References of "PIERARD, Gérald"
     in
Bookmark and Share    
Full Text
See detailRegard sur la peau diabétique et ses méhins.
PIERARD, Gérald ULg; RADERMECKER, Régis ULg; SCHEEN, André ULg

in Revue de l'Association Belge du Diabète (2013), 56

La peau exprime certains changements qui sont souvent proportionnels à la durée et la sévérité du diabète. La plupart des composants de la peau sont affectés à des degrés divers, parfois cliniquement ... [more ▼]

La peau exprime certains changements qui sont souvent proportionnels à la durée et la sévérité du diabète. La plupart des composants de la peau sont affectés à des degrés divers, parfois cliniquement imperceptibles, parfois très sévères et invalidants. [less ▲]

Detailed reference viewed: 16 (4 ULg)
Full Text
Peer Reviewed
See detailThe skin landscape in diabetes mellitus. Focus on dermocosmetic management.
PIERARD, Gérald ULg; Seite, Sophie; HERMANNS, Trinh ULg et al

in Clinical, Cosmetic and Investigational Dermatology (2013), 6

BACKGROUND: Some relationships are established between diabetes mellitus (DM) and a series of cutaneous disorders. Specific dermatoses are markers for undiagnosed DM. Other disorders represent supervening ... [more ▼]

BACKGROUND: Some relationships are established between diabetes mellitus (DM) and a series of cutaneous disorders. Specific dermatoses are markers for undiagnosed DM. Other disorders represent supervening complications in an already treated DM patient. OBJECTIVE: To review the information about dermocosmetic care products and their appropriate use in the management and prevention of dermatoses related to DM. METHOD: The peer-reviewed literature and empiric findings are covered. Owing to the limited clinical evidence available for the use of dermocosmetics, a review of the routine practices and common therapies in DM-related dermatoses was conducted. RESULTS: Some DM-related dermatoses (acanthosis nigricans, pigmented purpuric dermatosis) are markers of macrovascular complications. The same disorders and some others (xerosis, Dupuytren's disease) have been found to be more frequently associated with microangiopathy. Other skin diseases (alopecia areata, vitiligo) were found to be markers of autoimmunity, particularly in type 1 DM. Unsurprisingly, using dermocosmetics and appropriate skin care has shown objective improvements of some DM-related dermatoses, such effects improve the quality of life. The most common skin manifestations of DM fall along continuum between "dry skin," xerosis, and acquired ichthyosis, occurring predominately on the shins and feet. Dermocosmetic products improve the feeling of well-being for DM patients. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailComment j'explore ... l'atteinte fonctionnelle cutanee d'une sclerodermie.
HERMANNS, Trinh ULg; Franchimont, Claudine ULg; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2013), 68(3), 141-7

Scleroderma refers to distinct clinical presentations sharing in common a sclerotic process most often clinically obvious on the skin. The involvement possibly affects the skin alone in morphea or in ... [more ▼]

Scleroderma refers to distinct clinical presentations sharing in common a sclerotic process most often clinically obvious on the skin. The involvement possibly affects the skin alone in morphea or in combination with internal lesions in systemic sclerosis. Some objective and non-invasive functional assessments are useful for better appreciating the severity and evolution of the disease, as well as to monitor the therapeutic efficacy. In this endeavour, in vivo measurements of the skin mechanical properties are unsurprisingly informative. [less ▲]

Detailed reference viewed: 18 (7 ULg)
Full Text
Peer Reviewed
See detailRisquer sa peau pour quelques "joints".
Hermanns-Lê, Trinh ULg; DELVENNE, Philippe ULg; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 311-314

Detailed reference viewed: 15 (6 ULg)
Full Text
See detailSensory irritation to surfactant-based products.
PIERARD, Gérald ULg

in The International Society of Stratum Corneum Research Newsletter. (2013), 6

Detailed reference viewed: 5 (2 ULg)
Full Text
Peer Reviewed
See detailLa vignette diagnostique de l'etudiant. Le spectre des toxidermies.
Hermanns-Le, T.; Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2013), 68(1), 44-50

Drug eruptions are frequently encountered and they represent "diseases of medical progress". They are expected in about 2% of treated patients. Their putative diagnosis is based on a set of imputability ... [more ▼]

Drug eruptions are frequently encountered and they represent "diseases of medical progress". They are expected in about 2% of treated patients. Their putative diagnosis is based on a set of imputability factors. Several distinct drug-induced skin disorders are identified. They are initially recognized from personal experience, but the implication to a specific drug derives from the collective experience of published evidence. Their histopathological aspect is often evocative or demonstrative for the nature of the dermatosis. Some drug eruptions follow an indolent course, while others are life-threatening. [less ▲]

Detailed reference viewed: 9 (2 ULg)
Full Text
Peer Reviewed
See detailScleroderma: skin stiffness assessment using the stress-strain relationship under progressive suction.
PIERARD, Gérald ULg; HERMANNS, Trinh ULg; Franchimont, Claudine ULg

in Expert Opinion on Medical Diagnostics (2013), 7(2), 119-25

Introduction: A few non-invasive biometrological methods are available for monitoring skin stiffening in systemic scleroderma. Among them, the Cutometer(R) is used for years by several clinical teams ... [more ▼]

Introduction: A few non-invasive biometrological methods are available for monitoring skin stiffening in systemic scleroderma. Among them, the Cutometer(R) is used for years by several clinical teams. Objectives: To revisit the microscopic structure of the dermal fibrous networks in scleroderma and the relationship with changes in viscoelasticity. Methods: The suction method delivered by the Cutometer(R) was applied following the progressive stress-vs-strain modality. Results: The test procedure was sensitive enough to document the initial progression steps of acroscleroderma. Four stages were thus identified including i) the incipient, ii) the progressive, iii) the overt, and iv) the regressive acroscleroderma. Conclusion: The non-invasive determination of skin biomechanical functions is relevant both in routine clinical practice and in antisclerotic drug development. It is complementary although not a substitute for the determination of selected serum biomarkers. [less ▲]

Detailed reference viewed: 29 (6 ULg)
Full Text
Peer Reviewed
See detailCritical assessment of diabetic xerosis.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Scheen, André ULg

in Expert Opinion on Medical Diagnostics (2013), 7(2), 201-7

Introduction: Diabetes mellitus is commonly responsible for skin changes including discrete to mild xerosis. Areas covered: This review focuses on some selected relevant bioinstrumental methods assessing ... [more ▼]

Introduction: Diabetes mellitus is commonly responsible for skin changes including discrete to mild xerosis. Areas covered: This review focuses on some selected relevant bioinstrumental methods assessing diabetes xerosis. Peer-reviewed articles on objective non-invasive methods were scrutinized. The reviewed methods address i) the xerosis severity grading scale, ii) corneodynamics referring to the desquamation rate, iii) electrometric assessment of skin hydration including skin capacitance mapping and iv) implication of the imperceptible perspiration. The subjective clinical assessment often fails to disclose diabetic xerosis with confidence and precision. By contrast, a multipronged biometrological approach identifies a cluster of diabetic patients who experience alterations in the structural and functional maturation of the stratum corneum. Expert opinion: A multipronged biometrological approach helps identifying the changes in the stratum corneum of diabetic xerosis. There is a continuum between the 'dry skin' feeling, xerosis and ichthyosiform presentations, particularly on the shins and feet of diabetic patients. [less ▲]

Detailed reference viewed: 25 (3 ULg)
Full Text
Peer Reviewed
See detailCharacterization of spontaneous collagen fibrillogenesis in a cell-free and tension-free environment.
PIERARD, Gérald ULg; Hermanns-Lê, Trinh ULg; Delvenne, Philippe ULg et al

in Clinical & Experimental Dermatology (2013)

The collagen fibril packing that forms threads and bundles is poorly defined, despite the fact that it is important for distinct aspects of the adventitial and reticular dermis. The present study explored ... [more ▼]

The collagen fibril packing that forms threads and bundles is poorly defined, despite the fact that it is important for distinct aspects of the adventitial and reticular dermis. The present study explored an in vitro fibrillogenesis model using the property of heat polymerization. The process was performed on glass slides with mixtures of collagen I and III, and the material was viewed by scanning electron microscopy. In all instances, collagen I and III formed fibrils with regular sizes. The formation of threads was influenced by the relative proportions of collagen I and III; increasing the relative proportion of collagen I resulted in the formation of threads showing increasing variations in thickness. These findings are in line with the differential presentation and compositions of the different parts of the dermis. The possible interventions of stromal cells and of other macromoleules of the extracellular matrix were not considered in this study. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailComprehensive clinical and molecular analysis of 12 families with type 1 recessive cutis laxa.
Callewaert, Bert; Su, Chi-Ting; Van Damme, Tim et al

in Human Mutation (2013), 34(1), 111-21

Autosomal recessive cutis laxa type I (ARCL type I) is characterized by generalized cutis laxa with pulmonary emphysema and/or vascular complications. Rarely, mutations can be identified in FBLN4 or FBLN5 ... [more ▼]

Autosomal recessive cutis laxa type I (ARCL type I) is characterized by generalized cutis laxa with pulmonary emphysema and/or vascular complications. Rarely, mutations can be identified in FBLN4 or FBLN5. Recently, LTBP4 mutations have been implicated in a similar phenotype. Studying FBLN4, FBLN5, and LTBP4 in 12 families with ARCL type I, we found bi-allelic FBLN5 mutations in two probands, whereas nine probands harbored biallelic mutations in LTBP4. FBLN5 and LTBP4 mutations cause a very similar phenotype associated with severe pulmonary emphysema, in the absence of vascular tortuosity or aneurysms. Gastrointestinal and genitourinary tract involvement seems to be more severe in patients with LTBP4 mutations. Functional studies showed that most premature termination mutations in LTBP4 result in severely reduced mRNA and protein levels. This correlated with increased transforming growth factor-beta (TGFbeta) activity. However, one mutation, c.4127dupC, escaped nonsense-mediated decay. The corresponding mutant protein (p.Arg1377Alafs(*) 27) showed reduced colocalization with fibronectin, leading to an abnormal morphology of microfibrils in fibroblast cultures, while retaining normal TGFbeta activity. We conclude that LTBP4 mutations cause disease through both loss of function and gain of function mechanisms. [less ▲]

Detailed reference viewed: 6 (1 ULg)
Full Text
Peer Reviewed
See detailThe weather-beaten dorsal hand. Clinical rating, shadow casting optical profilometry and skin capacitance mapping.
Delvenne, Marie; FRANCHIMONT, Claudine ULg; SEIDEL, Laurence ULg et al

in BioMed Research International (2013), 2013

Detailed reference viewed: 22 (8 ULg)
Full Text
Peer Reviewed
See detailCyclic catamenial dermatoses.
HERMANNS, Trinh ULg; Hermanns, Jean François; Lesuisse, Marianne et al

in BioMed Research International (2013), 2013

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailL'addiction au Soleil, son estocade et la parade des crèmes solaires.
FRANCHIMONT, Claudine ULg; HERMANNS, Trinh ULg; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 321-325

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailEhlers-Danlos syndrome type VIII: a rare cause of leg ulcers in young patients.
Ronceray, Sophie; Miquel, J.; Lucas, A. et al

in Case Reports in Dermatological Medicine (2013), 2013

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailAnalytic dermoscopy of superficial basal cell carcinoma.
FRANCHIMONT, Claudine ULg; Hermanns, Jean-Francois; Caucanas, Marie et al

in Journal of Case Reports in Medicine (2013), 3

Detailed reference viewed: 21 (6 ULg)
Full Text
Peer Reviewed
See detailFondements physico-biologiques de la fluorescence cutanee - Revue.
SZEPETIUK, Grégory ULg; FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg et al

in Pathologie Biologie (2012), 60

Fluorescence is a peculiar aspect of photoluminescence. Some intrinsic components of the skin are fluorophores. Other synthetic components are metabolized into fluorophores. These characteristics may be ... [more ▼]

Fluorescence is a peculiar aspect of photoluminescence. Some intrinsic components of the skin are fluorophores. Other synthetic components are metabolized into fluorophores. These characteristics may be used for identifying some specific aspects of skin physiopathology. Recent technological evolution has provided new devices bringing sensitive and specific information from the skin. This review presents a synthesis of the progress made in the field of fluorescence and specular reflexion of incident UV light on the skin. [less ▲]

Detailed reference viewed: 25 (4 ULg)
Full Text
See detailDermatoses non infectieuses de la grossesse.
HERMANNS-LE THI KIM, Trinh ULg; Franchimont, Claudine ULg; Delvenne, Philippe ULg et al

in Thérapeutique Dermatologique (2012)

Detailed reference viewed: 4 (2 ULg)
Full Text
See detailFibromes cutanés.
PIERARD, Gérald ULg; Franchimont, Claudine ULg

in Fondation René Touraine (Ed.) Thérapeutique Dermatologique (2012)

Detailed reference viewed: 4 (2 ULg)
Full Text
See detailParapsoriasis en plaques.
HERMANNS-LE THI KIM, Trinh ULg; PIERARD, Gérald ULg

in Thérapeutique Dermatologique (2012)

Detailed reference viewed: 22 (2 ULg)