References of "PITCHOT, William"
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See detailRelationship between alpha 2-adrenergic function and suicidal behavior in depressed patients.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in Psychiatry Research (1994), 52(2), 115-23

The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible ... [more ▼]

The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible implication of the noradrenergic function. In the present study, we assessed the growth hormone response to clonidine, a selective alpha 2-adrenergic agonist, in 15 DSM-III-R major depressive inpatients with a history of suicide attempts, compared with 15 age- and gender-matched major depressive inpatients without a history of suicidal behavior. Mean (+/- SD) growth hormone peak responses to clonidine were significantly lower in the group of suicide attempters than in the control group: 2.93 +/- 3.01 ng/ml vs. 8.28 +/- 8.15 ng/ml. Therefore, these results suggest that a blunted growth hormone response to clonidine could be a biological correlate of suicidal behavior. [less ▲]

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See detailL'état de stress post-traumatique chez les brûlés : Une revue.
Machurot, Pierre-Yves; Hansenne, Michel ULg; Pitchot, William ULg et al

in Acta Psychiatrica Belgica (1993), 93 Spec No

While post-traumatic stress disorder has drawn increasing interest over the last years, very few studies have been focused to burned patients. In its first part, this article provides a brief reminder of ... [more ▼]

While post-traumatic stress disorder has drawn increasing interest over the last years, very few studies have been focused to burned patients. In its first part, this article provides a brief reminder of the symptomatology of post-traumatic stress disorder, of its various pathogenic theories as well as its various treatment approaches. The second part of the article reviews more specifically the literature about post-traumatic stress disorder in burned patients, emphasizing the need of a rapid and effective psychological therapy. [less ▲]

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See detailRole du systeme dopaminergique dans la depression: correlats cliniques du test a l'apomorphine.
Pitchot, William ULg; Gonzalez Moreno, Antonio; Hansenne, Michel ULg et al

in Acta Psychiatrica Belgica (1993), 93 Spec No

Disturbances in dopaminergic neurotransmission seem to play an important role in biochemical mechanisms involved in depressive disorders. The study of the growth hormone (GH) response to apomorphine, a ... [more ▼]

Disturbances in dopaminergic neurotransmission seem to play an important role in biochemical mechanisms involved in depressive disorders. The study of the growth hormone (GH) response to apomorphine, a dopaminergic agonist, provides an indirect index of dopaminergic neurotransmission at the postsynaptic level. In the present study, we assessed the role of the dopaminergic system in some psychopathological dimensions in depression: personality dimensions, suicidal behavior, psychomotor disturbances and dichotomy unipolar/bipolar. Our studies included major depressed inpatients matched for gender, age and, in the case of women, menopausal status. Our results show that dopaminergic disturbances are related to social introversion and anxiety according to dopaminergic hypothesis of schizophrenic disorders and dopaminergic hyperactivity hypothesis of anxiety disorders. A blunted GH response to apomorphine could be considered as a biological marker of suicidal behavior. Moreover motor retardation appeared to be in relationship with dopaminergic disturbances. Finally, the dopaminergic system did not appear to play a significant role in the dichotomy unipolar/bipolar. The results show the interest of the apomorphine test in the assessment of the relationship between biochemical disturbances and clinical correlates. [less ▲]

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See detailPilot study of flesinoxan in major depression. Effect on REM latency and body temperature
ANSSEAU, Marc ULg; PITCHOT, William ULg; Gonzalez Moreno, Antonio et al

in Human Psychopharmacology (1993)

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See detailEvaluation neuroendocrienne de la fonction catécholaminergique dans le comportement suicidaire
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez, Moreno et al

in Psychologie Médicale (1992), 24

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See detailGrowth hormone response to clonidine in male untreated panic patients
Scittecatte, Michel; ANSSEAU, Marc ULg; Charles, Gerard et al

in Psychological Medicine (1992)

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See detailTherapeutic window for 5-HT reuptake inhibitors
PITCHOT, William ULg; Gonzalez Moreno, Antonio; ANSSEAU, Marc ULg

in Lancet (1992)

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See detailSuicidal behavior and growth hormone response to apomorphine test.
Pitchot, William ULg; Hansenne, Michel ULg; Moreno, A. G. et al

in Biological Psychiatry (1992), 31(12), 1213-9

Several cerebrospinal fluid (CSF) studies have provided support for a possible role for the dopaminergic system as a biological correlate of suicidal behavior. Indeed, low CSF levels of the dopamine ... [more ▼]

Several cerebrospinal fluid (CSF) studies have provided support for a possible role for the dopaminergic system as a biological correlate of suicidal behavior. Indeed, low CSF levels of the dopamine metabolite homovanillic acid (HVA) have been described in depressed patients with a history of suicide attempts. In this study, we assessed the dopamine receptor sensitivity in relationship to suicidal behavior by measuring growth hormone (GH) response to apomorphine 0.5 mg subcutaneously (sc) in 15 DSM-III-R (APA 1987) major depressive inpatients with a history of suicide attempts, compared to age-matched and gender-matched major depressive inpatients without a history of suicide. Patients with a history of suicidal behavior exhibited a significantly lower GH response to apomorphine than patients who never attempted suicide (t = 3.60, df = 1.28, p = 0.0012). Therefore, these results suggest that a blunted GH response to apomorphine could represent a biological marker of suicidal behavior. [less ▲]

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See detailDopaminergic function in panic disorder: comparison with major and minor depression.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in Biological Psychiatry (1992), 32(11), 1004-11

Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine ... [more ▼]

Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine drug-free inpatients meeting Research Diagnostic Criteria (RDC) for panic disorder who were age-matched and gender-matched with nine major depressive, and nine minor depressive inpatients. The three groups differed significantly in their mean GH peak response: 5.29 +/- 2.75 ng/ml in major depressives, 26.27 +/- 12.71 ng/ml in minor depressives, and 37.28 +/- 10.58 ng/ml in panics, with a significantly higher response in panic than in either minor or major depressive patients. These results support dopaminergic overactivity in panic disorder as compared with major and minor depression. [less ▲]

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See detailPsychotic reactions to zolpidem.
Ansseau, Marc ULg; Pitchot, William ULg; Hansenne, Michel ULg et al

in Lancet (1992), 339(8796), 809

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See detailThe lack of relationship between DST nonsuppression in the dexamethasone suppression test and EEG abnormalities.
Pitchot, William ULg; Hansenne, Michel ULg; Ansseau, Marc ULg

in European Archives of Psychiatry & Clinical Neuroscience (1991), 241(3), 193-4

As a recent study suggested a relationship between cortisol escape following dexamethasone suppression test (DST) and electroencephalogram (EEG) abnormalities, we tried to replicate these findings in 52 ... [more ▼]

As a recent study suggested a relationship between cortisol escape following dexamethasone suppression test (DST) and electroencephalogram (EEG) abnormalities, we tried to replicate these findings in 52 major depressive inpatients. A total of 23 patients exhibited DST nonsuppression (44%) and 18 patients had EEG abnormalities (35%). No relationship existed between DST and EEG results. [less ▲]

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See detailThe clonidine test in posttraumatic stress disorder.
Hansenne, Michel ULg; Pitchot, William ULg; Ansseau, Marc ULg

in American Journal of Psychiatry (The) (1991), 148(6), 810-1

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See detailAspects pratiques de l'utilisation des antidépresseurs
Pitchot, William ULg; Ansseau, Marc ULg; Franck, Georges ULg

in Revue Médicale de Liège (1990), 45(12), 597-613

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See detailPsychopathological correlates of dopaminergic disturbances in major depression.
Pitchot, William ULg; Hansenne, Michel ULg; Moreno, A. G. et al

in Neuropsychobiology (1990), 24(4), 169-72

In a recent report, we confirmed the role of dopamine in the pathophysiology of depression by demonstrating a blunted response of growth hormone (GH) to apomorphine, a selective dopaminergic agonist, in ... [more ▼]

In a recent report, we confirmed the role of dopamine in the pathophysiology of depression by demonstrating a blunted response of growth hormone (GH) to apomorphine, a selective dopaminergic agonist, in endogenous depressive patients. Few data are available on the possible psychopathological correlates of disturbances in the apomorphine test. In this study, we assessed the relationship between GH response to apomorphine and the Minnesota multiphasic personality inventory (MMPI) scales in a sample of 20 major depressive inpatients. The GH response (area under the curve) after apomorphine injection was positively correlated with the social introversion scale scores (r = 0.56, df = 19, p less than 0.01) and the anxiety scale scores (r = 0.45, df = 19, p = 0.04). These results suggest dopaminergic overactivity in anxious psychopathology rather than in depressive psychopathology. The relationship between the social introversion scale score and the apomorphine test is in agreement with the dopaminergic hypothesis of schizophrenic disorders. [less ▲]

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See detailHyponatrémie induite par la carbamazépine et affection rénale : à propos d'un cas
PITCHOT, William ULg; ANSSEAU, Marc ULg; PAPART, Patrick ULg et al

in Psychiatrie et psychobiologie (1989)

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See detailIntérêt de l'EEG de sommeil dans les états dépressifs
PITCHOT, William ULg

in Revue Médicale de Liège (1989), 34

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