References of "PIERARD, Luc"
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See detailEvaluation et traitement de la stenose aortique.
Pirlet, C.; Magne, Julien ULg; Lancellotti, Patrizio ULg et al

in Revue medicale suisse (2011), 7(306), 1606-11

Surgical aortic valve replacement is the sole validated treatment of aortic stenosis. The indications for surgery rely on risk/benefit ratio and on the official recommendations. A symptomatic patient with ... [more ▼]

Surgical aortic valve replacement is the sole validated treatment of aortic stenosis. The indications for surgery rely on risk/benefit ratio and on the official recommendations. A symptomatic patient with severe aortic stenosis should be submitted to surgery. The indication of valve replacement is more difficult in asymptomatic patients. The decision should integrate a combination of an exercise test and prognostic parameters associated with poor outcome. Most of them are obtained by Doppler echocardiography. Patients presenting with severe aortic stenosis and low transvalvular gradient constitute a subgroup of patients who require appropriate echocardiographic assessment to determine the potential benefit and risk of surgery. Transluminal aortic valve implantation is a new modality for patients at high surgical risk. [less ▲]

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See detailUse of contrast echocardiography in intensive care and at the emergency room.
Cosyns, Bernard; Roossens, Bram; Hernot, Sophie et al

in Current Cardiology Reviews (2011), 7(3), 157-62

Bedside echocardiography in emergency room (ER) or in intensive care unit (ICU) is an important tool for managing critically ill patients, to obtain a timely accurate diagnosis and to immediately stratify ... [more ▼]

Bedside echocardiography in emergency room (ER) or in intensive care unit (ICU) is an important tool for managing critically ill patients, to obtain a timely accurate diagnosis and to immediately stratify the risk to the patient's life. It may also render invasive monitoring unnecessary. In these patients, contrast echocardiography may improve quality of imaging and also may provide additional information, especially regarding myocardial perfusion in those with suspected coronary artery disease. This article focuses on the principle of contrast echocardiography and the clinical information that can be obtained according to the most frequent presentations in ER and ICU. [less ▲]

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See detailComment j'explore... Une arythmie ventriculaire chez le sportif
Tombeux, C.; MELON, Pierre ULg; Close, P. et al

in Revue Médicale de Liège (2011), 66(1), 30-33

How I explore : ventricular arrhythmhmias in athletes <br />SUMMARY : Documented ventricular tachyarrhythmias or related symptoms need meticulous cardiac investigations. The mechanism of ventricular ... [more ▼]

How I explore : ventricular arrhythmhmias in athletes <br />SUMMARY : Documented ventricular tachyarrhythmias or related symptoms need meticulous cardiac investigations. The mechanism of ventricular arrhythmia must be defined. The prognosis is related to underlying cardiac electrical or structural disorders. In the absence of cardiovascular abnormalities, the prognosis is good. No disqualification to competitive activity is required in most cases. Assessment of the risk of sudden death remains a continuing challenge in athletes. This article reviews the diagnostic and therapeutic approaches of ventricular arrhythmias encountered in trained athletes. [less ▲]

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See detailClinical significance of active myeloperoxidase in carotid atherosclerotic plaques
GACH, Olivier ULg; Magne, Julien ULg; Franck, Thierry ULg et al

in International Journal of Cardiology (2011), 152(1), 149-151

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See detailImpact of aortic stiffness on left ventricular function and B-type natriuretic peptide release in severe aortic stenosis.
Rosca, M.; Magne, Julien ULg; Calin, A. et al

in European Journal of Echocardiography (2011), 12(11), 850-856

Aims: In aortic stenosis (AS), both reduced systemic arterial compliance and increased valvular load have been shown to contribute to impaired left ventricular (LV) function. However, the relationship ... [more ▼]

Aims: In aortic stenosis (AS), both reduced systemic arterial compliance and increased valvular load have been shown to contribute to impaired left ventricular (LV) function. However, the relationship between LV function and aortic stiffness has not yet been investigated. We aimed to assess the relationship between aortic stiffness and LV global longitudinal strain (GLS), LV filling pressures (E/E′) and B-type natriuretic peptide (BNP) in AS. <br />Methods and results : A comprehensive echocardiogram was performed in 48 consecutive patients with severe AS (,0.6 cm2/m2) and preserved LV ejection fraction (≥50%). Aortic stiffness index (beta) was calculated based on aortic diameters measured by echocardiography and blood pressure. Systemic arterial compliance (SAC) and valvulo-arterial impedance (Zva) <br />were also determined. Aortic beta index was significantly correlated with Zva (r ¼ 0.30, P ¼ 0.03) and SAC (r ¼ 20.29, P ¼ 0.04). GLS (r ¼ 0.45, P ¼ 0.001), E/E′ (r ¼ 0.48, P ¼ 0.001) and BNP levels (r ¼ 0.45, P ¼ 0.001) were significantly related to aortic beta index. No significant correlation was found between GLS or E/E′ and SAC or Zva. In multivariate regression analysis, aortic beta index remained correlated with GLS, E/E′, and BNP levels. <br />Conclusions : In patients with severe AS and preserved LV ejection fraction, independently of the valvular load, an increase in aortic rigidity, as assessed by aortic beta index, is independently correlated with reduced LV longitudinal function, increased LV filling pressures, and BNP levels. [less ▲]

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See detailDeterminant and Impact on Outcome of Exercise Pulmonary Hypertension in Asymptomatic Severe Aortic Stenosis.
Magne, Julien ULg; Donal, E; O'Connor, K et al

Conference (2011)

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See detailBrain natriuretic peptide in asymptomatic degenerative mitral regurgitation: determinants and impact on outcome.
Van de Heyning, C; Magne, Julien ULg; Mahjoub, H et al

Conference (2011)

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See detailValvular heart disease: mitral valve disease
LANCELLOTTI, Patrizio ULg; Magne, Julien ULg; O'Connor, K et al

in The EAE textbook of echocardiography (2011)

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See detailPrediction of exercise pulmonary hypertension in asymptomatic degenerative mitral regurgitation
Magne, Julien ULg; Lancellotti, Patrizio ULg; O'Connor, K. et al

in Journal of the American Society of Echocardiography (2011), 24(9), 1004-1012

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See detailAssessment and management of aortic stenosis [Evaluation et traitement de la sténose aortique]
Pirlet, C.; Magne, Julien ULg; Lancellotti, Patrizio ULg et al

in Revue Medicale Suisse (2011), 7(306), 1606-1611

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See detailStress testing in valvular heart disease: Clinical benefit of echocardiographic imaging
Roşca, M.; Lancellotti, Patrizio ULg; Magne, Julien ULg et al

in Expert Review of Cardiovascular Therapy (2011), 9(1), 81-92

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See detailInfluence of thermoelectric coupling on ectopic beats generated by mechano-electric feedback (MEF) in a one-dimensional cardiac fiber model
Collet, Arnaud ULg; Desaive, Thomas ULg; Pierard, Luc ULg et al

in 9th Belgian Day on Biomedical Engineering, Friday November 26th 2010 in the Academy Palace, Hertogstraat 1, 1000 Brussels (2010, November 26)

The influence of thermal processes on electrophysiology has clearly been underlined by Bini et al., using a FitzHugh--Nagumo-type (FHN-type) model. When the temperature is raised, the action potential ... [more ▼]

The influence of thermal processes on electrophysiology has clearly been underlined by Bini et al., using a FitzHugh--Nagumo-type (FHN-type) model. When the temperature is raised, the action potential duration (APD) has been shown to shorten, while the action potential (AP) amplitude decreases, and the conduction velocity increases. In this research, we investigate the effects of thermoelectric coupling on mechano-electric feedback (MEF), and more specifically, on ectopic beats generated by MEF. To investigate these effects, thermoelectric coupling is introduced in a one-dimensional electromechanical model of a cardiac fiber, which considers excitation-contraction coupling (ECC), as well as MEF. [less ▲]

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See detailInfluence of thermoelectric coupling on ectopic beats generated by mechano-electric feedback (MEF) in a one-dimensional cardiac fiber model
Collet, Arnaud ULg; Desaive, Thomas ULg; Pierard, Luc ULg et al

Poster (2010, November 26)

The influence of thermal processes on electrophysiology has clearly been underlined by Bini et al., using a FitzHugh--Nagumo-type (FHN-type) model. When the temperature is raised, the action potential ... [more ▼]

The influence of thermal processes on electrophysiology has clearly been underlined by Bini et al., using a FitzHugh--Nagumo-type (FHN-type) model. When the temperature is raised, the action potential duration (APD) has been shown to shorten, while the action potential (AP) amplitude decreases, and the conduction velocity increases. In this research, we investigate the effects of thermoelectric coupling on mechano-electric feedback (MEF), and more specifically, on ectopic beats generated by MEF. To investigate these effects, thermoelectric coupling is introduced in a one-dimensional electromechanical model of a cardiac fiber, which considers excitation-contraction coupling (ECC), as well as MEF. [less ▲]

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See detailActualités thérapeutiques dans la cardiomyopathie hypertrophique.
Moonen, Marie ULg; Pierard, Luc ULg

in Revue Médicale Suisse (2010), 6(260), 1591-4

The management of patients with hypertrophic cardiomyopathy has largely evolved over the past two decades. One important finding is that medical treatment appears under used. Invasive procedure are ... [more ▼]

The management of patients with hypertrophic cardiomyopathy has largely evolved over the past two decades. One important finding is that medical treatment appears under used. Invasive procedure are reserved to patients with obstructive hypertrophic cardiomyopathy who remain symptomatic despite optimal medical treatment. Indications for implantable cardiac defibrillator are still debated. A global and multidisciplinary approach of the patient and of his family is mandatory. [less ▲]

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See detailRisk stratification in asymptomatic moderate to severe aortic stenosis: the importance of the valvular, arterial and ventricular interplay.
Lancellotti, Patrizio ULg; Donal, Erwan; Magne, Julien ULg et al

in Heart (2010), 96(17), 1364-71

OBJECTIVE: We sought to evaluate prognostic markers of clinical outcome in asymptomatic patients with moderate to severe aortic stenosis (AS). DESIGN: Prospective follow-up of asymptomatic patients with ... [more ▼]

OBJECTIVE: We sought to evaluate prognostic markers of clinical outcome in asymptomatic patients with moderate to severe aortic stenosis (AS). DESIGN: Prospective follow-up of asymptomatic patients with moderate to severe AS. The patients underwent clinical and Doppler echocardiographic evaluation. SETTING: Department of Cardiology. PATIENTS: 163 patients with moderate to severe AS (aortic valve area < or =0.6 cm(2)/m(2)). MAIN OUTCOME MEASURES: Risk stratification. Predefined endpoints for assessing the outcome were the occurrence during follow-up of symptoms, aortic valve replacement or death. RESULTS: During follow-up (mean, 20 (19) months), 11 patients developed symptoms but were not operated on, 57 required aortic valve replacement and six patients died. In multivariable Cox regression analysis, four parameters that were associated with the outcome were identified: peak aortic jet velocity, left ventricular systolic (LV) longitudinal deformation, valvulo-arterial impedance and indexed left atrial area. Using receiver-operator characteristic curve analysis, a peak aortic jet velocity > or =4.4 m/s, a LV longitudinal myocardial deformation < or =15.9%, a valvular-arterial impedance > or =4.9 mm Hg/ml per m(2) and an indexed left atrial area > or =12.2 cm(2)/m(2) were identified as the best cut-off values to be associated with events. CONCLUSIONS: In asymptomatic patients with moderate to severe AS, measurements that integrate the ventricular, vascular and valvular components of the disease improve risk stratification. [less ▲]

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