References of "Melin, Pierrette"
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See detailDiagnosis and Screening for Cytomegalovirus Infection in Pregnant Women in Cuba as Pronostic Markers of Congenital Infection in Newborns: 2007-2008
Kouri, Vivian; Correa, Consuelo B; Verdasquera, Denis et al

in The Pediatrics Infectious Disease Journal (2010), 29(12), 1105-1110

Background: Human cytomegalovirus (HCMV) has established itself as the most significant cause of congenital infection in the developed world. The objective of this research was prenatal identification of ... [more ▼]

Background: Human cytomegalovirus (HCMV) has established itself as the most significant cause of congenital infection in the developed world. The objective of this research was prenatal identification of pregnant women at risk for developing active infection due to HCMV as well as to diagnose congenitally infected newborns. Methods: A diagnostic algorithm based on specific immunoglobulin G (IgG), IgM, and, IgG avidity was used to screen serum from 1131 pregnant women enrolled prospectively from 3 municipalities from Havana City, Cuba during 2007–2008. Qualitative multiplex nested PCR and quantitative real time-based PCR testing for HCMV DNA were performed on urine and saliva specimens from women detected with active infection and from their newborns. Results: Most women were seropositive to HCMV (92.7%), with 2.38% (27 women) having active infection. Primary infection was detected in 20 pregnant women (1.77%) while 7 patients (0.62%) had active nonprimary infection. HCMV DNA was detected in specimens from 9 of the 27 pregnant women by both PCR methods. HCMV congenital infection was diagnosed in 12 (1.06%) of the 26 live children born from 25 mothers with active infection, for a vertical transmission rate of 46.2%. Two fetal deaths were reported from 2 women with active infection; furthermore 2 newborns were symptomatic at birth and 2 showed sequelae during the follow-up done until 6 months age. Conclusions: Mothers with active infection during the pregnancy and with HCMV excretion had significant risks, RR = 1.16 and RR = 1.35, respectively, to have congenitally infected children. [less ▲]

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See detailEUCAST et stratégie antibiotique: impact en pneumologie
Melin, Pierrette ULg

Conference (2010, November 08)

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See detailFilamentous fungi recovered from the water distribution system of a Belgian university hospital
Hayette, Marie-Pierre ULg; Christiaens, Geneviève ULg; Mutsers, Jacques ULg et al

in Medical Mycology (2010), 48(7), 969-974

A study was carried out over a 4-month winter period in order to assess the presence of filamentous fungi in the water distribution system of the University Hospital of Liège. A total of 197 hot and cold ... [more ▼]

A study was carried out over a 4-month winter period in order to assess the presence of filamentous fungi in the water distribution system of the University Hospital of Liège. A total of 197 hot and cold water samples were collected from the main water supply lines and from the taps at three different hospital sites. Overall, filamentous fungi were recovered from 55% and 50% of the main water distribution system and tap water samples, respectively, with a mean of 3.5 ± 1.5 colony forming units per 500 ml water. Nine different genera were identified, all belonging to the Hyphomycetes class. Aspergillus spp. were recovered from 6% of the samples of the water distribution system and A. fumigatus was the most frequently recovered species (66.6%). However, this species was not isolated from water taps. Fusarium spp. was predominant at one site, where it was found in 28% of tap water samples. No Aspergillus spp. but some Fusarium spp. isolates were identified in samples collected from high-risk units. Filters were introduced at the point-of-use in the haematology unit after completion of the study. The findings of the present study confirm the need for further documented studies to evaluate the safety of the hospital water system and to define new preventive measures. [less ▲]

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See detailHCMV seroprevalence and associated risk factors in pregnat women, Havana City, 2007 to 2008
Correa, C. B.; Kouri, V.; Verdasquera, D. et al

in Prenatal Diagnosis (2010), 30(9), 888-92

Objective To prenatally identify pregnant women at risk of developing congenital infection due to human cytomegalovirus (HCMV). Methods One thousand one hundred and thirty-one pregnant women from three ... [more ▼]

Objective To prenatally identify pregnant women at risk of developing congenital infection due to human cytomegalovirus (HCMV). Methods One thousand one hundred and thirty-one pregnant women from three municipalities from Havana City were serologically screened for HCMV infection (IgM/IgG, IgG avidity) from January 2007 to January 2008. Demographical, epidemiological, and clinical variables were correlated to serologic status to identify predictors of seroconversion in pregnancy. Results The majority of women were seropositive to HCMV (92.6%); 27 women (2.4%) developed HCMV active infection during pregnancy, defined by the detection of IgG+ and IgM+ (7 women), IgM+ and IgG− (2 women), and IgG seroconversion (18 women). Susceptibility of active HCMV infection during pregnancy was associated with maternal age <20 years and nulligravidity. Primary infection was detected in 20 pregnant women (1.8%), whereas 7 patients (0.6%) had active non-primary infection. Conclusion Although pregnant women in Cuba have high seroprevalence rates for HCMV, those younger than 20 years and nulligravidae are at risk of acquiring infection during pregnancy. [less ▲]

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See detailAntibiotic consumption and bacterial resistance
ZAOUI, Kuider; MELIN, Pierrette ULg; CHRISTIAENS, Geneviève ULg et al

in Newsletter SIZ, special issue, abstracts Spring Meeting (2010, June 25)

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See detailGroup B streptococcal Screening, Diagnosis and Clinically Relevant Resistance
Melin, Pierrette ULg

Conference (2010, June 17)

In the setting of a maternal GBS-screening program and successful implementation of the strategy, efforts to improve screening for GBS status remain important. Critical factors that influence the accuracy ... [more ▼]

In the setting of a maternal GBS-screening program and successful implementation of the strategy, efforts to improve screening for GBS status remain important. Critical factors that influence the accuracy of detecting GBS maternal colonization are the choice of culture media, the body sites sampled, and the timing of sampling. The evolution of the different culture options to improve the GBS-screening strategy will be reviewed. Despite efforts related to sampling and culture procedures, false-negative GBS-screening contributing to continuing EOGBS cases and false-positive screening leading to unecessary IAP, occur. As GBS carriage is highly variable, the predictive values of GBS antenatal cultures are not always good predictors of the maternal GBS status at presentation for delivery. Rapid non-cultural GBS screening methods have been developed: antigenic tests are not sensitive enough to replace antenatal screening cultures but available real-time PCR have faired better in the detection of GBS. Real-time PCR tests could improve effectiveness of the screening-based strategy and lead to a further reduction of the incidence of EOGBS disease. However questions of costs and logistics remain unanswered. Either for therapy or for intrapartum chemoprophylaxis, penicillin G for its bactericidal activity and narrow spectrum, remains the agent of choice. But in the true penicillin allergic patients, clindamycin or erythromycin have been recommended as alternative drugs. However, probably as a consequence of the important use of macrolides, related drug resistance among streptococcal isolates is currently recognized in many countries. Epidemiology of resistance to antimicrobial agents will be presented. [less ▲]

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See detailComparative studies for the serodiagnosis of Chlamydophila and Mycoplasma pneumoniae infections
Huynen, Pascale ULg; Goebel, Marie-Rose ULg; Meex, Cécile ULg et al

in ESCMID (Ed.) Abstract book of the 20th ECCMID (2010, April)

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See detailEUCAST et stratégie antibiotique
MELIN, Pierrette ULg

Conference (2010, February 09)

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See detailThe Sanford Guide to Antimicrobial Therapy 22nd edition of the Belgian/Luxembourg Version 2010-2011
independent Belgian/Luxembourg Working Party on Antimicrobial Therapy, SBIMC-BVIKM; MELIN, Pierrette ULg

Book published by SBIMC-BVIKM - Adapted for use by the medical profession in Belgium and Luxembourg by the independent Belgian/Luxembourg Working Party on Antimicrobial Therapy (2010)

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See detailSpectrométrie de masse MALDI-TOF en bactériologie clinique ou comment identifier une bactérie en une minute
Descy, Julie ULg; Meex, Cécile ULg; Melin, Pierrette ULg et al

in Revue Médicale de Liège (2010), 65(Suppl. Synthèse 2010), 29-34

The major application of MALDI-TOTOF mass spectrometry in clinical microbiology is the bacterial identification based on the analysis of all their proteins (ribosomal and membrane-associated proteins ... [more ▼]

The major application of MALDI-TOTOF mass spectrometry in clinical microbiology is the bacterial identification based on the analysis of all their proteins (ribosomal and membrane-associated proteins). This technology allows the identification of most of bacteria within a few minutes. The method is fast, accurate, reliable and cost-effective by comparison to conventional phenotypic techniques. Other applications of MALDI-TOF mass spectrometry are still under development, as the detection of bacterial toxins or resistance mechanisms to antimicrobial agents. [less ▲]

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See detailEUCAST Recommandations: Practical aspects
Melin, Pierrette ULg

Conference (2009, November 26)

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See detailEUCAST: Disk Diffusion Testing
MELIN, Pierrette ULg

Conference (2009, November 17)

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See detailHigh incidence of invasive group B streptococcal infections in uninfected infants born to HIV-1 mothers
Epalza, C.; Goetghebuer, T.; Hainaut, M. et al

Poster (2009, June)

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See detailGBS Training Course Specimen collection and culture procedure
Melin, Pierrette ULg

Scientific conference (2009, May 29)

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