References of "NISOLLE, Michelle"
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See detailLe cas clinique du mois. L'adenomyose.
JASON, Maxime; DECHENNE, Valérie ULg; CHANTRAINE, Frédéric ULg et al

in Revue Médicale de Liège (2013), 68(4), 160-2

Adenomyosis is a medical benign condition of the endometrium-myometrium interface that is histopathologically characterized by the presence of ectopic tissue (endometrial glands and stroma) in myometrium ... [more ▼]

Adenomyosis is a medical benign condition of the endometrium-myometrium interface that is histopathologically characterized by the presence of ectopic tissue (endometrial glands and stroma) in myometrium. The diagnosis is complicated by the low specificity of its symptoms and the frequent associations with others gynaecologic pathologies. Consequently, paraclinic investigations are essential to make the diagnosis. [less ▲]

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See detailAssuétudes et grossesse: comment détruire un projet de naissance
Emonts, Patrick ULg; MASSON, Véronique ULg; CHANTRAINE, Frédéric ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 239-244

Les femmes enceintes sont conscientes que toute forme d’addiction durant leur grossesse peut être préjudiciable à leur enfant. Pourtant, de nombreuses gestantes continuent de fumer, de boire de l’alcool ... [more ▼]

Les femmes enceintes sont conscientes que toute forme d’addiction durant leur grossesse peut être préjudiciable à leur enfant. Pourtant, de nombreuses gestantes continuent de fumer, de boire de l’alcool, de consommer des drogues illicites ou d’absorber des médicaments, car ces dépendances sont particulièrement tenaces. Le quatuor de tête en termes de préjudice fœtal est composé du tabac, de l’alcool, de la cocaïne et de l’ecstasy. La période de grossesse est le meilleur moment pour mettre fin à ces addictions. Aussi, est-il indispensable de sensibiliser le grand public, les pouvoirs politiques ainsi que les médecins sur le fait que les assuétudes durant la grossesse représentent une inégalité de santé et d’espérance de vie importante pour l’enfant à naître. [less ▲]

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See detailHysteroscopic resection of abnormally invasive placenta residuals.
Nisolle, Michelle ULg; DELBECQUE, Katty ULg; PERRIER d'HAUTERIVE, Sophie ULg et al

in Acta Obstetricia et Gynecologica Scandinavica (2013), 92(4), 451-6

OBJECTIVE: To present our experience in hysteroscopic removal of abnormally invasive placenta (AIP) residuals using bipolar energy. DESIGN: Case series. SETTING: University hospital. POPULATION: Sixteen ... [more ▼]

OBJECTIVE: To present our experience in hysteroscopic removal of abnormally invasive placenta (AIP) residuals using bipolar energy. DESIGN: Case series. SETTING: University hospital. POPULATION: Sixteen patients with AIP residuals after 17 pregnancies. METHODS: Cases were identified by ultrasound, treated with hysteroscopic bipolar electrosurgery and oral contraceptives, and followed up by ultrasound or hysteroscopy. Nine subsequent pregnancies were described. MAIN OUTCOME MEASURES AND RESULTS: Complete removal of AIP residuals was achieved by hysteroscopic bipolar electrosurgery in all cases except one. No peroperative complications occurred. AIP residual recurred in one patient after a subsequent pregnancy and was successfully treated using the same procedure. CONCLUSIONS: AIP residual is a rare condition. Management by hysteroscopic resection using bipolar energy is save and feasible. [less ▲]

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See detailHypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation.
Coudyzer, Pauline; Lemoine, Pascale; Jordan, Benedicte F. et al

in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2013), sous presse

Menstrual endometrial breakdown induced by estradiol and progesterone withdrawal is regularly attributed to vasospasm of spiral arteries causing ischemia and hypoxia. We investigated whether hypoxia ... [more ▼]

Menstrual endometrial breakdown induced by estradiol and progesterone withdrawal is regularly attributed to vasospasm of spiral arteries causing ischemia and hypoxia. We investigated whether hypoxia actually occurred in an in vivo model of menstruation. Three complementary approaches were used to look for signs of hypoxia in fragments of human functionalis xenografted to ovariectomized immunodeficient mice bearing pellets-releasing estradiol and progesterone, and then deprived of ovarian steroids. Hormone withdrawal 21 d after grafting induced menstrual breakdown and MMP expression within 4 d. Local partial oxygen pressure (pO2) was measured by electron paramagnetic resonance using implanted lithium phtalocyanine crystals. In mice with hormone maintenance until sacrifice, pO2 was low one week after grafting (14.8+/-3.4 mmHg) but increased twofold from the second week when tissue was largely revascularized. After 3 wk, pO2 was not modified by hormone withdrawal but was slightly increased on hormone reimpregnation 4 d after removal (34.7+/-6.1 mmHg) by comparison with hormone maintenance (27.1+/-8.6 mmHg). These results were confirmed using fluorescence quenching-based OxyLite measurements. In a further search for signs of hypoxia, we did not find significant HIF1-alpha immunostaining, nor pimonidazole adducts after hormone withdrawal. We conclude that hypoxia is not needed to trigger menstrual-like tissue breakdown or repair in human endometrial xenograft.-Coudyzer, P., Lemoine, P., Jordan, B. F., Gallez, B., Galant, C., Nisolle, M., Courtoy, P. J., Henriet, P., and Marbaix, E. Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation. [less ▲]

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See detailIsoform 111 of vascular endothelial growth factor (VEGF111) improves angiogenesis of ovarian tissue xenotransplantation
Labied, Soraya ULg; Delforge, Yves ULg; Munaut, Carine ULg et al

in Transplantation (2013), 95(3), 426-433

Background: Cryopreservation of cortex ovarian tissue before anti-cancer therapy is a promising technique for fertility preservation mainly in children and young women. Ischemia in the early stage after ... [more ▼]

Background: Cryopreservation of cortex ovarian tissue before anti-cancer therapy is a promising technique for fertility preservation mainly in children and young women. Ischemia in the early stage after ovarian graft causes massive follicle loss by apoptosis. VEGF111 is a recently described VEGF isoform that does not bind to the extracellular matrix, diffuse extensively and is resistant to proteolysis. These properties confer a significantly higher angiogenic potential to VEGF111 in comparison to the other VEGF isoforms. Methods: We evaluated the morphology of cryopreserved sheep ovarian cortex, grafted in the presence or absence of VEGF111. Ovarian cortex biopsies were embedded in type I collagen with or without VEGF111 addition before transplantation to SCID mice ovaries. Transplants were retrieved 3 days or 3 weeks later. Follicular density, vasculature network, haemoglobin content and cell proliferation were analysed. Results: Addition of VEGF111 increased density of functional capillaries (p=0.01) 3 days after grafting. By double immunostaining of Ki-67 and von Willebrand Factor (vWF) we demonstrated that proliferating endothelial cells were found in 83% of the VEGF111 group when compared to 33% in the control group (p=0.001). This angio-stimulation was associated with a significant enhancement of haemoglobin content (p=0.03). Three weeks after transplantation, the number of primary follicles was significantly higher in VEGF111 grafts (p=0.02). Conclusion: VEGF111 accelerates blood vessels recruitment, functional angiogenesis and improves the viability of ovarian cortex by limiting ischemia and ovarian cortex damage. [less ▲]

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See detailAn overview of new surgical options in the management of menometrorrhagia
Nisolle, Michelle ULg

Conference (2012, October 09)

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See detailCumulative pregnancy rate after ICSI-IVF in patients with colorectal endometriosis: results of a multicentre study.
Ballester, Marcos; d'Argent, EM; Morcel, K et al

in Human Reproduction (2012), 27(4), 1043-9

BACKGROUND: There is currently no consensus about indications for surgery for infertility associated with colorectal endometriosis. The aim of this study was to evaluate cumulative pregnancy rates (CPRs ... [more ▼]

BACKGROUND: There is currently no consensus about indications for surgery for infertility associated with colorectal endometriosis. The aim of this study was to evaluate cumulative pregnancy rates (CPRs) after ICSI-IVF cycles in patients with colorectal endometriosis and to identify determinant factors of fertility outcome. METHODS: Prospective longitudinal multicentre study from January 2005 to June 2011. We included 75 patients with colorectal endometriosis and proved infertility without prior surgery for deep infiltrating endometriosis. Univariable analysis was used to identify determinant factors of pregnancy rate. CPR was calculated using cumulative-incidence methods from log-rank test and Kaplan-Meier curves. For multivariable analysis, Cox proportional hazards model was used. RESULTS: For CPR per patient analysis, the total number of cycles was 113 and the median number of cycles per patient was 1 (range: 1-3). In the whole population the CPR per patient after three ICSI-IVF cycles was 68.6%. The CPR for patients with or without associated adenomyosis was 19 and 82.4%, respectively (P= 0.01). In addition, a patient age over 35 years (P= 0.02) and anti-Mullerian hormone serum level under 2 ng/ml (P= 0.02) were associated with a decreased CPR per patient. At multivariable analysis, adenomyosis [HR = 0.34, 95% CI (0.12-0.99), P= 0.49] was associated with a decreased CPR. CONCLUSIONS: Our data confirm that ICSI-IVF offers a high CPR per patient. However, determinant factors of CPR should be taken into account when informing couples of their options. [less ▲]

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See detailIndividual decisions in placenta increta and percreta: a case series.
CHANTRAINE, Frédéric ULg; NISOLLE, Michelle ULg; PETIT, Philippe ULg et al

in Journal of Perinatal Medicine (2012), 40(3), 265-70

Abstract Objective: Placenta increta or percreta is an uncommon pathology, sometimes associated with high maternal morbidity. Its prevalence increases proportionally to the number of cesarean sections ... [more ▼]

Abstract Objective: Placenta increta or percreta is an uncommon pathology, sometimes associated with high maternal morbidity. Its prevalence increases proportionally to the number of cesarean sections. This study analyzed the changes of our management strategy to devise treatment guidelines for this uncommon disorder. Materials and methodology: Between 2005 and 2011, 10 cases of placenta increta or percreta were managed at our university hospital maternity department. Results: Among the 10 cases, seven were diagnosed prenatally. Two patients were diagnosed early, at 14 and 17 weeks of gestational age, and their pregnancies were terminated. Five had hysterectomies during the intrapartum period, and despite attempted conservative treatment for the two others, hysterectomy proved necessary 2 months postpartum because of intrauterine infections. Seven of the 10 women had hysterectomies. Conclusion: Prenatal diagnosis of placenta increta or percreta is essential to plan the delivery in a competent tertiary care center. The decision to perform a cesarean hysterectomy or leave the placenta in situ for spontaneous delivery is based on the extent of infiltration, the patient's hemodynamic status, and her desire to remain fertile. The high-risk of infection and severe hemorrhage must not be overlooked should conservative treatment be chosen. This situation requires prolonged close monitoring. [less ▲]

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See detailInsuffisance ovarienne prématurée : de la génétique à la clinique
Rege, G; Foidart, Jean-Michel ULg; NISOLLE, Michelle ULg et al

in Revue Médicale de Liège (2012), 67(7-8), 413-419

L’Insuffisance Ovarienne Prématurée (IOP) est une pathologie dont la présentation clinique est complexe. Elle survient chez 1% des femmes avant 40 ans, 0,1% avant 30 ans. Les causes sont multiples : les ... [more ▼]

L’Insuffisance Ovarienne Prématurée (IOP) est une pathologie dont la présentation clinique est complexe. Elle survient chez 1% des femmes avant 40 ans, 0,1% avant 30 ans. Les causes sont multiples : les anomalies génétiques, les maladies auto-immunes, les atteintes ovariennes iatrogènes secondaires à la chirurgie, radiothérapie, chimiothérapie, aux facteurs environnementaux tels que les virus, les toxines, le tabac, et aux facteurs métaboliques. Cependant, dans la majorité des cas, l’étiologie de l’IOP est idiopathique. [less ▲]

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See detailIsoform 111 of vascular endothelial growth factor (VEGF111) improves angiogenesis of ovarian tissue xenotransplantation
Labied, Soraya ULg; Delforge, Yves ULg; Blacher, Silvia ULg et al

in Journal of Assisted Reproduction & Genetics (2012), 28(11), 1009

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See detailDoes vascular endothelial growth factor improve ovarian tissue recovery after cryopreservation?
Henry, Laurie ULg; Fransolet, Maïté ULg; Labied, Soraya ULg et al

in Giornale italiano di obstetricia e gynecologia (2012)

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See detailEndométriose : pourquoi se développe-telle ?
BELIARD, Aude ULg; Foidart, Jean-Michel ULg; Nisolle, Michelle ULg

in Références en Gynécologie Obstétrique (2012), 14

Endometriosis is an estrogen-dependent disorder that can result in substantial morbidity, including multiple operations, and pelvic pain. New findings on the genetics, the possible roles of the ... [more ▼]

Endometriosis is an estrogen-dependent disorder that can result in substantial morbidity, including multiple operations, and pelvic pain. New findings on the genetics, the possible roles of the environment, the immune system, and the inflammation have given insight into the pathogenesis of this disorder and serve as the background for new treatments and new diagnostic approach. [less ▲]

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See detailUna panoramica sulle nuove opzioni chirurgiche nella gestione della menometrorragia
Nisolle, Michelle ULg

in Novità nella gestione medico-chirurgica della menometrorragia (2012)

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See detailLe role de la genetique et de l'environnement dans le developpement de l'endometriose.
Ballester, M.; Dehan, Pierre ULg; BELIARD, Aude ULg et al

in Revue Médicale de Liège (2012), 67(5-6), 374-80

Endometriosis is usually described as a complex multifactorial disease involving dysregulation of estrogen metabolism, inflammatory and immunological mechanisms. Recently, many authors have questioned the ... [more ▼]

Endometriosis is usually described as a complex multifactorial disease involving dysregulation of estrogen metabolism, inflammatory and immunological mechanisms. Recently, many authors have questioned the environmental pollution and toxins in the formation and development of endometriotic lesions. Therefore, while dioxins and PCBs have been implicated, insufficient data are available until now to confirm this theory. Endometriosis has also been considered as a genetic disease. Indeed, early familial aggregation and twin studies noted a higher risk of endometriosis among relatives. However, demonstration of a genetic component in the pathogenesis of such a multifactorial disease is quite difficult due to many limitations such as ethnic differences, involvement of environmental factors and size of needed patients cohorts. Over the last decade, the epigenetic approach (DNA methylation, histones modifications and microRNA) has allowed to consider many new perspectives. Indeed, dysregulation (hyper- or hypomethylation) of many genes has already been highlighted. This method of analysis is the subject of numerous studies in order to develop diagnostic, prognostic and therapeutic tools for this disease which is becoming a real public health problem. [less ▲]

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See detailLE CAS CLINIQUE DU MOIS Cas rare d’endométriose urétérale neuf ans après une hystérectomie
Bawin, I; Troisfontaines, E; Nisolle, Michelle ULg

in Revue Médicale de Liège (2012), 67

Ureteral endometriosis is a rare entity, espe- cially when it occurs in the postmenopausal period. In certain circumstances, this severe disease can cause obstruction, leading to ureterohydronephrosis and ... [more ▼]

Ureteral endometriosis is a rare entity, espe- cially when it occurs in the postmenopausal period. In certain circumstances, this severe disease can cause obstruction, leading to ureterohydronephrosis and, finally, to a progressive and often silent loss of renal function. The symptomatology is variable and non specific, making pre- operative diagnosis difficult. The treatment is mainly surgical. Its aim is the relief of obstruction to preserve the renal function. We report the case of a 39 year old patient, hysterect- omised for endometriosis nine years earlier, who developed a recurrence demonstrated by ureteral endometriosis and revealed by ureterohydronephrosis. Robot-assisted lapa- roscopic ureterolysis allowed a complete resection of the lesion and resolved the obstruction. No recurrence of ure- terohydronephrosis was found at the fifth and ninth postop- erative month ultrasonographic controls. [less ▲]

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