters, Dominique ULg

Conference (2001, November)

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