Dermal ultrastructure in low Beighton score members of 17 families with hypermobile-type Ehlers-Danlos syndrome.

in Journal of Biomedicine & Biotechnology (2012), 2012

The distinction between the Ehlers-Danlos syndrome hypermobile type (EDSH) and the benign joint hypermobility syndrome (BJHS) is unclear. The aim of the present study was to compare skin ultrastructural ... [more ▼]

The distinction between the Ehlers-Danlos syndrome hypermobile type (EDSH) and the benign joint hypermobility syndrome (BJHS) is unclear. The aim of the present study was to compare skin ultrastructural abnormalities of EDSH and BJHS among different families. Skin of 23 EDSH, 27 BJHS, and 41 asymptomatic subjects from 17 families was examined using transmission electron microscopy. Similar ultrastructural abnormalities were found irrespective of the Beighton score. Flower-like collagen fibrils represented the key change and elastic fibers were altered as well. Beighton score is a clinical parameter rating joint mobility that appeared unrelated to quantitative and qualitative collagen ultrastructural alterations in the skin. Some EDSH family members fit with BJHS diagnosis. BJHS possibly represents a mild variant of EDSH. [less ▲]

Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis. A primer.

in Journal of Biomedicine & Biotechnology (2012), 2012(147413),

Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well ... [more ▼]

Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well as the involvement of T helper cells (Th)1 and Th17 cells. There is upregulation of the p40 subunit shared by IL-12 and IL-23 and of the IL-23 p19 subunit, but not an increased expression of the IL-12 p35 subunit. This indicates that IL-23 appears more involved than IL-12 in the pathogenesis of psoriatic plaques. Ustekinumab is a fully human monoclonal antibody of the immunoglobulin (Ig) G1 class targeting the p40 subunit common to both IL-12 and IL-23, thus inhibiting both IL-12 and IL-23 receptor-mediated signalling. Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases. [less ▲]

Intense pulsed-light therapy for proliferative superficial strawberry haemangiomas of infancy.

in Case Reports in Dermatological Medicine (2011), 2011(art.253607), 1-5

''Malignant melanoma microecosystem'': Immunohistopathological insights into the stromal cell phenotype (Review)

in Experimental and Therapeutic Medicine (2011), 2

Field melanin mapping of the hairless scalp.

in Skin Research & Technology (2011)

BACKGROUND: Mottled subclinical melanoderma (MSM) is frequently seen on facial skin using the ultraviolet light enhanced visualization (ULEV) method. The corresponding aspect on the hairless scalp remains ... [more ▼]

BACKGROUND: Mottled subclinical melanoderma (MSM) is frequently seen on facial skin using the ultraviolet light enhanced visualization (ULEV) method. The corresponding aspect on the hairless scalp remains unknown. OBJECTIVE: To explore the field distribution of melanin on the scalp of fair-skinned Caucasian subjects. METHOD: The scalp was examined in 43 men with androgenic alopecia. The Visioscan((R)) camera provided the ULEV pictures. Another optical (Visioface((R)) Quick) device was used under white light illumination followed by colour contrast enhancement. This was reached after specific computer filtration of the cyan hue wavelengths. RESULTS: Under white light illumination, the scalp looked normal. MSM patterns were disclosed by both optical procedures as evenly scattered discrete patchy fields of hypermelanosis. The smaller rounded spots were restricted to the lips of the hair infundibula. Larger irregularly shaped spots predominated in the interfollicular areas. A few hypomelanotic spots were scattered over the scalp. CONCLUSION: The present observations based on dual optical methods possibly provide information about a patterned pathobiology of melanocytes on the scalp. The spotty MSM pattern looked similar to the reported aspects on the face. It somewhat resembled the widespread PUVA-induced lentiginosis. [less ▲]

Survol des keratodermies palmo-plantaires acquises.

in Revue Médicale de Liège (2011), 66(10), 535-9

Palmoplantar keratodermas affect a vast group of the population. Their origin is genetic or acquired. They represent manifestations of several distinct diseases. The precise semiologic examination is ... [more ▼]

Palmoplantar keratodermas affect a vast group of the population. Their origin is genetic or acquired. They represent manifestations of several distinct diseases. The precise semiologic examination is important for elucidating the differential diagnosis. [less ▲]

Bronzer a tout crin ou se depigmenter avec acharnement: des modes d'addiction ethnique au gout du jour.

in Revue Médicale de Liège (2011), 66(4), 191-4

Sun is at the origin of life and is responsible for death as well. In the past decades cutaneous melanoma has affected more and more young adults. In the White population, sun exposures and sunbeds are ... [more ▼]

Sun is at the origin of life and is responsible for death as well. In the past decades cutaneous melanoma has affected more and more young adults. In the White population, sun exposures and sunbeds are pointed out as the main culprits responsible for addictive behaviour. Preventive measures to be taken aim at avoiding the effects of ultraviolet light addiction. Sunlight exposure particularly in moderation is indeed beneficial through vitamin D3 synthesis and improved psychological wellbeing. Hence, we are facing the dilemma between too much and too little ultraviolet light exposure.In the Black population, the reverse situation is prevalent. It concerns skin depigmentation which may turn out to be a caricature in some subjects. [less ▲]

Pseudofolliculites et affections apparentees chez les sujets a peau noire.

in Revue Médicale de Liège (2011), 66(3), 140-3

The unique structure of the hair in Black people is responsible for a few specific follicular disorders. Pseudofolliculitis of the beard similar to pili incarnati as well as, the so-called keloidal acne ... [more ▼]

The unique structure of the hair in Black people is responsible for a few specific follicular disorders. Pseudofolliculitis of the beard similar to pili incarnati as well as, the so-called keloidal acne and the follicular degeneration syndrome are frequent clinical entities in ethnic dermatology. [less ▲]

Le melanome du sujet age.

in Revue Médicale de Liège (2011), 66(1), 34-40

Malignant melanoma developed after 60 years of age is not a rare neoplasm. It is mainly but not exclusively represented by the lentigo maligna (LM) and the invasive melanoma developed on LM (LMM). Men are ... [more ▼]

Malignant melanoma developed after 60 years of age is not a rare neoplasm. It is mainly but not exclusively represented by the lentigo maligna (LM) and the invasive melanoma developed on LM (LMM). Men are more often affected, and chronic sun exposure is the main cause. The diagnosis relies on the clinical, dermoscopic and dermatopathologic examinations. Surgical excision is recommended but alternative treatments are possible in case of contra-indication. [less ▲]

Relaxed skin tension lines imaging.

in Treatment Strategies. Dermatology (2011)