References of "PIERARD, Gérald"
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See detailPatterns of aluminum hydroxychloride deposition onto the skin.
Mayeux, Geraldine; Xhauflaire-Uhoda, Emmanuelle; PIERARD, Gérald ULg

in Skin Research & Technology (2012), 18(1), 64-9

BACKGROUND: Aluminum hydroxychloride (AlCl(3) ) is an antiperspirant. AIM: To revisit the AlCl(3) deposition in vivo and in vitro on glass slides and stratum corneum (SC) harvested by cyanoacrylate skin ... [more ▼]

BACKGROUND: Aluminum hydroxychloride (AlCl(3) ) is an antiperspirant. AIM: To revisit the AlCl(3) deposition in vivo and in vitro on glass slides and stratum corneum (SC) harvested by cyanoacrylate skin surface strippings (CSSS). METHODS: Transepidermal water loss (TEWL) was assessed following application of 5% AlCl(3) on the forearms. The AlCl(3) -coated skin, glass slides and CSSS were observed using two ultraviolet light-emitting CCD cameras in order to record changes in specular reflectance related to AlCl(3) deposition. In addition, the corneoxenometry bioassay was performed in order to predict AlCl(3) irritation. RESULTS: AlCl(3) deposited on glass slides looked as linear threads and rings of similar sizes. AlCl(3) deposits on skin were almost restricted inside the microrelief lines and as annular deposits at their crossings where acrosyringia are opening. After daily AlCl(3) applications, deposits extended on the CSSS plateaus. At rest in absence of sweating, TEWL was decreased following AlCl(3) applications. During physical exercise, the TEWL increase was limited on the AlCl(3) areas. CSSS appeared unreactive to AlCl(3) at the corneoxenometry bioassay. CONCLUSION: The similar aspect of AlCl(3) deposits on human SC and on glass slides suggested a physical property of AlCl(3) . Repetitive applications of AlCl(3) increased both the deposit area and the barrier function. [less ▲]

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See detailIpilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma?
PIERARD, Gérald ULg; Aubin, Francois; Humbert, Philippe

in Dermatology Research and Practice (2012), 2012

Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival ... [more ▼]

Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival advantage so far. Immunotherapy is another targeted option. Ipilimumab, a monoclonal antibody directed to CTLA-4 present on cytotoxic T cells boosts immunity, particularly its anti-MM activity. Under treatment, the overall survival of patients with MM metastases is moderately but significantly increased. The immuno-related adverse effects may be severe and life threatening. [less ▲]

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See detailThe skin ivory spot. A possible indicator for skinfield photocarcinogenesis in recreational sunbed addicts.
QUATRESOOZ, Pascale ULg; FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg

in International Journal of Environmental Research and Public Health (2012), 9

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See detailThigmotropism of Malignant Melanoma Cells
QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg; Noël, Fanchon ULg et al

in Dermatology Research and Practice (2012), (362784), 1-6

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See detailSmouldering malignant melanoma and metastatic dormancy: an update and review.
PIERARD, Gérald ULg; PIERARD-FRANCHIMONT, Claudine ULg; REGINSTER, Marie-Annick ULg et al

in Dermatology Research and Practice (2012), 2012

The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two ... [more ▼]

The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two special features of MM metastasis is reviewed. On the one hand, a long disease-free interval (MM dormancy) may occur before the surge of overt metastases. On the other hand, the so-called MM smouldering phenomenon refers to the condition where regional metastases wax and wane for long periods of time on restricted skin regions. It is important to emphasize that local micrometastases often predict sentinel lymph node involvement but may not reflect progression of the primary MM to full-blown visceral metastatic competence. It is likely that a combination of factors impacts the versatile MM metastasic progression. Among the main factors, one has to mention the phenotypic heterogeneity and variability in the phenotype of MM cells, the presence of MM stem cells and MM cells engaged in an amplification proliferation pool, as well as the host immune response, and possibly the induction of a particular stromal structure and vascularity. [less ▲]

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See detailMolecular dermatopathology in malignant melanoma.
REGINSTER, Marie-Annick ULg; PIERARD-FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg et al

in Dermatology Research and Practice (2012), 2012(684032), 1-6

At present, immunohistochemistry is taken for granted in the establishment of malignant melanoma (MM) diagnosis. In recent years, molecular diagnosis in dermatopathology has benefited from a vast array of ... [more ▼]

At present, immunohistochemistry is taken for granted in the establishment of malignant melanoma (MM) diagnosis. In recent years, molecular diagnosis in dermatopathology has benefited from a vast array of advances in the fields of genomics and proteomics. Sensitive techniques are available for detecting specific DNA and RNA sequences by molecular hybridization. This paper intends to update methods of molecular cytogenetics available as diagnostic adjuncts in the field of MM. Cytogenetics has highlighted the pathogenesis of atypical melanocytic neoplasms with emphasis on the activation of the mitogen-activated protein kinase (MAPK) signalling pathway during the initiation step of the neoplasms. 20 to 40% of MM families have mutations in the tumour suppressor gene p16 or CDKN2A. In addition, somatic mutations in p16, p53, BRAF, and cKIT are present in MM. Genome-wide scan analyses on MM indicate positive associations for genes involved in melanocytic naevi, but MM is likely caused by a variety of common low-penetrance genes. Molecular dermatopathology is expanding, and its use in the assessment of melanocytic neoplasms appears to be promising in the fields of research and diagnosis. Molecular dermatopathology will probably make its way to an increased number of diagnostic laboratories. The expected benefit should improve the patient management. This evolution points to a need for evolution in the training requirements and role of dermatopathologists. [less ▲]

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See detailDermal ultrastructure in low Beighton score members of 17 families with hypermobile-type Ehlers-Danlos syndrome.
Hermanns-Le, Trinh ULg; REGINSTER, Marie-Annick ULg; Franchimont, Claudine ULg et al

in Journal of Biomedicine & Biotechnology (2012), 2012

The distinction between the Ehlers-Danlos syndrome hypermobile type (EDSH) and the benign joint hypermobility syndrome (BJHS) is unclear. The aim of the present study was to compare skin ultrastructural ... [more ▼]

The distinction between the Ehlers-Danlos syndrome hypermobile type (EDSH) and the benign joint hypermobility syndrome (BJHS) is unclear. The aim of the present study was to compare skin ultrastructural abnormalities of EDSH and BJHS among different families. Skin of 23 EDSH, 27 BJHS, and 41 asymptomatic subjects from 17 families was examined using transmission electron microscopy. Similar ultrastructural abnormalities were found irrespective of the Beighton score. Flower-like collagen fibrils represented the key change and elastic fibers were altered as well. Beighton score is a clinical parameter rating joint mobility that appeared unrelated to quantitative and qualitative collagen ultrastructural alterations in the skin. Some EDSH family members fit with BJHS diagnosis. BJHS possibly represents a mild variant of EDSH. [less ▲]

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See detailMiconazole , a pharmacological barrier to skin fungal infections.
Pierard, Gérald ULg; Hermanns-Le, Trinh ULg; Delvenne, Philippe ULg et al

in Expert Opinion on Pharmacotherapy (2012), 13(8), 1187-94

Introduction: Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14alpha-demethylase ... [more ▼]

Introduction: Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14alpha-demethylase enzyme required for ergosterol biosynthesis, in fungal cell membranes. In addition, intracellular accumulation of toxic methylated sterols occurs and the synthesis of triglycerides and phospholipids is altered. Disturbances in oxidative and peroxidative enzyme activities lead to an intracellular toxic concentration of hydrogen peroxide. As a result, intracellular organelle destruction then leads to cell necrosis. Farnesol synthesis stimulated in Candida spp. prevents the yeast-to-mycelium formation. MCZ is further active against Gram-positive bacteria. Areas covered: This review aims at revisiting the MCZ antifungal activity in dermatomycoses. Expert opinion: MCZ's wide spectrum of activity appears noteworthy. The full pharmacological profile of MCZ indicates its fungistatic profile through its effect on ergosterol biosynthesis. In addition, it exhibits a fungicidal effect against a number of fungal species, due to hydrogen peroxide accumulation. MCZ is characterized by high safety, efficacy and versatility, and a unique, multifaceted nature of activity in the treatment of dermatomycoses. [less ▲]

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See detailUstekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis. A primer.
QUATRESOOZ, Pascale ULg; Hermanns-Le, Trinh ULg; Pierard, Gérald ULg et al

in Journal of Biomedicine & Biotechnology (2012), 2012(147413),

Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well ... [more ▼]

Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well as the involvement of T helper cells (Th)1 and Th17 cells. There is upregulation of the p40 subunit shared by IL-12 and IL-23 and of the IL-23 p19 subunit, but not an increased expression of the IL-12 p35 subunit. This indicates that IL-23 appears more involved than IL-12 in the pathogenesis of psoriatic plaques. Ustekinumab is a fully human monoclonal antibody of the immunoglobulin (Ig) G1 class targeting the p40 subunit common to both IL-12 and IL-23, thus inhibiting both IL-12 and IL-23 receptor-mediated signalling. Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases. [less ▲]

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See detailField melanin mapping of the hairless scalp.
PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg; Quatresooz, Pascale ULg

in Skin Research & Technology (2011), 18(4), 431-5

BACKGROUND: Mottled subclinical melanoderma (MSM) is frequently seen on facial skin using the ultraviolet light enhanced visualization (ULEV) method. The corresponding aspect on the hairless scalp remains ... [more ▼]

BACKGROUND: Mottled subclinical melanoderma (MSM) is frequently seen on facial skin using the ultraviolet light enhanced visualization (ULEV) method. The corresponding aspect on the hairless scalp remains unknown. OBJECTIVE: To explore the field distribution of melanin on the scalp of fair-skinned Caucasian subjects. METHOD: The scalp was examined in 43 men with androgenic alopecia. The Visioscan((R)) camera provided the ULEV pictures. Another optical (Visioface((R)) Quick) device was used under white light illumination followed by colour contrast enhancement. This was reached after specific computer filtration of the cyan hue wavelengths. RESULTS: Under white light illumination, the scalp looked normal. MSM patterns were disclosed by both optical procedures as evenly scattered discrete patchy fields of hypermelanosis. The smaller rounded spots were restricted to the lips of the hair infundibula. Larger irregularly shaped spots predominated in the interfollicular areas. A few hypomelanotic spots were scattered over the scalp. CONCLUSION: The present observations based on dual optical methods possibly provide information about a patterned pathobiology of melanocytes on the scalp. The spotty MSM pattern looked similar to the reported aspects on the face. It somewhat resembled the widespread PUVA-induced lentiginosis. [less ▲]

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See detailHypomelanosis of Ito: pigmentary mosaicism with immature melanosome in keratinocytes.
Devillers, Céline; QUATRESOOZ, Pascale ULg; Hermanns-Le, Trinh ULg et al

in International Journal of Dermatology (2011), 50(10), 1234-9

BACKGROUND: Hypomelanosis of Ito is a rare genetic disorder characterized by whorled areas of hypomelanosis. The purpose of the present study was to revisit some aspects of Ito's hypomelanosis. METHODS ... [more ▼]

BACKGROUND: Hypomelanosis of Ito is a rare genetic disorder characterized by whorled areas of hypomelanosis. The purpose of the present study was to revisit some aspects of Ito's hypomelanosis. METHODS: Clinical observations included ultraviolet-light-enhanced visualization (ULEV) method. Histochemistry, immunohistochemistry, and electron microscopy were performed on biopsy samples from the hypopigmented areas and the surrounding skin. RESULTS: Both the ULEV and microscopic examinations revealed the heterogeneity of the pigmentation. Hypomelanosis was characterized by a reduction in melanosomes, both in melanocytes and keratinocytes. These organelles were immature and atypical, showing a weak tyrosinase immunoreactivity. Melanosome macroautophagy was prominent in keratinocytes. Some clusters of the same cells exhibited strong immunoreactivity for the Mac 387 antibody (Ca(2+) -dependent calprotectin). Ulex europaeus agglutinin-1 (UEA-1) decorated the superficial layers of the epidermis. Such features are typically found in functionally altered keratinocytes. A number of dermal cells exhibited intense phagocytic activity linked to lysozyme immunoreactivity. CONCLUSIONS: Both the melanosome depletion and macroautophagy of immature melanosomes in keratinocytes appeared to represent prominent aspects of hypomelanosis of Ito. In sum, Ito's hypomelanosis combines structural and functional changes affecting both the melanocytes and keratinocytes in the skin. [less ▲]

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See detailIntense pulsed-light therapy for proliferative superficial strawberry haemangiomas of infancy.
CAUCANAS, Marie ULg; PAQUET, Philippe ULg; HENRY, Frédérique ULg et al

in Case Reports in Dermatological Medicine (2011), 2011(art.253607), 1-5

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See detailTraitement par anti-TNF-alpha et cancers de la peau
Pierard, Claudine ULg; Pierard, Gérald ULg; Quatresooz, Pascale ULg et al

in ONCO-HEMATO (2011), 5

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See detailHydroxyacids
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; PIERARD, Gérald ULg

in Cosmeceuticals-drugs vs cosmetics (2011)

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See detailSurvol des keratodermies palmo-plantaires acquises.
Devillers, C; FRANCHIMONT, Claudine ULg; Lesuisse, M et al

in Revue Médicale de Liège (2011), 66(10), 535-9

Palmoplantar keratodermas affect a vast group of the population. Their origin is genetic or acquired. They represent manifestations of several distinct diseases. The precise semiologic examination is ... [more ▼]

Palmoplantar keratodermas affect a vast group of the population. Their origin is genetic or acquired. They represent manifestations of several distinct diseases. The precise semiologic examination is important for elucidating the differential diagnosis. [less ▲]

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See detailReactions cutanees a l'encre de tatouage.
FRANCHIMONT, Claudine ULg; Hermanns, Jean-François ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2011), 66(7-8), 430-3

Ritual and artistic tattoos rely on the use of numerous pigments which are not all entirely inert once placed in the dermis. The compositions of some tattoo inks are identified. However, new but less well ... [more ▼]

Ritual and artistic tattoos rely on the use of numerous pigments which are not all entirely inert once placed in the dermis. The compositions of some tattoo inks are identified. However, new but less well identified compounds appear on the market. Allergic reactions can be present under different aspects. They may correspond to allergic contact dermatitis or to photodermatitis. Other reactions include allergic hypersensitivity reactions as well as lichenoid, granulomatous or pseudolymphoma reactions. Pulsed light and laser are typically used for regular tattoo removal. These procedures are not indicated in inflamed tattoos. Indeed, the pigment dispersed during photolysis may perpetuate the reaction. Pseudotattoos due to the stratum corneum staining are frequently responsible for photoeczema. [less ▲]

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See detailBronzer a tout crin ou se depigmenter avec acharnement: des modes d'addiction ethnique au gout du jour.
FRANCHIMONT, Claudine ULg; Henry, Frédéric ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2011), 66(4), 191-4

Sun is at the origin of life and is responsible for death as well. In the past decades cutaneous melanoma has affected more and more young adults. In the White population, sun exposures and sunbeds are ... [more ▼]

Sun is at the origin of life and is responsible for death as well. In the past decades cutaneous melanoma has affected more and more young adults. In the White population, sun exposures and sunbeds are pointed out as the main culprits responsible for addictive behaviour. Preventive measures to be taken aim at avoiding the effects of ultraviolet light addiction. Sunlight exposure particularly in moderation is indeed beneficial through vitamin D3 synthesis and improved psychological wellbeing. Hence, we are facing the dilemma between too much and too little ultraviolet light exposure.In the Black population, the reverse situation is prevalent. It concerns skin depigmentation which may turn out to be a caricature in some subjects. [less ▲]

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See detailL'image du mois. Le comble du coiffeur: avoir un poil dans la main.
CAUCANAS, Marie ULg; FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2011), 66(4), 177-8

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See detailPseudofolliculites et affections apparentees chez les sujets a peau noire.
FRANCHIMONT, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2011), 66(3), 140-3

The unique structure of the hair in Black people is responsible for a few specific follicular disorders. Pseudofolliculitis of the beard similar to pili incarnati as well as, the so-called keloidal acne ... [more ▼]

The unique structure of the hair in Black people is responsible for a few specific follicular disorders. Pseudofolliculitis of the beard similar to pili incarnati as well as, the so-called keloidal acne and the follicular degeneration syndrome are frequent clinical entities in ethnic dermatology. [less ▲]

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