References of "PIERARD, Luc"
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See detailLeft ventricular regional function and maximal exercise capacity in aortic stenosis.
DULGHERU, Raluca Elena ULg; Magne, J.; DAVIN, Laurent ULg et al

in European heart journal cardiovascular Imaging (2015)

AIMS: The objective assessment of maximal exercise capacity (MEC) using peak oxygen consumption (VO2) measurement may be helpful in the management of asymptomatic aortic stenosis (AS) patients. However ... [more ▼]

AIMS: The objective assessment of maximal exercise capacity (MEC) using peak oxygen consumption (VO2) measurement may be helpful in the management of asymptomatic aortic stenosis (AS) patients. However, the relationship between left ventricular (LV) function and MEC has been relatively unexplored. We aimed to identify which echocardiographic parameters of LV systolic function can predict MEC in asymptomatic AS. METHODS AND RESULTS: Asymptomatic patients with moderate to severe AS (n = 44, aortic valve area <1.5 cm2, 66 +/- 13 years, 75% of men) and preserved LV ejection fraction (LVEF > 50%) were prospectively referred for resting echocardiography and cardiopulmonary exercise test. LV longitudinal strain (LS) of each myocardial segment was measured by speckle tracking echocardiography (STE) from the apical (aLS) 4-, 2-, and 3-chamber views. An average value of the LS of the analysable segments was provided for each myocardial region: basal (bLS), mid (mLS), and aLS. LV circumferential and radial strains were measured from short-axis views. Peak VO2 was 20.1 +/- 5.8 mL/kg/min (median 20.7 mL/kg/min; range 7.2-32.3 mL/kg/min). According to the median of peak VO2, patients with reduced MEC were significantly older (P < 0.001) and more frequently females (P = 0.05). There were significant correlations between peak VO2 and age (r = -0.44), LV end-diastolic volume (r = 0.35), LV stroke volume (r = 0.37), indexed stroke volume (r = 0.32), and E/e' ratio (r = -0.37, all P < 0.04). Parameters of AS severity and LVEF did not correlate with peak VO2 (P = NS for all). Among LV deformation parameters, bLS and mLS were significantly associated with peakVO2 (r = 0.43, P = 0.005, and r = 0.32, P = 0.04, respectively). With multivariable analysis, female gender (beta = 4.9; P = 0.008) and bLS (beta = 0.50; P = 0.03) were the only independent determinants (r2 = 0.423) of peak VO2. CONCLUSION: In asymptomatic AS, impaired LV myocardial longitudinal function determines reduced MEC. Basal LS was the only parameter of LV regional function independently associated with MEC. [less ▲]

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See detailClinical Significance of Exercise Pulmonary Hypertension in Secondary Mitral Regurgitation.
Lancellotti, Patrizio ULg; Magne, Julien; DULGHERU, Raluca Elena ULg et al

in The American journal of cardiology (2015)

In patients with heart failure, exercise echocardiography can help in risk stratification and decision making. The prognostic significance of exercise pulmonary hypertension (PH) in patients with ... [more ▼]

In patients with heart failure, exercise echocardiography can help in risk stratification and decision making. The prognostic significance of exercise pulmonary hypertension (PH) in patients with secondary mitral regurgitation (MR) remains unknown. The aim of the present study was to assess the prognostic value of exercise PH in patients with secondary MR and narrow QRS intervals. From 2005 to 2012, 159 consecutive patients with secondary MR, narrow QRS intervals, left ventricular dysfunction (mean ejection fraction 36 +/- 7%), and measurable systolic pulmonary arterial pressure (SPAP) during exercise echocardiography were included. Resting and exercise PH were defined as SPAP >50 and >60 mm Hg, respectively. Exercise PH was more frequent than resting PH (40% vs 13%, p <0.0001). On multivariate logistic regression, the independent determinants of exercise PH were resting SPAP (p <0.0001), exercise MR severity (p <0.0001), and e'-wave velocity (p = 0.004). The incidence of cardiac events during follow-up was significantly higher in patients with exercise PH compared with those without exercise PH (4 years: 40 +/- 7% vs 20 +/- 5%, p <0.0001). Patients with exercise PH exhibited higher rates of cardiac events and death than those with resting PH. In a multivariate Cox proportional hazards model, exercise PH was independently associated with the occurrence of cardiac events (p <0.0001). In conclusion, in patients with secondary MR, exercise PH is determined mainly by resting SPAP, left ventricular diastolic burden, and exercise MR severity. Exercise PH is a powerful predictor of poor outcomes, with a 5.3-fold increased risk for cardiac-related death during follow-up. These results highlight the added value of exercise echocardiography in secondary MR. [less ▲]

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See detailThe year in cardiology 2014: valvular heart disease.
Pierard, Luc ULg; Vahanian, Alec

in European heart journal (2015)

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See detailPoster session 6: Saturday 6 December 2014, 08:30-12:30Location: Poster area.
Henri, C.; DULGHERU, Raluca Elena ULg; Magne, J. et al

Poster (2014, December)

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See detailPoster session 5: Friday 5 December 2014, 14:00-18:00Location: Poster area.
Henri, C.; DULGHERU, Raluca Elena ULg; Magne, J. et al

Poster (2014, December)

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See detailOral Abstract session: Stress echo in clinical practice: Friday 5 December 2014, 08:30-10:00Location: Agora.
Magne, J.; Donal, E.; Dulgheru, R. et al

Conference (2014, December)

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See detailClub 35 Poster session 2: Thursday 4 December 2014, 08:30-18:00Location: Poster area.
Voilliot, D.; Magne, Jm; DULGHERU, Raluca Elena ULg et al

Poster (2014, December)

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See detail2014 ESC/ESA Guidelines on Non-cardiac Surgery: Cardiovascular Assessment and Management.
Kristensen, Steen Dalby; Knuuti, Juhani; Saraste, Antti et al

in European Heart Journal (2014), 35(35), 2383-431

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See detailAnatomie et physiologie à l'effort
PIERARD, Luc ULg

in Cardio & Sport (2014), 43

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See detailWhen the heart has its reason: the Takotsubo Syndrome
DAVIN, Laurent ULg; LEGRAND, Victor ULg; LANCELLOTTI, Patrizio ULg et al

in Acta Psychiatrica Belgica (2014)

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See detailL'insuffisance cardiaque du sujet age.
D'ORIO, Virginie ULg; LANCELLOTTI, Patrizio ULg; Pierard, Luc ULg

in Revue medicale de Liege (2014), 69(5-6), 309-14

Heart failure in the elderly represents a major public health problem.In this population, the general objective of therapy, defined by current guidelines, does not differ from that proposed for younger ... [more ▼]

Heart failure in the elderly represents a major public health problem.In this population, the general objective of therapy, defined by current guidelines, does not differ from that proposed for younger patients: the aims are to decrease symptoms, to improve quality of life, to decrease hospitalizations, and to increase survival. However, in this category of patients, respect for autonomy and quality of life remains a priority, and requires a personalized approach because of the geriatric characteristics of many patients. [less ▲]

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See detailPlace des nouveaux anticoagulants oraux directs.
Pierard, Luc ULg; SPRYNGER, Muriel ULg

in Revue medicale suisse (2014), 10(439), 1562-7

New oral anticoagulants (NOACs) are going to deeply modify the treatment of non valvular atrial fibrillation and thromboembolic disease. They are non-inferior to warfarin and trials show a similar ... [more ▼]

New oral anticoagulants (NOACs) are going to deeply modify the treatment of non valvular atrial fibrillation and thromboembolic disease. They are non-inferior to warfarin and trials show a similar bleeding rate (even lower for some NOACs). Nevertheless one must be cautious when dealing with patients at risk (elderly patients, frail ones, renal or liver impairment...) and practicians must be well aware of doses and contraindications. NOACs' long- term tolerance is not yet well-known. In cancer, their benefit-risk ratio compared to low molecular weight heparin remains to be determined. [less ▲]

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See detailThe year 2013 in the European Heart Journal - Cardiovascular Imaging: Part II.
Plein, Sven; Edvardsen, Thor; Pierard, Luc ULg et al

in European heart journal cardiovascular Imaging (2014), 15(8), 837-841

The new multi-modality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here we summarize the most important studies from the journal's second year in ... [more ▼]

The new multi-modality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here we summarize the most important studies from the journal's second year in two articles. Part I of the review has summarized studies in myocardial function, myocardial ischaemia, and emerging techniques in cardiovascular imaging. Part II is focussed on valvular heart diseases, heart failure, cardiomyopathies, and congenital heart diseases. [less ▲]

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See detailRéserve contractile dans l’insuffisance mitrale primaire asymptomatique
PIERARD, Luc ULg; MAGNE, Julien; DULGHERU, Raluca Elena ULg et al

in Revue Médicale de Liège (2014), 69(S2), 8-11

Résumé : L’étude rapportée avait pour but de quantifier la réserve contractile ventriculaire gauche (VG) et d’évaluer son utilité pour la stratification du risque chez les patients asymptomatiques avec ... [more ▼]

Résumé : L’étude rapportée avait pour but de quantifier la réserve contractile ventriculaire gauche (VG) et d’évaluer son utilité pour la stratification du risque chez les patients asymptomatiques avec insuffisance mitrale (IM) primaire. Une échocardiographie au repos et à l’effort, incluant le suivi des marqueurs acoustiques, a été effectuée chez 115 patients consécutifs, présentant une IM primaire modérée ou sévère.La réserve contractile du VG est définie comme une augmentation induite par l’effort de la fraction d’éjection VG ≥ 4% ou de la déformation longitudinale VG ≥ 2%. La réserve contractile VG est absente dans approximativement la moitié de la population. Cette absence est un facteur prédictif indépendant d’événement cardiaque, s’il est évalué par les changements induits par l’effort de la fonction longitudinale VG, mais pas ceux de la fraction d’éjection VG. [less ▲]

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See detailImpact of exercise pulmonary hypertension on postoperative outcome in primary mitral regurgitation.
Magne, Julien; Donal, Erwan; Mahjoub, Haifa et al

in Heart (British Cardiac Society) (2014)

AIMS: The management of asymptomatic patients with mitral regurgitation (MR) remains controversial. Exercise-induced pulmonary hypertension (ExPHT) was recently reported as a strong predictor of rapid ... [more ▼]

AIMS: The management of asymptomatic patients with mitral regurgitation (MR) remains controversial. Exercise-induced pulmonary hypertension (ExPHT) was recently reported as a strong predictor of rapid onset of symptoms. We hypothesised that ExPHT is a predictor of postoperative cardiovascular events in patients with primary MR. METHODS AND RESULTS: One hundred and two patients with primary MR, no or mild symptoms (New York heart association (NYHA) </=2), and no LV dysfunction/dilatation, were prospectively recruited in 3 centres and underwent exercise-stress echocardiography. The presence of ExPHT was defined as an exercise systolic pulmonary arterial pressure >60 mm Hg. All patients were closely followed up and operated on when indication for surgery was reached. Postoperative events were defined as the occurrence of atrial fibrillation (AF), stroke, cardiac-related hospitalisation or death. Among the 102 patients included, 59 developed ExPHT (58%). These patients were significantly older than those without ExPHT (p=0.01). During a mean postoperative follow-up of 50+/-23 months, 28 patients (26%) experienced a predefined cardiovascular event. Patients with ExPHT had significantly higher rate of postoperative events (39% vs 12%, p=0.005); the rate of events was still higher in these patients (32% vs 9%, p=0.013), even when excluding early postoperative AF (ie, within 48 h). Event-free survival was significantly lower in the ExPHT group (all events: 5-year: 60+/-8% vs 88+/-5%, p=0.007, events without early AF: 5-year: 67+/-7% vs 90+/-4%, p=0.02). Using Cox multivariable analysis, ExPHT remained independently associated with higher risk of postoperative events in all models (all p</=0.04). CONCLUSIONS: ExPHT is associated with increased risk of adverse cardiac events following mitral valve surgery in patients with primary MR. [less ▲]

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