Les antidépresseurs dans la dépression bipolaire: attention aux risques.

in Revue Médicale de Liège (2008), 63

Peptides neurohypophysaires et dépression unipolaire: quel avenir?.

in Revue Médicale de Liège (2008), 63

Plasma oxytocin levels and anxiety in patients with major depression

in Psychoneuroendocrinology (2007), 32(4), 407-410

Cerebrospinal fluid and plasmatic levels of oxytocin (OT) have been found to change in mood disorders. In post-mortem studies, the numbers of OT-expressing neurons in the paraventricular nucleus have been ... [more ▼]

Cerebrospinal fluid and plasmatic levels of oxytocin (OT) have been found to change in mood disorders. In post-mortem studies, the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased. Moreover, OT is considered as an endogenous antistress hormone. It has also revealed antidepressive effects. OT may contribute to the dysregulation of the HPA system in major depression. The aim of the study was to assess a possible relationship between anxiety and plasma oxytocin (OT) Levels in depressive patients. Severity of depression was estimated with the Hamilton Depression Rating Scale and anxiety by using the Spielberger State-Anxiety Inventory. Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r = -0.58, p = 0.003) and anxiety (r = -0.61, p = 0.005). (C) 2007 Elsevier Ltd. All rights reserved. [less ▲]

Syndrome de discontinuation associé aux antidépresseurs.

in Revue Médicale de Liège (2007), 62

Therapeutic utilisations of vasopressin and oxytocin in mood disorders.

in Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (2007), 1

AVP- and OT-neurophysins response to apomorphine and clonidine in major depression

in Psychoneuroendocrinology (2005), 30(9), 839-845

A number of studies have reported abnormalities of neurohypophyseal secretions in major depressive disorder. The purpose of the present study was to test the influence of apomorphine and clonidine ... [more ▼]

A number of studies have reported abnormalities of neurohypophyseal secretions in major depressive disorder. The purpose of the present study was to test the influence of apomorphine and clonidine injections on plasma vasopressin (AVP)-neurophysins and oxytocin(OT)-neurophysins levels, as direct index of posterior pituitary activation in major depression. Apomorphine and clonidine tests were carried out in 25 medication-free depressive patients and 25 age and gender-matched healthy controls. Blood for neurophysins analysis was drawn by venipuncture at t0, t+20, t+40, t+60 and t+120. Baseline AVP-neurophysins concentrations were significantly tower in depressives (0.12 +/- 0.14 ng/ml) than in healthy subjects (0.24 +/- 2.15 ng/ml) (p < 0.04). The response to apomorphine test revealed a significant reduced response at 20 (p=0.01), 40 (p=0.007) and 60 (p=0.02) and 120 (p=0.02) min. Following clonidine test, post hoc tests also revealed a significant decrease at 0 (p=0.04), 20 (p=0.01), 40 (p=0.007) and 60 (p=0.02) and 120 (p=0.006) min. Concerning OT-neurophysins, no significant differences were found between depressed and controls in response to clonidine or apomorphine injections. Following clonidine and apomorphine, major depressives exhibited a significantly lower peak GH response than controls. The study supports partially the hypothesis of a reduced vasopressinergic activity in depression. Moreover, we did not find any influence of acute apomorphine or clonidine injections on vasopressin-neurophysin or oxytocin-neurophysin in depressive patients. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

Therapeutic application of right prefrontal low repetitive transcranial magnetic stimulation on depressed patients

in European Neuropsychopharmacology (2004, October), 14(Suppl. 3), 226

Relationships between DRD2 and DAT polymorphisms and personality traits in healthy subjects

in European Neuropsychopharmacology (2003, September), 13(Suppl. 4), 427-428

Harm avoidance is related to mismatch negativity (MMN) amplitude in healthy subjects

in Personality & Individual Differences (2003), 34(6), 1039-1048

Event-related potential (ERP) studies evidenced that some personality dimensions induced different controlled cognitive attitudes towards the processing of information. However, few data are available on ... [more ▼]

Event-related potential (ERP) studies evidenced that some personality dimensions induced different controlled cognitive attitudes towards the processing of information. However, few data are available on the possible relationships between personality and automatic attention or early sensory processing. In the present study the relationships between the mismatch negativity (MMN) and personality described by the Cloninger model of personality were investigated. Subjects were 32 healthy volunteers. The MMN was recorded with frequent stimuli tones of 1470 Hz, 70 dB and 40 ms duration, and target (20%) tones of 1470 Hz, 70 dB, 80 ms duration. The subjects completed a French version of the 226-item self-questionnaire TCI within the day following psychophysiological recording. The results showed that the HA dimension was negatively correlated with the MMN amplitude. The association was more present among women than men. No significant relationship existed between the other dimensions of personality and either the MMN amplitude or latency. These findings suggest that the MMN is related to the behavioral inhibition system (BIS), a fact which is consistent with clinical studies conducted on schizophrenia and anxiety disorders. In conclusion, this study suggests that personality dimensions induce different automatic attitudes towards the processing of information. (C) 2002 Published by Elsevier Science Ltd. [less ▲]

Réactions cutanées indésirables aux antidépresseurs.

in Revue Médicale de Liège (2003), 58(1), 22-4

Due to the widespread usage of antidepressants by the population, they represent a class of drugs which is at high risk for cutaneous side effects. The diversity in the clinical presentations is large ... [more ▼]

Due to the widespread usage of antidepressants by the population, they represent a class of drugs which is at high risk for cutaneous side effects. The diversity in the clinical presentations is large. The variability in their severity is large as well. Morbidity may be quite severe, but the vital prognosis is rarely affected. [less ▲]