References of "PIERARD, Gérald"
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See detailHOX Gene Aberrant Expression in Skin Melanoma: A Review.
PIERARD, Gérald ULg; Franchimont, Claudine ULg

in Journal of skin cancer (2012), 2012

The homeobox family and its subset of HOX gene products represent a family of transcription factors directing DNA-protein and protein-protein interactions. In the embryo, they are central regulators in ... [more ▼]

The homeobox family and its subset of HOX gene products represent a family of transcription factors directing DNA-protein and protein-protein interactions. In the embryo, they are central regulators in cell differentiation during morphogenesis. A series of genes of the four HOX gene clusters A, B, C, and D were reported to show aberrant expressions in oncogenesis, particularly in cutaneous malignant melanoma (CMM). They are involved in cell proliferation and progression in the CMM metastatic path. We present relevant peer-reviewed literature findings about the aberrant expression of HOX genes in CMM. The number of CMM cell nuclei exhibiting aberrant HOX protein expression appears correlated with tumour progression. [less ▲]

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See detailLa drosophile, les récepteurs Toll-like et nous.
PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg; SZEPETIUK, Grégory ULg et al

in Dermatologie Actualité (2012), 132

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See detailL'image du mois. Ulcere infectieux synergistique apres morsure de chien.
PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(9), 447-8

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See detailPister et traiter les métastases du mélanome.
PIERARD, Gérald ULg; HUMBERT, Philippe; QUATRESOOZ, Pascale ULg

in Dermatologie Actualité (2012), 131

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See detailHair weathering and hair capacitance mapping: a pilot study.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Journal of Cosmetic Dermatology (2012), 11(3), 179-82

BACKGROUND: Currently, there is no reported objective method allowing confident assessment of hair hydration mapping. Thus, assessing hair moisture kinetics and versatility according to hair shaft damages ... [more ▼]

BACKGROUND: Currently, there is no reported objective method allowing confident assessment of hair hydration mapping. Thus, assessing hair moisture kinetics and versatility according to hair shaft damages and hair care products is difficult to perform. AIM: To explore a new method for assessing hair moisture. METHOD: A new method of hair capacitance mapping (HCM) is introduced for monitoring hair surface damage and hydration. This study was performed on intact and weathered hair locks. Samples were soaked in 10% solutions of regular shampoos or in tap water alone. HCM was performed using the SkinChip((R)) device based on a semiconductor image sensor technology. Time to complete water desorption from cuticular cells was recorded. RESULTS: Hair surface moisture was increased for <30 min after soaking in the shampoos or water alone. The method was sensitive enough to disclose a gradient of moisture from the base to the tip of the hair shafts. Weathered hairs lost their moisture more rapidly than intact hairs. CONCLUSION: Hair capacitance mapping appears to be a promising method in the assessment of the dynamics of hair surface moisture. [less ▲]

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See detailGender differences in skin aging and the changing profile of the sex hormones with age.
FARAGE, Miranda; MILLER, Kenneth W.; ZOUBOULIS, Christos C. et al

in Journal of Steroids and Hormonal Science (2012), 3(1000109),

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See detailClinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea.
Berardesca, Enzo; Iorizzo, Matilde; Abril, Elva et al

in Journal of Cosmetic Dermatology (2012), 11(1), 37-41

Background Rosacea is a chronic inflammatory skin disease affecting mostly facial skin. Its origin is multifactorial. Important steps in its treatment are avoidance of any triggering factor and control of ... [more ▼]

Background Rosacea is a chronic inflammatory skin disease affecting mostly facial skin. Its origin is multifactorial. Important steps in its treatment are avoidance of any triggering factor and control of skin inflammation. Aim To assess the benefit of topical applications of a new product (P-3075). Patients/Methods A randomized, multicenter, double-blind, placebo-controlled, parallel-group, pilot study was carried out to evaluate the efficacy and tolerability of a cream (P-3075) based on 5% potassium azeloyl diglycinate (PAD, Azeloglicina((R)) ) and 1% hydroxypropyl chitosan (HPCH). Forty-two patients (rosacea stages I and II) were enrolled and randomized, 28 in the P-3075 group and 14 in the placebo group. They were asked to apply the cream twice daily for 4 weeks. The main assessments were the objective quantification of erythema and skin hydration using the Mexameter((R)) and Corneometer((R)) devices, respectively. Clinical signs and symptoms were evaluated on a four-point scale. Results The P-3075 cream applied for 28 days was effective in skin protection by reducing erythema, evaluated both instrumentally and clinically. In addition, the clinical assessments of other symptoms such as flushing, stinging, and burning supported the beneficial effect of the P-3075 cream. Conclusions The anti-inflammatory and moisturizing effects of potassium azeloyl diglycinate combined with the protective properties of HPCH allow the new product to be a good candidate for controlling signs and symptoms of rosacea. [less ▲]

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See detailLes mille et un visages des cellules souches multipotentes de la peau. L'avenir a trouve de nouvelles racines.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(3), 143-6

Multipotent stem cells of adult skin are found in distinct biological locations identified as niches. These stem cell populations are defined by specific molecular and functional attributes. The epidermal ... [more ▼]

Multipotent stem cells of adult skin are found in distinct biological locations identified as niches. These stem cell populations are defined by specific molecular and functional attributes. The epidermal stem cells are found in the interfollicular areas and in the bulge and isthmus of the hair follicles. Dermal stem cells are harbored in the peripilar connective tissue sheaths and in the hair papilla. Some skin stem cells are found in extracutaneous sites. Other stem cells are involved in pathology, such as neoplastic stem cells identified in malignant melanomas. [less ▲]

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See detailAutoimmunity-related granulomatous dermatitis in association with hepatitis.
Szepetiuk, Gregory; Lesuisse, Marianne; PIERARD, Gérald ULg et al

in Case Reports in Dermatology (2012), 4(1), 80-4

AIM: Both interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic granulomatous dermatitis (PNGD) are rare disorders typically associated with systemic autoimmune conditions. They probably ... [more ▼]

AIM: Both interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic granulomatous dermatitis (PNGD) are rare disorders typically associated with systemic autoimmune conditions. They probably represent different aspects of a disease spectrum encompassing the concept of autoimmunity-related granulomatous dermatitis (ARGD). CASE REPORT: A 61-year-old woman presented with ARGD and autoimmune hepatitis. The clinical presentation suggested PNGD, while histopathology was consistent with IGD. DISCUSSION: The association of ARGD with autoimmune hepatitis is apparently a rare event. The present case shows that the clinicopathological correlation in ARGD does not always clearly fit with the classical presentations of IGD or PNGD. [less ▲]

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See detailSweaty skin, background and assessments.
Noel, Fanchon; Franchimont, Claudine ULg; PIERARD, Gérald ULg et al

in International Journal of Dermatology (2012), 51(6), 647-55

Overproduction of sweat, sweaty skin, and body malodors are felt unpleasant by many people in diverse social groups. This review summarizes the functional aspects of the eccrine, apocrine, and apoeccrine ... [more ▼]

Overproduction of sweat, sweaty skin, and body malodors are felt unpleasant by many people in diverse social groups. This review summarizes the functional aspects of the eccrine, apocrine, and apoeccrine sweat glands as encountered in health and disease. A series of measuring methods are conveniently used to explore any trouble in sweat production. These include the gravimetric method, water evaporation quantification, skin staining procedures, dye injections, casting replicas, average electrometric assessments, and skin capacitance mapping / imaging (SCM). Qualitative assessment is provided by collection of sweat and volatile compounds followed by chromatographic analysis. At present, SCM appears to be the most valuable method for assessing the number of active glands and their individual sweat production by the eccrine and apoeccrine glands. [less ▲]

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See detailSkin bioengineering
PIERARD, Gérald ULg; PAQUET, Philippe ULg; PREUDHOMME, Lorine et al

in Rustemeyer, T. (Ed.) Textbook of Kanerva’s occupational skin diseases. (2012)

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See detailLa comorbidite psoriasis-syndrome metabolique, une maladie multigenique complexe.
Franchimont, Claudine ULg; Quatresooz, Pascale ULg; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2012), 67(5-6), 337-40

Psoriasis is a common chronic inflammatory dermatitis mediated by cytokines released by dendritic plasmacytoid cells in combination with Th1- and Th17-cells. This complex and multifactorial condition is ... [more ▼]

Psoriasis is a common chronic inflammatory dermatitis mediated by cytokines released by dendritic plasmacytoid cells in combination with Th1- and Th17-cells. This complex and multifactorial condition is commonly associated with some comorbidities. The complexity of a coordinated management of such intricated pathologies is obvious. It calls for the so-called medicine "centered around the patient" which tops off the evidence-based medicine. Vitamin D by its immunomodulatory effect on T helper cells exerts a therapeutic benefit on psoriasis and some of its comorbidities including the metabolic syndrome. A vitamin D oral treatment was proposed in order to reduce the cardiovascular risk, and the ensuing morbidity and mortality. [less ▲]

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See detailLes cancers viro-induits: interrelations genetique-environnement
Delvenne, Philippe ULg; Renoux, V. M.; Arafa, M. et al

in Revue Médicale de Liège (2012), 67(5-6), 381-9

Among cancers diagnosed worldwide on a yearly basis, 20% are thought to be associated with a viral infection. The viruses involved are, by order of decreasing incidence, the hepatitis viruses, the ... [more ▼]

Among cancers diagnosed worldwide on a yearly basis, 20% are thought to be associated with a viral infection. The viruses involved are, by order of decreasing incidence, the hepatitis viruses, the papillomaviruses and the Epstein-Barr virus. These virus-induced cancers generate a high level of interest not only for the study of mechanisms involved in the neoplastic transformation, but also for the set-up of specific immunotherapies including prophylactic and therapeutic antitumor vaccination. [less ▲]

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See detailChronicle of a superficial pigmented basal cell carcinoma.
CAUCANAS, Marie ULg; FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg

in Case Reports in Dermatological Medicine (2012), 2012(693041),

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See detailUstekinumab biotherapy and real-time psoriasis capacitance mapping: a pilot study.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Journal of Biomedicine & Biotechnology (2012), 2012

In recent years, the treatment of moderate to severe psoriasis has benefited from the development of targeted biologicals. Assessing this new class of drugs calls for precise modalities of severity ... [more ▼]

In recent years, the treatment of moderate to severe psoriasis has benefited from the development of targeted biologicals. Assessing this new class of drugs calls for precise modalities of severity/improvement ratings of the disease. Bioengineering-driven dermometrology aims at improving objective and quantitative assessments of disease severity and treatment efficacy. Skin capacitance mapping/imaging is one of those emerging methods. Among its clinical applications, psoriasis capacitance mapping (PCM) was introduced in order to assess both skin scaliness and water trapping inside the stratum corneum (inflammatory serum deposits) on lesional skin. PCM was used for assessing the therapeutic effects of ustekinumab on target lesions of 5 psoriatic patients. The reduction in the inflammatory dampness of the stratum corneum was conveniently seen after a 1-month ustekinumab treatment. The present pilot study suggests that PCM could be used as a fast and convenient method for assessing the anti-inflammatory efficacy of ustekinumab and other biotherapies. University Hospital of Liege, 4000 Liege, Belgium. [less ▲]

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See detailLe staphylocoque et ses contre-mesures envers les peptides antimicrobiens epidermiques.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(4), 191-4

Staphylococci are microorganisms often involved in a colonization process on muco-cutaneous sites. They are responsible for various nosocomial and community-associated skin infections. The methicillin ... [more ▼]

Staphylococci are microorganisms often involved in a colonization process on muco-cutaneous sites. They are responsible for various nosocomial and community-associated skin infections. The methicillin-resistant staphylococci are particularly involved in various aspects of pathology. Epidermal antimicrobial peptides are part of the host defense mechanisms corresponding to the innate immunity. They may limit the extent in colonization. However, some staphylococci are able to bypass the antimicrobial peptides released by the host. [less ▲]

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See detailL'iatrogenie psoriasique.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(3), 139-42

Psoriasis is a common genetic disorder that may be initiated (drug-induced psoriasis) or exacerbated (drug-triggered psoriasis) by some drug intakes. Beta-blockers, lithium, some antimelarial drugs, non ... [more ▼]

Psoriasis is a common genetic disorder that may be initiated (drug-induced psoriasis) or exacerbated (drug-triggered psoriasis) by some drug intakes. Beta-blockers, lithium, some antimelarial drugs, non steroidal anti-inflammatory agents and tetracyclines are recognized to influence the clinical course of psoriasis. Other drugs are likely or possibly involved in this process. [less ▲]

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See detailComment j'explore. Les alopecies cicatricielles primitives.
FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(1), 44-50

Primary cicatricial alopecias (PCA) result from the inflammatory destruction of the hair follicle, followed by its replacement by a fibrotic streamer. The involvement of multipotent stem cells of the hair ... [more ▼]

Primary cicatricial alopecias (PCA) result from the inflammatory destruction of the hair follicle, followed by its replacement by a fibrotic streamer. The involvement of multipotent stem cells of the hair follicle is possible through a transdifferentiation pathway. The diagnosis relies on clinico-pathologic correlations. PCA are classified as the neutrophilic, lymphocytic and mixed types. Each of these groups gather specific disorders including folliculitis decalvans, dissecting folliculitis of the scalp, erosive pustulosis of the scalp, keloidal acne of the nape, frontal fibrosing alopecia, lichen planopilaris and lupus erythematosus. [less ▲]

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See detailUn semis ponctue d'apparition rapide sur la peau d'un adolescent.
CAUCANAS, Marie ULg; FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(1), 35-7

In some instances, a dermatosis exhibits a rapid and focal surge of seemingly similar tiny lesions. We report a few typical exemples occurring in adolescents.

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See detailTracking and treating malignant melanoma metastases.
PIERARD, Gérald ULg; HUMBERT, Philippe; QUATRESOOZ, Pascale ULg

in Dermatology Research and Practice (2012), 2012(art.173491), 1-2

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