References of "PITCHOT, William"
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See detailNouveautés dans le traitement des troubles de l'humeur.
Pitchot, William ULg; Ansseau, Marc ULg

in Acta Psychiatrica Belgica (2007), 107

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See detailTherapeutic utilisations of vasopressin and oxytocin in mood disorders.
Scantamburlo, Gabrielle ULg; Pitchot, William ULg; Pinto, Emmanuel ULg et al

in Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (2007), 1

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See detailLa duloxetine (Cymbalta)
Pitchot, William ULg

in Revue Médicale de Liège (2006), 61(11), 787-90

Duloxetine (Cymbalta is an antidepressant of the class of serotonin noradrenaline reuptake inhibitors. The efficacy of duloxetine 60 mg/day has been well demonstrated in the acute and long term treatment ... [more ▼]

Duloxetine (Cymbalta is an antidepressant of the class of serotonin noradrenaline reuptake inhibitors. The efficacy of duloxetine 60 mg/day has been well demonstrated in the acute and long term treatment of major depression. The level of effectiveness of duloxetine is particularly high and associated with a shorter latency of action. Duloxetine also exhibits antinociceptive properties independently of the antidepressant effect. The side-effect profile of duloxetine is particularly good and similar to selective serotonin reuptake inhibitors with mainly nausea. In total, duloxetine represents a real progress in the pharmacological treatment of major depression. [less ▲]

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See detailOXYTOCIN, VASOPRESSIN AND ANXIETY IN MAJOR DEPRESSION: AGO-ANTAGONIST NEUROHROMONES
Scantamburlo, Gabrielle ULg; Hansenne, Michel ULg; Fuchs, Sonia et al

in European Neuropsychopharmacology (2006), 16

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See detailPlasma oxytocin and anxiety in depressed patients
Scantamburlo, Gabrielle ULg; Fuchs, Sonia; Pitchot, William ULg et al

in European Neuropsychopharmacology (2005, October), 15(Suppl. 3), 430

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See detailAVP- and OT-neurophysins response to apomorphine and clonidine in major depression
Scantamburlo, Gabrielle ULg; Fuchs, Sonia; Pitchot, William ULg et al

in Psychoneuroendocrinology (2005), 30(9), 839-845

A number of studies have reported abnormalities of neurohypophyseal secretions in major depressive disorder. The purpose of the present study was to test the influence of apomorphine and clonidine ... [more ▼]

A number of studies have reported abnormalities of neurohypophyseal secretions in major depressive disorder. The purpose of the present study was to test the influence of apomorphine and clonidine injections on plasma vasopressin (AVP)-neurophysins and oxytocin(OT)-neurophysins levels, as direct index of posterior pituitary activation in major depression. Apomorphine and clonidine tests were carried out in 25 medication-free depressive patients and 25 age and gender-matched healthy controls. Blood for neurophysins analysis was drawn by venipuncture at t0, t+20, t+40, t+60 and t+120. Baseline AVP-neurophysins concentrations were significantly tower in depressives (0.12 +/- 0.14 ng/ml) than in healthy subjects (0.24 +/- 2.15 ng/ml) (p < 0.04). The response to apomorphine test revealed a significant reduced response at 20 (p=0.01), 40 (p=0.007) and 60 (p=0.02) and 120 (p=0.02) min. Following clonidine test, post hoc tests also revealed a significant decrease at 0 (p=0.04), 20 (p=0.01), 40 (p=0.007) and 60 (p=0.02) and 120 (p=0.006) min. Concerning OT-neurophysins, no significant differences were found between depressed and controls in response to clonidine or apomorphine injections. Following clonidine and apomorphine, major depressives exhibited a significantly lower peak GH response than controls. The study supports partially the hypothesis of a reduced vasopressinergic activity in depression. Moreover, we did not find any influence of acute apomorphine or clonidine injections on vasopressin-neurophysin or oxytocin-neurophysin in depressive patients. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailAlcohol craving and the A1 allele of the D2 dopamine receptor gene
Pinto, Emmanuel ULg; Gorwood, P.; Reggers, Jean ULg et al

in European Psychiatry (2005, March), 20(Suppl. 1), 25

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See detailTherapeutic application of right prefrontal low repetitive transcranial magnetic stimulation on depressed patients
Fuchs, S.; Reggers, Jean ULg; Pinto, Emmanuel ULg et al

in European Neuropsychopharmacology (2004, October), 14(Suppl. 3), 226

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See detailNeurohypophyseal response to apomorphine and clonidine stimulation in major depression
Scantamburlo, Gabrielle ULg; Fuchs, Sonia; Pitchot, William ULg et al

in European Neuropsychopharmacology (2004, October), 14(Suppl. 3), 291-292

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See detailRelationships between DRD2 and DAT polymorphisms and personality traits in healthy subjects
Pinto, Emmanuel ULg; Reggers, Jean ULg; Adam, Martine ULg et al

in European Neuropsychopharmacology (2003, September), 13(Suppl. 4), 427-428

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See detailMismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects.
Hansenne, Michel ULg; Pinto, Emmanuel ULg; Scantamburlo, Gabrielle ULg et al

in Human Psychopharmacology (2003), 18(3), 201-5

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its ... [more ▼]

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its functional significance, and may have clinical implications. In this context, some findings suggest that the scalp-recorded MMN reflects activity from multiple neuronal ensembles within or in the immediate vicinity of the primary auditory cortex and with possible contribution from the frontal cortex. However, few data are available concerning the influence of neurotransmitter systems on the MMN. In this study, the relationship between both noradrenergic and dopaminergic systems and the MMN were investigated in 34 healthy volunteers. Noradrenergic and dopaminergic activities were assessed with the apomorphine and clonidine challenge tests. The results showed no significant relationship between either growth hormone (GH) responses to apomorphine or clonidine and the MMN amplitude or latency. Therefore, this study does not demonstrate the implication of dopaminergic and noradrenergic activities as assessed by GH response to apomorphine and clonidine for the generation and/or the modulation of the MMN. However, given the complexity of the central neurotransmitter systems, these results cannot be considered as definitive evidence against a relationship between dopaminergic and noradrenergic activity and the MMN. [less ▲]

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See detailHarm avoidance is related to mismatch negativity (MMN) amplitude in healthy subjects
Hansenne, Michel ULg; Pinto, Emmanuel ULg; Scantamburlo, Gabrielle ULg et al

in Personality & Individual Differences (2003), 34(6), 1039-1048

Event-related potential (ERP) studies evidenced that some personality dimensions induced different controlled cognitive attitudes towards the processing of information. However, few data are available on ... [more ▼]

Event-related potential (ERP) studies evidenced that some personality dimensions induced different controlled cognitive attitudes towards the processing of information. However, few data are available on the possible relationships between personality and automatic attention or early sensory processing. In the present study the relationships between the mismatch negativity (MMN) and personality described by the Cloninger model of personality were investigated. Subjects were 32 healthy volunteers. The MMN was recorded with frequent stimuli tones of 1470 Hz, 70 dB and 40 ms duration, and target (20%) tones of 1470 Hz, 70 dB, 80 ms duration. The subjects completed a French version of the 226-item self-questionnaire TCI within the day following psychophysiological recording. The results showed that the HA dimension was negatively correlated with the MMN amplitude. The association was more present among women than men. No significant relationship existed between the other dimensions of personality and either the MMN amplitude or latency. These findings suggest that the MMN is related to the behavioral inhibition system (BIS), a fact which is consistent with clinical studies conducted on schizophrenia and anxiety disorders. In conclusion, this study suggests that personality dimensions induce different automatic attitudes towards the processing of information. (C) 2002 Published by Elsevier Science Ltd. [less ▲]

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See detailEvent-related potentials to emotional and neutral stimuli in alcoholism.
Hansenne, Michel ULg; Olin, Cecile; Pinto, Emmanuel ULg et al

in Neuropsychobiology (2003), 48(2), 77-81

Several studies have demonstrated that the emotional value of stimuli affects P300 amplitude. In the present study, the influence of alcohol-related stimuli in alcoholic patients was investigated ... [more ▼]

Several studies have demonstrated that the emotional value of stimuli affects P300 amplitude. In the present study, the influence of alcohol-related stimuli in alcoholic patients was investigated. Subjects were 10 alcoholic inpatients (3 female) and 10 age- and sex-matched controls. Eight alcohol-related and 8 neutral words served as stimuli in a visual oddball paradigm. Acohol-related words were targets (48 stimuli, 33%) and neutral words were standard stimuli (96 stimuli, 66%). Results showed that P300 amplitude for targets did not differ significantly between the two groups. However, P300 latency for targets as well as reaction time were significantly shorter in male alcoholic patients. In contrast, P300 latency was increased in female alcoholic patients but reaction time did not differ. These results suggest that male alcoholics process information linked to alcohol cues more rapidly than neutral cues, probably because a specific semantic network is activated in these patients. The decreased reaction time confirms the impulsive behavior frequently found in male alcoholism, as it has been described in type II alcoholism. Besides, the results imply that information processing was delayed in female alcoholic patients. Therefore this study demonstrates a gender-dependent impact of alcohol-related stimuli on information processing. [less ▲]

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See detailRéactions cutanées indésirables aux antidépresseurs.
Braham, C.; Paquet, Philippe ULg; Pitchot, William ULg et al

in Revue Médicale de Liège (2003), 58(1), 22-4

Due to the widespread usage of antidepressants by the population, they represent a class of drugs which is at high risk for cutaneous side effects. The diversity in the clinical presentations is large ... [more ▼]

Due to the widespread usage of antidepressants by the population, they represent a class of drugs which is at high risk for cutaneous side effects. The diversity in the clinical presentations is large. The variability in their severity is large as well. Morbidity may be quite severe, but the vital prognosis is rarely affected. [less ▲]

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See detailFurther evidence on the relationship between dopamine and novelty seeking: a neuroendocrine study
Hansenne, Michel ULg; Pinto, Emmanuel ULg; Pitchot, William ULg et al

in Personality & Individual Differences (2002), 33(6), 967-977

In the biosocial model of Cloninger, three major personality dimensions, novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are dependent on central monoaminergic systems, respectively ... [more ▼]

In the biosocial model of Cloninger, three major personality dimensions, novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are dependent on central monoaminergic systems, respectively dopaminergic, serotonergic, and noradrenergic. This study investigated the relationships between these major personality dimensions and growth hormone (GH) responses to both apomorphine and clonidine challenge tests in healthy subjects. GH responses to apomorphine were significantly correlated with NS when peak relative values were considered (r=0.47, P=0.03). HA and RD did not show any relationships with the endocrine responses. In contrast, no significant relationship existed between GH responses to clonidine and any of the three temperament dimensions. These results gave another support of the hypothesized link between NS and dopaminergic central neurotransmission. In contrast, the results did not confirm the association between RD and noradrenergic central neurotransmission, probably because RD is poorly validated. This partial confirmation might suggest that the link between personality traits and neurotransmission systems is probably indirect. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detail5-HT1A dysfunction in borderline personality disorder.
Hansenne, Michel ULg; Pitchot, William ULg; Pinto, Emmanuel ULg et al

in Psychological Medicine (2002), 32(5), 935-41

BACKGROUND: A number of challenge studies have reported abnormalities of serotonergic function in borderline personality disorder (BPD). There are, however, problems with the pharmacological probes used ... [more ▼]

BACKGROUND: A number of challenge studies have reported abnormalities of serotonergic function in borderline personality disorder (BPD). There are, however, problems with the pharmacological probes used in these studies since fenfluramine and m-CPP are not only serotonergic agents but also induce release of catecholamines, particularly dopamine. Therefore, we tested whether subjects with BPD showed a blunted prolactin (PRL) response to flesinoxan, a highly potent and selective 5-HT1A agonist. METHODS: Flesinoxan challenge test was carried out in 20 BPD in-patients and 20 healthy controls matched for gender but not for age. Since 16 BPD in-patients exhibited major depressive co-morbidity, a group of 20 depressed in-patients matched for gender but not for age was also included. RESULTS: BPD in-patients exhibited blunted PRL responses as compared to controls, whereas depressed in-patients did not differ from controls. Moreover, PRL responses were lower among BPD in-patients than among depressed in-patients. Among the BPD in-patients, PRL responses to flesinoxan were lower in patients with past history of suicide attempts (N = 8) than in those with a negative history. CONCLUSIONS: The results show major involvement of serotonergic function in BPD and are consistent with previous studies linking lower serotonergic activity with impulsivity. More particularly, our data suggest that BPD is characterized by lower 5-HT1A receptor sensitivity. Moreover, the data support the involvement of 5-HT1A activity in suicidal behaviour. However, this conclusion is limited because other hormonal responses such as ACTH and cortisol were not assessed, and because BPD was assessed by a self-report questionnaire and not a structured clinical interview. [less ▲]

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See detailSerotonin, personality and borderline personality disorder
Hansenne, Michel ULg; Pitchot, William ULg; Ansseau, Marc ULg

in Acta Neuropsychiatrica (2002), 14(2), 66-70

Serotonin is one of the neurotransmitters implicated in normal personality Many psychobiological models of personality include,some dimensions related to serotonin. For instance, the harm avoidance ... [more ▼]

Serotonin is one of the neurotransmitters implicated in normal personality Many psychobiological models of personality include,some dimensions related to serotonin. For instance, the harm avoidance dimension of the blosocial model developed by Cloninger is related to serotonergic activity Higher scores on the harm avoidance dimension should theoretically reflect increased serotonergic activity However, correlation studies related serotonin activity to harm avoidance dimension have not yielded consistent findings. These controversial results are probably related to the complexity of the neurotransmitter systems, and the different assessment techniques used in these studies. Finally, recent genetic studies have examined the association between personality dimensions and serotonergic receptor polymorphisms with mixed results. Serotonin is not only related to some dimensions of normal personality Several psychopathological disorders are associated with serotonergic dysfunction. More particularly, borderline personality disorder (BPD) can be defined by many of the symptoms associated with serotonergic dysregulation, including affective lability, suicidal behaviours, impulsivity and loss of impulse control. Indeed, several reports have demonstrated the efficacy of selective serotonin re-uptake drugs in treating the depressive and impulsive symptoms of patients with BPD. Moreover, some challenge studies have reported a lower serotonergic activity in BPD. Because these challenges are not specific, we have assessed the serotonergic activity in BPD with the flesinoxan challenge. Preliminary results showed that the prolactine responses to flesinoxan were significantly lower in BPD patients compared to those observed in controls. [less ▲]

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See detailReply to Letter to the Editor
PITCHOT, William ULg; ANSSEAU, Marc ULg

in Psychoneuroendocrinology (2001)

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See detailLe médicament parmi les thérapies relationnelles : Enquête et réflexions.
David, Claire; WAUTHY, Jacques ULg; Vaulet, Véronique et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2001)

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See detailAdding olanzapine to venlafaxine in treatment-refractory non-psychotic chronic depression
PITCHOT, William ULg; ANSSEAU, Marc ULg

in American Journal of Psychiatry (The) (2001)

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