References of "Pasleau, Françoise"
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See detailExpression transitoire du promoteur c-erbB2 dans les cellules épithéliales mammaires normales et tumorales en culture.
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Dijkmans, Huguette et al

Conference (1992, February)

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See detailCloning and sequencing the upstream regulatory region of the c-erbB2 gene, an adenocarcinoma specific oncogene.
Dijkmans, H.; Pasleau, Françoise ULg; Gol-Winkler, R.

Conference (1991, September)

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See detailHalf-life of the c-erbB2 mRNA synthesized in human mammary adenocarcinoma cell lines.
Pasleau, Françoise ULg; Grooteclaes, M.; Gol-Winkler, R.

Poster (1991, June)

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See detailCloning and sequencing the upstream regulatory regions of the c-erbB2 gene.
Pasleau, Françoise ULg; Dijkmans, H.; Bertrand, B. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1990), 98(B40),

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See detailLes oncogènes dans les cancers du sein.
Gol-Winkler, Rose; Pasleau, Françoise ULg; Dijkmans, Huguette

Conference (1990)

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See detailTowards the design and the synthesis of an artificial alpha/beta protein.
Goraj, K.; Gohimont, C.; Pasleau, Françoise ULg et al

Conference (1988, February)

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See detailExpression of a synthetic gene encoding human insulin-like growth factor I in cultured mouse fibroblasts.
Bayne, M. L.; Cascieri, M. A.; Kelder, B. et al

in Proceedings of the National Academy of Sciences of the United States of America (1987), 84

A synthetic gene encoding human insulin-like growth factor I (hIGF-I) was assembled and inserted into an expression vector containing the cytomegalovirus immediate early (CMV-IE) transcriptional ... [more ▼]

A synthetic gene encoding human insulin-like growth factor I (hIGF-I) was assembled and inserted into an expression vector containing the cytomegalovirus immediate early (CMV-IE) transcriptional regulatory region and portions of the bovine growth hormone gene. The recombinant plasmid encodes a 97 amino acid fusion protein containing the first 27 amino acids of the bovine growth hormone precursor and the 70 amino acids of hIGF-I. This plasmid, when transiently introduced into cultured mouse fibroblasts, directs synthesis of the fusion protein, subsequent proteolytic removal of the bovine growth hormone signal peptide, and secretion of hIGF-I into the culture medium. Conditioned medium from transfected cells inhibits binding of 125I-labeled IGF-I to type I IGF receptors on human placental membranes and to acid-stable human serum carrier proteins. The recombinant hIGF-I produced is biologically active, as monitored by the stimulation of DNA synthesis in vascular smooth muscle cells. [less ▲]

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See detailA comparison of bovine growth hormone expression directed by bGH genomic or intronless DNA in transiently transfected eukaryotic cells.
Pasleau, Françoise ULg; Leung, F. C.; Kopchick, J. J.

in Gene. (1987), 57

Two recombinant DNA plasmids were constructed with identical transcriptional and translational regulatory elements controlling expression of the bovine growth hormone (bGH) gene or the bGH gene lacking ... [more ▼]

Two recombinant DNA plasmids were constructed with identical transcriptional and translational regulatory elements controlling expression of the bovine growth hormone (bGH) gene or the bGH gene lacking introns. Transient expression of these plasmids in cultured eukaryotic cells, monitored by assaying secretion of bGH into the culture medium, was employed to examine the relative importance of introns in the expression of this gene. The bGH gene lacking introns is expressed more efficiently than the bGH gene in avian and mammalian cells. [less ▲]

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See detailLocation of transcriptional and regulatory sequences within the prolactin family genes
Belayew, A.; Bellefroid, Eric J.; Berwaer, M. et al

in Müller, E. E.; McLeod, R. M. (Eds.) Neuroendocrine Perspectives (1986)

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See detailLocalisation des séquences régulatrices de la transcription. Application aux gènes de la famille prolactine.
Belayew, A.; Bellefroid, Eric J.; Berwaer, M. et al

in Annales d'Endocrinologie (1986), 47

We are studying nucleotide sequences responsible for the regulation of eukaryotic gene expression. Our test system comprises the human genes coding for prolactin (hPRL), growth hormone (hGH-N) and ... [more ▼]

We are studying nucleotide sequences responsible for the regulation of eukaryotic gene expression. Our test system comprises the human genes coding for prolactin (hPRL), growth hormone (hGH-N) and placental lactogen (hCS-B). We have cloned these genes and are searching within their sequences for in vitro binding sites of the human glucocorticoid receptor on the hGH-N and hCS-B genes; the in vivo activity of such DNA sequences by assaying hybrid gene expression in transfected cells; in vivo "enhancer" activity of different hPRL gene fragments linked to a marker gene and transfected in cultured cells. [less ▲]

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See detailLocation of transcriptional regulatory sequences within the prolactin family genes.
Belayew, A.; Bellefroid, Eric J.; Berwaer, M. et al

in Neuroendocrine Perspectives. (1986)

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See detailExpression of the bovine growth hormone in cultured rodent cells.
Kopchick, J. J.; Pasleau, Françoise ULg; Leung, F. C.

in Basic Life Sciences (1986), 37

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See detailExpression of avian retroviral-bovine growth hormone recombinant DNA in rat GH3 cells.
Kopchick, John J.; Leung, Frederic C.; Pasleau, Françoise ULg

Conference (1985, June)

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See detailGrowth hormone gene expression in eukaryotic cells directed by the Rous sarcoma virus long terminal repeat or cytomegalovirus immediate-early promoter.
Pasleau, Françoise ULg; Tocci, M. J.; Leung, F. C. et al

in Gene. (1985), 38

The cytomegalovirus (CMV) immediate-early (IE) gene-regulatory region was found to be three- to fourfold more efficient than the Rous sarcoma retroviral long terminal repeat (LTR) in promoting expression ... [more ▼]

The cytomegalovirus (CMV) immediate-early (IE) gene-regulatory region was found to be three- to fourfold more efficient than the Rous sarcoma retroviral long terminal repeat (LTR) in promoting expression of the bovine growth hormone (bGH) gene by rat GH3 cells. [less ▲]

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See detailGenetic regulation of hepatic steroid 16 alpha-hydroxylase activities in inbred strains of mice.
Pasleau, Françoise ULg; Kolodzici, Claudine; Kremers, Pierre ULg et al

in Endocrinology (1984), 115

Steroid 16 alpha-hydroxylase activities and properties were studied in C57Bl/6J, 129/J, AKR/R, DBA/2J, C3H/I, and BALB/c mouse liver using four different substrates. The highest enzymatic activities were ... [more ▼]

Steroid 16 alpha-hydroxylase activities and properties were studied in C57Bl/6J, 129/J, AKR/R, DBA/2J, C3H/I, and BALB/c mouse liver using four different substrates. The highest enzymatic activities were measured in the female mice, with the exception of the 129/J females. As in the rat liver, the sexual differentiation of the steroid 16 alpha-hydroxylation observed in adult male and female mice took place at puberty. In the adult mouse liver, two steroid 16 alpha-hydroxylase activities (forms I and II) could be differentiated on the basis of their relative affinities for the various steroid substrates and their relative proportions in male and female mouse livers. In the immature mouse liver, no sexual differences could be detected, and the mice of both sexes presented phenotypes identical to those of the adult female. The adult 129/J females appeared genetically deficient with respect to the form I of the steroid 16 alpha-hydroxylase and presented a phenotype identical to that of the adult male mice of the various strains tested. Differences in hydroxylase activities between the C57Bl/6J and 129/J strains were investigated using standard genetic breeding protocols. Steroid 16 alpha-hydroxylase seemed to be inherited additively in the liver of the female mice obtained by crossing the C57Bl/6J male and the 129/J female or the 129/J male and the C57Bl/6J female. In the male mice, regardless of genotype, the observed phenotype was always identical to the two male parental types. Both hormonal and genetic regulations were responsible for the different phenotypes occurring in adult male and female C57Bl/6J and 129/J mouse livers. [less ▲]

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