References of "PIERARD, Gérald"
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See detailPlaidoyer pour la biodiversité au crépuscule du deuxième millénaire.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (1998), 55

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See detailObservation de la peau d'un hadrosaure vieux de 75 millions d'années.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (1998), 55

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See detailOiseau, d'où viens-tu?
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Association des Géologues Amateurs de Belgique Minibul (1998), 31(8), 20-22

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See detailLow-productive alpha-herpesviridae infection in chronic lichenoid dermatoses
Nikkels, Arjen ULg; Sadzot-Delvaux, Catherine ULg; Rentier, Bernard ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1998), 196(4), 442-446

BACKGROUND: Herpes simplex virus (HSV) and Varicella-zoster virus (VZV) are responsible for various atypical mucocutaneous manifestations in the immunosuppressed population. One of the causative ... [more ▼]

BACKGROUND: Herpes simplex virus (HSV) and Varicella-zoster virus (VZV) are responsible for various atypical mucocutaneous manifestations in the immunosuppressed population. One of the causative pathomechanisms suggests an altered virus-host cell relationship. OBJECTIVE/METHODS: This report investigates by histology, immunohistochemistry and in situ hybridization the histological and virological features of 6 protracted, indolent HSV infections and 2 prolonged zoster infections. RESULTS: Histopathology revealed a lichenoid dermatitis in all patients. Specific HSV-1, HSV-2 and VZV in situ hybridization proved the viral origin of the cutaneous lesions. Immunohistochemical assessment demonstrated the intracellular presence of the HSV glycoproteins gB, gC and gD in epidermal keratinocytes which did not exhibit cytolysis. Similar findings were obtained for the VZV gE and gB. CONCLUSION: These results suggest that in some instances HSV and VZV infections may present a protracted disease course associated with a lichenoid inflammatory pattern and a non-cytolytic virus-host cell relationship. [less ▲]

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See detailHerpes zoster
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Acta Dermato Venereologica (1998), 78

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See detailL'erytheme necrolytique migrateur.
Dandrifosse, J. F.; Dandrifosse, A. C.; Pierard, Gérald ULg et al

in Revue Médicale de Liège (1998), 53(12), 778-83

Necrolytic migratory erythema (NME) is generally associated with glucagonoma. It waxes and wanes by successive relapses and remissions. The clinical and microscopical diagnosis is complex. In addition to ... [more ▼]

Necrolytic migratory erythema (NME) is generally associated with glucagonoma. It waxes and wanes by successive relapses and remissions. The clinical and microscopical diagnosis is complex. In addition to glucagonoma treatments, the administration of corticoids, aminoacids, zinc or essential fatty acids can be helpful. There exist several etiological hypotheses for NME. These are based on modifications of pancreatic enzyme activities and on variations of aminoacids, fatty acids, zinc or glucagon concentrations. [less ▲]

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See detailChronic varicella-zoster virus skin lesions in patients with human immunodeficiency virus are related to decreased expression of gE and gB
Nikkels, Arjen ULg; Rentier, Bernard ULg; Pierard, Gérald ULg

in Journal of Infectious Diseases (1997), 176(1), 261-264

The pathogenesis of chronic, verrucous varicella-zoster virus (VZV) cutaneous lesions in human immunodeficiency virus (HIV)-infected persons is unknown. It has been hypothesized that these lesions are due ... [more ▼]

The pathogenesis of chronic, verrucous varicella-zoster virus (VZV) cutaneous lesions in human immunodeficiency virus (HIV)-infected persons is unknown. It has been hypothesized that these lesions are due to an altered pattern of virus gene expression. Immediate early and late (L) gene expression in five chronic verrucous VZV lesions, four full-blown herpes zoster vesicular lesions in HIV-infected persons, and eight vesicular herpes zoster lesions in immunocompetent individuals was semiquantitatively assessed immunohistochemically using specific antibodies to the IE63, gE (L), and gB (L) proteins. All patients had evidence of IE63 expression in keratinocytes; however, gE expression was either weak or absent in keratinocytes of three verrucous lesions, and gB was either weak or absent in two. These results suggest that chronic VZV skin lesions are associated with diminished gE and gB expression. It is inferred that the VZV behavior in keratinocytes may vary from a latency-like state to a fully developed, productive infection. [less ▲]

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See detailFatal Mural Endocarditis and Cutaneous Botryomycosis after Heart Transplantation
Defraigne, Jean-Olivier ULg; Demoulin, J. C.; Pierard, Gérald ULg et al

in American Journal of Dermatopathology (1997), 19(6), 602-5

Fatal mural endocarditis and botryomycosis occurred concurrently in a 62-year-old women 4 months after orthotopic heart transplantation. Subsequent to mild mitral regurgitation, infection developed on a ... [more ▼]

Fatal mural endocarditis and botryomycosis occurred concurrently in a 62-year-old women 4 months after orthotopic heart transplantation. Subsequent to mild mitral regurgitation, infection developed on a left atrial thrombus and was complicated by cerebral embolization. Simultaneously, skin nodules manifested on both forearms. Histologic examination revealed typical aspects of early evolving botryomycosis with massive infiltration of the dermis and hypodermis by necrotic granulomas framed by grains of Gram-positive coccoid forms. Bacteria were decorated by a nonspecific polyclonal antibody to Mycobacterium bovis. [less ▲]

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See detailHair follicle involvement in herpes zoster
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Virchows Archiv : An International Journal of Pathology (1997), 430

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See detailPolymorphous light eruption-like lesions on sun-protected injection sites of recombinant IFN-alpha-2b
Nikkels, Arjen ULg; Delwaide, Jean ULg; Letawe, C. et al

in Journal of Dermatological Treatment (1997), 8(4), 285

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See detailLe médicament du mois - Le Valaciclovir (Zelitrex)
Pierard, Gérald ULg; Nikkels, Arjen ULg

in Revue Médicale de Liège (1997), 52(8), 553-555

Un progrès important vient d'être réalisé dans le traitement du zona. Le valaciclovir (Zelitrex) est un nouveau médicament oral qui est en fait un précurseur de l'aciclovir. Sa biodisponibilité supérieure ... [more ▼]

Un progrès important vient d'être réalisé dans le traitement du zona. Le valaciclovir (Zelitrex) est un nouveau médicament oral qui est en fait un précurseur de l'aciclovir. Sa biodisponibilité supérieure à celle de l'aciclovir est à l'origine d'un progrès thérapeutique majeur dans la prise en charge du zona cutané chez des sujets immunocompétents de plus de 50 ans et du zona ophtalmique quel que soit l'âge du sujet. Le valaciclovir réduit tant la prévalence que la sévérité des douleurs associées au zona. [less ▲]

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See detailOccult genital herpes presenting as an endometrial infection detected at delivery: a report of two cases
Aghazarian, Saro; Nikkels, Arjen ULg; Grodos, Jacques et al

in Journal of the European Academy of Dermatology & Venereology (1997), 9

Background: The prevalence and clinical implications of asymptomatic genital herpes remain elusive. Objective/aim: We report two cases of clinically asymptomatic intrautcrine herpes simplex virus II (HSV ... [more ▼]

Background: The prevalence and clinical implications of asymptomatic genital herpes remain elusive. Objective/aim: We report two cases of clinically asymptomatic intrautcrine herpes simplex virus II (HSV-II) infection in order to discuss their pathological significance and demonstrate the potential utility of specific DNA probes and antibodies. Methods: Standard histology, immunohistochemistry (IHC) and in situ hybridization (ISH) were applied to formalin-tixed. paraffin-em bedded lissue sections of curettage specimens from women presenting deciditalised fragments retention after normal delivery. Results: Hisiological analysis revealed a focal clearing of endometrial epithelial cell nuclei, suggesting a viral etiology. ISH and IHC with differetit DNA probes or antibodies confirmed the diagnosis of HSV-II infection at the time of specimen collection. Clinical signs of muco-cutaneous involvement in the mothers and of neonatal HSV infection were not observed. Conclusion: These findings suggest that intrauterinc HSV-II infection is not always associated with disease. The IHC and ISH methods can be helpful to a.ssess the diagnosis of HSV-II intrauterine infections in the presence of optically clear cndotTietrial nuclei. Whether or not such HSV-II occult infection may be associated with viral shedding and risk of sexual transtnission was not evaluated in the present study. © 1997 Elsevier Science B.V. [less ▲]

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See detailNaevocyte Triggering by Recombinant Human Growth Hormone
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg et al

in Journal of Pathology (The) (1996), 180(1), 74-79

The influence of growth hormone and insulin-like growth factor I on human melanocytes is being increasingly recognized. Clinical evidence has shown that when recombinant human growth hormone (hGH) is ... [more ▼]

The influence of growth hormone and insulin-like growth factor I on human melanocytes is being increasingly recognized. Clinical evidence has shown that when recombinant human growth hormone (hGH) is administered to children of short stature, the growth of melanocytic naevi is boosted. This study was conducted on 56 hGH-triggered naevi and nine similar lesions excised before or after hGH therapy for hypopituitarism and Turner's syndrome. A series of 40 naevi excised from age-matched healthy children served as controls. Atypicality of naevocytes was investigated using image analysis, AgNOR counts, immunohistochemistry (HMB-45, NKI-C3, Ki-67, anti-bcl-2-oncoprotein), and DNA flow cytometry. The data associate hGH treatment with anisokaryosis and increased AgNOR and Ki-67 counts in naevocytes. The same cells also show abnormal patterns of HMB-45 immunolabelling. These indications of naevocyte activation were not suggestive of malignant transformation. hGH-triggered melanocytomas should be added to the list of atypical melanocytic naevi. The long-term evolution of these lesions remains unknown and the potential risk of malignant transformation awaits careful evaluation. [less ▲]

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See detailFactor Xiiia-Positive Dendrocytes and Proliferative Activity of Cutaneous Cancers
Pierard-Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Nikkels, Arjen ULg et al

in Virchows Archiv : An International Journal of Pathology (1996), 429(1), 43-48

Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages and ... [more ▼]

Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages and antigen-presenting cells. Factor XIIIa, other tissue transglutaminases, alpha 2-macroglobulin and tumour necrosis factor-alpha represent a complex network of mediators influencing tumour progression in the skin. In the present study we searched for the presence of dendrocytes and alpha 2-macroglobulin deposits inside and in the vicinity of cutaneous carcinomas (90 basal cell carcinomas and 46 squamous cell carcinomas) and malignant melanomas (69 primary and 28 metastatic tumours). We also studied the proliferation of the same neoplasms by Ki-67 immunohistochemistry. Dendrocytes were numerous, abutting on and infiltrating most basal cell carcinomas and thin malignant melanomas. In contrast, they were present in only low numbers or even absent in thick primary malignant melanomas and in their metastases. They appeared unmodified around squamous cell carcinomas compared with the surrounding skin. Extracellular deposits of alpha 2-macroglobulin were often found in locations where dermal dendrocytes were numerous. No correlation was found between the Ki-67 indices of carcinomas and the density of peritumoral dendrocytes. In contrast, negative relationships were found between the Ki-67 indices and the number of dendrocytes present inside basal cell carcinomas and thin malignant melanomas. This study has yielded circumstantial evidence to link the density of factor XIIIa-positive dendritic cells and a low proliferative rate of neoplastic cells in basal cell carcinomas and malignant melanomas. [less ▲]

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See detailHerpesviridae granulomas. Letter
Nikkels, Arjen ULg; Pierard, Gérald ULg

in European Journal of Dermatology (1996), 6(5), 394

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See detailDistribution of varicella-zoster virus and herpes simplex virus in disseminated fatal infections
Nikkels, Arjen ULg; Delvenne, Philippe ULg; Sadzot-Delvaux, Catherine ULg et al

in Journal of Clinical Pathology (1996), 49(3), 243-248

AIMS: To study the cutaneous and visceral distribution of herpes simplex virus (HSV) and varicella zoster virus (VZV) in fatal infections. METHODS: Standard histology, immunohistochemistry (monoclonal ... [more ▼]

AIMS: To study the cutaneous and visceral distribution of herpes simplex virus (HSV) and varicella zoster virus (VZV) in fatal infections. METHODS: Standard histology, immunohistochemistry (monoclonal antibodies VL8 and VL2 and polyclonal antibody IE63 directed against VZV; monoclonal antibodies IBD4 and HH2 and polyclonal antibodies directed against HSVI and HSVII) and in situ hybridisation (anti-HSV and anti-VZV probes) were applied to formalin fixed, paraffin wax sections. RESULTS: On histological examination, Herpesviridae infection was evident in various organs including the lungs, liver and skin. In addition, immunohistochemistry and in situ hybridisation revealed the presence of HSV and VZV antigens and nucleic acids in several cell types and tissues showing no cytopathological alterations suggestive of Herpesviridae infection. The organs with histological evidence of infection also contained VZV or HSV antigens and their genes. CONCLUSIONS: These findings suggest that organ failure in disseminated VZV and HSV infections is primarily caused by HSV or VZV induced cell damage and lysis. They also indicate that immunohistochemistry and in situ hybridisation can provide an accurate, type-specific diagnosis on formalin fixed, paraffin wax embedded tissue even when classic histological and cytological characteristics are lacking. [less ▲]

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See detailAntibiothérapie topique et infections cutanées
Henry, Frédérique ULg; Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (1996), 51(2), 160-162

Les infections cutanées bactériennes, qui restent souvent limitées en extension, méritent un traitement local. Dans cette indication, l'antibiothérapie topique est toujours d'actualité. Le choix du ... [more ▼]

Les infections cutanées bactériennes, qui restent souvent limitées en extension, méritent un traitement local. Dans cette indication, l'antibiothérapie topique est toujours d'actualité. Le choix du médicament doit être guidé par son spectre d'activité. Les risques de développement d'une résistance bactérienne et d'une hypersensibilité allergique à l'antibiotique ou à sa base galénique doivent également être pris en considération. [less ▲]

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See detailUne cause parfois meconnue de lesions vasculaires: la maladie de Behcet.
Defraigne, Jean-Olivier ULg; SAKALIHASAN, Natzi ULg; Pierard, Gérald ULg et al

in Revue Médicale de Liège (1996), 51(10), 639-46

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