Vimentinoma, an Unusual Neoplasm of the Skin

in Dermatology : International Journal for Clinical & Investigative Dermatology (1994), 189(1), 84-86

We report an unusual benign neoplasm that developed in a child. Tumoral cells were filled with vimentin intermediate filaments. No other features of differentiation were found by immunohistochemistry and ... [more ▼]

We report an unusual benign neoplasm that developed in a child. Tumoral cells were filled with vimentin intermediate filaments. No other features of differentiation were found by immunohistochemistry and electron microscopy. 'Vimentinoma' appears to be the most appropriate name for this neoplasm. [less ▲]

Que peut-on attendre des marqueurs immunohistochimiques du mélanome?

in Nouvelles Dermatologiques (1994), 13

Macrofagos y factor de necrosis tumoral alfa en la necrolisis epidermica toxica

in Archives of Dermatology (1994), 5

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular ... [more ▼]

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular inflamatorio varió dependiendo del estado de la enfermedad. La principal característica constante fue la importante implicación de la línea monocito-macrófago, incluyendo dendrocitos factor XIIIa+ HLA-DR+ y macrófagos CD68+ Mac 387+, antes y durante la necrosis epidérmica. El número de linfocitos CD4+ y CD8+ era comparativamente reducido. Ello se asociaba con un denso marcaje para el factor de necrosis tumoral alfa en la epidermis. CONCLUSIONES: Las células de estirpe monocito-macrófago superan en nùmero ampliamente a los linfocitos en las lesiones de la necrólisis epidérmica tóxica. El factor de necrosis tumoral alfa es problablemente una de las citocinas principales responsables de la necrosis. [less ▲]

Hamartome angiomateux eccrine néonatal en plaques plurifocales

in Giornale Internazionale di Dermatologia Pediatrica (1994), 6(1), 15-17

We report a case of eccrine angiomatous hamartoma disclosed in a 5-year-old girl. The lesion was painful and multifocal in plaques on a forearm. The diagnosis was made on the basis of histologic and ... [more ▼]

We report a case of eccrine angiomatous hamartoma disclosed in a 5-year-old girl. The lesion was painful and multifocal in plaques on a forearm. The diagnosis was made on the basis of histologic and immunohistochemistric assays. This conditions must be distinguished from other neonatal angiomatoses. [less ▲]

Immunohistochemical detection of immediate early and late phase proteins expressed during the varicella-zoster virus cycle

in British Journal of Dermatology. Supplement (1994), 131(44), 64

Oppervlakte-biopsie

in Nederlands Tijdschrift voor Dermatologie en Venereologie (1993), 3

Superficial skin surface stripping (SSSS) enables the study of the outermost cell layers of the stratum corneum. In this article we review the diagnostic value and the research possibilities offered by ... [more ▼]

Superficial skin surface stripping (SSSS) enables the study of the outermost cell layers of the stratum corneum. In this article we review the diagnostic value and the research possibilities offered by SSSS. This technique is non invasive and provides information useful in the differential diagnosis of erythematosquamous and eczematous lesions and pigmented neoplasms. For research purposes SSSS can also be used as substratum for scanning electron microscopic assessments and biochemical analysis. [less ▲]

Exploration et traitement des photodermatoses

in Revue Médicale de Liège (1993), 48(4), 189-194

Le diagnostic d'une photodermatose est facilement évoqué devant une éruption rythmée par l'exposition au soleil. L'exploration photobiologique est pourtant nécessaire pour le classement nosologique de ces ... [more ▼]

Le diagnostic d'une photodermatose est facilement évoqué devant une éruption rythmée par l'exposition au soleil. L'exploration photobiologique est pourtant nécessaire pour le classement nosologique de ces affections. Nous présentons une revue de l'exploration photobiologique, de ses indications et interprétation, ainsi que des mesures thérapeutiques qui peuvent en découler. [less ▲]

Evaluation quantitative de l'érythème par colorimétrie. Effets de l'histamine de corticostéroïdes et d'extraits végétaux

in Journal d'Actualités Médicales Belges (1993), 5

L'évaluation de l'érythème est difficile et souvent aléatoire en clinique. Afin d'étudier la couleur des téguments, la colorimétrie est proposée depuis quelques années. Elle permet plus de rigueur. En ... [more ▼]

L'évaluation de l'érythème est difficile et souvent aléatoire en clinique. Afin d'étudier la couleur des téguments, la colorimétrie est proposée depuis quelques années. Elle permet plus de rigueur. En tous cas, elle permet d'aligner des chiffres dont les variations peuvent être étudiées dans le temps. Le présent travail a permis de tester, de "calibrer" la méthodologie colorimétrique dans le domaine de l'érythème cutané. D'une part, l'effet vasodilatateur (érythémateux) de l'histamine, de l'autre, le blanchiment induit par l'application de topiques corticoïdes et phytopharmaceutiques ont été mesurés et discutés. [less ▲]

Neutrophilic Eccrine Hidradenitis. A Case Report

in Acta Clinica Belgica (1993), 48(6), 397-400

Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis occurring most frequently during induction chemotherapy for a variety of malignancies. We report a case of NEH in a 41-year-old ... [more ▼]

Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis occurring most frequently during induction chemotherapy for a variety of malignancies. We report a case of NEH in a 41-year-old woman with acute myeloblastic leukemia under daunorubicin, cytarabine and etoposide chemotherapy. She developed red, tender and painful nodules on a shoulder. The lesions resolved spontaneously. Histological examination is mandatory as the clinical presentation of this dermatosis is highly polymorphic. Leukemia cutis, sepsis, deep fungal infection and Sweet's syndrome must be excluded as these implicate different therapies. [less ▲]

CD68 and Factor XIIIa expressions in granular-cell tumor of the skin

in Dermatology : International Journal for Clinical & Investigative Dermatology (1993), 186(2), 106-108

Immunohistochemical and electron microscopic studies support a Schwann cell origin for most of the granular-cell tumors of the skin. We studied 9 granular-cell tumors by immunohistochemistry, using ... [more ▼]

Immunohistochemical and electron microscopic studies support a Schwann cell origin for most of the granular-cell tumors of the skin. We studied 9 granular-cell tumors by immunohistochemistry, using antibodies to CD68, S-100 proteins, factor XIIIa, L1 antigen, desmin and vimentin. The CD68 monocyte-macrophage-associated lysosomal antigen was expressed in granular cells which however had no Mac 387 reactivity. The 'satellite fibroblasts' were factor XIIIa-positive similarly to dendrocytes and perineurial cells. Our study reveals the lack of specificity of CD68 antibody to identify macrophages. It also presents granular cell tumor of the skin as an exception in the group of schwannomas by the presence of factor XIIIa-positive cells inside the neoplasm. [less ▲]